Search Genes Search miRNAs Search Pathways API Download Statistics Documentation Publications Team Bug reporting

Welcome

pathDIP is an annotated database of signaling cascades, comprising core pathways from major curated pathways databases, and extended pathways predicted by using physical protein interactions. Data integration and predictions increase coverage of pathway annotations for protein-coding genes to 90%, and provide novel annotations for 5,402 pathway orphans. pathDIP annotates 18,038 protein-coding genes with 4968 pathways, and provides multiple query, analysis and output options.


Please cite the following paper for this database:

Rahmati, S., Abovsky, M., Pastrello, C., Jurisica, I. pathDIP: An annotated resource for known and predicted human gene-pathway associations and pathway enrichment analysis. Nucl Acids Res 45(D1): D419-D426, 2017. WEB , PDF


Jurisica Lab , Krembil Research Institute
(some other lab projects)

- Integrated Interactions Database: Search Tissue specific protein interactions across species.

- Data Visualization and analysis with NAViGaTOR: Scalable network visualization and visual data mining graphic tool powered by OpenGL.

- SCRIPDB: Search for molecules across US Patents.

- NetwoRx: A database for linking drugs to pathways and networks.


Please enter one or more proteins/genes.    

You can search for known pathway memberships or predicted pathway associations.
Please select the set of annotations and the significance threshold:


IDs  


Hint: Separate IDs by: New Line, Semicolon, Comma, Space and Tab.


Hint: IDs Type auto-detection works at a search/save till it first time corrected manually. Click 'Clear' button to reset auto detection.

Pathway sources:
BioCartaEHMNHumanCyc
INOHIPAVSKEGG
NetPathOntoCancroPharmGKB
PIDRB-PathwaysReactome
stkesystems-biology.orgSignalink
SIGNORSMPDBSpike
UniProt_PathwaysWikiPathways
 
Literature curated (core) pathway memberships
Extended pathway associations
Integrate core pathways with:
- Protein interaction set:
- Minimum confidence level for predicted associations:





Hint: p-values smaller than 2.2e-160 are rounded to 0.



All contents copyright © Jurisica Lab, Krembil Research Institute, The University Health Network, Toronto, Canada. Last modified Oct. 2018, version 3.0.29.2 (Database version 3.0.0.3)