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Documentation

2. Number of orthologous pathways per species

3. Protein-protein interaction sources

PathDIP data sources

1. Pathway Sources

Source	Downloaded from	Citation	Organisms	Metabolites
ACSN2	ACSN2	http://doi.org/10.1038/oncsis.2015.19	Hs	No
BioCarta	MSigDB	http://doi.org/10.1089/152791601750294344	Hs	No
HumanCyc*	PathwayCommons	http://doi.org/10.1093/bib/bbx085	Hs	No
KEGG	CPDB	http://doi.org/10.1093/nar/gkaa970	Hs, Mm, Sc	Yes
MetabolicAtlas	MetabolicAtlas	https://doi.org/10.1073/pnas.2102344118	Hs, Ce, Dm, Mm, Rn, Sc	Yes
Panther	Panther	http://doi.org/10.1002/pro.4218	Hs, Bt, Ce, Cf, Dm, Ec, Gg, Mm, Rn, Sc, Ss	No
PathBank	PathBank	https://doi.org/10.1093/nar/gkz861	Hs, Bt, Ce, Dm, Mm, Rn, Sc	Yes
PharmGKB	PharmGKB	https://doi.org/10.1002/cpt.2350	Hs	Yes
Reactome	Reactome	https://doi.org/10.1093/nar/gkab1028	Hs, Bt, Ce, Cf, Dm, Gg, Mm, Rn, Sc, Ss	Yes
SIGNOR 2.0	SIGNOR	http://doi.org/10.1093/nar/gkac883	Hs	Yes
UniProt.Pathways	UniProt	https://doi.org/10.1093/nar/gkac1052	Hs, Bt, Ce, Cf, Cp, Dm, Ec, Gg, Mm, Oa, Oc, Rn, Sc, Ss	No
WikiPathways	WikiPathways	https://doi.org/10.1093/nar/gkaa1024	Hs, Bt, Ce, Cf, Dm, Ec, Gg, Mm, Rn, Sc, Ss	No

Hs = Homo sapiens, Bt = Bos taurus, Ce = Caenorhabditis elegans, Cf = Canis lupus familiaris, Cp = Cavia porcellus, Dm = Drosophila melanogaster, Ec = Equus caballus, Gg = Gallus gallus, Mm = Mus musculus, Oa = Ovis aries, Oc = Oryctolagus cuniculus, Rn = Rattus Norvegicus, Sc = Saccharomyces cerevisiae, Ss = Sus scrofa

2. Number of orthologous pathways per species

*Human_Source*	Cat	Chicken	Cow	Dog	Duck	Fly	Guinea_pig	Horse	Mouse	Pig	Rabbit	Rat	Sheep	Turkey	Worm	Yeast
*ACSN2*	93	94	94	94	93	58	93	93	94	93	94	94	93	92	55	43
*BioCarta*	292	288	292	292	286	107	292	292	292	292	292	292	292	283	72	22
*HumanCyc*	116	109	118	111	98	39	122	118	118	118	108	116	113	104	33	27
*KEGG*	330	329	330	330	328	282	331	329	338	329	330	331	330	328	263	179
*MetabolicAtlas*	122	120	120	121	120	121	122	121	129	119	119	128	118	118	123	97
*Panther_Pathway*	127	122	136	129	123	126	126	126	141	126	123	138	125	122	118	112
*PathBank*	950	924	965	957	917	435	955	957	971	958	955	969	947	921	297	352
*PharmGKB*	75	70	80	83	61	17	77	82	79	78	78	78	78	62	14	4
*REACTOME*	2116	2185	2176	2161	1997	1699	2130	2116	2185	2177	2053	2159	2089	1993	1200	1043
*SIGNOR 3.0*	95	93	95	94	94	42	95	94	94	95	94	94	92	92	26	5
*UniProt_Pathways*	74	76	101	70	63	40	80	75	144	78	67	118	70	63	47	93
*WikiPathways*	752	746	818	758	733	444	753	755	832	752	747	802	749	730	410	282

3. Protein-protein interaction sources

*Data type*	Sources
Database		Paper	Species	Interactions
Database		Paper	Species	Experimental	Orthologous	Predicted
Integrated Interactions Database version 2021-05		doi: 10.1093/nar/gkab1034	Cat	0	485,012	0
			Chicken	463	364,324	0
			Cow	667	469,632	0
			Dog	148	441,618	0
			Duck	0	326,331	0
			Fly	79,870	75,384	0
			Guinea pig	1	475,132	0
			Horse	5	485,245	0
			Human	560,628	92,600	660,503
			Mouse	75,145	476,147	0
			Pig	1	475,132	0
			Rabbit	159	361,778	0
			Rat	8,706	452,634	0
			Sheep	7	402,467	0
			Turkey	2	302,186	0
			Worm	33,379	70,357	0
			Yeast	165,443	17,270	0