| Interacting proteins: Q9Y4H2 and Q07817 |
Pubmed |
SVM Score :0.0 |
| IRS 2 but not IRS 3 binds to Bcl 2 , and IRS 1 associates with Bcl XL but not with Bax or Bik . ^^^ |
|
| Interacting proteins: Q9Y4H2 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Prolonged insulin treatment ( 24 hours ) increased expression of antiapoptotic genes ( Bcl xL ) , downregulated proapoptotic genes ( Bim and nuclear Foxo 1 ) , and decreased caspase 3 activity in wild type hepatocytes but not in IRS 2 ( / ) cells . ^^^ |
|
| Interacting proteins: Q9Y4H2 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Our results indicated : ( a ) out of four tested anti IRS 1 siRNAs , two siRNAs reduced IRS 1 protein by approximately three fold in both growing and IGF 1 stimulated cells without affecting a closely related protein , IRS 2 ; ( b ) these effects paralleled IRS 1 mRNA downregulation by approximately three fold , measured by quantitative real time polymerase chain reaction ; ( c ) action of anti IRS 1 siRNAs induced the apoptotic response , observed by altered mitochondrial membrane potential coupled with downregulation of NF kappaB target Bcl xL and reduced cell viability ; ( d ) anti IRS 1 siRNA treatment enhanced the cytotoxic effects of TAM by approximately 20 % . ^^^ |
|
| Interacting proteins: Q9Y4H2 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|