What is I2D?
I2D (Interologous Interaction Database) is an on-line database of known and predicted mammalian and eukaryotic protein-protein interactions.
What makes I2D different from other interaction databases?a) It has been built by mapping high-throughput (HTP) data between species. Thus, until experimentally verified, these interactions should be considered "predictions".
b) It remains one of the most comprehensive sources of known and predicted eukaryotic PPI.
How can I access I2D?I2D is searchable via a web interface here or can be downloaded in its entirety here.
What model organism data will I find in I2D?I2D includes data for S. cerevisiae, C. elegans, D. melonogaster, R. norvegicus, M. musculus, and H. sapiens. For complete information on data sources and references, refer to the statistics page.
What external databases are included into I2D?| I2D Version | I2D Release Date | External Database | Build | Species |
| 1.0 | 4/3/05 | Entrez Gene | 2005-03-31 | All I2D species |
| SWISSPROT | 45.0 | All I2D species | ||
| UNIGENE | Hs.166 | H. sapiens | ||
| UNIGENE | Mm.134 | M. musculus | ||
| 1.001 | 9/19/05 | Entrez Gene | 2005-09-19 | All I2D species |
| SWISSPROT | 45.0 | All I2D species | ||
| UNIGENE | Hs.166 | H. sapiens | ||
| UNIGENE | Mm.134 | M. musculus | ||
| 1.002 | 3/6/06 | Entrez Gene | 2006-03-06 | All I2D species |
| SWISSPROT | 45.0 | All I2D species | ||
| UNIGENE | Hs.166 | H. sapiens | ||
| UNIGENE | Mm.134 | M. musculus | ||
| 1.5 | 4/1/07 | Entrez Gene | 2007-02-08 | All I2D species |
| SWISSPROT | 51.5 | All I2D species | ||
| UNIGENE | Hs.199 | H. sapiens | ||
| UNIGENE | Mm.161 | M. musculus | ||
| UNIGENE | Rn.161 | R. norvegicus | ||
| 1.7 | 11/2/07 | Entrez Gene | 2007-02-08 | All I2D species |
| IPI | 3.36 | H. sapiens, M. musculus, R. norvegicus | ||
| SWISSPROT | 51.5 | All I2D species | ||
| UNIGENE | Hs.199 | H. sapiens | ||
| UNIGENE | Mm.161 | M. musculus | ||
| UNIGENE | Rn.161 | R. norvegicus | ||
| 1.71 | 1/24/08 | Entrez Gene | 2007-02-08 | All I2D species |
| IPI | 3.36 | H. sapiens, M. musculus, R. norvegicus | ||
| SWISSPROT | 51.5 | All I2D species | ||
| UNIGENE | Cel.37 | All I2D species | ||
| UNIGENE | Dm.54 | D. melanogaster | ||
| UNIGENE | Hs.208 | H. sapiens | ||
| UNIGENE | Mm.167 | M. musculus | ||
| UNIGENE | Rn.169 | R. norvegicus | ||
| 1.72 | 12/15/09 | Entrez Gene | 2007-02-08 | All I2D species |
| IPI | 3.36 | H. sapiens, M. musculus, R. norvegicus | ||
| SWISSPROT | 51.5 | All I2D species | ||
| UNIGENE | Cel.37 | All I2D species | ||
| UNIGENE | Dm.54 | D. melanogaster | ||
| UNIGENE | Hs.208 | H. sapiens | ||
| UNIGENE | Mm.167 | M. musculus | ||
| UNIGENE | Rn.169 | R. norvegicus | ||
| 1.8 | 4/23/10 | Entrez Gene | 2010-01-05 | All I2D species |
| IPI | 3.57 | H. sapiens, M. musculus, R. norvegicus | ||
| SWISSPROT | 57.15 | All I2D species | ||
| UNIGENE | Cel.45 | All I2D species | ||
| UNIGENE | Dm.64 | D. melanogaster | ||
| UNIGENE | Hs.208 | H. sapiens | ||
| UNIGENE | Mm.181 | M. musculus | ||
| UNIGENE | Rn.181 | R. norvegicus | ||
| 1.9 | 12/21/10 | Entrez Gene | 2010-01-05 | All I2D species |
| IPI | 3.57 | H. sapiens, M. musculus, R. norvegicus | ||
| SWISSPROT | 57.15 | All I2D species | ||
| UNIGENE | Cel.45 | All I2D species | ||
| UNIGENE | Dm.64 | D. melanogaster | ||
| UNIGENE | Hs.208 | H. sapiens | ||
| UNIGENE | Mm.181 | M. musculus | ||
| UNIGENE | Rn.181 | R. norvegicus | ||
| 2.0 | 2/2/12 | Entrez Gene | 2013-01-07 | All I2D species |
| IPI | 3.87 | H. sapiens, M. musculus, R. norvegicus | ||
| SWISSPROT | 2011_1 | All I2D species | ||
| UNIGENE | Cel.51 | All I2D species | ||
| UNIGENE | Dm.72 | D. melanogaster | ||
| UNIGENE | Hs.232 | H. sapiens | ||
| UNIGENE | Mm.192 | M. musculus | ||
| UNIGENE | Rn.191 | R. norvegicus | ||
| 2.3 | 11/26/13 | Entrez Gene | 2013-03-18 | All I2D species |
| IPI | 3.87 | H. sapiens, M. musculus, R. norvegicus | ||
| SWISSPROT | 2013_04 | All I2D species | ||
| UNIGENE | Cel.52 | All I2D species | ||
| UNIGENE | Dm.73 | D. melanogaster | ||
| UNIGENE | Hs.235 | H. sapiens | ||
| UNIGENE | Mm.193 | M. musculus | ||
| UNIGENE | Rn.194 | R. norvegicus | ||
| 2.9 | 7/10/15 | Entrez Gene | 2015-03-19 | All I2D species |
| IPI | 3.87 | H. sapiens, M. musculus, R. norvegicus | ||
| SWISSPROT | 2015_03 | All I2D species | ||
| UNIGENE | Cel.52 | All I2D species | ||
| UNIGENE | Dm.75 | D. melanogaster | ||
| UNIGENE | Hs.236 | H. sapiens | ||
| UNIGENE | Mm.194 | M. musculus | ||
| UNIGENE | Rn.195 | R. norvegicus |
