| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation Western blotting experiments showed that phosphorylation levels of IL 4Ralpha , Janus kinase 1 , insulin receptor substrate 1 , and insulin receptor substrate 2 , factors with molecular mass close to the observed 130 kDa major phosphorylation band , increased in response to the combined CD 40 ligation and IL 4 action . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that the Janus kinases , JAK 1 and JAK 3 , associate with IRS 1 and IRS 2 in T cells . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that , in addition to activation of the Jak 1 and Jak 3 kinases , IL 7 stimulation of human thymocytes results in the rapid tyrosine phosphorylation of insulin receptor substrate 1 ( IRS 1 ) and IRS 2 proteins . ^^^ We show that the Jak 1 and Jak 3 kinases are associated with both IRS 1 and IRS 2 in thymocytes . ^^^ This study suggests that IL 7R signaling diverges at the level of the IRS 1 and IRS 2 proteins , possibly with the two branches regulated by Jak 3 and Jak 1 activities , respectively . . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| S , conferred the ability to grow continuously in response to IL 13 ; to respond to IL 13 with tyrosine phosphorylation of JAK 1 , Tyk 2 , IL 4Ralpha , IRS 2 , and STAT 6 ; and to respond to IL 4 with tyrosine phosphorylation of Tyk 2 in addition to those induced in parental cell lines . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| We stimulated C2C12 myotubes with insulin ( 100 nmol / l , 5 min ) or leptin ( 0 . 62 nmol / l , 10 min ) and determined PI 3 kinase activity in immunoprecipitates with specific non crossreacting antibodies against insulin receptor substrate ( IRS 1 / IRS 2 ) and against janus kinase ( JAK 1 and JAK 2 ) . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| Binding of interleukin ( IL ) 4 to its transmembrane receptor results in the Jak mediated tyrosine phosphorylation of a number of protein components of the IL 4 signaling cascade , including Jak 1 , Jak 2 , Jak 3 , Tyk 2 , IL 4Ralpha , IRS 1 , IRS 2 , and Stat 6 in appropriate cell types . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| In vitro analyses using synthetic peptides of this region showed that the tyrosine kinase Janus kinase 1 ( JAK 1 ) , as well as IRS 1 and IRS 2 bind to the I4R motif irrespective of the polymorphism or a tyrosine phosphorylation . ^^^ In vivo immunoassays using T cells of four different groups of individuals ( S503 / Q576 ; P503 / Q576 ; S503 / R576 ; P503 / R576 ) revealed that only in case of both polymorphisms the phosphorylation of IRS 1 and IRS 2 , but not JAK 1 was increased . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| Treatment with H 7 did not affect IL 4R mediated immediate signaling events such as tyrosine phosphorylation of Jak 1 , Jak 3 , insulin receptor substrate ( IRS ) 1 and IRS 2 , or tyrosine phosphorylation and DNA binding of Stat 6 . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| Jak 1 , Tyk 2 and IRS 2 signals were reduced after IL 13 stimulation in Q 551 individuals . ^^^ SHP 1 seems to be predominately activated by IL 4 and to influence the PI 3 kinase , in contrast , SHP 2 seems to be predominately activated by IL 13 and to influence Jak 1 , Tyk 2 and IRS 2 . ^^^ |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4H2 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|