| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.67249017 |
| By immunoprecipitation and GST pull down , we show that DNMT3B interacts with HDAC 1 , HDAC 2 , HP 1 proteins , Suv39h1 , and the ATP dependent chromatin remodeling enzyme hSNF2H . 0.67249017^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.63910859 |
| The Dnmt3b mediated differentiation was attributed to its N terminal domain , which recruits histone deacetylase 2 ( Hdac 2 ) , as demonstrated by ( 1 ) impeding of differentiation by the Hdac inhibitors , ( 2 ) facilitation of the differentiation process by overexpression of the N terminal domain of Dnmt3b , ( 3 ) higher Hdac activity associated with Dnmt3b after NGF treatment , and ( 4 ) coimmunoprecipitation and cosedimentation of Dnmt3b specifically with Hdac 2 in a glycerol density gradient . 0.63910859^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Mutated ICP 8 gene plasmids cotransfected with HD 2 DNA yielded recombinant viruses with the mutant ICP 8 gene incorporated into the viral genome . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Excision repair , as measured by incision analysis and unscheduled DNA synthesis , is restored to normal or near normal levels in crosses involving HD 2 and cells from XP groups A , B , C , E , F , G , and 1 . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| It has only the HD 2 homeodomain motif as a potential DNA binding domain fused to an essential C terminal region of the HD 1 protein , which in a normal HD 1 HD2 protein complex may be the major activation domain . . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Overall , the DNA sequences are very different ( approximately 50 % homology ) , but two classes of genes can be distinguished on the basis of a conserved homeodomain motif in their predicted proteins ( HD 1 and HD 2 ) . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| A Gal 4 DNA binding domain mammalian RPD 3 fusion protein strongly represses transcription from a promoter containing Gal 4 binding sites . ^^^ These data suggest that YY 1 negatively regulates transcription by tethering RPD 3 to DNA as a cofactor and that this transcriptional mechanism is highly conserved from yeast to human . . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| The identification of a maize complementary DNA encoding the chromatin bound deacetylase HD 2 is reported . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Comparison of the HDAC 3 sequence with human HDAC 2 also yielded similar results , with 51 % identity in DNA sequence and 52 % identity in protein sequence . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Finally , although 90 % of mitotic recombinant events are initiated in the G 1 phase of the growth cycle ( i . e . , before DNA synthesis ) we show that RPD 3 is not regulated in a cell cycle dependent manner . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Supporting the direct interaction between TR and HDAC , in vitro assays showed that TR , through its DNA binding domain , strongly bound to HDAC 2 . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| ATR ' s association with CHD 4 and HDAC 2 suggests that there may be a linkage between ATR ' s role in mediating checkpoints induced by DNA damage and chromatin modulation via remodeling and deacetylation . . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Mad : Max heterodimers repress transcription by recruiting a large multi protein complex containing the histone deacetylases , HDAC 1 and HDAC 2 , to DNA . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Here , we use a purified Mi 2 complex containing six components , Mi 2 , Mta 1 like , p 66 , RbAp 48 , RPD 3 , and MBD 3 , to investigate the capacity of this complex to destabilize histone DNA interactions and deacetylate core histones . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| The histone deacetylase RPD 3 complex is recruited to DNA by the repressor UME 6 ( refs 4 , 5 ) ; similar mechanisms exist in other eukaryotes . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| A model is proposed in which HDAC 1 core complexes can be targeted to methylated DNA via MBD 2 with recruitment of HDAC 2 occurring through formation of HDAC1 / 2 cII dimers . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Coupling of Saccharomyces cerevisiae early meiotic gene expression to DNA replication depends upon RPD 3 and SIN 3 . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| This suggests that Rpd 3 is brought to many promoters by alternative recruiters , some of which may bind the putative cis regulatory DNA elements that we have identified in sets of Rpd 3 target genes . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| A multiprotein complex was recruited to the hLHR promoter via interaction with Sp 1 and Sp 3 , in which HDAC 1 and HDAC 2 were docked directly to Sp 1 bound DNA and indirectly to Sp 3 bound DNA through RbAp 48 , while mSin3A interacted with both HDACs . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Using co fractionation and co immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression , such as histone deacetylase 2 , constituents of chromatin such as core histones H2A , H2B , H 3 and H 4 , and Dek , a chromatin associated protein reported to change the topology of DNA in chromatin in vitro . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| RPD 3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase . rRNA transcription in Saccharomyces cerevisiae is performed by RNA polymerase 1 and regulated by changes in growth conditions . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| By means of quantitative reverse transcription polymerase chain reaction using SYBR Green to detect double stranded DNA , mRNA expression profiles for histone deacetylases ( HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 7 ) , histone acetyltransferases ( GCN 5 and HAT 1 ) , and histone H2A were established . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Deletion of either SIN 3 or RPD 3 in rad 9 or mec 1 checkpoint mutant strains suppresses sensitivity to replication blocks and DNA damage resulting from Cdc 9 ligase deficiency and UV irradiation . ^^^ SIN 3 or RPD 3 deletions also restored G ( 2 ) / M arrest after DNA damage without concomitant Rad 53 phosphorylation in mec 1 mutant strains . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| We also describe the use of ChrIP in combination with DNA microarrays ( ChrIP array ) to determine the pattern of Rpd 3 binding genomewide . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| To test the hypothesis that the delay reflected a dysfunction of ICP 0 in altering the structure of host protein viral DNA complexes , we examined the state of histone deacetylases ( HDACs ) ( HDAC 1 , HDAC 2 , and HDAC 3 ) . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Many of the coprecipitating cellular proteins are known members of large cellular complexes involved in ( 1 ) DNA replication or damage repair , including RPA and MSH 6 ; ( 2 ) nonhomologous and homologous recombination , including the catalytic subunit of the DNA dependent protein kinase , Ku 86 , and Rad 50 ; and ( 3 ) chromatin remodeling , including BRG 1 , BRM , hSNF2H , BAF 155 , mSin3a , and histone deacetylase 2 . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| The yeast histone acetyltransferase ( HAT ) gene gcn 5 and histone deacetylase ( HDAC ) gene rpd 3 were cloned from yeast genomic DNA by PCR amplification . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Groucho functions by recruiting the histone deacetylase Rpd 3 to the DNA template via interaction with site specific transcription factors , resulting in localized chromatin condensation and transcriptional silencing . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Loss of HDAC 2 did not reduce GR nuclear translocation , GR binding to glucocorticoid response element ( GRE ) on DNA , or GR induced DNA or gene induction but inhibited the association between GR and NF kappaB . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Most of these proteins fall into two distinct chromosomal distribution patterns : ( a ) kinetochore associated proteins ( Sin3A , PCAF , MYST and BAF 180 ) , which colocalize with metaphase kinetochores , but not any of the pericentric and other major heterochromatic regions ; and ( b ) heterochromatin associated proteins ( MeCP 2 , MBD 1 , MBD 2 , ATRX , HP1alpha , HDAC 1 , HDAC 2 , DNMT 1 and DNMT3b ) , which colocalize with centromeric / pericentric heterochromatin and all other major heterochromatic sites . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| DNMT3b is restricted to mitotic olfactory progenitors , whereas DNMT3a is expressed only in post mitotic immature neurons prior to ORN terminal maturation , coincident with histone deacetylase 2 ( HDAC 2 ) , a key downstream effector of methylation dependent chromatin condensation . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Association of histone deacetylase 2 ( Hdac 2 ) with T Cad promoter and restoration of the promoter activity from Dnmt3b mediated suppression upon treatment with Hdac inhibitor indicated involvement of histone deacetylation in this process . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| One hundred and thirty two RNA samples obtained from de novo adult AML patients were tested for FLT 3 , FLT 3 LG , NDST 1 , HDAC 2 , ATRX , FOS , DNMT 1 , DNMT3A , DNMT3B , NBS 1 , RAD 50 , MRE11A , Meis 1 and Meis 2 expression using quantitative PCR ( qPCR ) assays . ^^^ |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|