| Interacting proteins: Q9H7L9 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Evidence that the transcriptional regulators SIN 3 and RPD 3 , and a novel gene ( SDS 3 ) with similar functions , are involved in transcriptional silencing in S . cerevisiae . ^^^ SDS 16 and SDS 6 are known transcriptional modifiers , SIN 3 ( RPD1 / UME4 / SDI1 / GAM2 ) and RPD 3 ( SDI 2 ) , respectively , while the third is a novel gene , SDS 3 . ^^^ SDS 3 shares the meiotic functions of SIN 3 and RPD 3 in that it represses IME 2 in haploid cells and is necessary for sporulation in diploid cells . ^^^ However , sds 3 mutations differ from sin 3 and rpd 3 mutations in that they do not derepress TRK 2 . ^^^ Epistasis studies suggest that SDS 3 works in a different pathway from RPD 3 and SIN 3 to affect silencing at HMR . ^^^ |
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| Interacting proteins: Q9H7L9 and Q92769 |
Pubmed |
SVM Score :0.0 |
| The remaining gene from this screen described in this report is SDS 3 , previously identified in a screen for mutations that increase silencing at HML , HMR , and telomere linked genes , a phenotype also seen in sin 3 and rpd 3 mutants . ^^^ Genetic analysis demonstrates that SDS 3 functions in the same genetic pathway as SIN 3 and RPD 3 , and coimmunoprecipitation experiments show that Sds 3 is physically present in the Sin 3 complex . . ^^^ |
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| Interacting proteins: Q9H7L9 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Sds 3 ( suppressor of defective silencing 3 ) is an integral component of the yeast Sin 3 [ middle dot ] Rpd 3 histone deacetylase complex and is required for histone deacetylase activity . ^^^ In addition , sds 3 mutants have phenotypes very similar to those seen in sin 3 and rpd 3 mutants , suggesting that it functions in the same genetic pathway . ^^^ |
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| Interacting proteins: Q9H7L9 and Q92769 |
Pubmed |
SVM Score :0.0 |
| Similar mechanisms appear to be operative in yeast , in which epistasis experiments have established that the mSin 3 and HDAC orthologs ( SIN 3 and RPD 3 ) , along with a novel protein , SDS 3 , function in the same repressor pathway . ^^^ |
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| Interacting proteins: Q9H7L9 and Q92769 |
Pubmed |
SVM Score :0.0 |
| The Rpd 3 histone deacetylase complex contains several previously characterized proteins , including Rpd 3 , Sin 3 , Sds 3 , Sap 30 , and Pho 23 . ^^^ |
|
| Interacting proteins: Q9H7L9 and Q92769 |
Pubmed |
SVM Score :0.0 |
| These included Rpd 3 , Sds 3 , Pho 23 , Dep 1 , Rxt 2 , Sin 3 , Ash 1 , Ume 1 , Sap 30 , Cti 6 , Rxt 3 and Ume 6 . ^^^ |
|
| Interacting proteins: Q9H7L9 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9H7L9 and Q92769 |
Pubmed |
SVM Score :0.0 |
| NA |
|