| Interacting proteins: Q02447 and Q92769 |
Pubmed |
SVM Score :0.8899585 |
| The transcriptional repressor Sp 3 is associated with CK 2 phosphorylated histone deacetylase 2 . 0.8899585^^^ |
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| Interacting proteins: Q02447 and Q92769 |
Pubmed |
SVM Score :0.0 |
| A multiprotein complex was recruited to the hLHR promoter via interaction with Sp 1 and Sp 3 , in which HDAC 1 and HDAC 2 were docked directly to Sp 1 bound DNA and indirectly to Sp 3 bound DNA through RbAp 48 , while mSin3A interacted with both HDACs . ^^^ |
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| Interacting proteins: Q02447 and Q92769 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that Sp 1 and Sp 3 recruit HDAC 1 and HDAC 2 , with the latter being phosphorylated by protein kinase CK 2 . ^^^ |
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| Interacting proteins: Q02447 and Q92769 |
Pubmed |
SVM Score :0.0 |
| In the absence of estradiol ( E 2 ) , Sp 1 , Sp 3 , histone deacetylase 1 ( HDAC ) , and HDAC 2 , and low levels of acetylated H 3 and H 4 are associated with the native promoter , with the histones being engaged in dynamic reversible acetylation . ^^^ There is clearance of Sp 1 , but not of Sp 3 , from the promoter while HDAC 1 and HDAC 2 remain bound . ^^^ |
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| Interacting proteins: Q02447 and Q92769 |
Pubmed |
SVM Score :0.0 |
| We now report that Sp 3 , CAGA element binding proteins , and a corepressor complex consisting of mSin3A , histone deacetylase ( HDAC ) 1 , and HDAC 2 associates with a transcriptional repressor region within the mouse StAR promoter . 5 ' Promoter deletion analysis localized the negative regulatory region between 180 and 150 bp upstream of the transcription start site , and mutations in both the CAGA and Sp binding elements were required to relieve the repression of basal StAR promoter activity . ^^^ |
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