| Daxx and histone deacetylase 2 associate with chromatin through an interaction with core histones and the chromatin associated protein Dek . ^^^ Using co fractionation and co immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression , such as histone deacetylase 2 , constituents of chromatin such as core histones H2A , H2B , H 3 and H 4 , and Dek , a chromatin associated protein reported to change the topology of DNA in chromatin in vitro . ^^^ |