| Temporal analysis of IE 1 distribution revealed its initial segregation into ND 10 by binding to PML and / or Daxx and IE 1 dependent recruitment of the transcriptional repressor histone deacetylase 2 ( HDAC 2 ) to this site . ^^^ However , these protein aggregates are dissociated in cells producing sufficient IE 1 through titration of PML , Daxx , and HDAC 2 . ^^^ |