| Interacting proteins: Q92769 and P01106 |
Pubmed |
SVM Score :0.0 |
| Max Mad / Mxi1 heterodimers , which bind to E boxes in absence of co repressors , do not inhibit gene expression simply by competition with Myc Max heterodimers , but require Sin 3 and Rpd 3 for efficient repression of transcription . ^^^ |
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| Interacting proteins: Q92769 and P01106 |
Pubmed |
SVM Score :0.0 |
| METHODS : Transient reporter assays and trichostatin A ( TSA ) experiments were performed to evaluate several candidate genes , including Mxi 1 , c myc promoter binding protein 1 ( MBP 1 ) , Miz , and histone deacetylase 2 ( HDAC 2 ) , for their involvement in N myc autoregulation . ^^^ Autoregulation of the N myc gene is operative in neuroblastoma and involves histone deacetylase 2 . ^^^ Mxi 1 and HDAC 2 were examined further for their expression levels and effects on endogenous N myc levels . ^^^ Mxi 1 and HDAC 2 were up regulated by N Myc in an myc inducible cell line and in N myc expressing cell lines . ^^^ Increased association of HDAC 2 with the autoregulatory region within the N myc promoter by ChIP was observed upon down regulation of endogenous N myc . ^^^ |
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| Interacting proteins: Q92769 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|