| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In contrast , N CoR 2 contained predominantly HDAC 1 and HDAC 2 as well as several other subunits that are found in the Sin3A . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Moreover , it did not lead to the recruitment of the corepressor silencing mediator of retinoic acid and thyroid hormone receptor ( SMRT ) or histone deacetylase 1 ( HDAC 1 ) at the same sites . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In addition , we demonstrate that the recently characterized histone deacetylase 1 ( HDAC 1 ) interacts with Sin3A and SMRT to form a multisubunit repressor complex . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| SMRT originally was identified as a corepressor of unliganded retinoic acid and thyroid receptors and forms a repressive complex with a mammalian homolog of the yeast transcriptional repressor SIN 3 and the HDAC 1 histone deacetylase . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Both repression domains in SMRT and N CoR interact weakly with mSin3A , which in turn associates with a histone deacetylase HDAC 1 in a mammalian two hybrid assay . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In this report we show that prior to induction CBF1 / RBP Jkappa interacts with a corepressor complex containing SMRT ( silencing mediator of retinoid and thyroid hormone receptors ) and the histone deacetylase HDAC 1 . ^^^ The functional role for the SMRT / HDAC 1 complex in CBF1 / RBP Jkappa regulation reveals a novel genetic switch in which extracellular ligands control the status of critical nuclear cofactor complexes . . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We report here that PLZF , and a structurally similar transcriptional repressor , BCL 6 , can interact with a variety of corepressor proteins in addition to SMRT , including the mSin3A protein and ( for PLZF ) histone deacetylase 1 . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| However , in striking contrast with BCL 6 and PLZF , both HIC 1 and gammaFBP B similarly fail to interact with members of the HDAC complexes ( SMRT / N CoR , mSin3A or HDAC 1 ) in vivo and in vitro . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , however , numerous biochemical studies have not detected N CoR or SMRT in mSin 3 and HDAC 1 containing complexes . ^^^ Endogenous N CoR and SMRT each associate with HDAC 4 in a complex that does not contain mSin3A or HDAC 1 . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The mechanism by which SMRT represses basal transcription has been proposed to involve the indirect recruitment of histone deacetylase HDAC 1 via the adaptor mSin3A . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| N CoR and SMRT have been proposed to act by recruiting class 1 histone deacetylases ( HDAC 1 ) through an association with Sin 3 , although they have also been shown to recruit class 2 HDACs through a Sin 3 independent mechanism . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| SHARP is a potent transcriptional repressor whose repression domain ( RD ) interacts directly with SMRT and at least five members of the NuRD complex including HDAC 1 and HDAC 2 . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Recombinant corepressors mSin3A , SMRT , and HDAC 1 , but not NCoR 1 , interacted with GST SHP but each of these corepressors in liver nuclear extracts bound to GST SHP . ^^^ SMRT and NCoR 1 inhibited CAR mediated activation independent of SHP , but mSin3A and HDAC 1 had little effect alone , and were additive with SHP . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated recruitment of coactivators ( SRC 1 , SRC 2 , and SRC 3 ) and corepressors ( HDAC 1 , HDAC 2 , HDAC 3 , SMRT , and NCoR ) to the IkappaB alpha gene promoter after NF kappaB activation by tumor necrosis factor alpha . ^^^ The binding pattern suggests that the corepressor proteins formed two types of corepressor complexes , SMRT HDAC 1 and NCoR HDAC 3 . ^^^ |
|
| Interacting proteins: Q9Y618 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Similar to phosphorylation within the Rel homology domain of RelA / p65 , which governs an exchange of HDAC 1 for CBP / p300 acetyltransferases , we demonstrate that phosphorylation within the transactivation domain of RelA / p65 ( S 536 ) displaces SMRT HDAC 3 repressor activity , allowing p 300 to acetylate RelA / p65 . . ^^^ |
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