| Moreover , the binding of Hdac 1 represses the ability of Cdyl to bind CoA , and a Cdyl CoA interaction only occurs in the absence of HDACs . ^^^ However , the degradation of cellular Hdac 1 and Hdac 2 , as observed here in the elongating spermatids , may provide an HDAC free environment in which Cdyl could bind CoA and participate in the global chromatin remodelling that occurs in these cells . . ^^^ |