Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
HDAC 3 is homologous to other human HDACs and yeast RPD 3 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We have isolated HDAC 1 gene from the P . falciparum genomic and cDNA libraries . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Similarly , coexpression of HDAC 1 and mSin3A also showed repressive effects . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Furthermore , the TIF1beta / KRAB complex was devoid of mSin3A and HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here we show that DNMT3L can also repress transcription by binding directly to HDAC 1 protein . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Ebp 1 bound HDAC 2 , but not HDAC 1 , in vitro . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The same region is also found to associate specifically with HDAC 1 which is responsible for the repressive effect . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Conversely , overexpression of the HDAC 1 enzyme inhibited basal activity of the NIS promoter . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In contrast , HDAC 1 overexpression distinctly reduced Bmf expression . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Closely related HDAC 1 and HDAC 2 do not elicit humoral response in colon cancer patients . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Although p 21 binds both Class 1 and Class 2 HDACs in vitro , only weak association with HDAC 1 and 2 is seen in cells . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
HDAC 1 was present in the GV of the immature oocytes and localized on chromosomes after GVBD and AGVD . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
RESULTS : The PHI exposed LNCaP cells had diminished activity of HDAC 1 and 2 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
HBx , ERalpha and histone deacetylase 1 ( HDAC 1 ) form a ternary complex . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Inhibition data for 4 b , k against mouse HDAC 1 were consistent with those observed in the maize enzyme . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Between 1981 and 1998 , the GHSG conducted three trial generations for early , intermediate , and advanced HD involving a total of 5 , 411 patients ( called HD 1 through HD 9 ) . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In addition , we demonstrate that the recently characterized histone deacetylase 1 ( HDAC 1 ) interacts with Sin3A and SMRT to form a multisubunit repressor complex . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Cloning of the cDNA for a human histone deacetylase ( HDAC 1 ) has shown that it represents a human ortholog of the yeast transcriptional regulator RPD 3 . ^^^ Characterization of a human RPD 3 ortholog , HDAC 3 . ^^^ We have screened the expressed sequence tag database ( National Center for Biotechnology Information ) with the yeast RPD 3 sequence and identified a human ortholog of RPD 3 , HDAC 3 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Herein we report that CBHA and SAHA inhibit histone deacetylase 1 ( HDAC 1 ) and histone deacetylase 3 ( HDAC 3 ) activity in vitro . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
An in vitro histone deacetylase assay , using purified recombinant HDAC 1 , reveals that depudecin inhibits 50 % of the enzyme activity at a concentration of 4 . 7 microM . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
A role for histone deacetylase activity in HDAC 1 mediated transcriptional repression . ^^^ Antibodies directed against endogenous HDAC 1 , HDAC 2 , or HDAC 3 immunoprecipitate histone deacetylase activity that is inhibited in vitro by the small molecule trapoxin ( TPX ) , and all three HDACs are retained by a TPX affinity matrix . ^^^ HDAC 1 and HDAC 2 are associated in HeLa cells in a complex that is predominantly separate from an HDAC 3 immune complex . ^^^ Both Jurkat HDAC 1 and HeLa HDAC1 / 2 immune complexes deacetylate all four core histones and recombinant HDAC 1 deacetylates free and nucleosomal histones in vitro . ^^^ Purified recombinant HDAC 1 deacetylates core histones in the absence of protein cofactors . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Moreover , we show that LAZ 3 also interacts with an HDAC ( HDAC 1 ) through its POZ domain in vitro while the immunoprecipitation of LAZ 3 results in the coretention of an endogenous HDAC activity in vivo . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
SpHDAC 1 , a cDNA homolog of the yeast Rpd 3 and higher eukaryotic histone deacetylases ( HDAC ) , was cloned from the sea urchin Strongylocentrotus purpuratus . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The histone deacetylase domain of almost all members of higher eukaryotic histone deacetylases already identified ( HDAC family ) is highly homologous to that of yeast RPD 3 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Human HDAC 1 , HDAC 2 , and HDAC 3 proteins are members of the first class , whereas no class 2 human HDAC proteins had been identified . ^^^ Coimmunoprecipitation experiments indicate that these HDAC proteins are not components of the previously identified HDAC 1 and HDAC 2 NRD and mSin3A complexes . ^^^ This finding suggests that the human class 2 HDAC enzymes may function in cellular processes distinct from those of HDAC 1 and HDAC2 . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
An affinity purified HDAC 1 corepressor complex also contains MBD 2 , suggesting that MeCP 1 corresponds to a fraction of this complex . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here we describe the structure of the histone deacetylase catalytic core , as revealed by the crystal structure of a homologue from the hyperthermophilic bacterium Aquifex aeolicus , that shares 35 . 2 % identity with human HDAC 1 over 375 residues , deacetylates histones in vitro and is inhibited by TSA and SAHA . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
By DNA affinity binding assay , we show that the NRE constitutively binds to the histone deacetylase 1 ( HDAC 1 ) present in GH ( 3 ) cells . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
However , in striking contrast with BCL 6 and PLZF , both HIC 1 and gammaFBP B similarly fail to interact with members of the HDAC complexes ( SMRT / N CoR , mSin3A or HDAC 1 ) in vivo and in vitro . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Surprisingly , however , numerous biochemical studies have not detected N CoR or SMRT in mSin 3 and HDAC 1 containing complexes . ^^^ Endogenous N CoR and SMRT each associate with HDAC 4 in a complex that does not contain mSin3A or HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
To date , six HDACs have been identified in mammalian cells : the yeast RPD 3 homologs HDAC 1 , 2 , and 3 and the yeast HDA 1 homologs HDAC 4 , 5 , and 6 . ^^^ HDRP does not possess intrinsic HDAC activity but forms complexes with both HDAC 1 and HDAC 3 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Stra 13 expression is transcriptionally repressed and maintained at a low level in cells through a negative autoregulatory mechanism that is brought about by its interaction with the corepressor histone deacetylase ( HDAC 1 ) . ^^^ Further , once induced , Stra 13 strongly represses the expression of the cell proliferation associated gene c Myc through an HDAC 1 independent pathway that involves its interaction with the basal transcription factor TFIIB . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In support of this idea , GST pull down and immunoprecipitation assays show that p 53 interacts with HDAC 1 both in vitro and in vivo . ^^^ Furthermore , a pre acetylated p 53 peptide was significantly deacetylated by immunoprecipitated wild type HDAC 1 but not deacetylase mutant . ^^^ Also , co expression of HDAC 1 greatly reduced the in vivo acetylation level of p 53 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The class 1 deacetylases HDAC 1 and HDAC 2 are components of multisubunit complexes , one of which could associate with the nuclear hormone receptor corepressor , N CoR . ^^^ In comparison with HDAC 1 and HDAC 2 , HDAC 3 remains relatively uncharacterized , and very few proteins have been shown to interact with HDAC 3 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We find that HDAC 1 copurifies with the LTR binding YY 1 LSF repressor complex , the domain of YY 1 that interacts with HDAC 1 is required to repress the HIV 1 promoter , expression of HDAC 1 augments repression of the LTR by YY 1 , and the deacetylase inhibitor trichostatin A blocks repression mediated by YY 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
HDAC 8 shows a high degree of sequence similarity to HDAC 1 and HDAC 2 and thus belongs to the class 1 of HDACs . ^^^ Human cells overexpressing HDAC 8 localize the protein in sub nuclear compartments whereas HDAC 1 shows an even nuclear distribution . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here we present the complete nucleotide sequence of a cDNA clone , termed HDAC 8 , that encodes a protein product with similarity to the RPD 3 class ( 1 ) of HDACs . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Further , LEF 1 associates in vivo with HDAC 1 , and transcription of a model LEF 1 dependent target gene is modulated by the ratio of HDAC 1 to beta catenin , implying that repression by LEF 1 is mediated by promoter targeted HDAC . ^^^ Coexpression of beta catenin with LEF 1 and HDAC 1 results in the formation of a beta catenin / HDAC1 complex . ^^^ Surprisingly , the enzymatic activity of HDAC 1 associated with beta catenin is attenuated . ^^^ First , HDAC 1 is dissociated from LEF 1 and its enzymatic activity is attenuated . ^^^ Second , once HDAC 1 dependent repression has been overridden , beta catenin binds LEF 1 and the beta catenin LEF 1 complex is competent to activate the expression of downstream target genes . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Direct interaction of RIP 140 with HDAC 1 and HDAC 3 occurs in vitro and in vivo as demonstrated in co immunoprecipitation and glutathione S transferase pull down experiments . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In contrast , N CoR 2 contained predominantly HDAC 1 and HDAC 2 as well as several other subunits that are found in the Sin3A . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Purified recombinant human HDAC 1 protein was used to screen a cDNA expression library , and one of the clones identified encoded DNA topoisomerase 2 ( Topo 2 ) , an enzyme known to have a role in transcriptional regulation and chromatin organization . ^^^ Coimmunoprecipitation experiments indicate that HDAC 1 and HDAC 2 are associated with Topo 2 in vivo under normal physiological conditions . ^^^ Complexes containing Topo 2 possess HDAC activities , and complexes containing HDAC 1 or HDAC 2 possess Topo 2 activities . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The effects of apicidin on cell morphology , expression of gelsolin , and HDAC 1 activity in vivo and in vitro appeared to be irreversible , because withdrawal of apicidin did not reverse those effects , whereas the induction of p21WAF1 / Cip1 by apicidin was reversible . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Two genes appear to participate in feedback loops that modulate HDAC activity : ZRT 1 encodes a zinc transporter and is repressed by RPD 3 ( Rpd3p is zinc dependent ) ; BNA 1 encodes a nicotinamide adenine dinucleotide ( NAD ) biosynthesis enzyme and is repressed by SIR 2 ( Sir2p is NAD dependent ) . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We also discovered that Msx 3 mediated repression of Msx 1 promoter is synergized by the exogenous co expression of histone deacetylase 1 ( HDAC 1 ) . ^^^ Finally , we show that Msx 3 and HDAC 1 can be co immunoprecipitated in a complex that does not contain CBP and that Msx 3 and HDAC 1 proteins are co localized in the nucleus . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The hybrid compound cyclic hydroxamic acid containing peptide ( CHAP ) 1 inhibited HDAC 1 at low nanomolar concentrations . ^^^ The HDAC 1 inhibition by CHAP 1 was reversible as it was by TSA , in contrast to the irreversible inhibition by TPX . ^^^ Interestingly , HDAC 6 , but not HDAC 1 or HDAC 4 , was resistant to TPX and CHAP 1 , whereas TSA inhibited these HDACs to a similar extent . ^^^ HDAC 1 was highly sensitive to all these CHAPs much more than HDAC 6 , indicating that the structure of the cyclic tetrapeptide framework affects the target enzyme specificity . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here we show by immunoprecipitation , pull down with glutathione S transferase fusion proteins , and yeast two hybrid analysis that both topo IIalpha and beta physically interact with the histone deacetylase HDAC 1 . ^^^ The in vitro DNA decatenation activity of recombinant topo IIalpha and beta is inhibited by association with catalytically inactive , recombinant HDAC 1 . ^^^ We provide evidence for the in vivo significance of the topo 2 HDAC 1 association , showing that inhibition of HDAC activity with trichostatin A suppresses apoptosis induced by the topo 2 poison etoposide , but not by the topoisomerase 1 inhibitor camptothecin . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Immunoprecipitation experiments showed that HDAC 1 and hypophosphorylated retinoblastoma protein ( pRb ) are associated with Sp 1 in serum starved CHOC 400 cells . ^^^ HDAC 1 did not coprecipitate with p 130 E2F DNA binding complexes , the predominant E2F binding activity in cell extracts after serum starvation , suggesting that p 130 imposes a TSA insensitive state on the dhfr promoter . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In vitro , N CoR can interact with the Sin 3 corepressor , which in turn binds to the histone deacetylase Rpd 3 ( HDAC 1 ) , predicting the existence of a corepressor complex containing N CoR , Sin 3 , and histone deacetylase . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
N CoR and SMRT have been proposed to act by recruiting class 1 histone deacetylases ( HDAC 1 ) through an association with Sin 3 , although they have also been shown to recruit class 2 HDACs through a Sin 3 independent mechanism . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Overexpressed wild type HDAC 1 downregulated expression of p 53 and von Hippel Lindau tumor suppressor genes and stimulated angiogenesis of human endothelial cells . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here we show that EKLF can also interact with the corepressors mSin3A and HDAC 1 ( histone deacetylase 1 ) through its zinc finger domain . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Mammalian histone deacetylase 1 ( HDAC 1 ) is a nuclear protein that belongs to a growing family of evolutionarily conserved enzymes catalysing the removal of acetyl residues from core histones and other proteins . ^^^ Previously , we have identified murine HDAC 1 as a growth factor inducible protein in murine T cells . ^^^ Here , we characterise the molecular function of mouse HDAC 1 in more detail . ^^^ Co immunoprecipitation experiments with epitope tagged HDAC 1 protein reveal the association with endogenous HDAC 1 enzyme . ^^^ We show that HDAC 1 can homo oligomerise and that this interaction is dependent on the N terminal HDAC association domain of the protein . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The Rpd 3 histone deacetylase ( HDAC ) functions in a large complex containing many proteins including Sin 3 and Sap 30 . ^^^ Based on these observations , we explored whether Pho 23 is a component of the Rpd 3 HDAC complex . ^^^ Furthermore , similar levels of HDAC activity were detected in immunoprecipitates of HA Pho 23 , HA Rpd 3 , or HA Sap 30 . ^^^ In contrast , HDAC activity was not detected in immunoprecipitates of HA Pho 23 or HA Sap 30 from strains lacking Rpd 3 , suggesting that Rpd 3 is the HDAC associated with these proteins . ^^^ However , HDAC activity was detected in immunoprecipitates of HA Sap 30 or HA Rpd 3 from cells lacking Pho 23 , although levels were significantly lower than those detected in wild type cells , indicating that Rpd 3 activity is compromised in the absence of Pho 23 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Like other characterized co repressors , Dnmt3a associates with the histone deacetylase HDAC 1 using its ATRX homology domain . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Previous studies have established that YY 1 interacts with histone acetyltransferases p 300 and CREB binding protein ( CBP ) and histone deacetylase 1 ( HDAC 1 ) , HDAC 2 , and HDAC 3 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Cell cycle dependent recruitment of HDAC 1 correlates with deacetylation of histone H 4 on an Rb E2F target promoter . ^^^ Our data show that a histone deacetylase , HDAC 1 , is stably bound to an E2F target promoter during early G 1 in proliferating cells and released at the G 1 S transition . ^^^ In addition , our results reveal an inverse correlation between HDAC 1 recruitment and histone H 4 acetylation on specific lysines . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In addition , of eight histone deacetylases ( HDACs ) tested , only the class 1 HDACs HDAC 1 , HDAC 2 , and HDAC 3 bind ETO . ^^^ Furthermore , ETO 2 binds HDAC 1 , HDAC 2 , and HDAC 3 but also interacts with HDAC 6 and HDAC 8 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Additionally , mutation of the YY 1 binding site prevented repression of the promoter by HDAC 1 and partially prevented activation of the promoter by trichostatin A . ^^^ Mutation of the octamer element also significantly reduced the ability of HDAC 1 to confer repression of inducible HLA DRA promoter activation . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Since the timely presence of such enzymes may be of critical importance , our experiments were designed to determine whether the level of expression of HDAC 1 is cell cycle dependent and / or affected by a high cell density . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We hypothesized that histone deacetylases ( HDACs ) and DNA methyltransferases ( DNMTase ) are associated with prostate cancer and we examined the enzyme activity , gene , and protein expression of HDAC 1 and DNMT 1 in cell lines and tissues . ^^^ HDAC 1 and DNMT 1 protein expression was higher in prostate cancer compared to BPH . ^^^ This is the first report to demonstrate that DNMT 1 and HDAC 1 levels are up regulated in prostate cancer compared to BPH , suggesting their roles in inactivation of various genes , by DNA methylation induced chromatin remodeling , in prostate cancer . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The p 65 ( RelA ) subunit of NF kappaB interacts with the histone deacetylase ( HDAC ) corepressors HDAC 1 and HDAC 2 to negatively regulate gene expression . ^^^ Expression of HDAC 1 and HDAC 2 repressed tumor necrosis factor ( TNF ) induced NF kappaB dependent gene expression . ^^^ Consistent with this , we show that HDAC 1 and HDAC 2 target NF kappaB through a direct association of HDAC 1 with the Rel homology domain of p 65 . ^^^ HDAC 2 does not interact with NF kappaB directly but can regulate NF kappaB activity through its association with HDAC 1 . ^^^ Moreover , it suggests that the association of NF kappaB with the HDAC 1 and HDAC 2 corepressor proteins functions to repress expression of NF kappaB regulated genes as well as to control the induced level of expression of these genes . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
GATA 2 directly associates with HDAC 3 but not with HDAC 1 . ^^^ Consistent with this , HDAC 3 suppressed the transcriptional potential of GATA 2 , whereas HDAC 1 did not affect GATA 2 dependent transcription . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
MM 1 and TIF 1 beta complex in human HeLa cells was found to also contain c Myc , mSin 3 , and HDAC 1 . ^^^ Moreover , the inhibitory activity of MM 1 toward c Myc was canceled by trichostatin A , an inhibitor of HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The HDAC 1 inhibition by CHAPI was reversible , as is that by TSA , in contrast to irreversible inhibition by TPX . ^^^ Interestingly , HDAC 6 , but not HDAC 1 or HDAC 4 , was resistant to TPX and CHAP 1 , while TSA inhibited these HDACs to a similar degree . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
To date , the only known regulatory mechanism of HDAC 1 function is via interaction with associated proteins . ^^^ Although the control of HDAC 1 function by protein interaction and recruitment is well precedented , we were interested in exploring HDAC 1 regulation by post translational modification . ^^^ Human HDAC 1 protein was analyzed by ion trap mass spectrometry , and two phosphorylated serine residues , Ser ( 421 ) and Ser ( 423 ) , were unambiguously identified . ^^^ Loss of phosphorylation at Ser ( 421 ) and Ser ( 423 ) due to mutation to alanine or disruption of the casein kinase 2 consensus sequence directing phosphorylation reduced the enzymatic activity and complex formation of HDAC 1 . ^^^ Deletion of the highly charged carboxyl terminal region of HDAC 1 also decreased its deacetylase activity and protein associations , revealing its requirement in maintaining HDAC 1 function . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Moreover , class 1 HDACs ( HDAC 1 and 3 ) , not class 2 HDACs ( HDAC 4 , 5 , and 6 ) , were co immunoprecipitated with Smad 6 . ^^^ Endogenous HDAC 1 was also shown to interact with both Smad 6 and Hoxc 8 . ^^^ Mapping of the interaction domain indicates Smad 6 MH2 domain is mainly involved in recruiting HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In this study , we investigated the expression level of HDAC 1 in 25 paired primary human gastric cancer ( GC ) tissues and corresponding normal tissues through semi quantitative RT PCR and immunoblot analysis . ^^^ The HDAC 1 expression pattern was also topologically examined through immunohistochemistry . ^^^ Overexpression of HDAC 1 mRNA was detected in 68 % of GC tissues ( 17 of 25 ) , and the relative density of HDAC 1 mRNA in GC tissue was increased 1 . 8 fold versus the normal counterpart ( P < 0 . 01 ) . ^^^ Elevated expression of HDAC 1 protein was also detected in 61 % of GC samples ( 11 of 18 ) , which also showed an increased mRNA level of HDAC . ^^^ Immunohistochemically , overexpression of HDAC 1 was predominantly localized in the nuclei of most neoplastic cells , including embolic tumor cells , whereas normal glandular epithelial cells revealed only weak HDAC 1 expression that was focal in distribution . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We further demonstrate that the ability of E 7 to abrogate cell cycle arrest , activate cdc25A transcription , and increase cdc25A protein levels requires intact Rb and HDAC 1 binding domains . ^^^ Consequently , we propose that E7 . 16 can directly target cdc25A transcription and maintains cdc25A gene expression by disrupting Rb / E2F / HDAC 1 repressor complexes . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Complexes shown to contain HDAC 1 , HDAC 3 , HDAC 6 , and HDAC1+2 as their catalytic subunits have been used in an antibody based assay that detects deacetylation of whole histones at defined lysines . ^^^ In comparison to HDAC 1 , HDAC 3 preferentially deacetylated lysines 5 and 12 of H 4 and lysine 5 of H2A . ^^^ H 4 tails in purified mononucleosomes were refractory to deacetylation by both HDAC 1 and HDAC 3 , unless ATP was added to the reaction mix . ^^^ Another common ATP dependent chaperone , Hsp 90 , was absent from all HDAC complexes tested , whereas Hsp 60 associated with HDAC 1 only . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In humans , four highly homologous class 1 HDAC enzymes ( HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 ) have been identified to date . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The HDAC domain , homologous to the yeast repressors RPD 3 and HDA 1 , is considered necessary and sufficient for enzymatic activity . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The same regions of the protein that are required for repression physically interact with components of chromatin remodeling complexes , HDAC 1 , HDAC 2 , RbAp46 / 48 , MTA 1 , and MTA 2 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Overexpression of HDAC 1 leads to repression of the hTERT promoter activity . ^^^ We also show a physical interaction of Sp 1 with HDAC 1 and the presence of HDAC 1 at the hTERT promoter region . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here , we report the identification of a component of the mSin 3 HDAC complex that bears homology to yeast SDS 3 , physically associates with mSin 3 proteins in vivo , represses transcription in a manner that is partially dependent on HDAC activity , and enables HDAC 1 catalytic activity in vivo . ^^^ Similar mechanisms appear to be operative in yeast , in which epistasis experiments have established that the mSin 3 and HDAC orthologs ( SIN 3 and RPD 3 ) , along with a novel protein , SDS 3 , function in the same repressor pathway . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
After fractionation of extracts from treated versus untreated cells , HDAC 1 and 2 eluted in several peaks of deacetylase activity , assayed using mixed acetylated histones or acetylated histone H 4 peptide . ^^^ Stimulation of cells with okadaic acid led to hyperphosphorylation of HDAC 1 and 2 as well as changes in column elution of both enzymes . ^^^ Phosphorylated HDAC 1 and 2 showed a gel mobility retardation that correlated with a small but significant increase in activity , both of which were reversed upon phosphatase treatment in vitro . ^^^ However , the most pronounced effect of HDAC phosphorylation was to disrupt protein complex formation between HDAC 1 and 2 as well as complex formation between HDAC 1 and corepressors mSin3A and YY 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In this study , we test the hypothesis that histone deacetylase 1 ( HDAC 1 ) is physically associated with a basic component of the DNA replication machinery as a mechanism of coordinating histone deacetylation and DNA synthesis . ^^^ We show that PCNA interacts with HDAC 1 in human cells and in vitro and that a considerable fraction of PCNA and HDAC 1 colocalize in the cell nucleus . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We show that Gam 1 can effectively inhibit histone deacetylation by HDAC 1 and that Gam 1 binds to HDAC 1 both in vitro and in vivo . ^^^ A CELO virus lacking Gam 1 ( CELOdG ) is replication defective , but the defect can be overcome by either expressing an interfering HDAC 1 mutant or by treating infected cells with TSA . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Chem . 2001 , 44 , 2069 2072 ) , into the new modeled HDAC 1 catalytic core is presented , and enzyme / inhibitor interactions are discussed . ^^^ HDAC 1 10 ray coordinates were obtained by virtual `` mutation ' ' of those of histone deacetylase like protein , a bacterial HDAC homologue . ^^^ In in vitro antimaize HD 2 as well as antimouse HDAC 1 assay , compounds 1a c showed inhibitory activities in the low micromolar range . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
SUMO 1 modification of histone deacetylase 1 ( HDAC 1 ) modulates its biological activities . ^^^ Here , in the course of assessing possible post translational modifications of HDAC 1 , we demonstrated that HDAC 1 is a substrate for SUMO 1 ( small ubiquitin related modifier ) modification in vitro and in vivo . ^^^ The HDAC 1 lysines targeted for modification were identified as C terminal Lys 444 and Lys 476 , which are also present in mammalian HDAC 2 and lower vertebrate HDAC1 / 2 orthologs yet absent from other HDAC family members , pointing to a means of differential regulation among HDAC proteins . ^^^ Mutation of these target residues ( lysine to arginine substitution ) profoundly reduced HDAC 1 mediated transcriptional repression in reporter assays without affecting HDAC 1 ability to associate with mSin3A and eliminated HDAC 1 induced cell cycle and apoptotic responses upon overexpression . ^^^ Together , the results demonstrate that HDAC 1 is modified by SUMO 1 , and this modification can dramatically affect HDAC 1 activity in a number of surrogate biological assays . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
A series of new , structurally simple trichostatin A ( TSA ) like straight chain hydroxamates were prepared and evaluated for their ability to inhibit partially purified human histone deacetylase 1 ( HDAC 1 ) . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Originally isolated as a transcriptional co repressor , HDAC 2 possesses extensive amino acid sequence homology to HDAC 1 ( the founding member and most extensively studied HDAC enzyme ) . ^^^ Because of this high degree of sequence similarity between HDAC 1 and HDAC 2 , coupled with the fact that the two always co exist in the same complexes , it is difficult to assess whether different properties exist between these two proteins . ^^^ We report here that HDAC 2 is a phosphoprotein similar to HDAC 1 . ^^^ In addition , like HDAC 1 , the phospho acceptor sites in HDAC 2 are located in the C terminal portion of the protein . ^^^ However , unlike HDAC 1 , which can be phosphorylated by protein kinase CK 2 , cAMP dependent protein kinase , and protein kinase G , HDAC 2 is phosphorylated uniquely by protein kinase CK 2 in vitro . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In this report , we show that AME physically interacts in vivo with CtBP 1 and HDAC 1 and that these co repressors require distinct regions of AME for interaction . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
A particular pair of HAT ( Esa 1 ) and HDAC ( Rpd 3 ) is proposed to modify the same lysine residue in vitro and in vivo . ^^^ Here we show that HAT ( Esa 1 family ) and HDAC ( Rpd 3 family ) have similar amino acid stretches in the primary structures through evolution . ^^^ We did alanine scanning mutagenesis and found that the ER motif regions of Esa 1 or Rpd 3 are required for HAT activity of Esa 1 or HDAC activity of Rpd 3 , respectively . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Chromatin immunoprecipitation studies revealed that INI1 / hSNF5 was directly recruited to the cyclin D 1 promoter and that its binding correlated with recruitment of HDAC 1 and deacetylation of histones at the promoter . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
There was no difference in the site of HDAC 1 HDAC6 expression between normal subjects and subjects with asthma , but subjects with asthma had reduced HDAC enzymatic activity and reduced HDAC 1 and HDAC 2 protein expression , as measured by Western blotting . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The mammalian SIN 3 complex consists of histone deacetylases ( HDAC 1 , HDAC 2 ) , several known proteins ( SAP 30 , N CoR ) and as yet unidentified proteins . ^^^ We have shown that TIS 7 protein interacts with several proteins of the SIN 3 complex ( mSin3B , HDAC 1 , N CoR and SAP 30 ) by yeast two hybrid screening and co immunoprecipitations . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here , we show that Dnmt3L , like Dnmt3a and Dnmt3b , interacts both in vitro and in vivo with the histone deacetylase HDAC 1 . ^^^ We find that Dnmt3L can repress transcription and that this repression is dependent on HDAC 1 and is relieved by treatment with the HDAC inhibitor trichostatin A . ^^^ Binding of Dnmt3L to HDAC 1 as well as its repressive function require the PHD like motif . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
HDAC 1 and HDAC 2 were more strongly inhibited by redFK than HDAC 4 and HDAC 6 . redFK was less active than FK 228 in inhibiting in vivo HDAC activity , due to rapid inactivation in medium and serum . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The interaction of HTLV 1 Tax with HDAC 1 negatively regulates the viral gene expression . ^^^ Here , we demonstrate the physical and functional interaction between Tax and HDAC 1 . ^^^ We found that HDAC 1 represses the trans activation function of Tax in 293T and MT 4 cells . ^^^ We also observed physical interaction between Tax and HDAC 1 both in vitro and in vivo . ^^^ The N terminal region of HDAC 1 ( amino acid residues 28 97 ) was required for this binding . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here we report on the cloning of the first P . polycephalum HDAC ( PpHDAC 1 ) related to the S . cerevisiae Rpd 3 protein . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We show that ESET histone methyltransferase associates with histone deacetylase 1 ( HDAC 1 ) and HDAC 2 , and that ESET also interacts with the transcription co repressors mSin3A and mSin3B . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Association of histone deacetylase 1 ( HDAC 1 ) with the promoter decreased after treatment with TSA or 5 AzaC and was abolished after treatment with both inhibitors . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
A fusion protein ( HDAC EG ) of human HDAC 1 fused with the estrogen receptor DNA binding domain and the glucocorticoid receptor ligand binding domain allowed targeting of chimeric HDAC 1 activity on estrogen responsive elements ( EREs ) in the presence of glucocorticoid ligands . ^^^ The antiestrogen effect of OHT thus differs from that of an ERE targeted HDAC 1 activity that might participate in irreversible silencing but is not sufficient to trigger it . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Using fluorescence resonance energy transfer analysis , we demonstrated that the acetylase PCAF and histone deacetylase 1 ( HDAC 1 ) are in close spatial proximity in living cells , compatible with their physical interaction . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
By means of quantitative reverse transcription polymerase chain reaction using SYBR Green to detect double stranded DNA , mRNA expression profiles for histone deacetylases ( HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 7 ) , histone acetyltransferases ( GCN 5 and HAT 1 ) , and histone H2A were established . ^^^ The HDAC 1 , HDAC 2 ( class 1 HDAC ) , and HAT 1 ( type B HAT ) revealed similar expression profiles . ^^^ The HDAC 3 ( class 1 HDAC ) tends to have an expression profile similar to those of HDAC 1 , HDAC 2 , and HAT 1 , whereas the HDAC 7 ( class 2 HDAC ) and GCN 5 ( type A HAT ) profiles were different from those three . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Among them , 3 ( 4 benzoyl 1 methyl 1H 2 pyrrolyl ) N hydroxy 2 propenamide 1 was chosen as lead compound , and its binding mode into the modeled HDAC 1 catalytic core together with its histone hyperacetylation , antiproliferative , and cytodifferentiating properties in cell based assays were investigated ( Mai , A . ; et al . ^^^ Against mouse HDAC 1 , 8 showed an IC 50 = 0 . 5 micro M ( IC 50 of 1 = 4 . 9 micro M ) , and also in cell based assay , 8 was endowed with higher histone hyperacetylating activity than 1 , although it was less potent than TSA and SAHA . ^^^ Such enhancement of inhibitory activity can be explained by the higher flexibility of the pyrrole C 4 substituent of 8 which accounts for a considerably better fitting into the HDAC 1 pocket and a more favorable enthalpy ligand receptor energy compared to 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
STAT 5 induced Id 1 transcription involves recruitment of HDAC 1 and deacetylation of C / EBPbeta . ^^^ STAT 5 interacts with HDAC 1 in the PBE region , resulting in deacetylation of histones , as well as C / EBPbeta , whose acetylation diminishes its DNA binding activity . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Recent studies indicate that the initiator of the myogenic program , namely MyoD , can associate with the deacetylase HDAC 1 in vivo , and because HDACs are usually recruited to promoters by specific proteins , we considered the possibility that these two proteins might be acting together at the promoters of muscle specific genes to repress their transcription in myoblasts . ^^^ In this work , we show by chromatin immunoprecipitation ( ChIP ) assays that MyoD and HDAC 1 are both occupying the promoter of myogenin and that this gene is in a region of repressed chromatin , as revealed by enrichment in histone H 3 lysine 9 ( Lys 9 ) methylation and the underacetylation of histones . ^^^ Surprisingly , after the myoblasts are induced to differentiate , the promoter becomes absent of HDAC 1 , and eventually the acetyltransferase P / CAF takes it place alongside MyoD . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In this study , we examined the status of histone H 4 acetylation and the level of HDAC 1 expression in surgically resected specimens of human esophageal squamous cell carcinoma by immunohistochemistry . ^^^ The cases in which HDAC 1 was less expressed in esophageal carcinoma cells than in the normal mucosa significantly increased as the carcinoma invaded into the deeper layers of the esophageal wall . ^^^ Furthermore , both the hyperacetylation of histone H 4 and the high expression of HDAC 1 were shown to topologically colocalize in the same tumor . ^^^ These results suggested that a dynamic equilibrium between the HAT and HDAC activities is disrupted in esophageal carcinoma , thus implying that a certain interaction may exist between the hyperacetylation of histone H 4 and the HDAC 1 expression . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The OsHDAC 1 gene encoded a protein of approximately 57 kDa that shared 73 . 5 , 72 . 7 , 79 . 9 , and 57 . 1 % amino acid sequence identity with the OsHDAC 2 , OsHDAC 3 , maize RPD 3 , and human HDAC 1 proteins , respectively . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here we show that HDAC 1 associates with and blocks Ser 133 phosphorylation of CREB during pre stimulus and attenuation phases of the cAMP response . ^^^ HDAC 1 promotes Ser 133 dephosphorylation via a stable interaction with PP 1 , which we detected in co immunoprecipitation and co purification studies . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
It was found that DJBP repressed a testosterone dependent AR transactivation activity in monkey Cos 1 cells by recruiting histone deacetylase ( HDAC ) complex , including HDAC 1 and mSin 3 , and that DJ 1 partially restored its repressed activity by abrogating DJBP HDAC complex . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Western blot analysis of these complexes suggests that hCtBP 1 associates with class 1 HDACs , HDAC 1 , HDAC 2 and HDAC 3 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
CIITA binds to overexpressed and endogenous HDAC 1 , suggesting that HDAC and CIITA may affect each other by direct or indirect association . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In assays of isolated enzymes , CI 994 inhibited HDAC 1 and HDAC 2 in a concentration dependent fashion but had no effect on the activity of the prototypical histone acetyltransferase GCN 5 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Laminar flow increased the activity of histone deacetylase ( HDAC ) and the association of p 53 with HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Consistent with its ability to inhibit histone deacetylation by HDAC 1 , Gam 1 activates transcription . ^^^ Here we demonstrate that p 120 ( E4F ) interacts with HDAC 1 in vivo and in vitro , and that E4F mediated transcriptional repression is alleviated by the HDAC inhibitor trichostatin A or by overexpressing Gam 1 . ^^^ Moreover , our cofractionation experiments demonstrate that p 120 ( E4F ) , HDAC 1 and Gam 1 may be concomitantly present in protein complexes . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Furthermore , we determined that HDAC 1 complexed with Sp 1 in PDAC cells and that TSA treatment interfered with this association . ^^^ Diminished binding of HDAC 1 to the 112 to 65 bp region of the TbetaRII promoter after TSA treatment was confirmed by a DNA affinity precipitation assay . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Meiosis specific deacetylation may be a consequence of the accessibility of HDAC 1 to the chromosome , because HDAC 1 colocalized with the chromosome during meiosis but not during mitosis . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We demonstrated that Sp 1 and Sp 3 recruit HDAC 1 and HDAC 2 , with the latter being phosphorylated by protein kinase CK 2 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Che 1 arrests human colon carcinoma cell proliferation by displacing HDAC 1 from the p21WAF1 / CIP1 promoter . ^^^ We previously demonstrated that Che 1 inhibits the Rb growth suppressing function by interfering with Rb mediated HDAC 1 recruitment on E2F target gene promoters . ^^^ Taken together , our results indicate that Che 1 can be considered a general HDAC 1 competitor and its down regulation is involved in colon carcinoma cell proliferation . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We found two to four fold elevated levels of mRNAs for HDAC 5 , 6 , 7 and 9 in early differentiation times in comparison with proliferating neurospheres while mRNA levels for HDAC 1 , 2 and 3 did not change significantly . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We further show that PIASy can interact constitutively with histone deacetylase 1 ( HDAC 1 ) and that addition of HDAC inhibitor trichostatin A ( TSA ) can prevent the inhibitory function of PIASy . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Meanwhile , western blot and immunohistochemical analyses showed no remarkable change in the expression of class 1 HDAC proteins such as HDAC 1 and HDCA 8 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
HDAC 1 expression and effect of TSA on proliferation and apoptosis of A 549 cells ] . ^^^ BACKGROUND & OBJECTIVE : Histone deacetylase ( HDAC ) shows a high expression in many cancer cells and the inhibitor of HDAC 1 , trichostatin A ( TSA ) , can inhibit the growth of cancer cells . ^^^ This paper was designed to investigate the expression of HDAC 1 of A 549 cell strains in hypoxia condition and the effect of TSA on their proliferation and apoptosis . ^^^ The expression of HDAC 1 in A 549 cells was examined using Western blot analysis . ^^^ The expression of mRNA of HDAC 1 and the effect of TSA on it were determined using reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
At the same time , an IkappaBalpha mutant , which lacked a functional nuclear localization sequence , interacted very efficiently with HDAC 1 and 3 and intensively enhanced the transactivation potential of Pit 1 . ^^^ Our results support the hypothesis that the NF kappaB inhibitor IkappaBalpha regulates the transcriptional activity of homeodomain containing proteins positively through cytoplasmic sequestration of HDAC 1 and HDAC 3 , a mechanism that would assign a new and unexpected role to IkappaBalpha . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
To further explore the catalytic activity of HDACs , we expressed two additional human class 1 HDACs , HDAC 1 and HDAC 3 , in baculovirus . ^^^ Recombinant HDAC 1 and HDAC 3 fusion proteins remained soluble and catalytically active and were purified to near homogeneity . ^^^ Interestingly , trichostatin ( TSA ) was found to be a potent inhibitor for all three HDACs ( IC 50 value of approximately 0 . 1 0 . 3 microM ) , whereas another HDAC inhibitor MS 27 275 ( N ( 2 aminophenyl ) 4 [ N ( pyridin 3 methyloxycarbonyl ) aminomethyl ] benzamide ) preferentially inhibited HDAC 1 ( IC 50 value of approximately 0 . 3 microM ) versus HDAC 3 ( IC 50 value of approximately 8 microM ) and had no inhibitory activity toward HDAC 8 ( IC 50 value > 100 microM ) . ^^^ HDAC 1 protein was more abundantly expressed in SW 620 cells compared with that of HDAC 3 and HDAC 8 . ^^^ Using purified recombinant HDAC proteins , we identified several novel HDAC inhibitors that preferentially inhibit HDAC 1 or HDAC 8 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In this study , we treated tumor cells with TPX and HDAC 1 antisense oligonucleotides , and analysed the transcriptional consequences of HDAC inhibition . ^^^ Among other genes , the small GTPase RhoB was found to be significantly upregulated by TPX and repressed by HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We confirmed the association of MRGX with HDAC 1 by immunoprecipitation / Western analysis and determined that MRGX complexes had HDAC activity . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We show that histone deacetylase 1 ( HDAC 1 ) interacts with ER alpha in vitro and in vivo and suppresses ER alpha transcription activity . ^^^ Overexpression of histone deacetylase HDAC 1 modulates breast cancer progression by negative regulation of estrogen receptor alpha . ^^^ The interaction of HDAC 1 with ER alpha was mediated by the AF 2 and DBD domains of ER alpha . ^^^ We observed an endogenous interaction of HDAC 1 with ER alpha in breast cancer cells , which was decreased in the presence of estrogen . ^^^ Interestingly , overexpression of HDAC 1 in stable transfected MCF 7 clones induced loss of ER alpha and significantly increased cell proliferation and colony formation , as compared to the control MCF 7 cells , whereas treatment of stable MCF 7 clones with the HDAC specific inhibitor trichostatin A ( TSA ) induced re expression of ER alpha mRNA and protein . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The siRNA for HDAC 3 and HDAC 1 demonstrated significant morphological changes in HeLa S 3 consistent with those observed with HDAC inhibitors . ^^^ HDAC 1 and 3 siRNA produced a concentration dependent inhibition of HeLa cell proliferation ; whereas , HDAC 4 and 7 siRNA showed no effect . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here we examine the interaction of REST , Co REST , Sin3A , HDAC 1 , and HDAC 2 with two archetypical endogenous target genes , the M 4 muscarinic receptor and the sodium type 2 channel ( NaV1 . 2 ) genes . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Thus , upon transient transfection of E1A and Ras oncogenes in REF 52 cells or their stable expression in E1A+cHa ras cells , E1A contributes to the formation of inactive chromatin structure through association with p300 / CBP histone acetyltransferases at c fos promoters , whereas Ras mediates its effect through constitutive activation of the MAP / ERK kinase cascade , thereby promoting the recruitment of HDAC 1 to the Elk 1 transcription factor . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
BRMS 1 exists in large mSin 3 complex ( es ) of approximately 1 . 4 1 . 9 MDa , but also forms smaller complexes with HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
To test the hypothesis that the delay reflected a dysfunction of ICP 0 in altering the structure of host protein viral DNA complexes , we examined the state of histone deacetylases ( HDACs ) ( HDAC 1 , HDAC 2 , and HDAC 3 ) . ^^^ We report the following . ( 1 ) HDAC 1 and HDAC 2 , but not HDAC 3 , were modified in infected cells . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We found individual components of Mi2 / NuRD : MBD 3 , Mi 2 , HDAC 1 and HDAC 2 to be expressed from a very early stage of embryo development and to localize in close proximity with each other and with constitutive heterochromatin by the blastula stage . ^^^ Then it is also found to be in proximity with heterochromatin ( based on DAPI staining ) and with MBD 3 , Mi 2 and HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The HDAC 1 protein associates with both signal transducer and activator of transcription ( STAT ) 1 and STAT 2 , and IFN alpha stimulation induces deacetylation of histone H 4 . ^^^ Inhibition of HDAC 1 by small interfering RNA ( siRNA ) decreases IFN alpha responsiveness whereas expression of HDAC 1 augments the IFN alpha response , demonstrating that HDAC 1 modulates IFN alpha induced transcription . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We previously reported not only that chicken HIRA , a homolog of Saccharomyces cerevisiae transcriptional corepressors Hir1p and Hir2p , possesses seven WD dipeptide motifs and a LXXLL motif in its N terminal half and C terminal half , respectively , but also that the N terminal and C terminal halves , respectively , bind to CAF 1p48 and HDAC 1 and 2 in vitro . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Affinity isolation of protein serine / threonine phosphatases on the immobilized phosphatase inhibitor microcystin LR identified histone deacetylase 1 ( HDAC 1 ) , HDAC 6 , and HDAC 10 as novel components of cellular phosphatase complexes . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Snail mediates E cadherin repression by the recruitment of the Sin3A / histone deacetylase 1 ( HDAC 1 ) / HDAC2 complex . ^^^ Most importantly , we demonstrate an interaction between Snail , histone deacetylase 1 ( HDAC 1 ) and HDAC 2 , and the corepressor mSin3A . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Surprisingly , the OHT complexed ERalpha also recruited a chromatin remodeling NuRD complex in which histone deacetylase 1 ( HDAC 1 ) is associated with several polypeptides including metastasis associated protein 1 / 2 ( MTA1 / 2 ) , and SWI2 / SNF2 related ATPase Mi 2 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In the present study , the pattern of gelsolin and retinoic acid receptor ( RAR ) beta expression in GC tissues showing HDAC 1 overexpression was investigated . ^^^ METHODS : Expression profiles of HDAC 1 , gelsolin , and RARbeta were evaluated and compared using reverse transcription polymerase chain reaction , immunoblotting , and immunohistochemical analyses with 22 paired primary human GC tissues and corresponding normal tissues . ^^^ RESULTS : Compared with normal gastric tissue , increased expression of HDAC 1 mRNA and protein was detected in 17 ( 77 . 3 % ) of 22 GC tissues , while decreased expressions of gelsolin mRNA and protein were shown in 15 ( 68 . 1 % ) samples . ^^^ Among 17 GC tissues with increased HDAC 1 expression , the expressions of gelsolin and RARbeta were simultaneously decreased in 14 ( 82 . 4 % ) and 15 ( 88 . 2 % ) GC tissues , which indicates a strong inverse correlation between HDAC 1 and gelsolin / RARbeta expressions . ^^^ Correlation between HDAC 1 and gelsolin / RARbeta was also confirmed by immunohistochemistry . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Histone deacetylase ( HDAC ) inhibitor activation of p21WAF1 involves changes in promoter associated proteins , including HDAC 1 . ^^^ The HDACi caused a marked decrease in HDAC 1 and Myc and an increase in RNA polymerase 2 in proteins bound to the p 21 ( WAF 1 ) promoter . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
NaB stimulated recruitment of the transcription factors ZBP 89 and Sp 1 as well as GCN 5 , but did not influence recruitment of Sp 3 , HDAC 1 , p 300 , or CBP . ^^^ As recruitment of HDAC 1 to the promoter appeared not to account for NaB induced changes in histone acetylation , we aimed to influence HDAC activity by altering its phosphorylation status . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We show that the RD 1 domain binds HDAC 1 and HDAC 2 and that HDAC activity is required for PIASy mediated AR repression . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Biological activities of 3 and 4 were predicted by computational tools up to 617 fold more potent than that of 1 against HDAC 1 ; thus , 3 and 4 were synthesized and tested against both mouse HDAC 1 and maize HD 2 enzymes . ^^^ Ligand / receptor positive interactions made by 3 and 4 into the catalytic pocket , in addition to those showed by 1 , could at least in part account for their higher HDAC 1 inhibitory activities . ^^^ In particular , in mouse HDAC 1 inhibitory assay 3 and 4 were 19 and 6 times more potent than 1 , respectively , and 3 and 4 antimaize HD 2 activities were 16 and 76 times higher than that of 1 , 4 being as potent as SAHA in this assay . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Expression and functional characterization of recombinant human HDAC 1 and HDAC 3 . ^^^ Here we present the stable expression of human recombinant His tagged HDAC 1 and HDAC 3 in mammalian cells . ^^^ Full length human genes for HDAC 1 and HDAC 3 were cloned into the pcDNA 3 . 1 vector containing a N terminal His tag with an enterokinase cleavage site . ^^^ Western blots demonstrated the nickel affinity purified rhHDAC 1 preparation also contained endogenous HDAC 2 and HDAC 3 ; likewise , rhHDAC 3 preparation contained endogenous HDAC 1 and HDAC 2 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Inhibition of proteasomal proteolysis , but not of caspase activity rescued pRb from degradation and functionally restored its inhibitory effect on the cyclin E gene , known to be suppressed by pRb E2F 1 in conjunction with HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Our data showed Sp 1 associated HDAC 1 in cells was increased after ras induction . ^^^ By using DNA affinity precipitation assay , we found that induction of oncogenic ras enhanced the binding of HDAC 1 to the DNA probe corresponding to the Sp 1 site in the RECK promoter . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Consistent with prior studies , we find that RPD 3 , which encodes a histone deacetylase ( HDAC ) , is required for repression upon rapamycin treatment . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
To relate HDAC inhibition to the anti proliferative effects of NVP LAQ 824 , expression of HDAC 1 was inhibited using antisense and this was sufficient to activate p 21 expression , hypophosphorylate Rb and inhibit cell growth . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In this study , we have analyzed the role of histone deacetylase 1 ( HDAC 1 ) on HTLV 1 gene expression from an integrated template . ^^^ Second , using a cell line containing a single copy HTLV 1 long terminal repeat , we demonstrate that overexpression of HDAC 1 represses Tax transactivation . ^^^ We demonstrate that HDAC 1 is associated with the inactive , but not the Tax transactivated , HTLV 1 promoter . ^^^ In vitro and in vivo glutathione S transferase Tax pull down and coimmunoprecipitation experiments demonstrated that there is a direct physical association between Tax and HDAC 1 . ^^^ Importantly , biotinylated chromatin pull down assays demonstrated that Tax inhibits and / or dissociates the binding of HDAC 1 to the HTLV 1 promoter . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The expression of 10 histone deacetylases ( HDAC 1 10 ) mRNAs in mouse neuroblastoma Neuro 2a and microglia N 9 cell cultures after treatment by inhibitors of HDACs , sodium butyrate and trichostatin A was studied to elucidate whether HDAC inhibitors affect the gene expression of HDACs themselves . ^^^ Northern blot analysis demonstrated two to four fold elevated levels of mRNAs for HDAC 1 , 3 , 5 , and 6 after drug treatment in comparison with untreated cells , while mRNA levels for HDAC 2 and 7 did not change significantly . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
These HDAC inhibitors preferentially inhibited the enzymatic activities of HDAC 1 and HDAC 2 , as compared with the other HDAC isotypes , indicating that class 1 HDAC is the major target of SK 7041 and SK 7068 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The reaction of HDAC 8 with an alternative substrate was performed to assess the steric requirements of the HDAC 8 active site , and the effect of phosphorylation on HDAC 1 activity was examined . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
LRF associated with histone deacetylase 1 ( HDAC 1 ) , and experiments utilizing the HDAC inhibitor trichostatin A revealed that LRF mediated repression requires deacetylase activity . ^^^ LRF is the first transcription factor found to bind directly to the COMP gene promoter , to recruit HDAC 1 , and to regulate both COMP gene expression and chondrogenic differentiation . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
RESULTS : After exposure to any of 4 different polyamides that specifically block HDAC 1 recruitment by LSF to the HIV promoter , replication competent HIV was recovered from cultures of resting CD4+ T cells in 6 of 8 HIV infected patients whose viremia had been suppressed by therapy . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Furthermore , p73alpha , but not the oncogenic DeltaNp73alpha , binds directly to HDAC 1 . ^^^ We performed chromatin immunoprecipitation with antibodies against p 73 , DeltaNp 73 , NFYB , p 300 and HDAC 1 at different periods after serum stimulation in serum starved NIH3T3 cells . ^^^ Conversely , HDAC 1 was found bound at its maximum and the anti p 73 detecting both TAp 73 and DeltaNp 73 was found at all time points , indicating that p 73 , but not DeltaNp 73 , remains bound at this time . ^^^ Double immunofluorescence staining of TAp 73 and HDAC 1 revealed that both of these molecules exist in the nucleus at this time point , supporting the presence of endogenous interaction . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Thus , HDAC 2 appears to serve a preferential role in the prevention of apoptosis and not in cell cycle control similar to the specific importance of HDAC 1 for cell cycle regulation or HDAC 9 for the stress response of the heart . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
IUGR significantly increased acetylation of H 3 lysine 9 ( H3 / K9 ) , lysine 14 ( H3 / K14 ) , and lysine 18 ( H3 / K18 ) at day 0 of life , and these changes occurred in association with decreased nuclear protein levels of histone deacetylase 1 ( HDAC 1 ) and HDAC activity . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Apoptosis was associated with HDAC 1 dependent induction of Bax and acetylation of p 53 . ^^^ Down regulation of HDAC 1 by an antisense vector sensitized the cells to NaB induced apoptosis , whereas its overexpression conferred resistance to this agent . ^^^ Increased HDAC 1 levels and activity impaired NaB mediated activation of Bax promoter and Bax protein levels . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Overexpression of HDAC 1 negated the inhibitory effect of DEX on LEF / TCF transcriptional activity . ^^^ These results suggest that inhibition of a PI3K / Akt / GSK3beta / beta catenin / LEF axis and stimulation of HDAC 1 cooperate to mediate the inhibitory effect of DEX on Wnt signaling and the osteoblast differentiation related cell cycle . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In the absence of estradiol ( E 2 ) , Sp 1 , Sp 3 , histone deacetylase 1 ( HDAC ) , and HDAC 2 , and low levels of acetylated H 3 and H 4 are associated with the native promoter , with the histones being engaged in dynamic reversible acetylation . ^^^ There is clearance of Sp 1 , but not of Sp 3 , from the promoter while HDAC 1 and HDAC 2 remain bound . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Consistent with the observation of HDAC activity , RT PCR analysis demonstrated that an amebic hdac 1 homolog ( ehHDAC ) is expressed and appropriately spliced in E . histolytica trophozoites . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Co immunoprecipitation , DNA `` pull down , ' ' and chromatin immunoprecipitation experiments together showed that in cycling cells , estrogen receptor alpha and histone deacetylase 1 ( HDAC 1 ) are recruited to the proximal Sp 1 sites of the promoter to repress p21Waf1 expression . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Among the differentially expressed genes , we chose for further validation histone deacetylase 1 ( HDAC 1 ) , von Hippel Lindau and decorin as upregulated genes , and Sp 1 , hypoxia inducible factor 1 alpha and DNA primase as downregulated genes . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
To test this possibility , we have sought to screen the expression profiles of several class 1 and class 2 HDACs ( HDAC 1 8 ) in DU 145 , PC 3 and LNCaP human prostate cancer cell lines as well as in matched malignant and non malignant prostate tissues by use of real time RT PCR , immunoblot and immunohistochemistry . ^^^ In prostate tissues , the abundance of HDAC 1 protein , which was exclusively expressed in the cell nucleus , was similar in normal and malignant epithelial cells , but was usually lower in stromal cells . ^^^ Altogether , our findings indicate that epithelial and stromal cells exhibit distinct class 1 HDAC expression profiles , and the abundance of HDAC 1 is not altered in human prostate cancer . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The N terminal region directs hr to a speckled nuclear pattern that co localizes with the histone deacetylase 3 ( HDAC ) , but not with HDAC 1 or HDAC 7 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The yeast histone acetyltransferase ( HAT ) gene gcn 5 and histone deacetylase ( HDAC ) gene rpd 3 were cloned from yeast genomic DNA by PCR amplification . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Mouse lungs were assayed immunohistochemically for HDAC 1 , a major HDAC subtype , and for infiltration of CD4+ cells . ^^^ RESULTS : HDAC 1 was localized within most airway cells and infiltrating inflammatory cells of asthmatic lungs . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Herein , murine embryonic fibroblast ( MEF ) differentiation by PPARgamma ligand was associated with a reduction in histone deacetylase ( HDAC 1 ) activity . ^^^ Genetic deletion of cyclin D 1 reduced HDAC 1 activity . ^^^ Reconstitution of cyclin D 1 into the cyclin D 1 / MEFs increased HDAC 1 activity and blocked PPARgamma mediated adipogenesis . ^^^ Cyclin D 1 bound HDAC in vivo and preferentially physically associated with HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 5 . ^^^ Chromatin immunoprecipitation assay demonstrated that cyclin D 1 enhanced recruitment of HDAC 1 and HDAC 3 and histone methyltransferase SUV39H1 to the PPAR response element of the lipoprotein lipase promoter and decreased acetylation of total histone H 3 and histone H 3 lysine 9 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We further showed that Sp 1 bound to the endogenous eNOS promoter and associated with HDAC 1 in non endothelial HeLa cells . ^^^ Combined TSA and AzadC treatment increased Sp 1 binding to the endogenous eNOS promoter but decreased the association between HDAC 1 and Sp 1 in HeLa cells . ^^^ Our data suggest that HDAC 1 plays a critical role in eNOS repression , and the proximal Sp 1 site may serve a key target for HDCA 1 mediated eNOS repression in non endothelial cells . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
This was the result of cyclin E / CDK2 interfering with the interaction of Mad 1 with HDAC 1 and reducing HDAC activity . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Chromatin immunoprecipitation assays suggested that SLUG mediates its action by recruiting C terminal binding protein 1 ( CtBP 1 ) and histone deacetylase 1 ( HDAC 1 ) at the silencer E 2 box . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The activation of ER gene expression by 5 aza 2 ' deoxycytidine also involves the release of the repressor complex involving various methyl binding proteins , DNMTs , and HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
These results prompted us to study HDAC 1 and 3 expression in breast tumours to establish their potential therapeutic and prognostic significance . ^^^ HDAC 1 und HDAC 3 protein expression was analyzed immunohistochemically on a tissue microarray ( TMA ) containing 600 core biopsies from 200 patients . ^^^ HDAC 1 and 3 expression was correlated to steroid hormone receptor , Her2 / neu and proliferation status of tumours as well as to overall and disease free survival . ^^^ Moderate or strong nuclear immunoreactivity for HDAC 1 was observed in 39 . 8 % and for HDAC 3 in 43 . 9 % of breast carcinomas . ^^^ HDAC 1 and 3 expression correlated significantly with oestrogen and progesterone receptor expression ( both p < 0 . 001 ) . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Cell fractionation assays performed with primary human smooth muscle cells ( HSMCs ) showed that HDAC 8 , in contrast to HDAC 1 and HDAC 3 , was enriched in cytoskeleton bound protein fractions and insoluble cell pellets , suggesting an association of HDAC 8 with the cystoskeleton . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Furthermore , we observed that HDAC 1 was recruited to the 3 ' IgH enhancer hs 1 , 2 as determined by chromatin immunoprecipitation assays . ^^^ Over expression of HDAC 1 increased the activity of IgH enhancers , especially 3 ' IgH enhancers . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Following DNA damage , p 53 is rapidly acetylated at K 320 and K 373 to K 382 , histones are deacetylated , and the release of PCAF and p 300 correlates with the recruitment of histone deacetylases ( HDACs ) HDAC 1 before HDAC 4 and HDAC 5 and promoter repression . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
From GST pull down assays , we demonstrated a direct interaction between SHP and diverse histone deacetylases ( HDACs ) as well as a strong interaction between HDAC 1 and SHP inhibitory domains . ^^^ We further supported the evidence for an interaction between SHP and HDAC 1 by showing their co immunoprecipitation and provided evidence for the existence of a ternary complex comprising AR , SHP , and HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
When tested against human HDAC 1 and HDAC 4 , 2f showed no inhibitory activity against HDAC 1 but was able to inhibit HDAC 4 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Total RNA extracted from lung tissue and macrophages was used for quantitative reverse transcriptase polymerase chain reaction assay of HDAC 1 through HDAC 8 and interleukin 8 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Similarly , RNAi depletion or overexpression of human HDAC 1 also affected cell migration . ^^^ These findings suggest that HDA 1 / HDAC 1 may play a critical , evolutionarily conserved role in regulating the extracellular microenvironment . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Transcriptional repression by the MBD 4 is histone deacetylase ( HDAC ) dependent , and MBD 4 directly binds to Sin3A and HDAC 1 at three central regions that overlap transcriptional repression domains . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Overexpression of HDAC 1 further inhibits the Pod 1 mediated repressions and Pod 1 directly interacts with HDAC 1 . ^^^ Furthermore , chromatin immunoprecipitation assay reveals that HDAC 1 is recruited with Pod 1 to the endogenous AR promoter and the androgen regulated Pem promoter . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here , we report that histone deacetylase 1 ( Hdac 1 ) is required for the switch from proliferation to differentiation in the zebrafish retina . ^^^ The cloning of the add gene revealed that it encodes Hdac 1 . ^^^ These data suggest that Hdac 1 antagonizes these pathways to promote cell cycle exit and the subsequent neurogenesis in zebrafish retina . ^^^ Taken together , these data suggest that Hdac 1 functions as a dual switch that suppresses both cell cycle progression and inhibition of neurogenesis in the zebrafish retina . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Selected ligands were docked into the active site of human HDAC 1 . ^^^ Based on the docking results , a novel binding mode of indole amide analogues in the human HDAC 1 catalytic core is presented , and enzyme / inhibitor interactions are discussed . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
EGF , however , induces the association of histone deacetylase 1 ( HDAC 1 ) with the DR 5 gene , whereas etoposide treatment fails to induce this association . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Indirect immunofluorescence analysis of global DNA methylation , histone acetylation and HDAC distribution ( HDAC 1 , 2 and 3 ) , carried out in monospermic zygotes that reached the late PN stage , showed that IVM oocytes also had a reduced epigenetic competence . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
HDAC 3 but not HDAC 1 or HDAC 2 was required for AP 1 mediated stimulation of c jun expression . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Aza 2 ' deoxycytidine ( decitabine ) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 ( HDAC 1 ) without requiring p21WAF1 promoter demethylation . ^^^ However , decitabine induced p21WAF1 in AML cell lines KG 1 and KG 1a in association with release of HDAC 1 and increased acetylated histone H 3 at the unmethylated p21WAF1 promoter . ^^^ Our findings indicate that decitabine can relieve p21WAF1 repression in AML by a mechanism that involves release of HDAC 1 without requiring promoter demethylation . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Mutation analysis of the HDAC 1 , 2 , 8 and CDKL 5 genes in Rett syndrome patients without mutations in MECP 2 . ^^^ In the remaining seven girls we then analyzed the genes HDAC 1 , HDAC 2 , and HDAC 8 that encode for the histone deacetylases 1 , 2 , and 8 which interact with MeCP 2 and are essential for its function . ^^^ The genes HDAC 1 , HDAC 2 , and HDAC 8 do not seem to play a role in the pathogenesis of RTT and at least in our subgroup no mutations in the CDKL 5 gene were detected . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Since the chromatin remodeling enzyme histone deacetylase 1 ( HDAC 1 ) maintains latency of integrated HIV , we tested the ability of the HDAC inhibitor valproic acid to deplete persistent , latent infection in resting CD4+ T cells . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Coimmunoprecipitation analysis identified the presence of the mSin3A , HDAC 1 , and HDAC 2 corepressor complex in MA 10 cells . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
This differential expression is regulated by the recruitment of histone deacytelasse 1 ( HDAC 1 ) to the DR 5 gene by NFkappaB following EGF treatment but not etoposide treatment . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
To understand the physiological functions of HDACs , we characterized six different Drosophila HDACs , including Rpd 3 , HDAC 3 , HDAC 4 , HDAC 6 S , HDAC 6 L , and Sir 2 , by developmental expression pattern , transcriptional profiles of target genes , and sensitivity to HDAC inhibitors . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
With exposure to a histone deacetylase inhibitor ( HDAC 1 ) , trichostatin A , cell lines with the pattern 2 demonstrated strong and persistent induction of TGFbetaRII expression , while those with the pattern 3 showed only weak or no induction . ^^^ Treatment with 5 aza 2 ' deoxycytidine ( 5aza dC ) in addition to HDAC 1 resulted in strong and continuous induction of TGFbetaRII expression and H3K4 Me in ACC LC 176 , although 5aza dC alone was without such effects . ^^^ In ACC LC 91 , both H 3 Ac and H3K4 Me were promptly and simultaneously induced by HDAC 1 , and similarly inhibited by wortmannin , a PI3K family inhibitor , together with TGFbetaRII induction . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Quantitation of HDAC 1 mRNA expression in invasive carcinoma of the breast * . ^^^ The aim of this study was to determine the expression of the HDAC 1 gene in malignant human breast tissue and to correlate our observations with available clinical information . ^^^ In the present study , the level of expression of HDAC 1 mRNA was assessed by LightCycler based quantitative real time reverse transcriptase ( RT ) PCR analysis in 162 cases of invasive carcinoma of the breast . ^^^ Associations between HDAC 1 mRNA expression and different clinicopathological factors were sought . ^^^ It was found that HDAC 1 mRNA was expressed at significantly higher levels in tumors from patients over 50 years of age and in those tumors without axillary lymph node involvement , that are less than 2 cm , that are of a non high histological grade , that are HER 2 negative and that are ERalpha / PgR positive . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
The HDAC inhibitor , trichostatin A , reduced MMSET 1 repression activity and in vitro co immunoprecipitation analyses indicated that MMSET 1 specifically recruits HDAC 1 and mSin3b , but not HDAC 2 or HDAC 4 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Association of HDAC 3 and HDAC 1 with the relB VDR binding site was observed , but only HDAC 3 was reciprocally modulated by D ( 3 ) analog and LPS . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
To understand the difference between class 1 HDAC isoforms that could be exploited for the design of isoform specific HDAC inhibitors , we have built three dimensional models of four class 1 histone deacetylases , HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We also found that HDAC 1 levels decline during normal replicative senescence . ^^^ Reduced HDAC 1 expression levels in senescent cells may be an important event in mediating the transition to a senescent phenotype . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We also observed that STAT 3 interacts with histone deacetylases ( HDACs ) , specifically HDAC 1 , that down regulate IL 6 induced hAGT transactivation . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Nondenaturing co IP assays indicate that nuclear Bcl 3 associates with STAT 1 and histone deacetylase 1 ( HDAC 1 ) , increasing HDAC 1 recruitment to the IL 8 promoter . ^^^ A nuclear targeting deficient Bcl 3 is unable to enhance HDAC 1 mediated chemokine repression . ^^^ These data indicate that Bcl 3 is a virus inducible inhibitor of chemokine transcription by interfering with the NF kappaB and STAT / IRF signaling pathways by complexing with them and recruiting HDAC 1 to attenuate target promoter activity . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Knockdown of p 50 expression with specific small hairpin RNAs reduces HDAC 1 binding to the latent HIV LTR and induces RNA polymerase 2 recruitment . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
There were no changes in HDAC 1 , suggesting that NaBu might be able to kill transformed cells bypassing the HDAC inhibitory effect . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We found that cells treated with the pro inflammatory cytokine tumour necrosis factor alpha rapidly and substantially reduced HDAC 1 protein levels without affecting other class 1 HDACs . ^^^ In addition , HDAC 1 depletion occurred through protein degradation , required IKK 2 activity and resulted in increased transcription from both NF kappaB associated and unassociated gene promoters . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
CSE also reduced histone deacetylase ( HDAC ) activity and HDAC 1 , HDAC 2 , and HDAC 3 protein levels . ^^^ This was associated with posttranslational modification of HDAC 1 , HDAC 2 , and HDAC 3 protein by nitrotyrosine and aldehyde adduct formation . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Immunoprecipitation experiments showed that histone deacetylase 1 ( HDAC 1 ) and HDAC activity are associated with Sp 1 in serum starved cells or during serum stimulation . ^^^ However , HDAC 1 association with E2F was only detected in serum starved cells . ^^^ By chromatin immunoprecipitation assays , we detected both direct and indirect association of HDAC 1 with the CTalpha promoter . ^^^ Our data suggest that HDAC 1 plays a critical role in CTalpha repression and that Sp 1 and E2F may serve as key targets for HDAC 1 mediated CTalpha repression in fibroblasts . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
We herein demonstrate that the HDAC inhibitor , trichostatin A ( TSA ) , increases the level of acetylated GCMa and that HDAC 1 , 3 , 4 and 5 interact with and deacetylate GCMa . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Whereas a role for HDAC 1 and 2 in mediating components of the HDAC inhibitor response has been reported , the role of HDAC 3 is unknown . ^^^ Similar effects were observed for HDAC 2 and , to a lesser extent , for HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In addition , AP 4 interacted with HDAC 1 both in vivo and in vitro . ^^^ Moreover , chromatin immunoprecipitation assays have revealed that AP 4 and HDAC 1 are present in the HIV 1 LTR promoter in latently infected ACH 2 and U 1 cells , and they are dissociated from the promoter concomitantly with the association of acetylated histone H 3 , TBP , and RNA polymerase 2 upon TNF alpha stimulation of HIV 1 replication . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Recently , we found 2 histone deacetylase inhibitors ( HDAC 1 ) , valproic acid and ITF 2357 , exhibiting inherent therapeutic activity against HCC . ^^^ In TRAIL sensitive cancer cells , the mechanism of HDAC 1 induced cell death has been identified to be TRAIL dependent by inducing apoptosis in an autocrine fashion . ^^^ In contrast , in HCC derived cells , a prototype of TRAIL resistant tumor cells , we found a HDAC 1 mediated apoptosis that works independently of TRAIL and upregulation of death receptors or their cognate ligands . ^^^ Interestingly , TRAIL resistance could be overcome by a combinatorial application of HDAC 1 and TRAIL , increasing the fraction of apoptotic cells two to threefold compared with HDAC 1 treatment alone , whereas any premature HDAC 1 withdrawal rapidly restored TRAIL resistance . ^^^ Furthermore , a tumor cell specific downregulation of the FLICE inhibitory protein ( FLIP ) was observed , constituting a new mechanism of TRAIL sensitivity restoration by HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Silencing of Drosophila HDAC 1 ( DHDAC 1 ) , but not of the other DHDAC family members , leads to increased histone acetylation . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
CRA 024781 inhibited pure recombinant HDAC 1 with a K ( 1 ) of 0 . 007 mumol / L , and also inhibited the other HDAC isozymes HDAC 2 , HDAC3 / SMRT , HDAC 6 , HDAC 8 , and HDAC 10 in the nanomolar range . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Here , we demonstrate by a combination of antisense and chromatin immunoprecipitation ( ChIP ) analysis that E1A 12 is a physical component of the class 1 enhancer repression complex , known to comprise COUP TFII and histone deacetylase 1 ( HDAC 1 ) . ^^^ Significantly , E1A antisense was shown to co eliminate E1A 12 as well as HDAC 1 and HDAC 8 , but not HDAC 3 , from the enhancer repression complex . ^^^ Consistent with elimination of HDAC 1 and HDAC 8 , E1A antisense also resulted in a dramatic increase in histone acetylation , a hallmark of transcriptionally active chromatin . ^^^ These results demonstrate that E1A 12 is associated with the MHC class 1 complex and apparently mediates class 1 transcriptional down regulation by enacting chromatin repression through HDAC 1 and HDAC8 . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
LPS transiently repressed , then induced a number of HDACs ( Hdac 4 , 5 , 7 ) in BMM , whereas Hdac 1 mRNA was induced more rapidly . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Using different HDACi together with small interfering RNA for HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 6 , we report that inhibition of HDAC 1 and HDAC 2 but not HDAC 3 , HDAC 6 , and HDAC 8 are primarily responsible for sensitization to TRAIL induced apoptosis . ^^^ Based on these data and our previous studies , we propose that a clinical trial in CLL is warranted using a combination of a selective HDACi that inhibits HDAC 1 and / or HDAC 2 together with a form of TRAIL that signals through TRAIL receptor 1 . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Immunoprecipitation studies revealed that Tax co exists in a complex containing both histone deacetylase 1 ( HDAC 1 ) and 3 ( HDAC 3 ) . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Involvement of HDAC 1 and the PI3K / PKC signaling pathways in NF kappaB activation by the HDAC inhibitor apicidin . ^^^ Furthermore , apicidin activation of NF kappaB seems to result from HDAC 1 inhibition , as evidenced by the observation that overexpression of HDAC 1 , but not HDAC 2 , 3 or 4 , dramatically inhibits NF kappaB reporter gene activity . ^^^ Collectively , our results suggest that activation of NF kappaB signaling by apicidin requires both the PI3K / PKC signaling pathways and HDAC 1 , and functions as a critical modulator in determining the cellular effect of apicidin . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
DNA affinity precipitation assay ( DAPA ) shows that histone deacetylase 1 ( HDAC 1 ) is recruited to the Sp 1 sites after 1 , 25 dihydroxyvitamin D 3 stimulation . ^^^ Re CHIP assay verifies that binding of Sp 1 and HDAC 1 to p45Skp2 promoter is enhanced after 1 , 25 dihydroxyvitamin D 3 treatment . ^^^ Collectively , our results suggest that 1 , 25 dihydroxyvitamin D 3 induces the formation of VDR / Sp1 complex and acts via a Sp 1 and HDAC 1 depedent pathway to inhibit p45Skp2 transcription . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
CRA 026440 inhibited pure recombinant isozymes HDAC 1 , HDAC 2 , HDAC3 / SMRT , HDAC 6 , HDAC 8 , and HDAC 10 in the nanomolar range . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Reconstitution of recombinant complexes revealed a functional connection between HDAC 1 and BHC 110 only when nucleosomal substrates were used . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Specifically , HDAC 1 is linked with cell growth , a hallmark of cancer formation . ^^^ HDAC 1 is a phosphoprotein and phosphorylation at S 421 and S 423 promotes HDAC 1 enzymatic activity and protein association . ^^^ While single and double point mutants of HDAC 1 at S 421 and S 423 appear functionally similar , the evidence suggests that HDAC 1 is phosphorylated simultaneously at both S 421 and S 423 in vivo . ^^^ Additional experiments are necessary to probe the role of double phosphorylation of HDAC 1 at S 421 and S 423 . ^^^ RESULTS : To characterize HDAC 1 phosphorylation at S 421 and S 423 , limited proteolysis of HDAC 1 was performed for the first time . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
HDRP also interacts with histone deacetylase 1 ( HDAC 1 ) and recruits it to the c Jun gene promoter , resulting in an inhibition of histone H 3 acetylation at the c Jun promoter . ^^^ Although HDRP lacks intrinsic deacetylase activity , treatment with pharmacological inhibitors of histone deacetylases induces apoptosis even in the presence of ectopically expressed HDRP , underscoring the importance of c Jun promoter deacetylation by HDRP HDAC 1 in HDRP mediated neuroprotection . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
In functional assays , MITR negatively regulates MEF 2 dependent transcription and we show that this repression is mediated by direct binding of MITR to the histone deacetylase HDAC 1 . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
Finally , modification experiments indicate that the MEF 2 interacting transcription repressor ( MITR ) as well as HDAC 1 and 6 are similarly SUMO modified , indicating that sumoylation may be an important regulatory mechanism for the control of transcriptional repression mediated by both class 1 and 2 HDACs . . ^^^
Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UKV0 and Q13547	Pubmed	SVM Score :0.0
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