| In wild type virus infected cells , HDAC 1 dissociates from the CoREST / REST complex , CoREST and HDAC 1 are phosphorylated by a process mediated by viral protein kinases , and CoREST and HDAC 1 are partially translocated to the cytoplasm . ^^^ In cells infected with a virus mutant ( DeltaICP 4 ) , in which ICP 0 accumulates , but post alpha gene expression is blocked , HDAC 1 is dissociated from the CoREST / REST complex , but translocation to the cytoplasm does not occur . ^^^ These results suggest that , at low multiplicities of infection , ICP 0 blocks CoREST mediated silencing of viral genes by dissociation of HDAC 1 , whereas subsequent modifications and translocation of the components of the complex are the functions of other viral gene products made later in infection . . ^^^ |