| SENP 1 enhances androgen receptor dependent transcription through desumoylation of histone deacetylase 1 . ^^^ SENP 1 ' s ability to enhance AR dependent transcription is not mediated through desumoylation of AR , but rather through its ability to deconjugate histone deacetylase 1 ( HDAC 1 ) , thereby reducing its deacetylase activity . ^^^ HDAC 1 ' s repressive effect on AR dependent transcription could be reversed by SENP 1 and by deletion of its sumoylation sites . ^^^ RNA interference depletion of endogenous HDAC 1 also reduced SENP 1 ' s effect . ^^^ Thus , SENP 1 could regulate AR dependent transcription through desumoylation of HDAC 1 . ^^^ |