| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Two histone deacetylases , HD 1 and HD 2 , could be discriminated . ^^^ The order of acetylated substrate preference is H2A much greater than H 3 greater than or equal to H 4 greater than H2B for HD 1 and H 3 greater than H2A greater than H 4 for HD 2 , respectively ; HD 2 is inactive with H2B as substrate . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Two nuclear histone acetyltransferases , A 1 and A 2 , a cytoplasmic B enzyme and two nuclear histone deacetylases , HD 1 and HD 2 , have been identified . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Human histone deacetylase 2 , HDAC 2 ( Human RPD 3 ) , is localized to 6q21 by radiation hybrid mapping . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1 / WAF1 expression , independent of histone deacetylase 1 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| RFX 5 specifically interacts with histone deacetylase 2 ( HDAC 2 ) and the mammalian transcriptional repressor ( mSin3B ) , whereas RFX 1 preferably interacts with HDAC 1 and mSin3A . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Using 32P labelled oligonucleotides derived from the coding regions of dopamine D 1 , D 2 and D 3 receptor mRNAs we localized cells containing transcripts for these receptors in the human ( hD 1 , hD 2 ) and rat brain ( rD 1 , rD 2 , rD 3 ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Therefore , the effects of limited ( decrease in hematocrit [ Hct ] from 30 to 20 % , `` HD 1 ' ' ) and severe ( decrease in Hct from 20 to 14 % , `` HD 2 ' ' ) acute normovolemic HD with 6 % hydroxyethyl starch on splanchnic blood flows ( electromagnetic flow probes ) , O 2 uptakes and deliveries , surface O 2 tensions ( PO 2 ) ( Clark type electrode ) , hepatic metabolism ( organic acids ) , and hepatic histology ( liver biopsies ) were studied in nine pigs anesthetized and paralyzed with ketamine / flunitrazepam and pancuronium . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The two histone deacetylases , HD 1 and HD 2 , exhibit entirely different patterns . ^^^ Whereas HD 1 activity is low in the dry embryo and increases during germination , HD 2 is the predominant enzyme at the start of differentiation , but almost disappears at later stages . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Between July 1982 and June 1985 235 out of 436 untreated patients with Morbus Hodgkin ' s disease qualified for the protocols HD 1 ( stage IA to IIIA with risk factors ) , HD 2 ( stage IIIA ) and HD 3 ( stages IIIB and IVA / B ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Intermediate results of the study protocols HD 1 , HD 2 , and HD 3 ] . ^^^ Between July 1983 and September 1986 358 untreated patients with Hodgkin ' s lymphoma qualified for the protocols HD 1 ( stages 1 to IIIA with risk factors ) , HD 2 ( stage IIIA ) , and HD 3 ( stages IIIB and IVAB ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Quidel Allergy Screen ( QAS ) , an enzyme linked immunosorbent assay , has been developed for measuring IgE antibodies against 9 allergens ( HD 1 , HD 2 , Mite 1 , Mite 2 , Japanese cedar , ragweed , cat dander , sweet vernal grass , and egg white ) at the same time . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Two hemodialysis were performed at the 44th ( HD 1 ) and the 92nd ( HD 2 ) hour , and blood samples were drawn simultaneously on arterial and venous sides of the dialyzer at the onset of HD 1 and at the end of HD 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Intermediate results of therapy studies HD 1 , HD 2 and HD 3 of the German Hodgkin Study Group ] . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Fusion between HeLa and fibroblasts from complementation group D xeroderma pigmentosum ( XPD ) followed by challenge with small doses of ultraviolet light ( u . v . ) results in the production of hybrid cells expressing either HeLa ( HD 1 ) or XPD like ( HD 2 ) sensitivity to u . v . and related repair capacity . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Two clones , HCl and HC 2 , produced antibody capable of precipitating glycoprotein C and its precursor , whereas three clones , HD 1 , HD 2 , and HD 3 , produced antibody capable of precipitating glycoprotein D and its precursor . ^^^ Antibody produced by the HD 1 and HD 2 clones neutralized both HSV type 1 and HSV type 2 , whereas antibody produced by the HD 3 clone neutralized HSV type 1 but not HSV type 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| It was the aim of the study to investigate the quantity and quality of arrhythmias during HD and between two consecutive HD ( interval , 1 ) with regard to the reproducibility of the expected results . 15 patients ( 8 males , 7 females ) underwent continuous Holter monitoring ( LT ECG ) under ambulatory conditions over 96 h including two HD ( HD 1 + HD 2 ) and two intervals ( I 1 + I 2 ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The specificity genes are known to encode two classes of dissimilar homeodomain ( HD 1 and HD 2 ) proteins and have different allelic forms which show little or no cross hybridisation . ^^^ By partial sequencing we identified a divergently transcribed HD 1 ( a 1 2 ) and HD 2 ( a 2 2 ) gene in the A 43 alpha locus . a 2 2 failed to elicit clamp cell development in three different hosts , suggesting that it is non functional . a 1 2 elicited clamp cells in an A 42 host that has only an HD 2 gene ( a 2 1 ) in its alpha locus , thus demonstrating that the compatible A alpha mating interaction is between an HD 1 and an HD 2 protein . ^^^ The A 43 beta locus contains three specificity genes , the divergently transcribed HD 1 and HD 2 genes b 1 2 and b 2 2 and a third HD 1 gene ( d 1 1 ) that was shown by hybridisation and transformation analyses to be functionally equivalent to d 1 1 in A 42 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The A mating type genes of the mushroom Coprinus cinereus encode two classes of putative transcription factor with distinctive homeodomain motifs ( HD 1 and HD 2 ) . ^^^ Our molecular analysis of one of these mutations shows that it has generated a chimeric gene by inframe fusion of an HD 2 and an HD 1 gene . ^^^ The fusion protein retains most of the HD 2 sequence , but only the C terminal part of the HD 1 protein . ^^^ It has only the HD 2 homeodomain motif as a potential DNA binding domain fused to an essential C terminal region of the HD 1 protein , which in a normal HD 1 HD2 protein complex may be the major activation domain . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Overall , the DNA sequences are very different ( approximately 50 % homology ) , but two classes of genes can be distinguished on the basis of a conserved homeodomain motif in their predicted proteins ( HD 1 and HD 2 ) . ^^^ Development is postulated to be triggered by an HD 1 and an HD 2 gene from different A loci . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Our isolates HD 1 and HD 2 showed nt sequence homologies of about 72 81 % and aa homologies of 76 88 % to U . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The A genes that trigger development encode two different classes of homeodomain proteins , and for a successful mating , a protein of one class , HD 1 , must interact with a protein of the other class , HD 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Stable transfectants were selected from human astrocytoma cells ( U 373 ) after transfection with recombinant expression vectors carrying the human cytomegalovirus ( HCMV ) glycoprotein B ( gB ; gpUL 55 ) gene with alternative deletions of hydrophobic domain segment 1 ( hd 1 ) or segment 2 ( hd 2 ) of the carboxy terminal potential bipartite membrane anchor domain . ^^^ Comparative analysis of HCMV gB forms from cell lines gB ( Mhd 1 ) and gB ( Mhd 2 ) , expressing mutagenized gB , and those from cells expressing authentic gB showed that deletion of hd 1 , but not that of hd 2 , interfered with efficient proteolytic cleavage of the gB precursor . ^^^ Deletion of hd 2 , but not that of hd 1 , caused loss of membrane anchoring of the gB molecule , resulting in secretion of the respective gB form into the culture medium . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The correlation coefficients between the Magic Lite SQ and the Phadebas RAST were as follows : 0 . 87 for D . p . , 0 . 89 for D . f . , 0 . 87 for HD 1 , 0 . 55 for HD 2 , 0 . 76 for orchard grass , 0 . 93 for cat dander , 0 . 78 for Alternaria , 0 . 88 for egg white , 0 . 75 for egg york , 0 . 81 for milk , 0 . 75 for say bean , and 0 . 60 for shrimp . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The A mating type genes of the mushroom , Coprinus cinereus , encode two classes of homeodomain containing proteins distinguished as HD 1 and HD 2 on the basis of conserved , but distinctly different motifs . ^^^ We have previously described a rare mutation in which an HD 2 : : HD 1 gene fusion generates a ' fused dimer ' lacking much of HD 1 including the homeodomain yet capable of constitutively promoting development [ Kes et al . , EMBO J . 13 ( 1994b ) 4054 4059 ] . ^^^ We show that the HD 2 homeodomain is essential ; deletion within the HD 1 homeodomain can be tolerated in a normal heterodimer , as well as in the mutant fusion protein , but not substitution of a critical amino acid . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Ion exchange ( Q Sepharose ) and gel exclusion ( Superdex 200 ) chromatography of extracts from erythrocyte nuclei showed two forms ( HD 1 and HD 2 ) of histone deacetylase . ^^^ HD 1 , with a molecular mass of about 55 kDa , preferred free H 3 H4 relative to H2A H2B , while HD 2 , with a molecular mass of approx . 220 kDa , had a slight preference for H 3 H4 . ^^^ HD 1 and HD 2 differed in pH and ion strength dependence . ^^^ HD 2 dissociated into HD 1 when treated with 1 . 6 M NaCl or when applied to a Q Sepharose column . ^^^ The enzymic properties of nuclear matrix bound histone deacetylase showed a striking difference from that of HD 1 and HD 2 , particularly in its strong preference for H2A H2B . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Significant antithrombic effect was exhibited by HD 1 , HD 2 , HD 3 , and HD 4 which decreased progressively . ^^^ Only HD 1 , HD 2 , and HD 3 augmented hemorrhagic activity but to a lower degree than UFH and LMWH . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The genes encode two classes of homeodomain containing proteins designated HD 1 and HD 2 . ^^^ We demonstrate that each A locus contains members of three paralogous pairs of HD 1 and HD 2 genes . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| These domains , designated as HD 1 , HD 2 and HD 3 , are located between amino acid residues 160 and 204 , 247 and 298 , and 706 and 749 , respectively . ^^^ Further analysis showed that the HD 1 and HD 2 domains can bind to themselves and to each other . ^^^ We also mapped a domain in p 127 between amino acid residues 377 and 438 , which strongly reduces the degree of multimerization of chimaeric proteins containing HD 1 and / or HD 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| CASTing experiments reveal a TCCT motif recognized by HD 1 but a GATC tetranucleotide as the recognition sequence of HD 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The novel benzoindane S 18126 possessed > 100 fold higher affinity at cloned , human ( h ) D 4 ( Ki = 2 . 4 nM ) vs . hD 2 ( 738 nM ) , hD 3 ( 2840 nM ) , hD 1 ( > 3000 nM ) and hD 5 ( > 3000 nM ) receptors and about 50 other sites , except sigma 1 receptors ( 1 . 6 nM ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Maize embryos contain three histone deacetylase families : RPD 3 type deacetylases ( HD 1 B ) , nucleolar phosphoproteins of the HD 2 family , and a third form unrelated to RPD 3 and HD 2 ( HD 1 A ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In CAPD group assessment was carried out during the routine monthly check up , in HD group before ( HD 1 ) and after ( HD 2 ) dialysis session . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| As in other species , the C . bilanatus A factor contains several different genes that encode two different types of homeodomain transcription factor ( HD 1 and HD 2 ) ; and some of these genes are active in the heterologous host C . cinereus . ^^^ The HD 1 and HD 2 genes are distributed over two closely linked subloci , Aalpha and Abeta . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Meanwhile , a major photoperiod sensitive dominant genes Se 1 and other modified photoperiod sensitive genes : 1 Se 1 , E 3 , Hd 3 ( En Se 1 ) , Hd 5 and Hd 6 , were identified in Zhenshan 97A by crossing with QTL nearly isogenic lines : NIL ( Hd 1 ) , NIL ( Hd 2 ) , NIL ( Hd 3 ) , NIL ( Hd 5 ) and NIL ( Hd 6 ) . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In in vitro antimaize HD 2 as well as antimouse HDAC 1 assay , compounds 1a c showed inhibitory activities in the low micromolar range . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Lastly , the dimerization domain , the interaction domain with NF YA , and the repressor domain are mapped to a region including the HD 1 region , and two nuclear localization signals are mapped to the N terminal through Znf 1 and the HD 2 region , respectively . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The dimerization domain with both ZHX 1 and ZHX 2 is the region containing HD 1 , the domain that interacts with NF YA is the HD 1 to HD 2 region , the repressor domain is the HD 1 to a proline rich region . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Preliminary hemodialysis of the priming solution was initiated in eight children ( HD 1 group ) , while both preliminary and continuous hemodialysis during ECC was performed in another eight children ( HD 2 group ) . ^^^ In the HD 1 and HD 2 groups , the total urine volume during ECC was greater than in control group , but there was no significant difference . ^^^ In the control group , the perfusion pressure temporally decreased after the pump was operating for five minutes , but the perfusion pressures remained stable in the HD 1 and HD 2 groups . ^^^ Water balance in the control group tended to be in positive balance , but both the HD 1 and HD 2 groups appeared to be in negative balance . ^^^ Significant differences between HD 1 and HD 2 in contrast to the control group ( p < 0 . 05 ) and p < 0 . 04 , respectively ) were observed . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate changes in serum CyC concentration during two low flux membrane haemodialyses ( HD 1 , HD 2 ) and relationship between serum CyC a creatinine concentrations . ^^^ PATIENTS AND METHODS : Serum CyC was determined in 17 patients on chronic haemodialysis during HD 1 and HD 2 by immunonephelometric method ( Dade Behring , Austria ) . ^^^ RESULTS : Significant correlation between serum CyC and creatinine before HD 1 and before / after HD 2 was found ( p < 0 . 001 ) . ^^^ Serum CyC before HD 2 ( 6 . 4 mg / l , 5 . 8 7 . 2 ) increased after HD 2 ( 8 . 0 mg / l , 7 . 3 9 ) ( p < 0 . 001 ) , while serum creatinine decreased after HD 1 and HD 2 ( p < 0 . 001 ) . ^^^ There was correlation between the increase in serum CyC and albumin during HD 1 ( p < 0 . 001 ) and HD 2 ( p < 0 . 01 ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| B9H1 and B9H2 domains corresponded to HD 1 and HD 2 domains of Drosophila lgs , functioning as binding regions for Pygo and Arm , respectively . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| QTLs for the beta value were detected in the four known flowering time QTL ( Hd 1 , Hd 2 , Hd 6 and Hd 8 ) regions , while QTLs for the G value were detected only in the Hd 1 and Hd 2 regions . ^^^ This result was consistent with previous reports on near isogenic lines ( NILs ) of Hd 1 , Hd 2 and Hd 6 , where these loci were involved in photoperiod sensitivity , and where Hd 1 and Hd 2 conferred altered flowering under both 10 and 14 h photoperiods , while Hd 6 action was only affected by the 14 h photoperiod . ^^^ Interestingly , Hd 1 and Hd 2 were associated with a QTL for the alpha value , which might support the previous hypothesis that the process of photoinduction depends on temperature . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| B9H1 and B9H2 domains , and N terminal part of B9H3 domain were identical to HD 1 , HD 2 , and HD 3 domains conserved between human BCL 9 and Drosophila lgs . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| While mutation of the Phox2a homeodomain binding sites HD 1 , HD 2 , and HD 3 results in the loss of HAND2 / Phox2a transactivation of DBH , it is the interaction of HAND2 / Phox2a at the CRE / AP1 HD1 / 2 domains in the DBH enhancer that are required for synergistic activation by HAND 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Hho1p is assumed to serve as a linker histone in Saccharomyces cerevisiae and , notably , it possesses two putative globular domains , designated HD 1 ( residues 41 118 ) and HD 2 ( residues 171 252 ) , that are homologous to histone H 5 from chicken erythrocytes . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Biological activities of 3 and 4 were predicted by computational tools up to 617 fold more potent than that of 1 against HDAC 1 ; thus , 3 and 4 were synthesized and tested against both mouse HDAC 1 and maize HD 2 enzymes . ^^^ In particular , in mouse HDAC 1 inhibitory assay 3 and 4 were 19 and 6 times more potent than 1 , respectively , and 3 and 4 antimaize HD 2 activities were 16 and 76 times higher than that of 1 , 4 being as potent as SAHA in this assay . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The histone deacetylases HDAC 1 and HDAC 2 and the histone binding proteins RbAp 48 and RbAp 46 form a core complex shared between NuRD and Sin 3 histone deacetylase complexes . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Mad : Max heterodimers repress transcription by recruiting a large multi protein complex containing the histone deacetylases , HDAC 1 and HDAC 2 , to DNA . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Interestingly the murine HDAC 1 gene strongly resembles the previously published mouse HDAC 2 gene ( Zeng et al . , J . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Sin3p , the S . cerevisiae homolog of mSin 3 , functions in the same pathway as Rpd3p , a protein related to two recently identified mammalian histone deacetylases , HDAC 1 and HDAC 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We have found that the mammalian transcriptional repressor Sin 3 ( mSin 3 ) exists in a complex with histone deacetylases HDAC 1 and HDAC 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Similar to HDAC 1 and HDAC 2 , HDAC 3 is ubiquitously expressed in many different cell types . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Antibodies directed against endogenous HDAC 1 , HDAC 2 , or HDAC 3 immunoprecipitate histone deacetylase activity that is inhibited in vitro by the small molecule trapoxin ( TPX ) , and all three HDACs are retained by a TPX affinity matrix . ^^^ HDAC 1 and HDAC 2 are associated in HeLa cells in a complex that is predominantly separate from an HDAC 3 immune complex . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Here , we identify SAP 30 as a novel component of the human histone deacetylase complex that includes Sin 3 , the histone deacetylases HDAC 1 and HDAC 2 , histone binding proteins RbAp 46 and RbAp 48 , as well as other polypeptides . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The transcriptional corepressor mSin 3 is found in a large multiprotein complex containing the histone deacetylases HDAC 1 and HDAC 2 , in addition to at least five tightly associated polypeptides . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| This corepressor protein constitutes the core of a multiprotein complex that includes histone deacetylases ( HDAC 1 and HDAC 2 ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Human HDAC 1 , HDAC 2 , and HDAC 3 proteins are members of the first class , whereas no class 2 human HDAC proteins had been identified . ^^^ Coimmunoprecipitation experiments indicate that these HDAC proteins are not components of the previously identified HDAC 1 and HDAC 2 NRD and mSin3A complexes . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Moreover , the BRCT domain associates with the histone deacetylases HDAC 1 and HDAC 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The class 1 deacetylases HDAC 1 and HDAC 2 are components of multisubunit complexes , one of which could associate with the nuclear hormone receptor corepressor , N CoR . ^^^ In comparison with HDAC 1 and HDAC 2 , HDAC 3 remains relatively uncharacterized , and very few proteins have been shown to interact with HDAC 3 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| HDAC 8 shows a high degree of sequence similarity to HDAC 1 and HDAC 2 and thus belongs to the class 1 of HDACs . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In contrast , N CoR 2 contained predominantly HDAC 1 and HDAC 2 as well as several other subunits that are found in the Sin3A . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation experiments indicate that HDAC 1 and HDAC 2 are associated with Topo 2 in vivo under normal physiological conditions . ^^^ Complexes containing Topo 2 possess HDAC activities , and complexes containing HDAC 1 or HDAC 2 possess Topo 2 activities . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Human histone deacetylases 1 ( HDAC 1 ) and 2 ( HDAC 2 ) are homologous proteins ( 84 % identity ) that catalyze release of acetyl groups from modified N terminal lysines of core histones . ^^^ In this study , we analyzed complexes containing HDAC 1 and HDAC 2 to identify the proteins most stably associated with these deacetylases . ^^^ Under native conditions , cI and cII may contain HDAC 1 , HDAC 2 or both ; these can be dissociated to cI and cII core complexes containing only HDAC 1 or HDAC 2 . ^^^ A model is proposed in which HDAC 1 core complexes can be targeted to methylated DNA via MBD 2 with recruitment of HDAC 2 occurring through formation of HDAC1 / 2 cII dimers . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The failure to deacetylate and thus repress transcription by the Class 1 histone deacetylases HDAC 1 and HDAC 2 due to disruption of the Rb family of proteins has been firmly established as a mechanism leading to increases in growth rate and cellular proliferation . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the same HDAC 1 domain is also necessary for in vitro binding of HDAC 2 and HDAC 3 , association with RbAp 48 and for catalytic activity of the enzyme . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| SHARP is a potent transcriptional repressor whose repression domain ( RD ) interacts directly with SMRT and at least five members of the NuRD complex including HDAC 1 and HDAC 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Class 1 members , such as HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 , are well known enzymatic transcriptional corepressors homologous to yeast Rpd 3 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Repression by Rb is mediated , at least in part , by a histone deacetylase complex , whose enzymatic activity relies on HDAC 1 , HDAC 2 or HDAC 3 . ^^^ Recently , we have shown that the Rb associated histone deacetylase complex contains RbAp 48 protein , which interacts with HDAC 1 and HDAC 2 . ^^^ Taken together , our data suggest a model in which Rb mediates the recruitment to E2F regulating promoters of a repressive complex containing either HDAC 1 , HDAC 2 or HDAC 3 and the histone binding protein RbAp48 . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Previous studies have established that YY 1 interacts with histone acetyltransferases p 300 and CREB binding protein ( CBP ) and histone deacetylase 1 ( HDAC 1 ) , HDAC 2 , and HDAC 3 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Here we show that FKBP 25 physically associates with the histone deacetylases HDAC 1 and HDAC 2 and with the HDAC binding transcriptional regulator YY 1 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In humans , four highly homologous class 1 HDAC enzymes ( HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 ) have been identified to date . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Sin 3 is an evolutionarily conserved corepressor that exists in different complexes with the histone deacetylases HDAC 1 and HDAC 2 . ^^^ We have previously found that a human Sin 3 HDAC complex includes HDAC 1 and HDAC 2 , the histone binding proteins RbAp 46 and RbAp 48 , and two novel polypeptides SAP 30 and SAP 18 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Consistent with this interpretation , the N terminal transcriptional repression domain of Suv39H1 bound the so called ' core histone deacetylase complex ' , composed of HDAC 1 , HDAC 2 and the Rb associated proteins RbAp 48 and RbAp 46 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The same regions of the protein that are required for repression physically interact with components of chromatin remodeling complexes , HDAC 1 , HDAC 2 , RbAp46 / 48 , MTA 1 , and MTA 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Furthermore , NAPP 2 functions as a corepressor and interacts specifically with histone deacetylase l ( HDAC 1 ) , but not HDAC 2 or HDAC 3 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The HDAC 1 lysines targeted for modification were identified as C terminal Lys 444 and Lys 476 , which are also present in mammalian HDAC 2 and lower vertebrate HDAC1 / 2 orthologs yet absent from other HDAC family members , pointing to a means of differential regulation among HDAC proteins . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The expression of HDAC 2 and HDAC 3 is induced in HDAC 1 deficient cells , but can not compensate for loss of the enzyme , suggesting a unique function for HDAC 1 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In addition , of eight histone deacetylases ( HDACs ) tested , only the class 1 HDACs HDAC 1 , HDAC 2 , and HDAC 3 bind ETO . ^^^ Furthermore , ETO 2 binds HDAC 1 , HDAC 2 , and HDAC 3 but also interacts with HDAC 6 and HDAC 8 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The p 65 ( RelA ) subunit of NF kappaB interacts with the histone deacetylase ( HDAC ) corepressors HDAC 1 and HDAC 2 to negatively regulate gene expression . ^^^ Expression of HDAC 1 and HDAC 2 repressed tumor necrosis factor ( TNF ) induced NF kappaB dependent gene expression . ^^^ Consistent with this , we show that HDAC 1 and HDAC 2 target NF kappaB through a direct association of HDAC 1 with the Rel homology domain of p 65 . ^^^ HDAC 2 does not interact with NF kappaB directly but can regulate NF kappaB activity through its association with HDAC 1 . ^^^ Moreover , it suggests that the association of NF kappaB with the HDAC 1 and HDAC 2 corepressor proteins functions to repress expression of NF kappaB regulated genes as well as to control the induced level of expression of these genes . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We show that ESET histone methyltransferase associates with histone deacetylase 1 ( HDAC 1 ) and HDAC 2 , and that ESET also interacts with the transcription co repressors mSin3A and mSin3B . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| By means of quantitative reverse transcription polymerase chain reaction using SYBR Green to detect double stranded DNA , mRNA expression profiles for histone deacetylases ( HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 7 ) , histone acetyltransferases ( GCN 5 and HAT 1 ) , and histone H2A were established . ^^^ The HDAC 1 , HDAC 2 ( class 1 HDAC ) , and HAT 1 ( type B HAT ) revealed similar expression profiles . ^^^ The HDAC 3 ( class 1 HDAC ) tends to have an expression profile similar to those of HDAC 1 , HDAC 2 , and HAT 1 , whereas the HDAC 7 ( class 2 HDAC ) and GCN 5 ( type A HAT ) profiles were different from those three . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In this report , we show that EBNA3C complexed with ProTalpha can also recruit deacetylase activity and associates in a complex that includes HDAC 1 and HDAC 2 in human B cells . ^^^ A complex of EBNA3C and ProTalpha coimmunoprecipitated with HDAC 1 and HDAC 2 in cell lines stably expressing EBNA3C . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Originally isolated as a transcriptional co repressor , HDAC 2 possesses extensive amino acid sequence homology to HDAC 1 ( the founding member and most extensively studied HDAC enzyme ) . ^^^ Because of this high degree of sequence similarity between HDAC 1 and HDAC 2 , coupled with the fact that the two always co exist in the same complexes , it is difficult to assess whether different properties exist between these two proteins . ^^^ We report here that HDAC 2 is a phosphoprotein similar to HDAC 1 . ^^^ In addition , like HDAC 1 , the phospho acceptor sites in HDAC 2 are located in the C terminal portion of the protein . ^^^ However , unlike HDAC 1 , which can be phosphorylated by protein kinase CK 2 , cAMP dependent protein kinase , and protein kinase G , HDAC 2 is phosphorylated uniquely by protein kinase CK 2 in vitro . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| A multiprotein complex was recruited to the hLHR promoter via interaction with Sp 1 and Sp 3 , in which HDAC 1 and HDAC 2 were docked directly to Sp 1 bound DNA and indirectly to Sp 3 bound DNA through RbAp 48 , while mSin3A interacted with both HDACs . ^^^ HDAC 1 and HDAC 2 were shown to potently repress the hLHR gene transcription , and mSin3A potentiated the inhibition mediated by HDAC 1 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| There was no difference in the site of HDAC 1 HDAC6 expression between normal subjects and subjects with asthma , but subjects with asthma had reduced HDAC enzymatic activity and reduced HDAC 1 and HDAC 2 protein expression , as measured by Western blotting . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The mammalian SIN 3 complex consists of histone deacetylases ( HDAC 1 , HDAC 2 ) , several known proteins ( SAP 30 , N CoR ) and as yet unidentified proteins . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| HDAC 1 and HDAC 2 were more strongly inhibited by redFK than HDAC 4 and HDAC 6 . redFK was less active than FK 228 in inhibiting in vivo HDAC activity , due to rapid inactivation in medium and serum . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| However , the degradation of cellular Hdac 1 and Hdac 2 , as observed here in the elongating spermatids , may provide an HDAC free environment in which Cdyl could bind CoA and participate in the global chromatin remodelling that occurs in these cells . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Most of these proteins fall into two distinct chromosomal distribution patterns : ( a ) kinetochore associated proteins ( Sin3A , PCAF , MYST and BAF 180 ) , which colocalize with metaphase kinetochores , but not any of the pericentric and other major heterochromatic regions ; and ( b ) heterochromatin associated proteins ( MeCP 2 , MBD 1 , MBD 2 , ATRX , HP1alpha , HDAC 1 , HDAC 2 , DNMT 1 and DNMT3b ) , which colocalize with centromeric / pericentric heterochromatin and all other major heterochromatic sites . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Here we examine the interaction of REST , Co REST , Sin3A , HDAC 1 , and HDAC 2 with two archetypical endogenous target genes , the M 4 muscarinic receptor and the sodium type 2 channel ( NaV1 . 2 ) genes . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| When prostate cancer cell lines were treated with hypomethylating agent , 5 aza 2 ( ' ) deoxycytidine ( DNMT inhibitor ) , HDAC 1 and HDAC 2 expression was decreased . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis of these complexes suggests that hCtBP 1 associates with class 1 HDACs , HDAC 1 , HDAC 2 and HDAC 3 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Ebp 1 bound HDAC 2 , but not HDAC 1 , in vitro . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In assays of isolated enzymes , CI 994 inhibited HDAC 1 and HDAC 2 in a concentration dependent fashion but had no effect on the activity of the prototypical histone acetyltransferase GCN 5 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Much of the corepressor function of mSin3A derives from associations with the histone deacetylases HDAC 1 and HDAC 2 ; however , the contributions of the other mSin3A associated polypeptides remain largely unknown . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In the absence of steroid , C / EBPbeta associated with a transcriptional corepressor complex containing mSin3A and histone deacetylase 1 ( HDAC 1 ) , but lacking HDAC 2 and RbAp46 / 48 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that Sp 1 and Sp 3 recruit HDAC 1 and HDAC 2 , with the latter being phosphorylated by protein kinase CK 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| When co expressed in mammalian cells , Gfi 1 associates with histone deacetylse 1 ( HDAC 1 ) , HDAC 2 , and HDAC 3 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We also show that the chromatin modifying enzymes HDAC 1 and HDAC 2 , which are intrinsic nuclear matrix components and thought to function as corepressors of CTCF , are incapable of associating with CTCF . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| A ROG response element in the IL 13 gene exon 4 displayed Tc 2 specific binding of ROG , HDAC 1 , and HDAC 2 and exhibited repression of IL 4 gene activation . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| These HDAC inhibitors preferentially inhibited the enzymatic activities of HDAC 1 and HDAC 2 , as compared with the other HDAC isotypes , indicating that class 1 HDAC is the major target of SK 7041 and SK 7068 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Moreover , two isoforms of human BHC 80 were distinguished from each other by reduced binding to HDAC 1 and HDAC 2 , despite the presence of the PHD finger domain . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NuRD complex , including HDAC 1 , HDAC 2 , MTA 2 , MBD 2 , RbAp 46 , and RbAp 48 , but MBD 3 is not found in the MBD3L1 bound fraction . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| To test the hypothesis that the delay reflected a dysfunction of ICP 0 in altering the structure of host protein viral DNA complexes , we examined the state of histone deacetylases ( HDACs ) ( HDAC 1 , HDAC 2 , and HDAC 3 ) . ^^^ We report the following . ( 1 ) HDAC 1 and HDAC 2 , but not HDAC 3 , were modified in infected cells . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We found individual components of Mi2 / NuRD : MBD 3 , Mi 2 , HDAC 1 and HDAC 2 to be expressed from a very early stage of embryo development and to localize in close proximity with each other and with constitutive heterochromatin by the blastula stage . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Most importantly , we demonstrate an interaction between Snail , histone deacetylase 1 ( HDAC 1 ) and HDAC 2 , and the corepressor mSin3A . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Human class 1 HDACs possess homology to the yeast RPD 3 protein and include HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 . ^^^ While HDAC 1 , HDAC 2 , and HDAC 3 have been characterized extensively , almost nothing is known about HDAC 8 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We show that the RD 1 domain binds HDAC 1 and HDAC 2 and that HDAC activity is required for PIASy mediated AR repression . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Western blots demonstrated the nickel affinity purified rhHDAC 1 preparation also contained endogenous HDAC 2 and HDAC 3 ; likewise , rhHDAC 3 preparation contained endogenous HDAC 1 and HDAC 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| By immunoprecipitation and GST pull down , we show that DNMT3B interacts with HDAC 1 , HDAC 2 , HP 1 proteins , Suv39h1 , and the ATP dependent chromatin remodeling enzyme hSNF2H . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis demonstrated two to four fold elevated levels of mRNAs for HDAC 1 , 3 , 5 , and 6 after drug treatment in comparison with untreated cells , while mRNA levels for HDAC 2 and 7 did not change significantly . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Nuclear signals of BRM , Ini 1 , retinoblastoma , mSin3A , HDAC 1 , and HAT 1 clustered together , whereas nuclear signals of BRG 1 , BAF 155 , HDAC 2 , BAF 170 , and RbAP 48 formed a second cluster . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Thus , HDAC 2 appears to serve a preferential role in the prevention of apoptosis and not in cell cycle control similar to the specific importance of HDAC 1 for cell cycle regulation or HDAC 9 for the stress response of the heart . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The pancreatic duodenal homeobox 1 protein ( Pdx 1 ) interacts with histone deacetylases Hdac 1 and Hdac 2 on low levels of glucose . ^^^ In this study , we demonstrate that the histone deacetylases Hdac 1 and Hdac 2 are rapidly recruited to the insulin promoter in the mouse insulinoma cell line MIN 6 when cells are switched from high to low glucose media . ^^^ Moreover , we demonstrate that the beta cell specific homeodomain protein Pdx 1 interacts with histone deacetylases Hdac 1 and Hdac 2 at low levels of glucose . ^^^ In vitro studies indicate that the interaction between Pdx 1 and Hdac 1 or Hdac 2 is direct and requires the C terminus of Pdx 1 . ^^^ Treatment of MIN 6 cells with okadaic acid , which inhibits the activity of protein phosphatases , abolishes the interaction of Pdx 1 with Hdac 1 and Hdac 2 on low levels of glucose , suggesting the requirement of a dephosphorylation event for this interaction to occur . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In the absence of estradiol ( E 2 ) , Sp 1 , Sp 3 , histone deacetylase 1 ( HDAC ) , and HDAC 2 , and low levels of acetylated H 3 and H 4 are associated with the native promoter , with the histones being engaged in dynamic reversible acetylation . ^^^ There is clearance of Sp 1 , but not of Sp 3 , from the promoter while HDAC 1 and HDAC 2 remain bound . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In glutathione S transferase pull down assays , MBD3L2 is found associated with several known components of the Mi 2 NuRD complex , including HDAC 1 , HDAC 2 , MTA 1 , MBD 3 , p 66 , RbAp 46 , and RbAp 48 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Cyclin D 1 bound HDAC in vivo and preferentially physically associated with HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 5 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated recruitment of coactivators ( SRC 1 , SRC 2 , and SRC 3 ) and corepressors ( HDAC 1 , HDAC 2 , HDAC 3 , SMRT , and NCoR ) to the IkappaB alpha gene promoter after NF kappaB activation by tumor necrosis factor alpha . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Myt 1 Sin3B complexes were co immunoprecipitated from transfected mammalian cells and included HDAC 1 and HDAC 2 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Closely related HDAC 1 and HDAC 2 do not elicit humoral response in colon cancer patients . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| HDAC 3 but not HDAC 1 or HDAC 2 was required for AP 1 mediated stimulation of c jun expression . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In the remaining seven girls we then analyzed the genes HDAC 1 , HDAC 2 , and HDAC 8 that encode for the histone deacetylases 1 , 2 , and 8 which interact with MeCP 2 and are essential for its function . ^^^ The genes HDAC 1 , HDAC 2 , and HDAC 8 do not seem to play a role in the pathogenesis of RTT and at least in our subgroup no mutations in the CDKL 5 gene were detected . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation analysis identified the presence of the mSin3A , HDAC 1 , and HDAC 2 corepressor complex in MA 10 cells . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In human colorectal tissue samples , the gene expressions of 4 coactivators , p 300 , pCAF , TIF 2 and TRAP 220 , and 7 corepressors , N CoR , REA , MTA 1 , MTA1L1 , HDAC 1 , HDAC 2 and HDAC 3 , linked to estrogen receptors ( ER ) , were revealed by traditional RT PCR . ^^^ The decline of mRNA levels of all coactivators and the increase of NCoR , HDAC 1 , HDAC 2 and MTA 1 were observed from normal to tumor tissue , whereas REA , HDAC 3 and MTA1L1 expressions were similar in both tissue compartments . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| These included self renewal genes ( Bmi 1 , Nanog , Gfi 1 ) , epithelial mesenchymal genes ( Tcfe2a , Ctnb 1 , Sin3a , Hdac 1 , Hdac 2 , Muc 1 , Cldn 11 ) , survival genes ( Bcl 2 , Bbc 3 ) , and cell cycle / damage genes ( Cdkn1a , Rbl 1 , Mdm 2 ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| CSE also reduced histone deacetylase ( HDAC ) activity and HDAC 1 , HDAC 2 , and HDAC 3 protein levels . ^^^ This was associated with posttranslational modification of HDAC 1 , HDAC 2 , and HDAC 3 protein by nitrotyrosine and aldehyde adduct formation . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Similar effects were observed for HDAC 2 and , to a lesser extent , for HDAC 1 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Specifically , we report the following . ( 1 ) Both kinases mediate the phosphorylation of HDAC 1 , HDAC 2 , and the PKA regulatory IIalpha subunit in the absence of other viral proteins . ( 2 ) Both enzymes mediate the phosphorylation of largely identical sets of proteins carrying the phosphorylation consensus site of PKA , but only U ( S ) 3 blocks apoptosis , suggesting that it is U ( S ) 3 and not PKA that is responsible for the phosphorylation of the proteins bearing the shared consensus phosphorylation site and the antiapoptotic activity . ( 3 ) Both kinases cofractionate with mitochondria . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Here we report characteristic patterns of expression of 12 members of 3 classes of chromatin modifier genes in 6 different cancer types : histone acetyltransferases ( HATs ) EP 300 , CREBBP , and PCAF ; histone deacetylases ( HDACs ) HDAC 1 , HDAC 2 , HDAC 4 , HDAC 5 , HDAC7A , and SIRT 1 ; and histone methyltransferases ( HMTs ) SUV39H1and SUV39H2 . ^^^ Mutation analysis of HDAC 1 , HDAC 2 , SUV39H1 , and SUV39H2 revealed only two out of 181 cancer samples ( both cell lines ) with significant coding sequence alterations . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| CRA 024781 inhibited pure recombinant HDAC 1 with a K ( 1 ) of 0 . 007 mumol / L , and also inhibited the other HDAC isozymes HDAC 2 , HDAC3 / SMRT , HDAC 6 , HDAC 8 , and HDAC 10 in the nanomolar range . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The HDAC inhibitor , trichostatin A , reduced MMSET 1 repression activity and in vitro co immunoprecipitation analyses indicated that MMSET 1 specifically recruits HDAC 1 and mSin3b , but not HDAC 2 or HDAC 4 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| To understand the difference between class 1 HDAC isoforms that could be exploited for the design of isoform specific HDAC inhibitors , we have built three dimensional models of four class 1 histone deacetylases , HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 8 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Searches of several sequence databases reveal that human HD 1 , yeast HDA 1 , yeast RPD 3 and other eukaryotic histone deacetylases share nine motifs with archaeal and eubacterial enzymes , including acetoin utilization protein ( acuC ) and acetylpolyamine amidohydrolase . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Recently , the mammalian histone deacetylase HD 1 was cloned from Jurkat T cells , and shown to be 60 % identical to the yeast global gene regulator Rpd 3 ( Taunton et al . , 1996 ) . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Cloning of the cDNA for a human histone deacetylase ( HDAC 1 ) has shown that it represents a human ortholog of the yeast transcriptional regulator RPD 3 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The interaction of the corepressors with the components involved in chromatin remodelling , such as the recruiting proteins Sin3A / B and the histone deacteylases HDAc 1 and RPD 3 , has been analysed in detail . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Histone deacetylases such as human HDAC 1 and yeast RPD 3 are trichostatin A ( TSA ) sensitive enzymes that are members of large , multiprotein complexes . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Using different HDACi together with small interfering RNA for HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 6 , we report that inhibition of HDAC 1 and HDAC 2 but not HDAC 3 , HDAC 6 , and HDAC 8 are primarily responsible for sensitization to TRAIL induced apoptosis . ^^^ Based on these data and our previous studies , we propose that a clinical trial in CLL is warranted using a combination of a selective HDACi that inhibits HDAC 1 and / or HDAC 2 together with a form of TRAIL that signals through TRAIL receptor 1 . . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Furthermore , apicidin activation of NF kappaB seems to result from HDAC 1 inhibition , as evidenced by the observation that overexpression of HDAC 1 , but not HDAC 2 , 3 or 4 , dramatically inhibits NF kappaB reporter gene activity . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| CRA 026440 inhibited pure recombinant isozymes HDAC 1 , HDAC 2 , HDAC3 / SMRT , HDAC 6 , HDAC 8 , and HDAC 10 in the nanomolar range . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| HDAC 1 and HDAC 2 were also shown to interact with the fourth intron region of the beta chain gene . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Isolation and mapping of a human gene ( RPD3L1 ) that is homologous to RPD 3 , a transcription factor in Saccharomyces cerevisiae . ^^^ We have isolated a novel human gene RPD3L1 , that is highly homologous to a transcription factor in Saccharomyces cerevisiae , RPD 3 ( reduced potassium dependency 3 ) , from a human fetal lung cDNA library . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| A recently identified mammalian histone deacetylase ( HD 1 ) shows homology to the yeast Rpd 3 protein , which together with Sin 3 affects the transcription of several genes . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Sequence alignments revealed that murine HD 1 is highly homologous to the yeast RPD 3 pleiotropic transcriptional regulator . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| To date , six HDACs have been identified in mammalian cells : the yeast RPD 3 homologs HDAC 1 , 2 , and 3 and the yeast HDA 1 homologs HDAC 4 , 5 , and 6 . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| AtHD 1 is a homolog of human HD 1 and RPD 3 global transcriptional regulator in yeast . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In vitro , N CoR can interact with the Sin 3 corepressor , which in turn binds to the histone deacetylase Rpd 3 ( HDAC 1 ) , predicting the existence of a corepressor complex containing N CoR , Sin 3 , and histone deacetylase . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We show that Drosophila Hdac 1 , an Rpd 3 type gene , interacts cooperatively with Polycomb group repressors in silencing the homeotic genes that are essential for axial patterning of body segments . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The OsHDAC 1 gene encoded a protein of approximately 57 kDa that shared 73 . 5 , 72 . 7 , 79 . 9 , and 57 . 1 % amino acid sequence identity with the OsHDAC 2 , OsHDAC 3 , maize RPD 3 , and human HDAC 1 proteins , respectively . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Arabidopsis thaliana histone deacetylase 1 ( AtHD 1 or AtHDA 19 ) , a homolog of yeast RPD 3 , is a global regulator of many physiological and developmental processes in plants . ^^^ |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92769 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|