| Interacting proteins: Q16665 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Among the differentially expressed genes , we chose for further validation histone deacetylase 1 ( HDAC 1 ) , von Hippel Lindau and decorin as upregulated genes , and Sp 1 , hypoxia inducible factor 1 alpha and DNA primase as downregulated genes . ^^^ |
|
| Interacting proteins: Q16665 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Metastasis associated protein 1 enhances stability of hypoxia inducible factor 1alpha protein by recruiting histone deacetylase 1 . ^^^ MTA 1 induced the deacetylation of HIF 1alpha by increasing the expression of histone deacetylase 1 ( HDAC 1 ) . ^^^ Collectively , our data provide evidence of a positive cross talk between HIF 1alpha and MTA 1 , which is mediated by HDAC 1 recruitment , and indicate a close connection between MTA 1 associated metastasis and HIF 1 induced tumor angiogenesis . . ^^^ |
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