| Interacting proteins: Q16254 and Q13547 |
Pubmed |
SVM Score :0.0 |
| TSA enhanced the protein expression of p 21 ( WAF 1 ) , CREB binding protein , cyclinE , cyclin A , Bak and Bax , while it reduced the expression of E2F 1 , E2F 4 , HDAC 1 , p 53 and hyperphosphorylated form of Rb . ^^^ |
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| Interacting proteins: Q16254 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We also demonstrate that p 107 is able to interact simultaneously with HDAC 1 and E2F4 , suggesting a model in which p 107 recruits HDAC 1 to repress E2F sites . ^^^ |
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| Interacting proteins: Q16254 and Q13547 |
Pubmed |
SVM Score :0.0 |
| In a second series of experiments we showed that pRb2 / p130 , p 107 , E2F4 , and pRb2 / p130 HDAC 1 complexes are all inner nuclear matrix associated proteins and localize to sites different from pRb / p105 ones . ^^^ |
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| Interacting proteins: Q16254 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Remarkably , loss of pRB had no effect on HDAC 1 or mSin3B recruitment . p107 / p130 deficiency triggered a dramatic loss of E2F4 nuclear localization as well as transcriptional derepression , which is suggested by nucleosome mapping studies to be the result of localized hyperacetylation of nucleosomes proximal to E2F binding sites . ^^^ Taken together , these findings show that p 130 escorts E2F4 into the nucleus and , together with corepressor complexes that contain mSin3B and / or HDAC 1 , directly represses transcription from target genes as cells withdraw from the cell cycle . . ^^^ |
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| Interacting proteins: Q16254 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Here we show that p 130 is the predominant Rb family member associated with E2F in neurons , that its major partner for repression of pro apoptotic genes is E2F4 , and that the p 130 E2F4 complex recruits the chromatin modifiers HDAC 1 and Suv39H1 to promote gene silencing and neuron survival . ^^^ |
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| Interacting proteins: Q16254 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
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