| Interacting proteins: Q15910 and Q13547 |
Pubmed |
SVM Score :0.78545172 |
| Additionally , we observed that Ezh 2 interacts with the C terminal region of pRb2 / p130 , essential for interaction with HDAC 1 . 0.78545172^^^ |
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| Interacting proteins: Q15910 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Both Ezh 2 and YY 1 were detected , with the deacetylase HDAC 1 , at genomic regions of silent muscle specific genes . ^^^ Upon gene activation , Ezh 2 , HDAC 1 , and YY 1 dissociated from muscle loci , H 3 K27 became hypomethylated and MyoD and SRF were recruited to the chromatin . ^^^ |
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| Interacting proteins: Q15910 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Increased Ezh 2 expression in normal prostatic epithelial cells by cDNA transfection facilitates the recruitment of other components of Ezh 2 complex to the hDAB2IP promoter region accompanied with the increased levels of methyl histone H 3 ( H 3 ) and histone deacetylase ( HDAC 1 ) . ^^^ Consistently , data from PCa cells transfected with Ezh 2 small interfering RNA demonstrated that reduced Ezh 2 levels resulted in the dissociation of Ezh 2 complex accompanied with decreased levels of both methyl H 3 and HDAC 1 from hDAB2IP gene promoter . ^^^ |
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| Interacting proteins: Q15910 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Recently , investigations of CRC cases have focused on the interaction between EZH 2 and histone deacetylase 1 ( HDAC 1 ) . ^^^ The expression of HDAC 1 in CRC cases was also examined in order to compare its levels with those of EZH 2 . ^^^ In addition , a significant correlation between EZH 2 and HDAC 1 expression was observed in 61 CRC cases ( p < 0 . 05 ) . ^^^ Moreover , 20 cases of both high EZH 2 and high HDAC 1 expression showed poor prognoses than did 19 cases in which there was low EZH 2 and low HDAC 1 expression ( p < 0 . 05 ) . ^^^ We discovered there was concordant expression of HDAC 1 with EZH 2 in clinical CRC cases , in addition to the fact that higher expression levels of both genes predicted a poor prognosis . . ^^^ |
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