| Interacting proteins: Q03181 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here regulation of occupancy of HDAC 1 at a positioned nucleosome ( nuc 1 ) near the transcription start site of integrated LTR . ^^^ We find that expression of YY 1 increases occupancy by HDAC 1 , decreases acetylation at nuc 1 , and downregulates LTR expression . ^^^ A YY 1 mutant without an HDAC 1 interaction domain and incompetent to inhibit LTR activation fails to recruit HDAC 1 to LTR or decrease nuc 1 acetylation . ^^^ Further , expression of a dominant negative mutant of LSF ( dnLSF ) , which inhibits LSF occupancy and LTR repression , results in acetylation and decreased HDAC 1 occupancy at nuc 1 . ^^^ Conversely , exposure of cells to the histone deacetylase inhibitor trichostatin A or activation of LTR expression by HIV 1 Tat results in the displacement of HDAC 1 from nuc 1 , in association with increased acetylation of histone H 4 . ^^^ |
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| Interacting proteins: Q03181 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We first demonstrate that C / EBPalpha and C / EBPbeta , but not C / EBPdelta , inhibit the expression of PPARbeta through the recruitment of a transcriptional repressor complex containing HDAC 1 to a specific C / EBP binding site on the PPARbeta promoter . ^^^ |
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| Interacting proteins: Q03181 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03181 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03181 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
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