| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Conversely , E2F1 , cdc25B and HDAC 1 were down regulated in these transfectants . ^^^ |
|
| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Like full length prohibitin , the coiled coil domain also recruited histone deacetylase 1 to repress E2F1 . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| ICBP 90 , an E2F 1 target , recruits HDAC 1 and binds to methyl CpG through its SRA domain . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that Rb , the founding member of the pocket proteins family , represses E2F1 activity by recruiting the histone deacetylase HDAC 1 . ^^^ |
|
| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Coexpression of E2F1 interferes with HDAC 1 binding to Sp 1 and abolishes Sp 1 mediated transcriptional repression . ^^^ Our results indicate that one component of Sp 1 dependent gene regulation involves competition between the transcriptional repressor HDAC 1 and the transactivating factor E2F1 . . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Finally , we found that E2F1 and RbAp 48 are physically associated in the presence of Rb and HDAC 1 , suggesting that RbAp 48 could be involved in transcriptional repression of E2F responsive genes . . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Acetylation of E2F 1 can be reversed by histone deacetylase 1 , indicating that reversible acetylation is a mechanism for regulation also of non histone proteins . . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| DNMT 1 forms a complex with Rb , E2F1 and HDAC 1 and represses transcription from E2F responsive promoters . ^^^ Here we show that the predominant mammalian DNA methyltransferase , DNMT 1 , co purifies with the retinoblastoma ( Rb ) tumour suppressor gene product , E2F1 , and HDAC 1 and that DNMT 1 cooperates with Rb to repress transcription from promoters containing E2F binding sites . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| TSA enhanced the protein expression of p 21 ( WAF 1 ) , CREB binding protein , cyclinE , cyclin A , Bak and Bax , while it reduced the expression of E2F 1 , E2F 4 , HDAC 1 , p 53 and hyperphosphorylated form of Rb . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Increased p 21 ( WAF 1 ) is associated with CDK 2 and CDK 4 . pRb is dephosphorylated in the presence of p 21 CDK2 / 4 complexes , and the Rb E2F1 complex increases after TPA treatment , whereas the Rb HDAC 1 complex decreases slightly . ^^^ In turn , hypophosphorylated pRb are mainly complexed with E2F1 , but HDAC 1 appears not to be a key component in this process . . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We demonstrated previously that angiotensin 2 stimulates hypertrophy in C2C12 myoblasts by transient activation of the cyclin dependent kinase 4 complex , subsequent phosphorylation of retinoblastoma protein , release of histone deacetylase 1 from the retinoblastoma protein inhibitory complex , and partial activation of the transcription factor E2F 1 . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Following the subcloning of the promoter regions into a gene reporter system , we found that at least four promoter haplotypes associated with CCND 1 , E2F1 , HDAC 1 and RB 1 significantly influenced transcriptional activity in an allele specific manner . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Here we show that HMGA 2 interacts with pRB and induces E2F1 activity in mouse pituitary adenomas by displacing HDAC 1 from the pRB / E2F1 complex a process that results in E2F1 acetylation . ^^^ |
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| Interacting proteins: Q01094 and Q13547 |
Pubmed |
SVM Score :0.0 |
| This mechanism has been recently described by our group : it entails the acetylation of E2F1 , and its consequent enhanced activity , following the displacement of HDAC 1 from the pRB / E2F1 inhibitory complex . ^^^ |
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