| Interacting proteins: Q00987 and Q13547 |
Pubmed |
SVM Score :0.5823436 |
| Using chromatin immunoprecipitation ( ChIP ) and re ChIP analyses , we show that Mdm 2 associates with AR and HDAC 1 at the active androgen responsive PSA promoter in LNCaP prostate cancer cells . 0.5823436^^^ |
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| Interacting proteins: Q00987 and Q13547 |
Pubmed |
SVM Score :0.0 |
| MDM 2 HDAC 1 mediated deacetylation of p 53 is required for its degradation . ^^^ Here we show that MDM 2 can promote p 53 deacetylation by recruiting a complex containing HDAC 1 . ^^^ The HDAC 1 complex binds MDM 2 in a p 53 independent manner and deacetylates p 53 at all known acetylated lysines in vivo . ^^^ Ectopic expression of a dominant negative HDAC 1 mutant restores p 53 acetylation in the presence of MDM 2 , whereas wild type HDAC 1 and MDM 2 deacetylate p 53 synergistically . ^^^ Fibroblasts overexpressing a dominant negative HDAC 1 mutant display enhanced DNA damage induced p 53 acetylation , increased levels of p 53 and a more pronounced induction of p 21 and MDM 2 . ^^^ |
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| Interacting proteins: Q00987 and Q13547 |
Pubmed |
SVM Score :0.0 |
| These included self renewal genes ( Bmi 1 , Nanog , Gfi 1 ) , epithelial mesenchymal genes ( Tcfe2a , Ctnb 1 , Sin3a , Hdac 1 , Hdac 2 , Muc 1 , Cldn 11 ) , survival genes ( Bcl 2 , Bbc 3 ) , and cell cycle / damage genes ( Cdkn1a , Rbl 1 , Mdm 2 ) . ^^^ |
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| Interacting proteins: Q00987 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00987 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
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