| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| D 1 transcription through down regulation of Bcl 3 and inducing increased association of the p 52 NF kappaB subunit with histone deacetylase 1 . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| Transcription factor NF kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1 . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| Respiratory syncytial virus inducible BCL 3 expression antagonizes the STAT / IRF and NF kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin 8 promoter . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated recruitment of coactivators ( SRC 1 , SRC 2 , and SRC 3 ) and corepressors ( HDAC 1 , HDAC 2 , HDAC 3 , SMRT , and NCoR ) to the IkappaB alpha gene promoter after NF kappaB activation by tumor necrosis factor alpha . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| The p 65 ( RelA ) subunit of NF kappaB interacts with the histone deacetylase ( HDAC ) corepressors HDAC 1 and HDAC 2 to negatively regulate gene expression . ^^^ Expression of HDAC 1 and HDAC 2 repressed tumor necrosis factor ( TNF ) induced NF kappaB dependent gene expression . ^^^ Consistent with this , we show that HDAC 1 and HDAC 2 target NF kappaB through a direct association of HDAC 1 with the Rel homology domain of p 65 . ^^^ HDAC 2 does not interact with NF kappaB directly but can regulate NF kappaB activity through its association with HDAC 1 . ^^^ Moreover , it suggests that the association of NF kappaB with the HDAC 1 and HDAC 2 corepressor proteins functions to repress expression of NF kappaB regulated genes as well as to control the induced level of expression of these genes . . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation status of nuclear NF kappa B determines its association with CBP / p300 or HDAC 1 . ^^^ We now demonstrate that transcriptionally inactive nuclear NF kappaB in resting cells consists of homodimers of either p 65 or p 50 complexed with the histone deacetylase HDAC 1 . ^^^ Only the p 50 HDAC 1 complexes bind to DNA and suppress NF kappa B dependent gene expression in unstimulated cells . ^^^ Appropriate stimulation causes nuclear localization of NF kappa B complexes containing phosphorylated p 65 that associates with CBP and displaces the p 50 HDAC 1 complexes . ^^^ Our results demonstrate that phosphorylation of p 65 determines whether it associates with either CBP or HDAC 1 , ensuring that only p 65 entering the nucleus from cytoplasmic NF kappa B : Ikappa B complexes can activate transcription . . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| Ebp 1 bound HDAC 2 , but not HDAC 1 , in vitro . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| ARF represses the transcriptional activation domain of the NF kappa B family member RelA by inducing its association with the histone deacetylase , HDAC 1 . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| Our results support the hypothesis that the NF kappaB inhibitor IkappaBalpha regulates the transcriptional activity of homeodomain containing proteins positively through cytoplasmic sequestration of HDAC 1 and HDAC 3 , a mechanism that would assign a new and unexpected role to IkappaBalpha . . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| More remarkably , chromatin immunoprecipitation experiments demonstrate that IkappaBalpha is recruited to the promoter regions of the Notch target gene , hes 1 , together with HDAC 1 and 5 , whereas we did not detect IkappaBalpha associated with classical NF kappaB target genes such as IL 6 and RANTES . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| PI 3 kinase and PDK 1 regulate HDAC 1 mediated transcriptional repression of transcription factor NF kappaB . ^^^ Here we demonstrate that PDK 1 plays a pivotal role in transcriptional activation of NF kB by dissociating the transcriptional co repressor HDAC 1 from the p 65 subunit of NF kB . ^^^ Overexpression of a dominant negative PDK 1 mutant decreased etoposide induced NF kB transcription and further down regulated the ectopic HDAC 1 mediated decrease in NF kB transcriptional activity . ^^^ Thus activation of PDK 1 relieves the HDAC 1 mediated repression of NF kB that may be related to basal as well as activated transcription by NF kB . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| ATF3deltaZip2 interacts with a p 65 ( RelA ) cofactor complex containing CBP / p300 and HDAC 1 at NF kappaB sites of the proximal promoter region of the cIAP 2 gene in vivo and down regulates the recruitment of CBP / p300 . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| In addition , HDAC 1 depletion occurred through protein degradation , required IKK 2 activity and resulted in increased transcription from both NF kappaB associated and unassociated gene promoters . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| Mechanical stretch also reduced the interaction of HDAC 1 with RelA subunit of NF kappaB in diaphragm muscle . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| Involvement of HDAC 1 and the PI3K / PKC signaling pathways in NF kappaB activation by the HDAC inhibitor apicidin . ^^^ Furthermore , apicidin activation of NF kappaB seems to result from HDAC 1 inhibition , as evidenced by the observation that overexpression of HDAC 1 , but not HDAC 2 , 3 or 4 , dramatically inhibits NF kappaB reporter gene activity . ^^^ Collectively , our results suggest that activation of NF kappaB signaling by apicidin requires both the PI3K / PKC signaling pathways and HDAC 1 , and functions as a critical modulator in determining the cellular effect of apicidin . . ^^^ |
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| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|