TAL 1 was found , in addition , to interact with the histone deacetylase HDAC 1 in vitro and in vivo , and a specific histone deacetylase inhibitor , trichostatin A ( TSA ) , relieved TAL 1 mediated repression of an E box containing promoter and a GAL 4 reporter linked to a thymidine kinase minimal promoter . 0.90851756^^^