| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.93347275 |
| We now show that MyoD associates with a histone deacetylase 1 ( HDAC 1 ) in these cells and that this interaction is responsible for silencing MyoD dependent transcription of endogenous p 21 as well as muscle specific genes . 0.93347275^^^ |
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| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.0 |
| We describe a functional and biochemical link between the myogenic activator MyoD , the deacetylase HDAC 1 , and the tumor suppressor pRb . ^^^ Interaction of MyoD with HDAC 1 in undifferentiated myoblasts mediates repression of muscle specific gene expression . ^^^ Dephosphorylation of pRb promotes the formation of pRb HDAC 1 complex in differentiated myotubes . pRb HDAC 1 association coincides with disassembling of MyoD HDAC 1 complex , transcriptional activation of muscle restricted genes , and cellular differentiation of skeletal myoblasts . ^^^ A single point mutation introduced in the HDAC 1 binding domain of pRb compromises its ability to disrupt MyoD HDAC 1 interaction and to promote muscle gene expression . ^^^ |
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| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.0 |
| At the molecular level , pRb myogenic functions are mediated by cooperation with MyoD , Myocyte enhancer factor 2 ( MEF 2 ) , High mobility group box protein 1 ( HBP 1 ) and histone deacetylase 1 , affecting chromatin configuration and tissue specific transcription , and by post translational modification in response to intracellular signaling cascades . . ^^^ |
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| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Recent studies indicate that the initiator of the myogenic program , namely MyoD , can associate with the deacetylase HDAC 1 in vivo , and because HDACs are usually recruited to promoters by specific proteins , we considered the possibility that these two proteins might be acting together at the promoters of muscle specific genes to repress their transcription in myoblasts . ^^^ In this work , we show by chromatin immunoprecipitation ( ChIP ) assays that MyoD and HDAC 1 are both occupying the promoter of myogenin and that this gene is in a region of repressed chromatin , as revealed by enrichment in histone H 3 lysine 9 ( Lys 9 ) methylation and the underacetylation of histones . ^^^ Surprisingly , after the myoblasts are induced to differentiate , the promoter becomes absent of HDAC 1 , and eventually the acetyltransferase P / CAF takes it place alongside MyoD . ^^^ |
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| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Conversely , histone deacetylase 1 blunts MyoD dependent expression of the UCP 3 promoter and reduces PPAR dependent responsiveness . ^^^ |
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| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.0 |
| The p 300 binding protein E1A competes with HDAC 1 for C / H3 binding ; and , like E1A , HDAC 1 overexpression interferes with either activation of Gal4p300 fusion protein or p 300 dependent co activation of two C / H3 binding proteins , MyoD and p 53 . ^^^ |
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| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.0 |
| Upon gene activation , Ezh 2 , HDAC 1 , and YY 1 dissociated from muscle loci , H 3 K27 became hypomethylated and MyoD and SRF were recruited to the chromatin . ^^^ |
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| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15172 and Q13547 |
Pubmed |
SVM Score :0.0 |
| NA |
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