| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :1.3577728 |
| We show that PCNA interacts with HDAC 1 in human cells and in vitro and that a considerable fraction of PCNA and HDAC 1 colocalize in the cell nucleus . 1.3577728^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| The COOH terminal region of pRb2 / p130 binds to histone deacetylase 1 ( HDAC 1 ) , enhancing transcriptional repression of the E2F dependent cyclin A promoter . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Functionally , the association of p21 / cyclin A / cdk2 decreased histone H 1 phosphorylation in vitro , as observed in immunoprecipitations followed by kinase assays , and affected other substrates , such as the C terminus of Rb protein involved in c Abl and histone deacetylase 1 ( HDAC 1 ) regulation . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| The histone deacetylase 1 as well as Roscovitine , which blocks the activation of the histone acetyltransferase ( HAT ) activity of CBP by cyclin E Cdk 2 , prevents E 2 ( Ad 12 ) promoter activation through E1A ( 12S ) . p300 / CBP counteracts the repressive function of histone deacetylase 1 in a HAT domain dependent manner whereas the p300 / CBP associated factor PCAF failed to rescue E 2 ( Ad 12 ) promoter activity . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| We found that pRb represses the cyclin E promoter through histone deacetylation of a single nucleosome , to which it and histone deacetylase 1 bind . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| We also provide evidence of the alternative recruitment of p 300 and histone deacetylase 1 to the cyclin E promoter in proliferating and senescent melanocytes , respectively . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| We find that Rb can recruit histone deacetylase to E2F and that Rb cooperates with HDAC 1 to repress the E2F regulated promoter of the gene encoding the cell cycle protein cyclin E . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| We have examined the expression pattern of the human histone deacetylase gene HDAC 1 and the cyclin dependent kinase inhibitor p57Kip2 in the hepatocellular carcinoma cell line Hep 3B . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| CtBP is shown here to bind the histone deacetylase HDAC 1 , suggesting that a promoter targeted CtBP HDAC 1 complex can silence transcription from the PCNA promoter through a deacetylation mechanism . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| The results reported in this study strongly suggest a novel pathway involving HDAC 1 in G ( 2 ) / M checkpoint control through the interaction with a functional Rad complex that may utilize a PCNA like structure . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Functionally , the association of p21 / cyclin A / cdk2 decreased the histone H 1 phosphorylation in vitro , as observed in immunoprecipitations followed by kinase assays , as well as affecting other substrates such as the C terminus of Rb protein involved in c Abl and HDAC 1 regulation . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| TSA enhanced the protein expression of p 21 ( WAF 1 ) , CREB binding protein , cyclinE , cyclin A , Bak and Bax , while it reduced the expression of E2F 1 , E2F 4 , HDAC 1 , p 53 and hyperphosphorylated form of Rb . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Down regulation of cyclin D 2 mRNA expression in differentiating HL 60 cells is preceded by a switch of promoter occupancy from Myc / Max to Mad / Max complexes , loss of TRRAP binding , increased HDAC 1 binding , and histone deacetylation . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Chromatin immunoprecipitation studies revealed that INI1 / hSNF5 was directly recruited to the cyclin D 1 promoter and that its binding correlated with recruitment of HDAC 1 and deacetylation of histones at the promoter . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Because p 300 and histone deacetylase ( HDAC 1 ) were co immunoprecipitated with PCNA , they are likely responsible for the acetylation and deacetylation of PCNA , respectively . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| This process coincides with the release from the same DNA region of a transcriptional repressor complex including Yin Yang 1 ( YY 1 ) and histone deacetylase 1 and is sufficient to induce the assembly of the basal transcription machinery on the promoter and to lead to initial cyclin D 1 accumulation in the cell . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| We have previously demonstrated that INI 1 represses Cyclin D 1 transcription in rhabdoid cells by directly recruiting histone deacetylase 1 complex to its promoter , leading to G ( 0 ) G ( 1 ) arrest . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Moreover , in the nucleus , the epidermal growth factor / epidermal growth factor receptor complex ( EGF / EGFR ) functions as a transcriptional regulator that activates the cyclin D 1 gene . 9 hydroxystearic acid ( 9 HSA ) induces cell proliferation arrest and differentiation in HT 29 colon cancer cells by inhibiting histone deacetylase 1 ( HDAC 1 ) . 9 HSA treated HT 29 , when stimulated with EGF , are not responsive and surprisingly undergo a further arrest . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| The effect of HDAC 1 on cell cycle exit is cell autonomous , and loss of HDAC 1 in the retina leads to up regulation of cyclin D and E transcripts . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Relocalization occurs concomitantly with interaction with a subset of nuclear proteins , including PCNA , p 53 and several regulators of acetylation such as the p300 / CBP and PCAF histone acetyltransferases ( HATs ) , as well as the histone deacetylases HDAC 1 and hSir 2 . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Co immunoprecipitation of INSM 1 , cyclin D 1 and HDACs ( histone deacetylases ) in mammalian cells revealed that INSM 1 interacts with HDAC 1 and 3 and that this interaction is mediated through cyclin D 1 . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Ezh 2 reduces the ability of HDAC 1 dependent pRb2 / p130 transcriptional repression of cyclin A . ^^^ We show that Ezh 2 is able to reverse pRb2 / p130 HDAC 1 mediated repression of the cyclin A promoter . ^^^ Finally , electromobility shift assays ( EMSA ) demonstrated that overexpression of Ezh 2 caused the abrogation of the pRb2 / p130 HDAC 1 complex on the cyclin A promoter . ^^^ These data , taken together , suggest that Ezh 2 competes with HDAC 1 in binding to pRb2 / p130 , disrupting their occupancy on the cyclin A promoter . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Inhibition of proteasomal proteolysis , but not of caspase activity rescued pRb from degradation and functionally restored its inhibitory effect on the cyclin E gene , known to be suppressed by pRb E2F 1 in conjunction with HDAC 1 . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| Genetic deletion of cyclin D 1 reduced HDAC 1 activity . ^^^ Reconstitution of cyclin D 1 into the cyclin D 1 / MEFs increased HDAC 1 activity and blocked PPARgamma mediated adipogenesis . ^^^ Cyclin D 1 bound HDAC in vivo and preferentially physically associated with HDAC 1 , HDAC 2 , HDAC 3 , and HDAC 5 . ^^^ Chromatin immunoprecipitation assay demonstrated that cyclin D 1 enhanced recruitment of HDAC 1 and HDAC 3 and histone methyltransferase SUV39H1 to the PPAR response element of the lipoprotein lipase promoter and decreased acetylation of total histone H 3 and histone H 3 lysine 9 . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| This was the result of cyclin E / CDK2 interfering with the interaction of Mad 1 with HDAC 1 and reducing HDAC activity . ^^^ |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|