| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| Furthermore , histone deacetylase 1 ( HDAC 1 ) bound the AR both in vivo and in cultured cells and HDAC 1 binding to the AR was disengaged in a DHT dependent manner . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| Tip 60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| SENP 1 enhances androgen receptor dependent transcription through desumoylation of histone deacetylase 1 . ^^^ SENP 1 ' s ability to enhance AR dependent transcription is not mediated through desumoylation of AR , but rather through its ability to deconjugate histone deacetylase 1 ( HDAC 1 ) , thereby reducing its deacetylase activity . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| Regulation of androgen receptor and histone deacetylase 1 by Mdm 2 mediated ubiquitylation . ^^^ Regulation of the AR is achieved by alternate binding of either histone acetyltransferase ( HAT ) containing co activator proteins , or histone deacetylase 1 ( HDAC 1 ) . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| Modulation of the expression and transactivation of androgen receptor by the basic helix loop helix transcription factor Pod 1 through recruitment of histone deacetylase 1 . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| Human PIRH 2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| In this study we report on immunological characterization of one of the major components , termed HD 1 , with an apparent molecular mass of 500 kD . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| In order to specifically inhibit the AR pathway , dominant negative ARs were constructed by inactivation of the major transactivation domains of the wild type AR and fusing this mutant ( AR 122 ) to the Krppel associated box ( KRAB ) repressor domain and / or histone deacetylase ( HDAC 1 ) . ^^^ The HDAC 1 KRAB AR 122 protein was the most successful dominant negative AR , capable of repressing the wild type AR ninefold when co expressed at a 1 : 1 plasmid ratio . ^^^ A maximal repression of 41 fold was achieved when HDAC 1 KRAB AR 122 was cotransfected with the wild type AR at a 4 : 1 plasmid ratio . ^^^ HDAC 1 KRAB AR 122 repressed transcription in a ligand dependent manner since it inhibited a constitutively active AR mutant ( AR 5 ) only in the presence of agonists . ^^^ High concentrations of partial agonists such as RU 486 , cyproterone acetate , and estradiol were also capable of triggering repression by HDAC 1 KRAB AR 122 . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| It was found that DJBP repressed a testosterone dependent AR transactivation activity in monkey Cos 1 cells by recruiting histone deacetylase ( HDAC ) complex , including HDAC 1 and mSin 3 , and that DJ 1 partially restored its repressed activity by abrogating DJBP HDAC complex . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| We show that the RD 1 domain binds HDAC 1 and HDAC 2 and that HDAC activity is required for PIASy mediated AR repression . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| We further supported the evidence for an interaction between SHP and HDAC 1 by showing their co immunoprecipitation and provided evidence for the existence of a ternary complex comprising AR , SHP , and HDAC 1 . ^^^ |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|