| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.59851914 |
| Here we show that Rb associates with a histone deacetylase , HDAC 1 , through the Rb ' pocket ' domain . 0.59851914^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Functionally , the association of p21 / cyclin A / cdk2 decreased histone H 1 phosphorylation in vitro , as observed in immunoprecipitations followed by kinase assays , and affected other substrates , such as the C terminus of Rb protein involved in c Abl and histone deacetylase 1 ( HDAC 1 ) regulation . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that Rb , the founding member of the pocket proteins family , represses E2F1 activity by recruiting the histone deacetylase HDAC 1 . ^^^ HDAC 1 interacts with p 107 and Rb through an `` LXCXE ' ' like motif , similar to that used by viral transforming proteins to bind and inactivate pocket proteins . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Rb represses S phase genes through the recruitment of an enzyme which modifies DNA structure , the histone deacetylase HDAC 1 . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| We show here that the histone deacetylase HDAC 1 is able to mediate the formation of a ternary complex containing Rb and RbAp 48 . ^^^ Finally , we found that E2F1 and RbAp 48 are physically associated in the presence of Rb and HDAC 1 , suggesting that RbAp 48 could be involved in transcriptional repression of E2F responsive genes . . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| DNMT 1 forms a complex with Rb , E2F1 and HDAC 1 and represses transcription from E2F responsive promoters . ^^^ Here we show that the predominant mammalian DNA methyltransferase , DNMT 1 , co purifies with the retinoblastoma ( Rb ) tumour suppressor gene product , E2F1 , and HDAC 1 and that DNMT 1 cooperates with Rb to repress transcription from promoters containing E2F binding sites . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Cellular proteins such as histone deacetylases 1 and 2 ( HDAC 1 and 2 ) also contain an LXCXE like sequence , which they use to interact with Rb . ^^^ Thus , the LXCXE mutations appear to separate Rb ' s ability to bind and inactivate E2F from its ability to efficiently recruit HDAC 1 and 2 and actively repress transcription . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Functionally , the association of p21 / cyclin A / cdk2 decreased the histone H 1 phosphorylation in vitro , as observed in immunoprecipitations followed by kinase assays , as well as affecting other substrates such as the C terminus of Rb protein involved in c Abl and HDAC 1 regulation . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| TSA enhanced the protein expression of p 21 ( WAF 1 ) , CREB binding protein , cyclinE , cyclin A , Bak and Bax , while it reduced the expression of E2F 1 , E2F 4 , HDAC 1 , p 53 and hyperphosphorylated form of Rb . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| The failure to deacetylate and thus repress transcription by the Class 1 histone deacetylases HDAC 1 and HDAC 2 due to disruption of the Rb family of proteins has been firmly established as a mechanism leading to increases in growth rate and cellular proliferation . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Repression by Rb is mediated , at least in part , by a histone deacetylase complex , whose enzymatic activity relies on HDAC 1 , HDAC 2 or HDAC 3 . ^^^ Recently , we have shown that the Rb associated histone deacetylase complex contains RbAp 48 protein , which interacts with HDAC 1 and HDAC 2 . ^^^ However , we found that it shared with HDAC 1 the ability to favour the recruitment of RbAp 48 to Rb . ^^^ Taken together , our data suggest a model in which Rb mediates the recruitment to E2F regulating promoters of a repressive complex containing either HDAC 1 , HDAC 2 or HDAC 3 and the histone binding protein RbAp48 . . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Cell cycle dependent recruitment of HDAC 1 correlates with deacetylation of histone H 4 on an Rb E2F target promoter . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| We further demonstrate that the ability of E 7 to abrogate cell cycle arrest , activate cdc25A transcription , and increase cdc25A protein levels requires intact Rb and HDAC 1 binding domains . ^^^ Consequently , we propose that E7 . 16 can directly target cdc25A transcription and maintains cdc25A gene expression by disrupting Rb / E2F / HDAC 1 repressor complexes . . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Consistent with this interpretation , the N terminal transcriptional repression domain of Suv39H1 bound the so called ' core histone deacetylase complex ' , composed of HDAC 1 , HDAC 2 and the Rb associated proteins RbAp 48 and RbAp 46 . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| The retinoblastoma gene product , Rb , is a cell cycle regulator protein that represses transcription by recruiting histone deacetylase ( HDAC 1 ) . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Constitutive expression of the Id 1 promoter in human metastatic breast cancer cells is linked with the loss of NF 1 / Rb / HDAC 1 transcription repressor complex . ^^^ Using DNA affinity precipitation assays ( DAPA ) , we show that this complex contains SP 1 , NF 1 , Rb and HDAC 1 proteins . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| We describe an in vitro model of hypertrophy in C2C12 skeletal myoblasts and demonstrate that induction of hypertrophy involves transient activation of Cdk 4 , subsequent phosphorylation of Rb , and release of HDAC 1 from the Rb inhibitory complex . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Che 1 affects cell growth by interfering with the recruitment of HDAC 1 by Rb . ^^^ Here we show that Che 1 contacts the Rb pocket region and competes with HDAC 1 for Rb binding site , removing HDAC 1 from the Rb / E2F complex in vitro and from the E2F target promoters in vivo . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Prohibitin co localizes with Rb in the nucleus and recruits N CoR and HDAC 1 for transcriptional repression . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated that Che 1 inhibits the Rb growth suppressing function by interfering with Rb mediated HDAC 1 recruitment on E2F target gene promoters . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| To relate HDAC inhibition to the anti proliferative effects of NVP LAQ 824 , expression of HDAC 1 was inhibited using antisense and this was sufficient to activate p 21 expression , hypophosphorylate Rb and inhibit cell growth . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Here we show that p 130 is the predominant Rb family member associated with E2F in neurons , that its major partner for repression of pro apoptotic genes is E2F4 , and that the p 130 E2F4 complex recruits the chromatin modifiers HDAC 1 and Suv39H1 to promote gene silencing and neuron survival . ^^^ |
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| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Following the subcloning of the promoter regions into a gene reporter system , we found that at least four promoter haplotypes associated with CCND 1 , E2F1 , HDAC 1 and RB 1 significantly influenced transcriptional activity in an allele specific manner . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| Che 1 contacts the Rb and competes with HDAC 1 for Rb binding site , removing HDAC 1 from the Rb / E2F cell cycle regulated promoters . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| HDAC 1 , an LXCXE protein that plays a critical role in Rb mediated transcription repression , abrogates the effect of Rb on E2F 1 induced cell death . ^^^ |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|