| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| SNP induced p 65 dissociation was associated with the recruitment of histone deacetylase 1 and 2 to the endogenous c myc gene promoter and the subsequent deacetylation of its chromatin histone . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| MM 1 has been reported to repress the E box dependent transcription activity of c Myc by recruiting histone deacetylase 1 complex via TIF1beta / KAP1 . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| MM 1 was identified as a c Myc binding protein and has been reported to repress the E box dependent transcription activity of c Myc by recruiting HDAC 1 complex via TIF 1 beta / KAP1 . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| Interestingly , APC mediated repression of c Myc transcription in HT 29 APC colorectal cancer cells is initiated by the transient binding of APC , betaTrCP , and the CtBP corepressor to the c Myc enhancer , followed by stable binding of the TLE 1 and HDAC 1 corepressors . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| Max Mad / Mxi1 heterodimers , which bind to E boxes in absence of co repressors , do not inhibit gene expression simply by competition with Myc Max heterodimers , but require Sin 3 and Rpd 3 for efficient repression of transcription . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| The finding that Mad / Max complexes interact with Sin 3 and HD 1 in vivo suggests a model for the role of Mad proteins in antagonizing the function of Myc proteins . . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| Further , once induced , Stra 13 strongly represses the expression of the cell proliferation associated gene c Myc through an HDAC 1 independent pathway that involves its interaction with the basal transcription factor TFIIB . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| Down regulation of cyclin D 2 mRNA expression in differentiating HL 60 cells is preceded by a switch of promoter occupancy from Myc / Max to Mad / Max complexes , loss of TRRAP binding , increased HDAC 1 binding , and histone deacetylation . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| MM 1 and TIF 1 beta complex in human HeLa cells was found to also contain c Myc , mSin 3 , and HDAC 1 . ^^^ Moreover , the inhibitory activity of MM 1 toward c Myc was canceled by trichostatin A , an inhibitor of HDAC 1 . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| Additional studies showed that HDAC 1 treatment inhibited c Myc expression , which was further shown to be important for CD 154 gene activation . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| The HDACi caused a marked decrease in HDAC 1 and Myc and an increase in RNA polymerase 2 in proteins bound to the p 21 ( WAF 1 ) promoter . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| IPA implicated Myc and Hdac 1 as candidate genes involved in genome activation and the development of the transcriptionally repressive state , respectively . . ^^^ |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13547 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|