| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.93343551 |
| Subsequently , a recombinant LT beta R was shown to bind LT alpha LT beta heteromeric complexes . 0.93343551^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| This system consists of three ligands , TNF , LT alpha ( LT alpha ) and LT beta ( LT beta ) , and three membrane associated receptors , p 55 , p 75 and LT beta receptor ( LT beta R ) . ^^^ The biological effects of TNF and LT alpha homotrimers are mediated by p 55 and p 75 receptors , while the heteromeric complex of LT alpha / LT beta transduces its cellular signal via LT beta R . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin ( LT ) alpha beta heterotrimer is a membrane anchored ligand expressed by activated T cells which binds specifically to the LT beta receptor ( LT beta R ) , a member of the TNFR family . ^^^ The LT beta R is implicated as a critical element in controlling lymph node development and cellular immune reactions . ^^^ To address this hypothesis we have isolated a mouse cDNA encoding a single transmembrane protein of 415 amino acids with 76 % identity to human LT beta R . ^^^ The gene encoding mouse LT beta R , Ltbr , contains 10 exons spanning 6 . 9 kb and maps to mouse chromosome 6 , which is closely linked to Tnfr 1 , consistent with the tight linkage of the human homologue of these genes on chromosome 12p13 . ^^^ Mouse LT beta R mRNA is expressed by cell lines of monocytic and epithelial origin but not by a CTL line , and in vivo it is constitutively expressed in visceral and lymphoid tissues . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| A genetic linkage , as evidence for evolutionary relatedness , is found by chromosomal cluster of TNFR p 80 , CD 30 , 4 1BB , and OX 40 for 1p36 ; TNFR p 60 , TNFR RP , and CD 27 for 12p13 ; TNF , LT alpha , and LT beta for 6 ( MHC locus ) ; CD27L and 4 1BBL for 19p13 ; and FASL and OX40L for 1q25 . ^^^ Of the TNF ligand superfamily , TNF , LT alpha , and LT beta and their receptors ( TNFR p 60 , TNFR p 80 , and TNFR RP ) interact in a complex fashion of cross binding . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Surface lymphotoxin ( LT ) is a heteromeric complex of LT alpha and LT beta chains that binds to the LT beta receptor ( LT beta R ) , a member of the tumor necrosis factor ( TNF ) family of receptors . ^^^ Since signaling through other members of this receptor family can induce cell death , e . g . , the TNF and Fas receptors , it is important to determine if similar signaling events can be communicated via the LT beta R . ^^^ When immobilized on a plastic surface , anti LT beta R monoclonal antibodies ( mAbs ) induced the death of these cells , demonstrating direct signaling via the LT beta R . ^^^ Anti LT beta R mAbs were also identified that inhibited ligand induced cell death , whereas others were found to potentiate the activity of the ligand when added in solution . ^^^ The human WiDr adenocarcinoma line forms solid tumors in immunocompromised mice , and treatment with an anti LT beta R antibody combined with human IFN gamma arrested tumor growth . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Cellular responses are initiated by a corresponding family of specific receptors that includes two distinct TNFR ( TNFR 60 and TNFR 80 ) , Fas ( CD 95 ) , CD 40 , p75NTF , and the recently identified lymphotoxin beta receptor ( LT beta R ) , among others . ^^^ The TRAF family of Zn RING / finger proteins bind to TNFR 80 ; CD 40 and LT beta R are involved in induction NF kappa B and cell survival . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| A genetic linkage , as evidence for evolutionary relatedness , is also found by chromosomal cluster for CD 30 , CD120b , 4 1BB and OX 40 to 1p36 ; CD 27 , CD120a and TNFR RP to 12p13 ; TNF , LT alpha and LT beta to 6p21 ; CD27L and 4 1BBL to 19p13 ; CD95L and OX40L to 1q25 . ^^^ TNF , LT alpha and LT beta and their receptors ( CD120a , CD120b , TNFR RP ) interact in a complex fashion . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The major and minor membrane forms , LT alpha 1 beta 2 and LT alpha 2 beta 1 , respectively , bind a unique receptor , LT beta R . ^^^ In this report we have compared the effects of ligand engagement of TNF R and LT beta R by evaluating the ability of soluble LT alpha beta complexes to initiate activities of human umbilical vein endothelial cells which are characteristically signalled by TNF . ^^^ We recently reported that soluble LT alpha 1 beta 2 signals via LT beta R to mediate cytotoxicity of a subset of gamma interferon ( IFN gamma ) treated carcinomas . ^^^ Thus , the ability of LT alpha beta complexes to efficiently initiate tumoricidal but not inflammatory activities distinguishes the LT / LT beta R from the LT / TNF R pathways and suggest novel strategies for exploiting the LT ligands in tumor therapy and for inhibiting TNF R mediated inflammatory sequellae . . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Here we report that blocking LT alpha beta / lymphotoxin beta receptor ( LT beta R ) interaction in vivo by generating mice which express a soluble LT beta R Fc fusion protein driven by the human cytomegalovirus promoter results in an array of anatomic abnormalities affecting both the spleen and Peyer ' s patches , but not the lymph nodes . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The lymphotoxin alpha beta complex ( LT alpha beta ) is found on the surface of activated lymphocytes and binds to a specific receptor called the LT beta receptor ( LT beta R ) . ^^^ Here we have used soluble receptor Ig forms of LT beta R and TNF R 55 and mAbs specific for murine LT alpha , LT beta , and LT beta R to characterize the appearance of surface LT alpha beta complexes and LT beta R on several common murine cell lines . ^^^ Cells that bound LT beta R also bound anti LT alpha and anti LT beta mAbs in a FACS analysis . ^^^ Primary mouse leukocytes from spleen , thymus , lymph node , and peritoneum were activated in vitro , and CD4+ and CD8+ T cells as well as B cells expressed surface LT ligand but not the LT beta R . ^^^ Conversely , elicited peritoneal monocytes / macrophages were surface LT negative yet LT beta R positive . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Both secreted human LT alpha and TNF have similar biological activities mediated via the TNF receptors , whereas the cell surface LT alpha beta complex binds to a separate receptor called the LT beta receptor ( LT beta R ) . ^^^ Coexpression of both mLT alpha and a soluble version of mLT beta in insect cells led to an LT alpha beta form that was cytotoxic in the WEHI 164 assay via the LT beta R . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| In the present study , the expression of TNF , LT alpha ( the soluble form of LT ) , LT beta ( the beta chain of LT alpha beta , the membrane bound form of LT ) , TNF RI , TNF RII , LT beta R , FasL , and Fas receptor in MS lesions has been examined by immunohistochemistry for protein and by RT PCR for mRNA . ^^^ LT beta expression was seen on astrocytes and oligodendrocytes , and LT beta R on astrocytes . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The cell surface form of LT exists as a heteromer of LT alpha and LT beta subunits and this complex specifically binds the LT beta receptor ( LT beta R ) . ^^^ To discriminate the functions of the LT and TNF systems , soluble LT beta R immunoglobulin ( Ig ) or TNF R Ig fusion proteins were introduced into embryonic circulation by injecting pregnant mice . ^^^ Exposure to LT beta R Ig during gestation disrupted lymph node development and splenic architecture in the progeny indicating that both effects are mediated by the surface LT alpha / beta complex . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Thus , certain actions of LT alpha to regulate spleen white pulp architecture are mediated by receptors other than TNFR 1 , most likely by the LT beta R or a closely related receptor . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| We previously identified murine TRAF 5 ( mTRAF 5 ) and showed that it specifically interacts with the lymphotoxin beta receptor ( LT beta R ) and activates the transcription factor NF kappa B . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The lymphotoxin beta receptor ( LT beta R ) , a member of the tumor necrosis factor ( TNF ) receptor family , plays a crucial role in lymphoid organogenesis by signaling through its functional ligand LT alpha ( 1 ) beta ( 2 ) . ^^^ In order to characterize the mouse LT beta R gene expression on a molecular level , we isolated about 1 kb of the 5 ' flanking region of the LT beta R gene . ^^^ Northern blot analysis showed that the LT beta R is abundantly expressed in the mouse fibroblast cell line NIH 3T3 , and to a lesser extent , in the mouse macrophage like cell line RAW 264 . 7 . ^^^ Transfection experiments using these reporter gene constructs showed that the isolated 5 ' flanking region is transcriptionally active in NIH 3T3 and RAW 264 . 7 cells , and determined a minimum length required for the transcriptional activity of the LT beta R promoter in these cells . ^^^ Interestingly , incubation of NIH 3T3 cells with dexamethasone resulted in an elevated mRNA level of the LT beta R gene . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| In vitro binding assays demonstrated that TRAF 4 interacts with the cytosolic domain of the lymphotoxin beta receptor ( LT beta R ) and weakly with the p 75 nerve growth factor receptor ( NGFR ) but not with TNFR 1 , TNFR 2 , Fas , or CD 40 . ^^^ Immunohistochemical assays of normal human adult tissues revealed prominent cytosolic immunostaining in thymic epithelial cells and lymph node dendritic cells but not in lymphocytes or thymocytes , paralleling the reported patterns of LT beta R expression . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Although recent reports have shown that the interaction between lymphotoxin ( LT ) and the LT beta receptor ( Ltbeta r , encoded by Ltbr ) provides a critical signal for LN genesis in mice , the aly locus on chromosome 11 is distinct from those for LT and its receptor . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Four members of the tumor necrosis factor ( TNF ) ligand family , TNF alpha , LT alpha , LT beta , and LIGHT , interact with four receptors of the TNF / nerve growth factor family , the p 55 TNF receptor ( CD120a ) , the p 75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in either TNFR 1 or LT beta R also fail to develop splenic FDC clusters and germinal centers , indicating that signaling through both TNFR 1 and LT beta R is required for the development of these structures . ^^^ These studies demonstrate that LT alpha and the aly gene product together control lymphoid organogenesis with a close mechanistic relationship in their biochemical pathways through governing distinct cellular compartments ; the former acting as a circulating ligand and the latter as a LT beta R signaling molecule expressed by the stroma of the lymphoid organs . . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor ( LT beta R ) is a member of tumor necrosis factor receptor family and plays essential roles in the embryonic development and organization of secondary lymphoid tissues . ^^^ However , the molecular mechanism of the activation of these signaling pathways by LT beta R is not clear . ^^^ Because there is no enzymatic activity associated with the receptor itself , the signal transduction of LT beta R is mediated by cytoplasmic proteins recruited to receptors . ^^^ LT beta R complex was affinity purified from U 937 cells , and proteins associated with the complex were identified by mass spectrometry . ^^^ Their association with LT beta R was further confirmed by coimmunoprecipitation in U 937 cells and HEK 293 cells . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| To identify novel mechanisms involved in combating intracellular infections , experiments were performed in mice with selective defects in the lymphotoxin ( LT ) / LT beta R pathway . ^^^ Indeed , mice deficient in the receptor for LT alpha ( 1 ) beta ( 2 ) heterotrimers ( LT beta R knockout ( KO ) mice ) also had significantly higher numbers of M . tuberculosis in infected lungs and exhibited widespread pulmonary necrosis already by day 35 after intranasal infection . ^^^ Furthermore , LT beta R KO mice were dramatically more susceptible than wild type mice to i . p . infection with Listeria monocytogenes . ^^^ Compared with wild type mice , LT beta R KO mice had similar transcript levels of TNF and IFN gamma and recruited similar numbers of CD 3 ( + ) T cells inside granulomatous lesions in M . tuberculosis infected lungs . ^^^ Flow cytometry revealed that the LT beta R is expressed on pulmonary macrophages obtained after digestion of M . tuberculosis infected lungs . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| DcR3 / TR6 is a soluble death decoy receptor belonging to the tumor necrosis factor ( TNF ) receptor family , and it can block apoptosis mediated by several TNF receptor family members such as Fas and LT beta R . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxins ( LT alpha and LT beta ) , LIGHT [ homologous to LT , inducible expression , competes with herpes simplex virus ( HSV ) glycoprotein D for HSV entry mediator ( HVEM ) , a receptor expressed on T lymphocytes ] , tumor necrosis factor ( TNF ) , and their specific receptors LT beta R , HVEM , and TNF receptor 1 ( TNFR 1 ) and TNFR 2 , form the immediate family of the larger TNF superfamily . ^^^ Target genes regulated by the LT alpha beta LT beta R pathway include the tissue organizing chemokines , CXCL 13 , CCL 19 , and CCL 21 , which establish cytokine circuits that regulate LT expression on lymphocytes , leading to organized lymphoid tissue . ^^^ Here , regulation of interferon beta by LT beta R and TNFR signaling may play a crucial role in certain viral infections . ^^^ Regulation of autoimmune regulator in the thymus via LT beta R implicates LT / LIGHT involvement in central tolerance . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LAP 1 binds to the p 80 TNFR , CD 40 , and the lymphotoxin beta receptor , while EBI 6 associates with the p 80 TNFR . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Homology searches revealed that this clone encodes the mouse lymphotoxin beta receptor ( LT beta R ) . ^^^ The murine lymphotoxin beta receptor cDNA : isolation by the signal sequence trap and chromosomal mapping . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The LT complex is found on activated lymphocytes and binds to the lymphotoxin beta receptor , which is generally present on nonlymphoid cells . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| TRAFamn is identical to a recently reported protein ( CD40bp , CAP 1 , CRAF 1 , LAP 1 ) that can bind the cytoplasmic domains of CD 40 and the lymphotoxin beta receptor ( LTbetaR ) , both of which are known members of the TNF receptor superfamily . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Inhibition of LIGHT ( a cellular ligand for herpes virus entry mediator and lymphotoxin receptor ) / herpes simplex virus entry mediator ( HVEM ) and LIGHT / lymphotoxin beta receptor ( LT beta R ) interactions decreases mortality in MHC class 1 and 2 disparate graft vs host disease ( GVHD ) . ^^^ An inhibitor protein of LIGHT and LT alpha beta 2 ( LT beta R Ig ) and an inhibitor protein of LIGHT ( HVEM Ig ) caused similar decreases in alloresponses of control B 6 or B6 . 129S1 IL12rb2 ( tm1Jm ) ( B6 . ^^^ GVHD induced wasting disease in MHC class 2 disparate recipients of B 6 CD4+ SpC who received either the LT beta R Ig encoding adenovirus ( LT beta R Ig Adv ; 13 . 1 + / 10 . 9 % ; n = 10 ; p = 0 . 0004 ) or the HVEM Ig encoding adenovirus ( HVEM Ig Adv ; 16 . 4 + / 9 . 9 % ; n = 13 ; p = 0 . 0008 ) was significantly reduced compared with that in recipients of a control adenovirus ( 30 . 4 + / 8 . 8 % ; n = 13 ) . ^^^ Furthermore , gut GVHD histologic scores of recipients of B 6 CD4+ SpC who received the LT beta R Ig Adv ( 0 . 8 + / 0 . 8 ; n = 5 ; p = 0 . 0007 ) or the HVEM Ig Adv ( 1 . 4 + / 0 . 5 ; n = 5 ; p = 0 . 008 ) were reduced compared with scores of recipients of a control adenovirus ( 2 . 5 + / 0 . 75 ; n = 11 ) . ^^^ In the intestine , both LT beta R Ig Adv and HVEM Ig Adv decreased CD4+ T cells ( 0 . 35 + / 0 . 4 10 10 ( 6 ) ( n = 6 ) vs 0 . 36 + / 0 . 02 10 10 ( 6 ) ( n = 9 ) ; p = 0 . 03 and p = 0 . 007 ) compared with control adenovirus ( 0 . 86 + / 0 . 42 10 10 ( 6 ) ; n = 9 ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Using several approaches of functional genomics , we enumerated transcripts affected in mice by suppressing LT beta receptor ( LTbetaR ) signaling and / or overrepresented in FDC enriched GC isolates . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that DCs express the lymphotoxin ( LT ) beta receptor ( LT beta R ) and that in mice lacking the LT beta R in hematopoietic cells , spleen , and lymph node , CD 8 DC numbers are reduced . ^^^ Furthermore , we find that about 5 % of splenic DCs are undergoing cell division , and the number of dividing CD 8 DCs is disproportionately reduced in the absence of the LT beta R . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell types . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| TRAF 6 does not associate with the cytoplasmic tails of TNFR 2 , CD 30 , lymphotoxin beta receptor , and LMP 1 of Epstein Barr virus . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin beta receptor . ^^^ Interestingly , more than half of these clones encode the cytoplasmic domain of lymphotoxin beta receptor ( LT betaR ) , which is a member of the tumor necrosis factor receptor family . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| TRAF 5 is the newest member of the TRAF family that binds to lymphotoxin beta receptor and CD 40 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| TRAF 5 , an activator of NF kappaB and putative signal transducer for the lymphotoxin beta receptor . ^^^ In vitro translated TRAF 5 binds to the cytoplasmic region of the lymphotoxin beta receptor ( LT betaR ) but not to several other related receptors including CD 40 , both TNF receptors , Fas , and nerve growth factor receptor . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor signaling complex : role of tumor necrosis factor receptor associated factor 3 recruitment in cell death and activation of nuclear factor kappaB . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin alphabeta ( LTalphabeta ) / lymphotoxin beta receptor ( LTbeta R ) signaling is critical for the organogenesis of lymph nodes and Peyer ' s patches and for the structural compartmentalization of the splenic white pulp into distinct B and T cell areas and marginal zones . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Serine / threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin beta receptor in HepG 2 cells . ^^^ The lymphotoxin beta receptor ( LT betaR ) has been shown to be the receptor for the membrane bound lymphotoxin heterotrimers LTalpha1 / beta2 and LTalpha2 / beta1 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| An adenoviral vector was created that encodes for a lymphotoxin beta inhibitor protein consisting of the extracellular domain of the lymphotoxin beta receptor fused to IgG heavy chain . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin beta receptor modulates the signal pathway of the lymphotoxin beta receptor . ^^^ One such cellular gene was isolated and characterized as the gene encoding the lymphotoxin beta receptor ( LT betaR ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Ligation of the lymphotoxin beta receptor ( LTbetaR ) recruits tumor necrosis factor receptor associated factor 3 ( TRAF 3 ) and initiates cell death in HT 29 adenocarcinoma cells . ^^^ Dominant negative mutants of TRAF 3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin beta receptor . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin alpha beta ( LT alpha beta ) / lymphotoxin beta receptor ( LT beta R ) signaling is critical for the organogenesis of lymph nodes and Peyer ' s patches and for the structural compartmentalization of the splenic white pulp into distinct B and T cell areas and marginal zones . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The encoded protein has typical structural characteristics shown in the TRAF family of proteins and binds to the cytoplasmic region of lymphotoxin beta receptor more efficiently than to that of CD 40 and CD 30 . ^^^ These results suggest that the human TRAF 5 protein could be involved in the signal triggered by various members of the tumor necrosis factor receptor ( TNFR ) superfamily including CD 40 , CD 30 and lymphotoxin beta receptor . . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Previously , we have shown that the core protein binds to the cytoplasmic domain of lymphotoxin beta receptor , which is a member of tumor necrosis factor receptor ( TNFR ) family . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin alpha ( LTalpha ) signals via tumor necrosis factor receptors ( TNFRs ) as a homotrimer and via lymphotoxin beta receptor ( LTbetaR ) as a heterotrimeric LTalpha1beta2 complex . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Other strategies include the alterations in cytokine expression such as demonstrated with the hepatitis B virus ( HBV ) core protein and terminal protein which can inhibit interferon beta gene expression , the interactions of the hepatitis C virus core protein to lymphotoxin beta receptor and the effects of the interferon signal transduction pathway by adenovirus EIA oncogene and HBV by reducing levels or activity of the cytosolic latent transcriptional factors ( STATS ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor ( LTbetaR ) / mice were created by gene targeting . ^^^ The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymph node genesis is induced by signaling through the lymphotoxin beta receptor . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT protein triggers apoptosis of various tumor cells expressing both lymphotoxin beta receptor ( LTbetaR ) and TR2 / HVEM receptors , and its cytotoxicity can be blocked specifically by addition of a LTbetaR Fc or a TR2 / HVEM Fc fusion protein . ^^^ LIGHT , a novel ligand for lymphotoxin beta receptor and TR2 / HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Expression of three members of the TNF R family of receptors ( 4 1BB , lymphotoxin beta receptor , and Fas ) in human lung . ^^^ In this study , immunohistochemical techniques were used to evaluate the expression of three receptors of this family ( 4 1BB , lymphotoxin beta receptor ( LTbeta R ) , and Fas ) in normal human lung , lung carcinomas and by tuberculous and sarcoid granulomas . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Hepatitis C virus core protein enhances NF kappaB signal pathway triggering by lymphotoxin beta receptor ligand and tumor necrosis factor alpha . ^^^ Our previous study indicated that the core protein of hepatitis C virus ( HCV ) can associate with tumor necrosis factor receptor ( TNFR ) related lymphotoxin beta receptor ( LT betaR ) and that this protein protein interaction plays a modulatory effect on the cytolytic activity of recombinant form LT betaR ligand ( LT alpha1beta2 ) but not tumor necrosis factor alpha ( TNF alpha ) in certain cell types . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| It takes part in the signal transduction of the TNF receptor 2 ( TNFR 2 ) , the lymphotoxin beta receptor ( LT betaR ) , CD 40 , CD 30 , and LMP 1 ; is induced by LMP 1 in vitro ; and protects lymphoid cells from apoptosis . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The lymphotoxin beta receptor ( LTbetaR ) , and its ligand , LTalpha1beta2 , have been proposed to play a key role in the development and organization of lymphoid tissues . ^^^ Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic domain of the lymphotoxin beta receptor mediates cell death in HeLa cells . ^^^ Activation of lymphotoxin beta receptor ( LT betaR ) by conjugation with heterotrimeric lymphotoxin , LT alpha1 / beta2 , or by cross linking with anti LT betaR antibodies can trigger apoptosis . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Signaling through the lymphotoxin beta receptor stimulates HIV 1 replication alone and in cooperation with soluble or membrane bound TNF alpha . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| It has been shown that LIGHT triggers apoptosis of various tumor cells including HT 29 cells that express both lymphotoxin beta receptor ( LTbetaR ) and HVEM / TR2 receptors . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| TRAF 5 [ tumor necrosis factor ( TNF ) receptor associated factor 5 ] is implicated in NF kappaB and c Jun NH ( 2 ) terminal kinase / stress activated protein kinase activation by members of the TNF receptor superfamily , including CD 27 , CD 30 , CD 40 , and lymphotoxin beta receptor . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Among them are also molecules belonging to superfamily of tumor necrosis factor receptor ( TNFR ) which beside CD 30 include CD 27 , CD 40 , TNFR 1 and 2 , Fas ( CD 95 ) , OX 40 , 4 1BB ( CDw 137 ) , nerve growth factor receptor , lymphotoxin beta receptor , Apo3 / DR3 / Ws1 1 / lymphocyte associated receptor of death , DR 4 , DR5 / TNF related apoptosis inducing ligand , osteoprotegerin , and TNFR related 2 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| This study describes a mouse model of virus induced systemic shock and respiratory distress , and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease . . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Most lymphotoxin alpha ( ltalpha ) and all lymphotoxin beta receptor ( ltbetar ) deficient mice are completely devoid of lymph nodes ( LNs ) ; however , most lymphotoxin beta ( ltbeta ) deficient mice develop mesenteric LNs . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| A role for lymphotoxin beta receptor in host defense against Mycobacterium bovis BCG infection . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| It may bind to the death domain of tumor necrosis factor receptor 1 ( TNFR 1 ) and to the cytoplasmic tail of lymphotoxin beta receptor , implying that it may be involved in the apoptosis and anti apoptosis signaling pathways . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor ( LTbetaR ) , a member of the tumor necrosis factor receptor superfamily , is essential for the development and organization of secondary lymphoid tissue . ^^^ Discrete signaling regions in the lymphotoxin beta receptor for tumor necrosis factor receptor associated factor binding , subcellular localization , and activation of cell death and NF kappaB pathways . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a recently identified member of the TNF superfamily and its receptors , herpesvirus entry mediator and lymphotoxin beta receptor , are found in T cells and stromal cells . ^^^ Blockade of LIGHT by its soluble receptors , lymphotoxin beta receptor Ig or HVEM Ig , inhibits the induction of DC mediated primary allogeneic T cell response . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Analysis of DTRAF 1 binding to different members of the human TNF receptor family showed that this protein can interact through its TRAF domain with the p 75 neurotrophin receptor and weakly with the lymphotoxin beta receptor . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a tumor necrosis factor ( TNF ) ligand superfamily member , which binds two known cellular receptors , lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HveA ) . ^^^ The lymphotoxin beta receptor is necessary and sufficient for LIGHT mediated apoptosis of tumor cells . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Treatment of mice with soluble lymphotoxin beta receptor results in the disappearance of mature FDCs from the spleen . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Although a stromal defect caused by impaired lymphotoxin beta receptor signaling accounts for their abnormal lymphoid organogenesis , the exact mechanisms underlying the development of immunodeficiency in aly mice are poorly understood . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| A member of the tumor necrosis factor ( TNF ) superfamily , human TNFSF 14 ( hTNFSF 14 ) / HVEM L ( herpes virus entry mediator ligand ) was isolated as a cellular ligand for HVEM / TR2 and human lymphotoxin beta receptor ( LTbetaR ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Alymphoplasia mice ( aly / aly ) have been shown to be deficient for a nuclear factor kappaB inducing kinase involved in signal transduction of lymphotoxin beta receptor ( LT betaR ) and of CD 40 , resulting in structural defects of secondary lymphoid organs and highly increased susceptibility to viral infections . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in lymphotoxin beta receptor ( LTbetaR ) or interleukin 7 receptor alpha ( IL 7Ralpha ) lack Peyer ' s patches ( PPs ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| With the use of in vivo mouse models , rather than with enforced gene expression systems , we have investigated the role of NIK and IKKalpha in signaling through the type 1 tumor necrosis factor ( TNF ) receptor ( TNFR 1 ) and the lymphotoxin beta receptor ( LTbetaR ) , a receptor essential for lymphoid organogenesis . ^^^ Essential role of nuclear factor ( NF ) kappaB inducing kinase and inhibitor of kappaB ( IkappaB ) kinase alpha in NF kappaB activation through lymphotoxin beta receptor , but not through tumor necrosis factor receptor 1 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Homozygosity for the aly point mutation in NF kappaB inducing kinase ( NIK ) results in alymphoplasia in mice , a phenotype similar to that of homozygosity for deletion of the lymphotoxin beta receptor ( LTbetaR ) . ^^^ Effects of the NIK aly mutation on NF kappaB activation by the Epstein Barr virus latent infection membrane protein , lymphotoxin beta receptor , and CD 40 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| These mice , although grossly normal , showed phenotypic alterations in secondary lymphoid organs reminiscent of those of the TNF receptor 1 and of the lymphotoxin beta receptor gene deficient mice . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NF kappaB inducing kinase is dispensable for activation of NF kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF kappaB in primary human fibroblasts . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a member of the tumor necrosis factor ( TNF ) superfamily , which binds two known receptors , lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HVEM ) / TR2 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Compared with lymphotoxin beta knockout mice ( LTbeta / ) , LTbeta receptor knockout ( LTbetaR / ) mice present with more severely disorganized splenic structures , suggesting the potential involvement of another ligand . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor immune interaction promotes tumor growth by inducing angiogenesis . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NF kappa B inducing kinase ( NIK ) is involved in lymphoid organogenesis in mice through lymphotoxin beta receptor signaling . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The human lymphotoxin beta receptor ( LTbetaR ) , a member of the tumor necrosis factor ( TNF ) receptor superfamily , is essential for not only the development and organization of secondary lymphoid tissues , but also for chemokine release . ^^^ Lymphotoxin beta receptor induces interleukin 8 gene expression via NF kappaB and AP 1 activation . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The lymphotoxin beta receptor ( LTbetaR ) plays critical roles in inflammation and lymphoid organogenesis through activation of NF kappaB . ^^^ The lymphotoxin beta receptor induces different patterns of gene expression via two NF kappaB pathways . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NF kappaB inducing kinase ( NIK ) has been shown to play an essential role in the NF kappaB activation cascade elicited by lymphotoxin beta receptor ( LTbetaR ) signaling . ^^^ The NF kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p 65 at serine 536 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor ( LTbetaR ) is a member of the tumor necrosis factor receptor ( TNFR ) superfamily that activates nuclear factor kappaB ( NF kappaB ) through the IkappaB kinase ( IKK ) complex , the core of which is comprised of IKK 1 , IKK 2 and NF kappaB essential modulator ( NEMO ) . ^^^ Lymphotoxin beta receptor mediates NEMO independent NF kappaB activation . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor ( LTbetaR ) induced activation of NF kappaB in mouse embryo fibroblasts was mediated by the classical pathway and by an alternative or second pathway . ^^^ Lymphotoxin beta receptor induces sequential activation of distinct NF kappa B factors via separate signaling pathways . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT ( homologous to lymphotoxins , shows inducible expression , and competes with herpes simplex virus glycoprotein D for herpesvirus entry mediator , a receptor expressed by T lymphocytes ) is a member of the tumor necrosis factor superfamily that can interact with lymphotoxin beta receptor ( LTbetaR ) , herpes virus entry mediator , and decoy receptor ( DcR 3 ) . ^^^ The role of apoptosis signal regulating kinase 1 in lymphotoxin beta receptor mediated cell death . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Neither lymphotoxin alpha nor lymphotoxin beta receptor expression is required for biogenesis of lymphoid aggregates or differentiation of natural killer cells in the pregnant mouse uterus . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor alpha ( TNF alpha ) and lymphotoxin beta receptor ( LTbetaR ) signaling both play important roles in inflammatory and immune responses through activation of NF kappaB . ^^^ RelB / p50 dimers are differentially regulated by tumor necrosis factor alpha and lymphotoxin beta receptor activation : critical roles for p 100 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin sufficient B lymphocytes , lymphotoxin beta receptor , and TNF receptor 1 function . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a new member of the tumor necrosis factor superfamily , which binds to lymphotoxin beta receptor , herpes virus entry mediator , or TR 6 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a member of tumor necrosis factor ( TNF ) superfamily , and its receptors have been identified as lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HVEM ) / ATAR / TR2 , both of which lack the cytoplasmic sequence termed the `` death domain . ' ' The present study has demonstrated that LIGHT inhibits TNFalpha mediated apoptosis of human primary hepatocytes sensitized by actinomycin D ( ActD ) , but not Fas or TRAIL mediated apoptosis . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Activation of the lymphotoxin beta receptor ( LTbetaR ) , a member of the tumor necrosis factor receptor family , plays a crucial role in lymphoid organogenesis and tumor development . ^^^ Activation of the lymphotoxin beta receptor induces NFkappaB dependent interleukin 6 and MIP 2 secretion in mouse fibrosarcoma cells . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Mice with inactivation of lymphotoxin beta receptor ( LTbetaR ) system have profound defects in the development and maintenance of peripheral lymphoid organs . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Signaling through lymphotoxin beta receptor ( LTbetaR ) initiates the unfolding of a host of developmental programs ranging from the organogenesis of lymph nodes and Peyer ' s patches ( PPs ) to the coordination of splenic microarchitecture . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor ( LTbetaR ) and CD 40 are members of the tumor necrosis factor family of signaling receptors that regulate cell survival or death through activation of NF kappaB . ^^^ Structurally distinct recognition motifs in lymphotoxin beta receptor and CD 40 for tumor necrosis factor receptor associated factor ( TRAF ) mediated signaling . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The failure of Aire induction in the thymi of lymphotoxin deficient and lymphotoxin beta receptor deficient mice contributes to overt autoimmunity against self antigens normally protected by Aire . ^^^ Conversely , stimulation of lymphotoxin beta receptor by agonistic antibody leads to increased expression of Aire and tissue restricted antigens in both intact thymi and cultured thymic epithelial cell line . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor superfamily member LIGHT ( also known as TNFSF 14 ) is a ligand of stromal cell expressed lymphotoxin beta receptor and T cell expressed herpes viral entry mediator ( HVEM ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The embryonic development of Peyer ' s patches , postnatal lamina propria B cell development , and isolated lymphoid follicle development all depend on lymphotoxin beta receptor interactions . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Intestinal inflammation mediated by LIGHT , a ligand for lymphotoxin beta receptor ( LTbetaR ) , not only stimulates IgA overproduction in the gut but also results in defective IgA transportation into the gut lumen , causing a dramatic increase in serum polymeric IgA . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a tumor necrosis factor ( TNF ) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator ( HVEM ) and the lymphotoxin beta receptor ( LTbetaR ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Using lymphotoxin beta receptor IgG fusion protein as a model system , we have demonstrated a greater than 20 fold increase in specific productivity ( 0 . 49 11 . 5 pg cell ( 1 ) day ( 1 ) ) ( pcd ) without the use of methotrexate ( MTX ) mediated selection or amplification . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| We show that thymocytes and medullary epithelial cells ( MECs ) communicate via the lymphotoxin beta receptor ( LTbetaR ) signaling axis . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The tumor necrosis factor ( TNF ) superfamily member LIGHT , which binds herpes virus entry mediator ( HVEM ) and lymphotoxin beta receptor ( LTbetaR ) , plays important roles in regulating the immune response . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The aim of this work was to test whether lymphotoxin beta receptor signaling ( LTbetaR ) , which plays a central role in PPs ' organogenesis , mediates CCL 20 gene expression in intestinal epithelial cells . ^^^ METHODS : CCL 20 , lymphotoxin beta ( LTbeta ) and LTbetaR expression were monitored during embryonic development by in situ hybridization of mouse intestine . ^^^ Lymphotoxin beta receptor signaling induces the chemokine CCL 20 in intestinal epithelium . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| During murine embryogenesis , the formation of Peyer ' s patches ( PPs ) is initiated by CD 45 ( + ) CD 4 ( + ) CD 3 ( ) lymphoid tissue inducers that trigger adhesion molecule expression and specific chemokine production from an organizing stromal cell population through ligation of the lymphotoxin beta receptor . ^^^ This in turn encompasses CD 45 ( + ) CD 4 ( + ) CD 3 ( ) cells interspersed with ICAM 1 / VCAM 1 / mucosal addressin cell adhesion molecule 1 , lymphotoxin beta receptor positive , chemokine producing cells analogous to the organizing population previously observed in PPs . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The formation of the meshwork is induced by stimulation with tumor necrosis factor alpha or lymphotoxin alpha in combination with agonistic antibody to lymphotoxin beta receptor in a nuclear factor kappaB ( RelA ) dependent manner . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| We investigated the basis for the IKKalpha dependence of the induction of these genes in response to engagement of the lymphotoxin beta receptor ( LTbetaR ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The ability to augment TRAIL initiated cell death was not observed with soluble lymphotoxin beta receptor or soluble death receptor 3 , indicating that binding to LIGHT or TL1A alone is insufficient to trigger TRAIL sensitivity . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT binds to lymphotoxin beta receptor ( LTbetaR ) , and cooperates with LTbeta in lymphoid organogenesis and development of lymphoid structure . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Interestingly , villous M cells are developed in various PP [ or gut associated lymphoid tissue ( GALT ) ] null mice , such as in utero lymphotoxin beta receptor ( LTbetaR ) Ig treated , lymphotoxin alpha ( LTalpha ) ( / ) , tumor necrosis factor / LTalpha ( / ) , and inhibition of differentiation 2 ( Id 2 ) ( / ) mice . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Interactions between lymphotoxin ( LT ) alpha ( 1 ) beta ( 2 ) on inducer cells and the lymphotoxin beta receptor ( LTbetaR ) on stromal cells initiate development of lymph nodes and Peyer ' s patches . ^^^ Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Temporary dedifferentiation of follicular dendritic cells ( FDCs ) by treatment with an inhibitor of the lymphotoxin beta receptor signalling pathway ( LTbetaR Ig ) 3 days before or 14 days after inoculation via the skin , blocked the early accumulation of PrP ( Sc ) and TSE infectivity within the draining lymph node . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Similar to the formation of Peyer ' s patches ( PPs ) , lymphotoxin beta receptor ( LTbetaR ) dependent events are required for ILF formation ; however , the timing of these events and the cellular source of LT differ . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lack of AIRE was associated with normal or even increased levels of keratin and lymphotoxin beta receptor mRNAs , while mRNAs of the self antigens insulin , cytochrome P 450 1a2 , and fatty acid binding protein were undetectable in thymi from immunodeficiency patients . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The lymphotoxin beta receptor is critical for control of murine Citrobacter rodentium induced colitis . ^^^ Blocking of lymphotoxin alpha 1 beta 2 / lymphotoxin beta receptor interactions prevents experimental colitis in mice , and this suggests a potential treatment principle of human inflammatory bowel disease . ^^^ We studied the role of lymphotoxin alpha 1 beta 2 / lymphotoxin beta receptor signaling in Citrobacter rodentium induced colitis . ^^^ METHODS : Mice with disrupted lymphotoxin alpha 1 beta 2 / lymphotoxin beta receptor interactions secondary to gene defects ( lymphotoxin alpha / , lymphotoxin beta / , and lymphotoxin beta receptor / ) or treatment with the antagonist lymphotoxin beta receptor immunoglobulin G fusion protein were infected with Citrobacter rodentium . ^^^ RESULTS : Inhibition of lymphotoxin alpha 1 beta 2 / lymphotoxin beta receptor interactions was associated with increased severity of Citrobacter rodentium induced colitis , as indicated by increased disease related mortality , more severe weight loss , intestinal bacterial abscesses , and a higher burden of Citrobacter rodentium in the spleen and liver of / and lymphotoxin beta receptor immunoglobulin G treated mice . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Absence of lymph nodes in NOD mice treated with lymphotoxin beta receptor immunoglobulin protects from diabetes . ^^^ Pregnant nonobese diabetic ( NOD ) mice were treated with lymphotoxin beta receptor immunoglobulin fusion protein ( LTbetaR Ig ) or control human immunoglobulin on days embryonic day 11 ( E 11 ) and E 14 , and offspring were followed for the development of anti beta cell antibodies , islet pathology , and hyperglycemia . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a member of the TNF superfamily , and its receptors have been identified as lymphotoxin beta receptor ( LTbetaR ) , herpes virus entry mediator ( HVEM ) , and decoy receptor 3 ( DcR 3 ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT mediated intestinal disease is dependent on both of its identified signaling receptors , lymphotoxin beta receptor and herpes virus entry mediator , because LIGHT Tg mesenteric lymph node cells do not cause intestinal inflammation when transferred into the lymphotoxin beta receptor deficient mice , and herpes virus entry mediator on donor T cells is required for the full development of disease . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Contribution of the lymphotoxin beta receptor to liver regeneration . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| SUMMARY Disruption of the lymphotoxin beta receptor ( LTbetaR ) gene has been shown to result in enhanced resistance of female mice to blood stage Plasmodium chabaudi malaria . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LIGHT is a member of the tumor necrosis factor ( TNF ) superfamily , and its function is mediated by at least two receptors , including lymphotoxin beta receptor ( LTbetaR ) and herpes simplex virus entry mediator . ^^^ TRAF 2 plays a key , nonredundant role in LIGHT lymphotoxin beta receptor signaling . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Prenatal blockage of lymphotoxin beta receptor and TNF receptor p 55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Disrupted signaling through lymphotoxin beta receptor ( LTbetaR ) results in severe defects of the spleen and even loss of all other secondary lymphoid tissues , making mice susceptible to diverse infectious agents . ^^^ Testosterone responsiveness of spleen and liver in female lymphotoxin beta receptor deficient mice resistant to blood stage malaria . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Ly 49 and CD94 / NKG2 receptor acquisition by NK cells does not require lymphotoxin beta receptor expression . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| However , in this study , we show that human melanoma cells express LIGHT / TNFSF14 , a ligand of herpesvirus entry mediator on T cells and of lymphotoxin beta receptor on stromal cells . ^^^ In vivo , LIGHT was found in metastatic lesions , and the extent of lymphotoxin beta receptor expression on the stromal cells was significantly associated with a `` brisk ' ' T cell infiltrate in the neoplastic tissue . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Splenic trapping of pBRC was strongly reduced in the absence of MZM and marginal metallophilic macrophages ( MMM ) , as it is in noninfected mice with a disrupted lymphotoxin beta receptor ( LTbetaR ( / ) ) , and it was still significantly reduced when the number of MZM and MMM was diminished , as in tumor necrosis factor alpha deficient ( TNF alpha ( / ) ) mice . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Role of lymphotoxin in experimental models of infectious diseases : potential benefits and risks of a therapeutic inhibition of the lymphotoxin beta receptor pathway . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| One of the cDNAs thus identified encodes an NH ( 2 ) terminally truncated form of the lymphotoxin beta receptor ( LTBR ) . ^^^ Transforming activity of the lymphotoxin beta receptor revealed by expression screening . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The homeostasis of splenic DCs has mostly been attributed to their migration to the spleen via the chemokine microenvironment induced by lymphotoxin beta receptor ( LTbetaR ) signaling on splenic stromal cells . ^^^ Stimulating lymphotoxin beta receptor on the dendritic cells is critical for their homeostasis and expansion . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxin beta receptor signaling is required for the homeostatic control of HEV differentiation and function . ^^^ The cellularity of lymph nodes in adult mice was reduced by systemic blockade of lymphotoxin beta receptor ( LTbeta R ) signaling with a soluble decoy receptor both in resting and reactive settings . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that CCL 25 expression in murine small intestinal epithelial cells is independent of signaling through the lymphotoxin beta receptor and is not enhanced by inflammatory stimuli , pathways involved in driving the expression of most other chemokines . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| TNFSF14 / LIGHT is a member of the tumor necrosis factor superfamily that binds to lymphotoxin beta receptor ( LTbetaR ) to induce cell death via caspase dependent and caspase independent pathways . ^^^ Inhibition of lymphotoxin beta receptor mediated cell death by survivin DeltaEx 3 . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Molecular mutagenesis studies suggest that soluble LIGHT protein produced by cleavage from the cell membrane plays an important role in this effect through the interaction with the lymphotoxin beta receptor ( LTbetaR ) but not herpes virus entry mediator . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In the presence and absence of RANKL , LIGHT induced osteoclast formation from both human peripheral blood mononuclear cells and murine macrophage precursors , in a dose dependent manner , whereas no inhibition was observed by adding osteoprotegerin , RANK : Fc , TNFalpha , or interleukin 8 or by blocking the LIGHT receptors herpesvirus entry mediator or lymphotoxin beta receptor . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that follicular dendritic cells ( FDC ) are also critical to thymus independent GC formation , as their depletion by blockade of lymphotoxin beta receptor signals abrogated GC development unless the responding B cells bound antigen with high affinity . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| In particular , CMV infection of immune compromised mice has revealed the immunotherapeutic potential of the lymphotoxin beta receptor ( LTbetaR ) signaling pathway to restore immune function and provide protection from CMV mortality . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The mature phenotype of peripheral lymph node ( LN ) high endothelial venules ( HEVs ) , defined as MAdCAM 1 ( low ) PNAd ( high ) LTbetaR ( high ) HEC 6ST ( high ) , is dependent on signaling through the lymphotoxin beta receptor ( LTbetaR ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Parenteral nutrition impairs gut associated lymphoid tissue and mucosal immunity by reducing lymphotoxin Beta receptor expression . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Blockade of TNFSF 14 signaling caused a substantial reduction in the expression of lymphotoxin beta receptor ( LTbetaR ) controlled migration factors within the islets and disrupts organization of tertiary structures , leading to prevention of diabetes . ^^^ Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor dependent tertiary lymphoid structure . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Since these initial findings , it is increasingly appreciated that signaling through the lymphotoxin beta receptor ( LTbetaR ) plays a key role in numerous biological processes in the adult animal , including the maintenance of specialized stromal cell types and the homeostatic control of chemokine expression within the lymphoid tissues . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LTalpha also assembles with LTbeta into a membrane anchored , heterotrimeric LTalpha1beta2 complex that engages a distinct cognate receptor , the LTbeta receptor ( LTbetaR ) . ^^^ In contrast , these mutant LTalpha proteins retain the ability to co assemble with LTbeta into membrane anchored LTalpha1beta2 complexes that engage the LTbetaR and trigger the death of HT 29 cells . ^^^ Membrane anchored LTbeta expressed on the cell surface in absence of the LTalpha subunit binds the LTbetaR but is functionally inactive in the cell death assay . ^^^ These results indicate that the TNF receptor binding regions of the LTalpha subunit are not necessary for engagement of the LTbetaR , but the LTalpha subunit is required for the assembly of LTbeta into a functional heteromeric ligand . . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| METHODS : Soluble LTbeta receptor ( LTbetaR ) immunoglobulin fusion protein was used to inhibit the LTalpha / beta / light axis in two independent rodent models of colitis : CD45RBhi CD 4 ( + ) reconstituted SCID mice and bone marrow transplanted tg 26 mice ( BM > tg 26 ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| These results indicate that neutrophil migration across HPAECs in vitro to IL 8 and LTB ( 4 ) is predominantly CD 18 independent and provides a much needed in vitro system for examination of the neutrophil endothelial interactions involved in this alternative migratory route . . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The heterotrimeric lymphotoxin alpha ( 1 ) beta ( 2 ) ( LTalpha ( 1 ) beta ( 2 ) ) complex and LIGHT , a new member of the tumor necrosis factor ( TNF ) superfamily , have been identified as membrane anchored ligands for the LTbeta receptor ( LTbetaR ) , a member of the TNF receptor ( TNFR ) superfamily . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| This suggests the existance of an additional undiscovered ligand for the LTbeta receptor ( LTbetaR ) or a weak LTalpha ( 3 ) LTbetaR interaction in vivo involved in the formation of secondary lymphoid organs . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| They form either a soluble homotrimeric ligand ( LTalpha ( 3 ) ) that binds to and signals through CD120a / b ( TNFRp 55 and TNFRp 75 ) , or a membrane associated heterotrimeric ligand ( LTalpha ( 1 ) beta ( 2 ) ) that binds to and signals through the LTbeta receptor ( LTbetaR ) . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| LTbeta receptor ( LTbetaR ) deficient mice also lack PPs , and we demonstrate that LTbetaR signaling induces p 52 RelB and classical p 50 RelA heterodimers , while tumor necrosis factor ( TNF ) activates only RelA . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The production of DCs from BM culture was significantly reduced in TNF ( / ) and TNF receptor ( TNFR ) p 55 ( / ) mice , but normal in LTalpha ( / ) , LTbeta ( / ) , LTbetaR ( / ) mice . ^^^ Conversely , numbers of mature DCs in spleen were significantly decreased in LTalpha ( / ) , LTbeta ( / ) , LTbetaR ( / ) mice , but not in TNF ( / ) and TNFRp 55 ( / ) mice . ^^^ Second , the microenvironment in peripheral lymphoid organs associated with LTalpha / LTbeta LTbetaR signaling and chemokine production is critical for recruitment efficiency of DCs , and this pathway is indispensable . . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Therefore , the role of the adhesion molecules intercellular adhesion molecule 1 ( ICAM 1 ) , LECAM 1 , CD 18 , leukocyte function associated antigen 1 ( LFA 1 ) and platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) on the BjV induced neutrophil accumulation and the correlation with release of LTB 4 , TXA 2 , tumor necrosis factor alpha , interleukin ( IL ) 1 and IL 6 have been investigated . ^^^ |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| To further understand PMN transepithelial migration , we sought to determine whether migration to C5a , IL 8 and LTB ( 4 ) was similarly Mac 1 , or even CD 18 dependent . ^^^ Whereas essentially all migration to fMLP across T 84 monolayers was prevented by anti CD 18 antibody , significant migration to C5a , IL 8 or LTB ( 4 ) persisted despite anti CD 18 antibody , indicating PMN are capable of beta ( 2 ) integrin independent transepithelial migration . ^^^ Co stimulation of PMN with C5a and fMLP or IL 8 plus LTB ( 4 ) and fMLP still resulted in CD 18 independent migration . ^^^ |
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| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Here we show that signaling of lymphotoxin ( LT ) alphabeta through the LTbeta receptor ( LTbetaR ) is indispensable for regulating peripheral but not thymic Valpha14i NKT cell numbers . ^^^ |
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| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| The Tlx 1 , Bapx 1 , Tcf 21 , Wt 1 and Dh genes are essential for development of the spleen , while mutations of Nkx 2 3 , Lta , Ltb , Ltbr , Map3k14 , Relb , Tnf , Tnfrsf1a , Cxcl 13 , Blr 1 ( Cxcr 5 ) , or cpdm genes result in disruption of normal splenic microarchitecture . ^^^ Here we review abnormalities of lymphoid organ development in immunodeficient mutant mice , including spontaneous and targeted mutations of Id 2 , Rorc , Tnf , Tnfrsf1a , Lta , Ltb , Ltbr , Tnfrsf11a , Tnfsf 11 , Relb , Map3k14 , IL7r , Blr 1 , and Cxcl 13 genes . . ^^^ |
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| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| Overexpressed only in adenoma : APOLLON , RIPK 1 , LTB , LTBR , CASP 2 , 13 , cIAP 2 , CIDEB . ^^^ |
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| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P36941 |
Pubmed |
SVM Score :0.0 |
| NA |
|