Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.63844891
LIGHT binds to lymphotoxin beta receptor ( LTbetaR ) , and cooperates with LTbeta in lymphoid organogenesis and development of lymphoid structure . 0.63844891^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
A member of the tumor necrosis factor ( TNF ) superfamily , human TNFSF 14 ( hTNFSF 14 ) / HVEM L ( herpes virus entry mediator ligand ) was isolated as a cellular ligand for HVEM / TR2 and human lymphotoxin beta receptor ( LTbetaR ) . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT is a 29 kDa type 2 transmembrane protein produced by activated T cells that also engages the receptor for the LTalphabeta heterotrimer but does not form complexes with either LTalpha or LTbeta . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT , a novel ligand for lymphotoxin beta receptor and TR2 / HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer . ^^^ LIGHT protein triggers apoptosis of various tumor cells expressing both lymphotoxin beta receptor ( LTbetaR ) and TR2 / HVEM receptors , and its cytotoxicity can be blocked specifically by addition of a LTbetaR Fc or a TR2 / HVEM Fc fusion protein . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
It has been shown that LIGHT triggers apoptosis of various tumor cells including HT 29 cells that express both lymphotoxin beta receptor ( LTbetaR ) and HVEM / TR2 receptors . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Four members of the tumor necrosis factor ( TNF ) ligand family , TNF alpha , LT alpha , LT beta , and LIGHT , interact with four receptors of the TNF / nerve growth factor family , the p 55 TNF receptor ( CD120a ) , the p 75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT is a recently identified member of the TNF superfamily and its receptors , herpesvirus entry mediator and lymphotoxin beta receptor , are found in T cells and stromal cells . ^^^ Blockade of LIGHT by its soluble receptors , lymphotoxin beta receptor Ig or HVEM Ig , inhibits the induction of DC mediated primary allogeneic T cell response . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
The lymphotoxin beta receptor is necessary and sufficient for LIGHT mediated apoptosis of tumor cells . ^^^ LIGHT is a tumor necrosis factor ( TNF ) ligand superfamily member , which binds two known cellular receptors , lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HveA ) . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
The heterotrimeric lymphotoxin alpha ( 1 ) beta ( 2 ) ( LTalpha ( 1 ) beta ( 2 ) ) complex and LIGHT , a new member of the tumor necrosis factor ( TNF ) superfamily , have been identified as membrane anchored ligands for the LTbeta receptor ( LTbetaR ) , a member of the TNF receptor ( TNFR ) superfamily . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Human placentae and two of the cell types in placentae ( cytotrophoblasts and macrophages ) were examined by RT PCR for transcripts of the eight TNF superfamily ligands known to induce death of activated immune cells , tumour cells , and virus infected cells ( TNFalpha , LT alpha , LT beta , FasL , TRAIL , TWEAK , LIGHT , 4 1BBL ) . ^^^ Although term cytotrophoblasts contained mRNAs specific for TNF alpha , LT alpha , TWEAK , and 4 1BBL , messages encoding LT beta , FasL , TRAIL , and LIGHT were absent . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
More severely disorganized splenic structures developed after blockade of endogenous LIGHT in LTbeta / mice . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT is a member of tumor necrosis factor ( TNF ) superfamily , and its receptors have been identified as lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HVEM ) / ATAR / TR2 , both of which lack the cytoplasmic sequence termed the `` death domain . ' ' The present study has demonstrated that LIGHT inhibits TNFalpha mediated apoptosis of human primary hepatocytes sensitized by actinomycin D ( ActD ) , but not Fas or TRAIL mediated apoptosis . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT ( homologous to lymphotoxins , shows inducible expression , and competes with herpes simplex virus glycoprotein D for herpesvirus entry mediator , a receptor expressed by T lymphocytes ) is a member of the tumor necrosis factor superfamily that can interact with lymphotoxin beta receptor ( LTbetaR ) , herpes virus entry mediator , and decoy receptor ( DcR 3 ) . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LT beta R complex revealed a novel mechanism of LIGHT . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT is a new member of the tumor necrosis factor superfamily , which binds to lymphotoxin beta receptor , herpes virus entry mediator , or TR 6 . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
In addition , the essential roles of the core members of the TNF superfamily , LTalpha , LTbeta , TNF , and LIGHT as well as their receptors during the organogenesis of secondary lymphoid organs and the maintenance of the architecture of lymphatic tissues now becomes appreciated . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT is a tumor necrosis factor ( TNF ) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator ( HVEM ) and the lymphotoxin beta receptor ( LTbetaR ) . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT is a member of the tumor necrosis factor ( TNF ) superfamily , which binds two known receptors , lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HVEM ) / TR2 . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Previous studies have shown that blockade of LIGHT , a T cell costimulatory molecule belonging to the TNF superfamily , by soluble lymphotoxin beta receptor Ig ( LTbetaR Ig ) inhibits the cytotoxic T lymphocyte ( CTL ) response to host antigenic disparities and ameliorates lethal graft versus host disease ( GVHD ) in a B 6 to BDF 1 mouse model . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Interestingly , a lower percentage of LIGHT ( / ) LTbeta ( / ) animals contain mesenteric lymph nodes as compared with LTbeta ( / ) mice , whereas the splenic microarchitecture of LIGHT ( / ) LTbeta ( / ) and LTbeta ( / ) mice shows a comparable state of disruption . ^^^ This for the first time provides in vivo evidence for a cooperative role for LIGHT and LTbeta in lymphoid organogenesis and indicates important costimulatory functions for LIGHT in T cell activation . . ^^^ Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
The tumor necrosis factor superfamily member LIGHT ( also known as TNFSF 14 ) is a ligand of stromal cell expressed lymphotoxin beta receptor and T cell expressed herpes viral entry mediator ( HVEM ) . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Intestinal inflammation mediated by LIGHT , a ligand for lymphotoxin beta receptor ( LTbetaR ) , not only stimulates IgA overproduction in the gut but also results in defective IgA transportation into the gut lumen , causing a dramatic increase in serum polymeric IgA . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
OBJECTIVE : The tumor necrosis factor ( TNF ) superfamily member LIGHT , which binds herpes virus entry mediator ( HVEM ) and lymphotoxin beta receptor ( LTbetaR ) , plays important roles in regulating the immune response . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
The ability to augment TRAIL initiated cell death was not observed with soluble lymphotoxin beta receptor or soluble death receptor 3 , indicating that binding to LIGHT or TL1A alone is insufficient to trigger TRAIL sensitivity . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Lymphotoxins ( LT alpha and LT beta ) , LIGHT [ homologous to LT , inducible expression , competes with herpes simplex virus ( HSV ) glycoprotein D for HSV entry mediator ( HVEM ) , a receptor expressed on T lymphocytes ] , tumor necrosis factor ( TNF ) , and their specific receptors LT beta R , HVEM , and TNF receptor 1 ( TNFR 1 ) and TNFR 2 , form the immediate family of the larger TNF superfamily . ^^^ Regulation of autoimmune regulator in the thymus via LT beta R implicates LT / LIGHT involvement in central tolerance . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
TRAF 2 plays a key , nonredundant role in LIGHT lymphotoxin beta receptor signaling . ^^^ LIGHT is a member of the tumor necrosis factor ( TNF ) superfamily , and its function is mediated by at least two receptors , including lymphotoxin beta receptor ( LTbetaR ) and herpes simplex virus entry mediator . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Inhibition of LIGHT ( a cellular ligand for herpes virus entry mediator and lymphotoxin receptor ) / herpes simplex virus entry mediator ( HVEM ) and LIGHT / lymphotoxin beta receptor ( LT beta R ) interactions decreases mortality in MHC class 1 and 2 disparate graft vs host disease ( GVHD ) . ^^^ An inhibitor protein of LIGHT and LT alpha beta 2 ( LT beta R Ig ) and an inhibitor protein of LIGHT ( HVEM Ig ) caused similar decreases in alloresponses of control B 6 or B6 . 129S1 IL12rb2 ( tm1Jm ) ( B6 . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
However , in this study , we show that human melanoma cells express LIGHT / TNFSF14 , a ligand of herpesvirus entry mediator on T cells and of lymphotoxin beta receptor on stromal cells . ^^^ In vivo , LIGHT was found in metastatic lesions , and the extent of lymphotoxin beta receptor expression on the stromal cells was significantly associated with a `` brisk ' ' T cell infiltrate in the neoplastic tissue . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT is a member of the TNF superfamily , and its receptors have been identified as lymphotoxin beta receptor ( LTbetaR ) , herpes virus entry mediator ( HVEM ) , and decoy receptor 3 ( DcR 3 ) . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
LIGHT mediated intestinal disease is dependent on both of its identified signaling receptors , lymphotoxin beta receptor and herpes virus entry mediator , because LIGHT Tg mesenteric lymph node cells do not cause intestinal inflammation when transferred into the lymphotoxin beta receptor deficient mice , and herpes virus entry mediator on donor T cells is required for the full development of disease . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Methods We screened for mutations in the coding and promoter regions of genes in the TNF LTA region , including BAT 1 , NFKBIL 1 , LTA , TNF , LTB , AIF , and BAT 2 , and conducted a transmission disequilibrium test of 41 polymorphisms in 137 families identified through pro bands with childhood onset atopic asthma . ( BAT 1 , HLA B associated transcript 1 ; NFKBIL 1 , nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 ; AIF , allograft inflammatory factor 1 ) . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Molecular mutagenesis studies suggest that soluble LIGHT protein produced by cleavage from the cell membrane plays an important role in this effect through the interaction with the lymphotoxin beta receptor ( LTbetaR ) but not herpes virus entry mediator . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
RESULTS : In the presence and absence of RANKL , LIGHT induced osteoclast formation from both human peripheral blood mononuclear cells and murine macrophage precursors , in a dose dependent manner , whereas no inhibition was observed by adding osteoprotegerin , RANK : Fc , TNFalpha , or interleukin 8 or by blocking the LIGHT receptors herpesvirus entry mediator or lymphotoxin beta receptor . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
Blockade of TNFSF 14 signaling caused a substantial reduction in the expression of lymphotoxin beta receptor ( LTbetaR ) controlled migration factors within the islets and disrupts organization of tertiary structures , leading to prevention of diabetes . ^^^
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
NA
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
NA
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
NA
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
NA
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
NA
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
NA
Interacting proteins: O43557 and Q06643	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.63844891
LIGHT binds to lymphotoxin beta receptor ( LTbetaR ) , and cooperates with LTbeta in lymphoid organogenesis and development of lymphoid structure . 0.63844891^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Four members of the tumor necrosis factor ( TNF ) ligand family , TNF alpha , LT alpha , LT beta , and LIGHT , interact with four receptors of the TNF / nerve growth factor family , the p 55 TNF receptor ( CD120a ) , the p 75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Human placentae and two of the cell types in placentae ( cytotrophoblasts and macrophages ) were examined by RT PCR for transcripts of the eight TNF superfamily ligands known to induce death of activated immune cells , tumour cells , and virus infected cells ( TNFalpha , LT alpha , LT beta , FasL , TRAIL , TWEAK , LIGHT , 4 1BBL ) . ^^^ Although term cytotrophoblasts contained mRNAs specific for TNF alpha , LT alpha , TWEAK , and 4 1BBL , messages encoding LT beta , FasL , TRAIL , and LIGHT were absent . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LT beta R complex revealed a novel mechanism of LIGHT . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Lymphotoxins ( LT alpha and LT beta ) , LIGHT [ homologous to LT , inducible expression , competes with herpes simplex virus ( HSV ) glycoprotein D for HSV entry mediator ( HVEM ) , a receptor expressed on T lymphocytes ] , tumor necrosis factor ( TNF ) , and their specific receptors LT beta R , HVEM , and TNF receptor 1 ( TNFR 1 ) and TNFR 2 , form the immediate family of the larger TNF superfamily . ^^^ Regulation of autoimmune regulator in the thymus via LT beta R implicates LT / LIGHT involvement in central tolerance . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Inhibition of LIGHT ( a cellular ligand for herpes virus entry mediator and lymphotoxin receptor ) / herpes simplex virus entry mediator ( HVEM ) and LIGHT / lymphotoxin beta receptor ( LT beta R ) interactions decreases mortality in MHC class 1 and 2 disparate graft vs host disease ( GVHD ) . ^^^ An inhibitor protein of LIGHT and LT alpha beta 2 ( LT beta R Ig ) and an inhibitor protein of LIGHT ( HVEM Ig ) caused similar decreases in alloresponses of control B 6 or B6 . 129S1 IL12rb2 ( tm1Jm ) ( B6 . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT is a recently identified member of the TNF superfamily and its receptors , herpesvirus entry mediator and lymphotoxin beta receptor , are found in T cells and stromal cells . ^^^ Blockade of LIGHT by its soluble receptors , lymphotoxin beta receptor Ig or HVEM Ig , inhibits the induction of DC mediated primary allogeneic T cell response . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
The lymphotoxin beta receptor is necessary and sufficient for LIGHT mediated apoptosis of tumor cells . ^^^ LIGHT is a tumor necrosis factor ( TNF ) ligand superfamily member , which binds two known cellular receptors , lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HveA ) . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
A member of the tumor necrosis factor ( TNF ) superfamily , human TNFSF 14 ( hTNFSF 14 ) / HVEM L ( herpes virus entry mediator ligand ) was isolated as a cellular ligand for HVEM / TR2 and human lymphotoxin beta receptor ( LTbetaR ) . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT is a member of the tumor necrosis factor ( TNF ) superfamily , which binds two known receptors , lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HVEM ) / TR2 . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Previous studies have shown that blockade of LIGHT , a T cell costimulatory molecule belonging to the TNF superfamily , by soluble lymphotoxin beta receptor Ig ( LTbetaR Ig ) inhibits the cytotoxic T lymphocyte ( CTL ) response to host antigenic disparities and ameliorates lethal graft versus host disease ( GVHD ) in a B 6 to BDF 1 mouse model . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT is a member of tumor necrosis factor ( TNF ) superfamily , and its receptors have been identified as lymphotoxin beta receptor ( LTbetaR ) and the herpesvirus entry mediator ( HVEM ) / ATAR / TR2 , both of which lack the cytoplasmic sequence termed the `` death domain . ' ' The present study has demonstrated that LIGHT inhibits TNFalpha mediated apoptosis of human primary hepatocytes sensitized by actinomycin D ( ActD ) , but not Fas or TRAIL mediated apoptosis . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT , a novel ligand for lymphotoxin beta receptor and TR2 / HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer . ^^^ LIGHT protein triggers apoptosis of various tumor cells expressing both lymphotoxin beta receptor ( LTbetaR ) and TR2 / HVEM receptors , and its cytotoxicity can be blocked specifically by addition of a LTbetaR Fc or a TR2 / HVEM Fc fusion protein . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
It has been shown that LIGHT triggers apoptosis of various tumor cells including HT 29 cells that express both lymphotoxin beta receptor ( LTbetaR ) and HVEM / TR2 receptors . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT ( homologous to lymphotoxins , shows inducible expression , and competes with herpes simplex virus glycoprotein D for herpesvirus entry mediator , a receptor expressed by T lymphocytes ) is a member of the tumor necrosis factor superfamily that can interact with lymphotoxin beta receptor ( LTbetaR ) , herpes virus entry mediator , and decoy receptor ( DcR 3 ) . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT is a new member of the tumor necrosis factor superfamily , which binds to lymphotoxin beta receptor , herpes virus entry mediator , or TR 6 . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT is a tumor necrosis factor ( TNF ) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator ( HVEM ) and the lymphotoxin beta receptor ( LTbetaR ) . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
The tumor necrosis factor superfamily member LIGHT ( also known as TNFSF 14 ) is a ligand of stromal cell expressed lymphotoxin beta receptor and T cell expressed herpes viral entry mediator ( HVEM ) . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Intestinal inflammation mediated by LIGHT , a ligand for lymphotoxin beta receptor ( LTbetaR ) , not only stimulates IgA overproduction in the gut but also results in defective IgA transportation into the gut lumen , causing a dramatic increase in serum polymeric IgA . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
OBJECTIVE : The tumor necrosis factor ( TNF ) superfamily member LIGHT , which binds herpes virus entry mediator ( HVEM ) and lymphotoxin beta receptor ( LTbetaR ) , plays important roles in regulating the immune response . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
The ability to augment TRAIL initiated cell death was not observed with soluble lymphotoxin beta receptor or soluble death receptor 3 , indicating that binding to LIGHT or TL1A alone is insufficient to trigger TRAIL sensitivity . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
TRAF 2 plays a key , nonredundant role in LIGHT lymphotoxin beta receptor signaling . ^^^ LIGHT is a member of the tumor necrosis factor ( TNF ) superfamily , and its function is mediated by at least two receptors , including lymphotoxin beta receptor ( LTbetaR ) and herpes simplex virus entry mediator . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
However , in this study , we show that human melanoma cells express LIGHT / TNFSF14 , a ligand of herpesvirus entry mediator on T cells and of lymphotoxin beta receptor on stromal cells . ^^^ In vivo , LIGHT was found in metastatic lesions , and the extent of lymphotoxin beta receptor expression on the stromal cells was significantly associated with a `` brisk ' ' T cell infiltrate in the neoplastic tissue . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT is a member of the TNF superfamily , and its receptors have been identified as lymphotoxin beta receptor ( LTbetaR ) , herpes virus entry mediator ( HVEM ) , and decoy receptor 3 ( DcR 3 ) . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT mediated intestinal disease is dependent on both of its identified signaling receptors , lymphotoxin beta receptor and herpes virus entry mediator , because LIGHT Tg mesenteric lymph node cells do not cause intestinal inflammation when transferred into the lymphotoxin beta receptor deficient mice , and herpes virus entry mediator on donor T cells is required for the full development of disease . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Molecular mutagenesis studies suggest that soluble LIGHT protein produced by cleavage from the cell membrane plays an important role in this effect through the interaction with the lymphotoxin beta receptor ( LTbetaR ) but not herpes virus entry mediator . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
RESULTS : In the presence and absence of RANKL , LIGHT induced osteoclast formation from both human peripheral blood mononuclear cells and murine macrophage precursors , in a dose dependent manner , whereas no inhibition was observed by adding osteoprotegerin , RANK : Fc , TNFalpha , or interleukin 8 or by blocking the LIGHT receptors herpesvirus entry mediator or lymphotoxin beta receptor . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Blockade of TNFSF 14 signaling caused a substantial reduction in the expression of lymphotoxin beta receptor ( LTbetaR ) controlled migration factors within the islets and disrupts organization of tertiary structures , leading to prevention of diabetes . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
LIGHT is a 29 kDa type 2 transmembrane protein produced by activated T cells that also engages the receptor for the LTalphabeta heterotrimer but does not form complexes with either LTalpha or LTbeta . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
The heterotrimeric lymphotoxin alpha ( 1 ) beta ( 2 ) ( LTalpha ( 1 ) beta ( 2 ) ) complex and LIGHT , a new member of the tumor necrosis factor ( TNF ) superfamily , have been identified as membrane anchored ligands for the LTbeta receptor ( LTbetaR ) , a member of the TNF receptor ( TNFR ) superfamily . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
More severely disorganized splenic structures developed after blockade of endogenous LIGHT in LTbeta / mice . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
In addition , the essential roles of the core members of the TNF superfamily , LTalpha , LTbeta , TNF , and LIGHT as well as their receptors during the organogenesis of secondary lymphoid organs and the maintenance of the architecture of lymphatic tissues now becomes appreciated . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
Methods We screened for mutations in the coding and promoter regions of genes in the TNF LTA region , including BAT 1 , NFKBIL 1 , LTA , TNF , LTB , AIF , and BAT 2 , and conducted a transmission disequilibrium test of 41 polymorphisms in 137 families identified through pro bands with childhood onset atopic asthma . ( BAT 1 , HLA B associated transcript 1 ; NFKBIL 1 , nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 ; AIF , allograft inflammatory factor 1 ) . ^^^
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q06643 and O43557	Pubmed	SVM Score :0.0
NA