| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.90253002 |
| Among the BMP ligands , BMP 7 which use ActRII as their type 2 receptor , strongly bind to ALK 2 as their type 1 receptor . 0.90253002^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| In particular , the brain is expressing high levels of bone morphogenetic protein receptor type 2 ( BMPR 2 ) , activin receptor type 1 ( ActR 1 ) , and activin receptor type IIA ( ActR 2 ) . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Activin increased ActRI ( 4 fold , at 2 h ) , ActRIIB ( 2 fold , at 24 h ) , and follistatin ( 2 fold , at 24 h ) mRNAs and FSH release ( 2 fold , at 24 h ) , but did not alter ActRIIA mRNA levels . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Expression of ActRI , ActRIIA , ActRIIB , and FS mRNA was measured on the afternoon of proestrus ( 1800 h ) and the morning of estrus ( 0800 h ) . ^^^ As gonadotropins could act via estradiol ( E 2 ) , HYPOX rats were given E 2 ; ActRI was decreased , but ActRIIA mRNA was increased . ^^^ Both a direct action on ActRIIA ( inhibition ) and an indirect action through E 2 on ActRI ( inhibition ) and FS ( stimulation ) suggest potential physiologic mechanisms for the reciprocal regulation of ActR subtype and FS mRNAs . . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| The ActRI subunits and ActRIIA exhibited widespread albeit variable expression across tissues , with the highest levels in the serous tumors . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) demonstrated the presence of various BMPs ( BMP 2 , 3 , 4 , 6 , 7 , and 8A and 8B ) , BMP type 1 and 2 receptors ( ALK 2 , ALK 3 , ALK 4 , BMPR 2 , and ActR IIA and IIB ) , BMP antagonists ( DAN , gremlin , chordin , cerberus , noggin , and tsg ) , and Smads 1 8 . mRNA expression of these genes did not change during differentiation , except for BMP 3 , BMP 8a , and noggin . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Using Northern blots , we have shown that the levels of ALK 2 , ALK 4 and ActRIIB mRNA were significantly higher before the preovulatory surge and during the secondary surge of FSH as compared with both during the preovulatory surge and the luteal phase , whereas the level of the ActRIIA mRNA was similar throughout the oestrous cycle . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| In this study we examine the spatio temporal expression patterns of activin receptors ( ActRIIA , ActRIIB , ALK 1 , and ALK 2 ) , BMP receptors ( BMPRII , ALK 3 , and ALK 6 ) , and the distribution of the phosphorylated forms of Smad 1 and Smad 2 during normal lens development ( E 12 P21 ) and aberrant development in transgenic mice that express dominant negative TGFbeta receptors . ^^^ RESULTS : RT PCR of RNA from postnatal lenses showed distinct expression of ActRIIA , ActRIIB , BMPRII , and ALK 3 but not ALK 1 , ALK 2 , or ALK 6 . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| There were no significant changes in expression of ActRI mRNA throughout the cycle although values were correlated with mRNA levels for both ActRIIA ( r = 0 . 77 ; P < 0 . 001 ) and beta glycan ( r = 0 . 45 ; P < 0 . 01 ) . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Granulosa ActRI mRNA peaked ( P < 0 . 05 ) in 8 9 . 9 mm follicles , whereas ActRIIA rose significantly from 6 7 . 9 mm to 8 9 . 9 mm , before falling to F3 / 2 ; levels then rose sharply ( 3 fold ) to F 1 levels . ^^^ Considering all follicles analysed , granulosa mRNA expression of betaglycan , ActRI , ActRIIA and ActRIIB were all significantly lower than in corresponding thecal tissue ( betaglycan , 11 . 4 fold ; ActRIIB , 5 . 1 fold ; ActRI , 3 . 8 fold ; ActRIIA , 2 . 8 fold ) . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| The global gene expression analysis also indicated that the transforming growth factor beta ( TGF beta ) / activin branch components inhibin BC , ACVR2A , ACVR 1 ( ALK 2 ) , TGFBR 1 ( ALK 5 ) , and SMAD 2 were found to be highly expressed in undifferentiated states of these five hESC lines and decreased upon differentiation . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Activins exert their effects by inducing heteromeric complexes of either of two different type 1 receptors , ActR 1 or ActR IB , and either of two type 2 receptors , ActR 2 or ActR IIB . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Osteogenic protein 1 ( OP 1 , also known as bone morphogenetic protein 7 or BMP 7 ) , a member of the TGF beta superfamily which belongs to the BMP subfamily , was found to bind activin receptor type 1 ( ActR 1 ) , and BMP receptors type IA ( BMPR IA ) and type IB ( BMPR IB ) in the presence of activin receptors type 2 ( ActR 2 ) and type IIB ( ActR IIB ) . ^^^ A transcriptional activation signal was transduced after binding of OP 1 to the complex of ActR 1 and ActR 2 , or that of BMPR IB and ActR 2 . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| We isolated rat homologs of previously identified clones for type 1 ( ALK 2 and ALK 5 ) and type 2 ( ActRII , TGF beta RII ) activin and TGF beta receptors , together with a novel clone , whose full length version was isolated from a GH 3 cell cDNA library . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| A family of activin receptors ( ActRI , ActRII , and ActRIIB ) has been identified , which is expressed in the pituitary as well as numerous other tissues in which activin is thought to act . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| In addition to these receptors , osteogenic protein 1 ( OP 1 , also known as BMP 7 ) binds to activin type 1 receptor ( ActR 1 ) as well as activin type 2 receptors ( ActR 2 and ActR IIB ) . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| The effect of activin is most likely mediated through specific receptors as mRNAs encoding several forms of activin receptors , namely ActR 1 , ActR IB , ActR 2 and ActR IIB are found in the preovulatory follicles as well as in cultured granulosa luteal cells . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| The recently cloned bone morphogenetic factor receptor type 2 ( BMPR 2 ) was compared with the ActR 2 and several type 1 receptors including ActR 1 , ActR IB , BMPR IA , BMPR IB and TbetaR 1 . ^^^ At E 15 , the expression of ActR 2 mRNA was stronger than that of BMPR 2 in the spinal cord , followed in intensity by the expression of ActR 1 , ActR IB , BMPR IA , BMPR IB and TbetaR 1 mRNA . ^^^ In the adult brain , mRNA for BMPR 2 was expressed in different patterns together with ActR 2 and ActR 1 . ^^^ ActR 2 , ActR 1 , ActR IB and , weakly , TbetaR 1 were all expressed in the dentate gyrus . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning has yielded genes encoding two type 2 receptors ( ActRII and ActRIIB ) and at least two type 1 receptors ( ALK 2 and ALK 4 ) . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| We have studied immunolocalization of activin receptors in the central nervous system using polyclonal antibodies ( IgG ) to type 1 ( 50 55 kDa , ActRI ) , type 2 ( 70 75 kDa , ActRII ) or a subtype of type 2 known as type IIB ( ActRIIB ) receptors of activin . ^^^ A total of 7 antisera to rat activin receptors was generated , i . e . 3 kinds of antisera to the extracellular domain ( ActRI ( 81 89 ) , ActRII ( 91 100 ) , or ActRIIB ( 90 99 ) ) and 4 antisera to the kinase domain ( ActRI ( 323 333 ) , ActRII ( 307 319 ) , ActRII ( 407 420 ) or ActRIIB ( 306 319 ) ) . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| We detected mRNAs for three activin receptors , type 1 ( ActRI ) , type 2 ( ActRII ) , and type IIB ( ActRIIB ) , in multiple skeletal tissues in rat , including tibia and costochondral growth plate , and also in cultured osteoblasts . ^^^ Relatively high levels of ActRI and ActRII expression were detected in the callus at 7 , 10 , and 14 days after fracture , times that correlate with the interval of rapid intramembranous bone formation and the initiation of endochondral bone formation . ^^^ Expression of the ActRIIB in the fracture callus was strikingly lower than either ActRI or ActRII . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| OP 1 / BMP 7 binds to BMPR 2 and ActR 2 and forms complexes with BMPR IA and IB and ActR 1 . ^^^ We studied the expression of BMPR IA , IB , and 2 , ActR 1 , ActR 2 , and OP 1 / BMP 7 by immunohistochemistry in ossified ligament tissues of patients with OPLL and control ligament tissues from patients with cervical disc herniation . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Testicular germ cell tumours of adolescents and adults ( TGCTs ) and spermatocytic seminomas expressed activin type 1 and type 2 receptors ( ActRI and ActRII respectively ) . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| In this study , we characterized the levels of expression of 3 activin / inhibin subunits ( betaA , betaB , alpha ) , and 2 type 1 and type 2 activin receptors ( actRI / Ib , actRII / IIb ) in pancreatic cancer cell lines and in human pancreatic tissues . ^^^ Furthermore , actRI , actRII and actRIIb were expressed in all cell lines and actRIb mRNA was evident in ASPC 1 , CAPAN 1 , COLO 357 and PANC 1 cells . ^^^ Pancreatic cancer tissues also markedly over expressed actRI , actRIb and actRII . ^^^ By in situ hybridization , activin / inhibin betaA , actRI , actRIb and actRII were strongly expressed in diffuse infiltrative and duct like cancer cells . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Primers specific for two type 1 and two type 2 activin receptors ( ActR 1 , ActR IB , ActR 2 , and ActR IIB ) were used in polymerase chain reaction ( PCR ) to amplify cDNAs prepared from granulosa luteal cells , placental tissues and isolated trophoblast cells . ^^^ PCR products with the expected sizes for ActR 1 , ActR IB , ActR 2 , and ActR IIB mRNAs were detected in freshly dissociated and 5 day cultured granulosa luteal cells ; and in trophoblast cells from both first trimester and term placentas . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Whereas the exact mechanism of competition is unclear , the role of ActR 2 in the competition between activin A and OP 1 is discussed in light of the observed interference in downstream signaling by CA ActR 1 and CA ActR IB . . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Activin A bound to ActR IB / ALK 4 and ActR 2 , and BMP 7 bound to ActR I / ALK 2 , BMP type 1 receptor ( BMPR 1 ) / ALK 3 , ActR 2 and BMPR 2 . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Both type 1 and type 2 activin receptor ( ActR 1 , ActR IB and ActR 2 ) mRNA expression was also detectable in the pheochromocytoma tissues . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| When coexpressed with type 1 activin receptor ActR 1 or ActR IB in concert with type 2 receptor ActR 2 , Smad 7 efficiently reduced an early transcriptional response mediated by ActR 1 but had only a minimal effect on the response mediated by ActR IB . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| The mRNAs of four activin receptors ( ActRI , ActRIB , ActRII , and ActRIIB ) were also detected in the peritoneal macrophages , and the mRNA levels , except for ActRIB , were decreased during the LPS treatment . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Analysis in native tissues from 12 normal thyroids , 16 goiters , and 5 Graves thyroids demonstrated mRNA expression of the activin subunit betaA , TGFbeta receptor type 1 and 2 , activin receptors type 1 receptors alk 2 and alk 4 , and activin type 2 receptors actRII and actRIIb . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| RT PCR revealed that cultured chondrocytes expressed mRNAs of inhibin / activin betaA and four activin receptors ( two type 1 ( ActRI and ActRIB ) and two type 2 ( ActRII and ActRIIB ) ) . ^^^ Immunohistochemical analyses showed that activin betaA , ActRI and ActRII were localized in proliferating chondrocytes and osteoblasts in tibiae of neonatal rats , and in implants of demineralized bone matrix , a well established model of ectopic bone formation . ^^^ The strong expression of ActRI was also detected in hypertrophic chondrocytes both in the tibial growth plate and in the implants , whereas immunoreactive ActRII was lower in hypertrophic chondrocytes . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| In this study , we found the expression of activin type 1 receptors ( ActR 1 and ActR IB ) and type 2 receptor ( ActR 2 ) on human fetal lung fibroblasts ( HFL 1 ) by RT PCR and immunocytochemistry . ^^^ This study demonstrated that ActR 1 , ActR 1B and ActR 2 are expressed on human fetal lung fibroblast and that activin A regulates fibroblast mediated collagen gel contraction , suggesting that activin A might contribute to human lung fibroblast activities and structural remodeling observed in pulmonary fibrosis . . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction of PASMC mRNA detected transcripts for type 1 ( TGF betaRI , Alk 1 , ActRI , and BMPRIB ) and type 2 ( TGF betaRII , BMPR 2 , ActRII , ActRIIB ) receptors . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to characterise , in colon cancer cell lines and in normal and malignant human colon tissues , levels of expression of inhibin subunits that are involved in activin / inhibin dimer formation , and of the type 1 and 2 activin receptors ( actRI and actRII ) . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| We have also explored if there are associated changes in activin receptor Alk 2 , ActRII and ActRIIB in these tissues . ^^^ Receptor Alk 2 protein levels were significantly elevated in T PE placentae ( P=0 . 0006 , Mann Whitney U test ) , ActRIIB levels were significantly lower in PT PE placentae ( P=0 . 01 ) and ActRII levels were significantly lower in PT PE choriodecidua ( P=0 . 0002 ) compared with controls . ^^^ There were no apparent differences in the distribution of the beta ( A ) subunit and receptors Alk 2 , ActRII and ActRIIB between control and preeclamptic tissues . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| The presence of inhibin subunits ( alpha , betaA and betaB ) , activin binding protein follistatin and activin receptors ( ActR 1 , ActR IB , ActR 2 and ActR IIB ) mRNA transcripts in bovine oocytes and preimplantation embryos was examined by reverse transcription polymerase chain reaction . ^^^ Furthermore , bovine oocytes and embryos express the activin receptors mainly by the combination of ActR 1 and either ActR 2 or ActR IIB . . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Activin A and receptors ( ActR 1 , ActR IB , ActR 2 ) are transcribed in corneal fibroblasts . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| No expression was detected within PTEC ; however , these cells were found to express mRNA for BMP receptors including , ActR 1 , BMPR IA , ActR 2 , ActR IIB , and BMPR 2 . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of activin A and its receptors ActRI and ActRII in intestinal epithelial IEC 6 cells and in tissues from IBD patients and non inflamed controls was evaluated using RT PCR and immunohistochemistry . ^^^ RESULTS : Expression of the activin betaA subunit and the activin receptors ActRI and ActRII in IEC 6 cells was demonstrated using RT PCR . ^^^ Expression of ActRI and ActRII was observed in all intestinal tissues from patients with IBD and in all controls . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| All three cell types expressed a range of BMP responsive type 1 ( BMPRIB , ActRI ) and type 2 ( BMPRII , ActRII , ActRIIB ) receptors supporting autocrine / paracrine roles within the follicle . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| DRAGON associates directly with BMP type 1 ( ALK 2 , ALK 3 , and ALK 6 ) and type 2 ( ActRII and ActRIIB ) receptors , and its signaling is reduced by dominant negative Smad 1 and ALK 3 or 6 receptors . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| In order to highlight the molecular promiscuity of these growth factors , emphasis has been placed on molecular features associated with the recognition by activin A and the bone morphogenic proteins of the corresponding extracellular domains of the ActRI and ActRII receptors . ^^^ |
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| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| BMP type 1 receptors , including activin receptor like kinase 2 ( ALK 2 ) ( also referred to as ActRIA ) and ALK 3 ( BMPRIA ) , both type 2 receptors , ActRII and BMPRII , as well as the ligands BMP 2 , 4 , and 7 and inhibin / activin subunits were expressed in PC 12 cells . ^^^ |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27037 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|