| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :1.2027698 |
| Overexpression of Smad 6 , an inhibitor of ALK 2 signaling , inhibits epithelial cell activation , whereas BMP 7 , a known ligand for ALK 2 , has no effect . 1.2027698^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.51065247 |
| Among the BMP ligands , BMP 7 which use ActRII as their type 2 receptor , strongly bind to ALK 2 as their type 1 receptor . 0.51065247^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.58546968 |
| In addition to these receptors , osteogenic protein 1 ( OP 1 , also known as BMP 7 ) binds to activin type 1 receptor ( ActR 1 ) as well as activin type 2 receptors ( ActR 2 and ActR IIB ) . 0.58546968^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| ALK 5 is a TGF beta type 1 receptor , ALK 2 and ALK 4 are activin type 1 receptors , and ALK 3 and ALK 6 are type 1 receptors for osteogenic protein 1 ( OP 1 ) / bone morphogenetic protein 7 ( BMP 7 ) and BMP 4 . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Osteogenic protein 1 ( OP 1 , also known as bone morphogenetic protein 7 or BMP 7 ) , a member of the TGF beta superfamily which belongs to the BMP subfamily , was found to bind activin receptor type 1 ( ActR 1 ) , and BMP receptors type IA ( BMPR IA ) and type IB ( BMPR IB ) in the presence of activin receptors type 2 ( ActR 2 ) and type IIB ( ActR IIB ) . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| We assessed the distribution and relative immunohistochemical staining intensity of the bone morphogenetic protein 7 , osteogenic protein 1 ( OP 1 ) , in its pro and mature forms , and four of its receptors , type 1 ( ALK 2 , ALK 3 , and ALK 6 ) and type 2 in normal adolescent New Zealand White rabbit articular cartilage . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| BMPR 2 is a transmembrane serine / threonine kinase that binds BMP 2 and BMP 7 in association with multiple type 1 receptors , including BMPR IA / Brk1 , BMPR IB , and ActR 1 , which is also an activin type 1 receptor . ^^^ BMP 2 and BMP 7 can induce a transcriptional response when added to cells coexpressing ActR 1 and BMPR 2 but not to cells expressing either receptor alone . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| To explore the molecular cascade of odontoblast differentiation , Northern blot analyses and reverse transcriptase polymerase chain reaction were here used to investigate the expression patterns of the genes for TGF beta superfamily members : TGF beta 1 , namely bone morphogenetic protein ( BMP ) 4 , BMP 7 , activin beta A and activin beta B , and their type 1 and type 2 receptors , namely activin receptor like kinase ( ALK ) 2 ( ActR 1 ) , ALK 3 ( BMPR IA ) , ALK 4 ( ActR IB ) , ALK 5 ( T beta R 1 ) , BMPR 2 and T beta R 2 , during differentiation of pulp cells into preodontoblasts in bovine adult pulp cell culture . ^^^ These results suggest that the differentiation of pulp cells into preodontoblasts may be regulated by changes in the temporally coordinated expression pattern of TGF beta superfamily members and their receptors , including up regulation of transcription of TGF beta 1 , BMP 4 , BMP 7 , ALK 2 , ALK 3 , and ALK 5 . . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Specific activation of Smad 1 signaling pathways by the BMP 7 type 1 receptor , ALK 2 . ^^^ The major BMP 7 type 1 receptor observed was ALK 2 , while activin bound exclusively to ALK 4 ( ActRIB ) . ^^^ Activated ALK 2 also induced the Tlx 2 promoter in the absence of BMP 7 . ^^^ Thus , ALK 1 and ALK 2 induce Smad 1 dependent pathways and ALK 2 functions to mediate BMP 7 but not activin signaling . . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Alk 2 , also known as ActRIA , Tsk7L , and SKR 1 , encodes a type 1 TGF beta family receptor for activins and BMP 7 . ^^^ Alk 2 , also known as ActRIA , Tsk7L , and SKR 1 , encodes a type 1 TGF beta family receptor for activins and BMP 7 . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Activin A bound to ActR IB / ALK 4 and ActR 2 , and BMP 7 bound to ActR I / ALK 2 , BMP type 1 receptor ( BMPR 1 ) / ALK 3 , ActR 2 and BMPR 2 . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| The Smad 1 and ALK 2 mRNAs were recruited to polysomes during oocyte maturation , whereas the BMP 7 and XSTK 9 mRNAs were recruited during the early stages of embryogenesis . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Chem . 269 , 16985 16988 ; Macias Silva , M . et al . ( 1998 ) `` Specific activation of Smad 1 signaling pathways by the BMP 7 type 1 receptor , ALK 2 ' ' , J . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| OP 1 bound to ALK 2 and ALK 6 efficiently , and to ALK 3 less efficiently , whereas BMP 4 bound to ALK 3 and ALK 6 efficiently . ^^^ Similarly , OP 1 bound to ALK 2 , ALK 3 , and / or ALK 6 in various nontransfected cell lines , although the binding profiles were different between different cell types . ^^^ These results suggest that ALK 3 and ALK 6 are type 1 receptors for OP 1 and BMP 4 ; in addition , ALK 2 is a type 1 receptor shared by activin and OP 1 , but not by BMP 4 . . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| The present results suggest that the ActR 1 , BMPR IA , and BMPR IB receptors and the BMPR 2 receptor are expressed and functional for OP 1 in FRC cells and that regulation of synthesis of these receptors may be a mechanism by which a specific cell type responds to OP 1 . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Transient transfection studies showed that competition between activin A and OP 1 also occurred at the type 1 receptor ( ActR 1 ) level ; constitutively active ( CA ) ActR 1 inhibited CA ActR IB mediated p3TP Lux reporter induction . ^^^ Whereas the exact mechanism of competition is unclear , the role of ActR 2 in the competition between activin A and OP 1 is discussed in light of the observed interference in downstream signaling by CA ActR 1 and CA ActR IB . . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Analysis of OP 1 receptor expression revealed transcripts for BMP receptors type IA and IB in HK 2 cells and transcripts for BMPR IA and ALK 2 in mesangial cells . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| We then investigated whether the sensitivity of the early long bone rudiments to OP 1 correlated with high expression of the OP 1 binding type 1 serine / threonine kinase receptors ( activin receptor like kinase : ALK 2 / ActR 1 , ALK 3 / BMPR IA or ALK 6 / BMPR IB ) at this early stage . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Of the three type 1 BMPR examined , OP 1 upregulated ActR 1 and BMPR IA mRNA expression slightly but with statistical significance . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| BMPR 2 receptor mRNA expression in FRC cells treated with OP 1 and IL 6 plus IL 6sR was stimulated further , while BMPR IA , IB , and ActR 1 expressions were not affected . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| OP 1 enhanced ActR 1 mRNA expression and significantly elevated the mRNA expressions of BMP 1 , BMP 4 , BMP 5 , GDF 6 , and GDF 8 . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| OP 1 treatment stimulated mRNA expression of BMPR IA and BMPR 2 , but had little effect on ActR 1 and BMPR IB mRNA expression . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| Here , the RNA of human adult dental pulp and pulp cells in culture was examined by reverse transcription ( RT ) polymerase chain reaction ( PCR ) for evidence of mRNA for BMPs . mRNAs for BMP 2 , 4 , osteogenic protein 1 , ActR 1 ( activin like kinase receptor ) , BMPR IA , IB and 2 were detected by RT PCR . ^^^ |
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| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18075 and Q04771 |
Pubmed |
SVM Score :0.0 |
| NA |
|