| Interacting proteins: Q15532 and P51531 |
Pubmed |
SVM Score :0.74647156 |
| In this work , we address how SYT interacts with hBRM and BRG 1 . 0.74647156^^^ The proto oncoprotein SYT , involved in the unique translocation t ( 10 ; 18 ) found in synovial sarcoma , is known to interact with human BRM ( hBRM ) , thus providing a link between chromatin remodelling factors and human cancer . 0.59698461^^^ |
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| Interacting proteins: Q15532 and P51531 |
Pubmed |
SVM Score :0.0 |
| Functional domains of the SYT and SYT SSX synovial sarcoma translocation proteins and co localization with the SNF protein BRM in the nucleus . ^^^ We demonstrate that the human homologue of the SNF2 / Brahama protein BRM co localizes with SYT and SYT SSX in nuclear speckles , and also interacts with SYT and SYT SSX proteins in vitro . ^^^ |
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| Interacting proteins: Q15532 and P51531 |
Pubmed |
SVM Score :0.0 |
| It was also found that SYT interacts and colocalizes in the nucleus with the BRM protein , a transcriptional coactivator , and that the SSX proteins colocalize in the nucleus with polycomb group proteins , which are transcriptional corepressors . ^^^ |
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| Interacting proteins: Q15532 and P51531 |
Pubmed |
SVM Score :0.0 |
| Instead , they appear to be transcriptional regulators whose actions are mediated primarily through protein protein interactions , with BRM in the case of SYT , and with Polycomb group repressors in the case of SSX . ^^^ Ongoing work on the SYT SSX fusion and synovial sarcoma should yield a variety of data of broader biological interest , in areas such as BRM and Polycomb group function and dysfunction , transcriptional targets of SYT SSX proteins and their native counterparts , differential gene regulation by SYT SSX 1 and SYT SSX 2 , control of glandular morphogenesis , among others . . ^^^ |
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| Interacting proteins: Q15532 and P51531 |
Pubmed |
SVM Score :0.0 |
| Transcriptional co activator activity of SYT is negatively regulated by BRM and Brg 1 . ^^^ The N terminal 70 amino acids of SYT bind not only to BRM , but also to Brg 1 , both of which are subunits of SWI / SNF chromatin remodelling complexes . ^^^ Here , we have investigated the functions of BRM and Brg 1 on the repression of SYT activity . ^^^ The negative regulation of SYT transcriptional co activator activity is dependent on the ATP hydrolysis of BRM and Brg 1 in the protein complexes . ^^^ |
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| Interacting proteins: Q15532 and P51531 |
Pubmed |
SVM Score :0.0 |
| SYT has a conserved N terminal domain ( SNH domain ) that interacts with the human paralog of Drosophila Brahma ( hBRM ) and Brahma related gene 1 ( BRG 1 ) chromatin remodeling proteins and a C terminal transactivating sequence rich in glutamine , proline , glycine , and tyrosine ( QPGY domain ) . ^^^ |
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