| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.88539747 |
| Allele specific genetic interactions between snr 1 ( E 1 ) and mutations in genes encoding other members of the Brm complex suggest that snr 1 ( E 1 ) mutant phenotypes result from reduced Brm complex function . 0.88539747^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| A human protein with homology to Saccharomyces cerevisiae SNF 5 interacts with the potential helicase hbrm . ^^^ This protein can be co immunoprecipitated with hbrm and the interaction between the two proteins is dependent on the region conserved between the human and the yeast SNF 5 . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| At the present time , three human homologues of yeast SNF / SWI proteins have been characterized : hbrm and BRG 1 , homologues of SNF2 / SWI2 , and hSNF 5 , a homologue of SNF 5 . ^^^ The mitotic phosphorylation of hbrm and BRG 1 is found not to disrupt the association of these proteins with hSNF 5 but correlates with a decreased affinity for the nuclear structure in early M phase . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| SWI2 / SNF2 is an ATPase whose homologues , BRG 1 and hBRM , mediate cell cycle arrest ; the SNF 5 homologue , INI1 / hSNF5 , appears to be a tumour suppressor . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The observed similarity between mammalian BAF 190 , BAF 170 , BAF 155 , BAF 60 , and BAF 47 and yeast SNF2 / SWI2 , SWI 3 , SWI 3 , SWP 73 , and SNF 5 , respectively , underscores the similarity of the mammalian and yeast complexes . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The Drosophila snr 1 and brm proteins are related to yeast SWI / SNF proteins and are components of a large protein complex . ^^^ The snr 1 gene is essential and genetically interacts with brm and trithorax ( trx ) , suggesting cooperation in regulating homeotic gene transcription . ^^^ The spatial and temporal patterns of expression of snr 1 are similar to those of brm . ^^^ The snr 1 and brm proteins are present in a large ( > 2 10 10 ( 6 ) Da ) complex , and they co immunoprecipitate from Drosophila extracts . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| MOR thus joins BRM and Snf 5 related 1 ( SNR 1 ) , two known Drosophila SWI SNF subunits that act as positive regulators of the homeotic genes . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Mutations in genes encoding other Brm complex components , including snr 1 ( BAP 45 ) , osa and deficiencies that remove BAP 60 and BAP 111 can also suppress the DmcycE ( JP ) eye phenotype . ^^^ We show that Brm complex mutants suppress the DmcycE ( JP ) phenotype by increasing S phases without affecting DmcycE protein levels and that DmcycE physically interacts with Brm and Snr 1 in vivo . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| SNR 1 is an essential subunit in a subset of Drosophila brm complexes , targeting specific functions during development . ^^^ The snr 1 gene of Drosophila melanogaster encodes a conserved component of the multiprotein Brahma ( Brm ) complex , a counterpart to the SWI / SNF complexes that participate in ATP dependent chromatin remodeling . ^^^ A widespread distribution of SNR 1 and BRM on the salivary gland polytene chromosomes showed that the Brm complex associated with many genes , but not always at transcribed loci , consistent with genetic data suggesting roles in both gene activation and repression . ^^^ Despite essential Brm complex functions in leg development , genetic and protein localization studies revealed that snr 1 was not required or expressed in all tissues dependent on Brm complex activities . ^^^ Thus , SNR 1 is essential for some , but not all Brm functions , and it likely serves as an optional subunit , directing Brm complex activity to specific gene loci or cellular processes . . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Our data reveals that SNR 1 ( SNF 5 Related 1 ) , a highly conserved subunit of the Brm complex , is required to restrict complex activity during the development of wing vein and intervein cells , illustrating a functional requirement for SNR 1 in modifying whole complex activation functions . ^^^ Specifically , we found that snr 1 and brm exhibited opposite mutant phenotypes in the wing and differential misregulation of genes required for vein and intervein cell development , including rhomboid , decapentaplegic , thick veins , and blistered , suggesting possible regulatory targets for the Brm complex in vivo . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| SNR 1 is an essential subunit of the Drosophila Brahma ( Brm ) ATP dependent chromatin remodeling complex , with counterparts in yeast ( SNF 5 ) and mammals ( INI 1 ) . ^^^ SNR 1 is an essential subunit of the Drosophila Brahma ( Brm ) ATP dependent chromatin remodeling complex , with counterparts in yeast ( SNF 5 ) and mammals ( INI 1 ) . ^^^ Our results reveal that SNR 1 helps mediate associations between the Brm complex and DmcycE / CDK2 both in vitro and in vivo . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The SNF 2 ( SWI 2 ) , SNF 5 , and SNF 6 genes are required for transcription of many diversely regulated genes in Saccharomyces cerevisiae . ^^^ Previously , we showed that SNF 2 , SNF 5 , and SNF 6 function interdependently in transcriptional activation , possibly forming a heteromeric complex . ^^^ Here , we present evidence that SNF 6 has a more direct role in stimulating transcription than SNF 2 and SNF 5 . ^^^ The global effects of mutations in SNF 2 , SNF 5 , and SNF 6 suggested that these SNF proteins may function coordinately with many gene specific activators . ^^^ We show that LexA GAL 4 and LexA Bicoid fusion proteins are both dependent on SNF 2 , SNF 5 , and SNF 6 for activation of target genes containing one or multiple lexA operators . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The non derepressible mutants snf 1 , snf 2 and snf 5 present a chromatin structure characteristic of the repressed state , irrespective of the presence or absence of glucose . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The SNF 2 , SNF 5 and SNF 6 genes are required for Ty transcription in Saccharomyces cerevisiae . ^^^ The Saccharomyces cerevisiae SNF 2 , SNF 5 and SNF 6 genes were initially identified as genes required for expression of SUC 2 and other glucose repressible genes . ^^^ Since mutations in SPT 6 had also been identified as suppressors of Ty and solo delta insertion mutations at the HIS 4 and LYS 2 loci , we have examined Ty transcription in snf 2 , snf 5 and snf 6 mutants and have found that Ty transcription is abolished or greatly reduced . ^^^ The snf 2 , snf 5 and snf 6 defect for Ty transcription , like the defect for SUC 2 transcription , is suppressed by spt 6 mutations . ^^^ This result suggests that the SNF 2 , SNF 5 and SNF 6 gene products act by a distinct mechanism from the SPT 3 , SPT 7 and SPT 8 gene products to promote transcription of Ty elements . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Functional interdependence of the yeast SNF 2 , SNF 5 , and SNF 6 proteins in transcriptional activation . ^^^ The SNF 2 , SNF 5 , and SNF 6 genes of Saccharomyces cerevisiae are required for expression of a variety of differently regulated genes . ^^^ Here , we examine the functional relationship of the SNF 2 , SNF 5 , and SNF 6 proteins . ^^^ Activation by DNA bound LexA SNF 5 fusion protein was greatly reduced in snf 2 and snf 6 mutants , indicating that activation by LexA SNF 5 requires SNF 2 and SNF 6 function . ^^^ An spt 6 mutation , which suppresses transcriptional defects caused by snf 2 , restored activation by LexA SNF 5 in a snf 2 mutant . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Genetic and molecular evidence suggested that SNF 6 is functionally related to the SNF 2 and SNF 5 genes . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Mutation of the SNF 2 or SNF 5 gene led to accumulation of PrB activity to levels ten times that of wild type . ^^^ Re examination of published data on SUC 2 expression in snf 2 and snf 5 mutants and examination of PRB 1 expression in these mutants paradoxically suggest that the SNF 2 and SNF 5 gene products might act as negative regulators of gene expression . . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Biol . 7 : 679 686 , 1986 ) showed that spt 6 and ssn 20 mutations ( isolated as suppressors of snf 2 and snf 5 [ sucrose nonfermenting ] mutations ) identify the same gene . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The snf 2 and snf 5 mutations had no apparent effect on glucose uptake . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that the roles of the SNF 2 , SNF 5 and SNF 6 genes in regulation of SUC 2 are functionally related and that SSN 20 plays a role in expression of a variety of yeast genes . . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Molecular analysis of SNF 2 and SNF 5 , genes required for expression of glucose repressible genes in Saccharomyces cerevisiae . ^^^ The SNF 2 and SNF 5 genes are required for derepression of SUC 2 and other glucose repressible genes of Saccharomyces cerevisiae in response to glucose deprivation . ^^^ Previous genetic evidence suggested that SNF 2 and SNF 5 have functionally related roles . ^^^ The SNF 2 gene encodes a 5 . 7 kilobase RNA , and the SNF 5 gene encodes a 3 kilobase RNA . ^^^ Neither was regulated by glucose repression , and the level of SNF 2 RNA was not dependent on SNF 5 function or vice versa . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Dominant and recessive mutations at the SSN 20 locus were previously isolated as extragenic suppressors of mutations in three genes ( SNF 2 , SNF 5 , and SNF 6 ) that are required in trans to derepress invertase expression . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| These mutations included five new snf 1 ( sucrose nonfermenting ) alleles and also defined five new complementation groups , designated snf 2 , snf 3 , snf 4 , snf 5 , and snf 6 . ^^^ The snf 2 , snf 4 , and snf 5 mutants produced little or no secreted invertase under derepressing conditions and were pleiotropically defective in galactose and glycerol utilization , which are both regulated by glucose repression . ^^^ In contrast , snf 2 ssn6 and snf 5 ssn6 strains produced only moderate levels of invertase under derepressing conditions and very low levels under repressing conditions . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Genetic analysis of the interactions of the snf 8 null mutation with spt6 / ssn20 and ssn 6 suppressors distinguished SNF 8 from the groups , SNF 1 , SNF 4 and SNF 2 , SNF 5 , SNF 6 . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The relationship of CCR 4 to the group of general transcription factors , SNF 2 , SNF 5 , SNF 6 and SWI 1 and SWI 3 , which comprise a multisubunit complex required for ADH 2 and other genes ' expression , was also examined . ^^^ In addition , a ccr 4 mutation had little effect on an ADH 2 promoter alteration in contrast to the large effects displayed by mutations in SNF 2 and SNF 5 . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The Saccharomyces cerevisiae SWI 1 , SWI 2 ( SNF 2 ) , SWI 3 , SNF 5 , and SNF 6 gene products play a crucial role in the regulation of transcription . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Genetic analysis of the interactions of the snf 7 null mutation with ssn 6 and spt6 / ssn20 suppressor mutations distinguished SNF 7 from the SNF 2 , SNF 5 and SNF 6 genes . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| We present evidence strongly suggesting that haf 1 = snf 2 , haf 3 = snf 1 and haf 4 = snf 5 . ^^^ By phenotypic criteria , the postulated HAF 2 gene ( which is none of the SNF genes tested ) appears to be similar to SNF 2 , SNF 5 and SNF 6 , and is possibly a non redundant extension of this group of functionally related SNF genes . . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The yeast SNF 2 ( SWI 2 ) protein functions with SNF 5 , SNF 6 , SWI 1 , and SWI 3 in the transcriptional activation of many differently regulated genes . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| Mutations in genes encoding two core subunits of RSC , the ATPase Sth1p and the Snf5p homolog Sfh1p , interact genetically with mutations in genes encoding kinetochore proteins and with a mutation in centromeric DNA . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| These and other observations suggest that SWI 1 , SWI 2 , SWI 3 , SNF 5 , and SNF 6 may be components of a large multi subunit complex . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| The yeast SWI / SNF chromatin remodeling complex is comprised of 11 tightly associated polypeptides ( SWI 1 , SWI 2 , SWI 3 , SNF 5 , SNF 6 , SNF 11 , SWP 82 , SWP 73 , SWP 59 , SWP 61 , and SWP 29 ) . ^^^ |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51531 and Q12824 |
Pubmed |
SVM Score :0.0 |
| NA |
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