Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P49840 and P10636	Pubmed	SVM Score :0.0
The localisation of GSK 3 within granular structures in pyramidal cells indicates that GSK 3 alpha and GSK 3 beta may have a role in the production of PHF tau in Alzheimer ' s disease . . ^^^
Interacting proteins: P49840 and P10636	Pubmed	SVM Score :0.0
But elevating GSK 3 activity in the COS cells by co transfection with GSK 3 alpha or GSK 3 beta decreased the electrophoretic mobility of tau so that it resembled that of PHF tau , and induced reactivity with eight PHF tau selective monoclonal antibodies . ^^^
Interacting proteins: P49840 and P10636	Pubmed	SVM Score :0.0
Previously , we identified protein kinase FA / glycogen synthase kinase 3 alpha ( GSK 3 alpha ) as a brain microtubule associated tau kinase that phosphorylates Ser 235 and Ser 404 of tau and causes its electrophoretic mobility shift in gels , a unique property characteristic of paired helical filament associated pathological tau ( PHF tau ) in Alzheimer ' s disease brains . ^^^ As Ser 235 , Ser 262 , Ser 324 , Ser 356 , and Ser 404 ( particularly the site of Ser 262 ) have been identified as five of the most potent sites in tau responsible for reducing microtubule binding possibly involved in neuronal degeneration , and Thr 231 , Ser 235 , Ser 262 , and Ser 404 are four of the most well documented sites abnormally phosphorylated in Alzheimer tau , the results provide initial evidence that protein kinase FA / GSK 3 alpha after heparin potentiation may represent one of the most potent systems possibly involved in the abnormal phosphorylation of PHF tau in Alzheimer ' s disease brains . . ^^^
Interacting proteins: P49840 and P10636	Pubmed	SVM Score :0.0
NA
Interacting proteins: P49840 and P10636	Pubmed	SVM Score :0.0
NA
Interacting proteins: P49840 and P10636	Pubmed	SVM Score :0.0
NA
Interacting proteins: P49840 and P10636	Pubmed	SVM Score :0.0
NA
Interacting proteins: P49840 and P10636	Pubmed	SVM Score :0.0
NA