| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.65201375 |
| We previously identified complement factor H as a serum binding protein for AM and showed that factor H regulates AM functions and vice versa . 0.65201375^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Future studies in regard to the distribution and expression levels of the molecules known to function as AM receptors , together with data on the action of complement factor H ( an AM binding protein ) , may help to better define the roles of AM during embryonic development . . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| The AM receptor , a complex formed by calcitonin receptor like receptor ( CRLR ) and receptor activity modifying proteins ( RAMPs ) , and the recently discovered AM binding protein , complement factor H ( fH ) , are expressed in the insulin producing beta cells . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| In addition , AM is an apoptosis survival factor for cancer cells and an indirect suppressor of the immune response through its binding protein , complement factor H , and regulation in expression of cytokines . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Addition of the AM binding protein , complement factor H , prevents this cleavage , providing a hitherto unknown mechanism of action for this binding protein . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| VO 2 VE , and heart rates ( fH ) were measured in 61 Colombian sugarcane cutters while harvesting cane in the AM and PM and in the laboratory during a VO2max test . ^^^ During the work measurements the VO 2 was 1 . 5 1 / min , VE 48 1 / min , and fH 135 beats / min ; there were no differences between AM and PM values . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Urol Clin North Am 1996 ; 23 : 521 530 ; Schroder FH , Alexander FE , Bangma CH , Hugosson J , Smith DS . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| We performed MRI volumetric measurements of the amygdala ( AM ) and hippocampal formation ( HF ) in a group of 43 patients with temporal lobe epilepsy not controlled by optimal drug treatment . ^^^ The mean values of AM and HF volumes ipsilateral to the EEG focus were significantly smaller than those of normal controls . ^^^ The volumetric measurements showed a more pronounced atrophy of the AM in patients with a history of PFC , although the HF volumes were also smaller in this group . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| We studied 70 epileptic patients by using magnetic resonance imaging volumetric measurements of amygdala ( AM ) and hippocampal formation ( HF ) . ^^^ In 91 % of the 45 TLE patients without foreign tissue lesions , there was significant smallness of the AM and / or HF coinciding with the side of electroencephalographic seizure onset . ^^^ We performed a linear regression analysis , plotting the number of years of recurrent seizures and the estimated seizure frequency against the volumes of the AM and HF . ^^^ There was no correlation between either of these two parameters and AM or HF volume ( p > 0 . 9 ) . ^^^ There was also no correlation between the patient ' s age and volumetric measurements of AM or HF , nor did these measurements correlate with the occurrence of generalized seizures . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| In this study we compared the results of qualitative visual analysis of MRI with volumetric studies of the amygdala ( AM ) and hippocampal formation ( HF ) in a group of 31 patients . ^^^ The volumetric measurements of AM and HF were accurate in lateralizing the epileptogenic area in patients with TLE , concordant with the EEG in 92 % ; there was no false lateralization . ^^^ In patients with non TLE , there was no volume asymmetry of AM or HF . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| We performed MRI volumetric measurements of the amygdala ( AM ) , the hippocampal formation ( HF ) , and the anterior temporal lobe in a group of 30 patients with intractable temporal lobe epilepsy ( TLE ) and in seven patients with extratemporal lobe foci . ^^^ Volumetric studies of AM and HF showed lateralization of measurable atrophy consistent with that derived from extracranial and intracranial EEG examinations . ^^^ Combined measurements of AM and HF showed lateralization in 93 % , always congruent with the results of EEG lateralization . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| We studied 31 consecutive patients with temporal and extratemporal epilepsy who underwent presurgical evaluation with stereotaxic depth EEG ( SEEG ) to assess the relationships between amygdalo hippocampal ( AM HF ) atrophy and the location of SEEG seizure onset and SEEG interictal abnormalities . ^^^ There was no significant correlation between the frequency of SEEG interictal spikes and the amount of AM HF atrophy . ^^^ However , we found a significant correlation between the severity of SEEG background disturbance in AM and HF and the degree of atrophy of these structures . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Human basophils participating in experimentally produced contact allergy display progressive secretion of electron dense secretory granule contents and retention of cytoplasmic granule containers in the absence of entire granule extrusion , a process termed piecemeal degranulation ( PMD ) and postulated to be effected by vesicular transport ( Dvorak HF , Dvorak AM : Clin Hematol 4 : 651 , 1975 ) . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| MRI based volumetry of the AM and hippocampal formation ( HF ) in 30 patients with unilateral TLDM and intractable partial epilepsy was performed . ^^^ A volume normalization process defined a normal range of HF and AM volumes in control subjects , and enabled the detection of bilateral volume loss . ^^^ Normalized volumes detected HF atrophy in 26 patients ( nine unilateral and 17 bilateral ) and AM atrophy in 18 patients ( three unilateral and 15 bilateral ) . ^^^ Dual pathology is frequent in patients with TLDM ( 87 % ) , and the AM HF abnormality is often bilateral ( 57 % ) . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Plasma adrenomedullin ( AM ) , a novel hypotensive peptide , has been shown to increase in heart failure ( HF ) . ^^^ This study sought to examine the cardiovascular and renal effects of intravenous infusion of AM in HF rats and sham operated rats ( control ) using two doses of AM that would not induce hypotension . ^^^ Low dose AM increased urine flow ( +21 % in HF , +29 % in control ) and urinary sodium excretion ( +109 % in HF , +123 % in control ) without changes in any hemodynamic variables . ^^^ In contrast , high dose AM slightly decreased mean arterial pressure ( 3 % in HF , 5 % in control ) and significantly increased cardiac output ( +20 % in HF , +12 % in control ) . ^^^ Infusion of high dose AM resulted in significant decreases in right ventricular systolic pressure ( 11 % ) and right atrial pressure ( 28 % ) only in HF rats . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| We attempted to correlate the clinical features with different patterns of hippocampal formation ( HF ) and amygdala ( AM ) atrophy in patients with TLE without foreign tissue lesion . ^^^ They were divided into five groups according to MRIvol results : pure AM atrophy ( n = 11 , 10 unilateral and one bilateral ) , unilateral HF atrophy ( n = 16 ) , bilateral HF atrophy ( n = 12 ) , unilateral AM + HF atrophy ( n = 13 ) , and patients with normal volumes of AM and HF ( n = 13 ) . ^^^ MRIvol of AM and HF were performed by using a protocol previously described by Watson et al . ( Neurology 1992 ; 42 : 1743 50 ) . ^^^ RESULTS : Patients with AM atrophy had later onset of seizures compared with those with unilateral HF atrophy ( p < 0 . 01 ) . ^^^ History of febrile convulsions ( p < 0 . 0001 ) and frequent secondarily generalized tonic clonic seizures ( GTCSs ) were more often found in patients with HF atrophy compared with those with pure AM atrophy and those with normal volumes ( p = 0 . 04 ) . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| The IL 6 , IL 8 and TGF contents in the supernatant of the culture of HF ADM were determined with ELISA method , and the secretion of hyaluronic acid and laminin from extracellular matrix was measured with RIA method . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Adrenomedullin ( ADM ) release is enhanced in pheochromocytoma , chronic heart failure ( HF ) , hypertension and renal diseases . ^^^ This study was designed to test the hypothesis that ADM secretion increases also in response to acute stimuli , such as static effort and to compare plasma ADM response to this stimulus in patients with chronic HF and healthy persons . ^^^ The baseline plasma ADM and noradrenaline levels were higher , whilst plasma adrenaline and SV were lower in HF patients than in C group . ^^^ The 1st exercise bout caused an increase in plasma ADM from 3 . 32 + / 0 . 57 to 4 . 98 + / 0 . 59 pmol l ( 1 ) ( p < 0 . 01 ) in C and from 6 . 88 + / 0 . 58 to 7 . 80 + / 0 . 43 pmol 10 l ( 1 ) ( p < 0 . 02 ) in HF patients . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| However , a high fat ( HF ) diet has been shown to enhance intake and weight gain relative to a high carbohydrate ( HC ) diet when both energy density and palatability are equated [ Am . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| J Am Chem Soc 1984 , 106 , 3623 ] for the second proton transfer of the reaction catalyzed by triosephosphate isomerase ( TIM ) is examined ab initio at the HF and MP2 / 6 31+G * * levels in vacuo for two conformers of the enediolate phosphate ( ENEP ) , with the ethereal oxygen of the phosphate group either syn ( 10 ) , as in the crystal structure , or anti ( Y ) with respect to the enediolate carbonyl O . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| The HF power of dogs with MR was significantly decreased between 6 AM and noon . ^^^ The ratio of LF to HF in dogs with MR was significantly increased for the periods between midnight and 6 AM , 6 AM and noon , and noon and 6 PM . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Fictive hindlimb motor output was recorded as electroneurograms ( ENGs ) from up to five peripheral nerves on the right side , including three knee extensors ( KE ; iliotibialis [ IT ] KE , ambiens [ AM ] KE , and femorotibialis [ FT ] KE ) , a hip flexor ( HF ) , and a hip extensor ( HE ) . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Increased plasma adrenomedullin ( ADM ) levels have been reported in congestive heart failure ( HF ) . ^^^ The present study was designed to investigate myocardial regulation of the different components of the ADM signaling system ( ADM , ADM receptor , and receptor activity modifying protein 2 , RAMP 2 ) during ischemic HF in rats and to identify the cells in the myocardium displaying ADM like immunoreactivity ( ADM ir ) . ^^^ Furthermore , the effects of endothelin ( ET ) receptor antagonism on expression of the myocardial ADM system during HF were investigated . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Am J Physiol Renal Physiol 277 : F 706 F710 , 1999 ; Wang JL , Cheng HF , and Harris RC . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| We investigated whether adrenomedullin ( AM ) participates in the pathophysiology during the transition from left ventricular hypertrophy ( LVH ) to heart failure ( HF ) . ^^^ Two molecular forms of AM levels in the plasma and myocardium at the LVH stage were significantly elevated compared with those in controls , and they were further increased at the HF stage . ^^^ Interestingly , the LV tissue AM mature / AM total ratio was higher only in the HF group than in controls and LVH . ^^^ AM gene expression was significantly increased at the LVH stage and was further increased at the HF stage . ^^^ Furthermore , gene expression of AM receptor system components such as calcitonin receptor like receptor ( CRLR ) , receptor activity modified protein 2 ( RAMP 2 ) , and RAMP 3 were significantly increased at the stage of LVH and HF . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Acute administration of adrenomedullin ( AM ) exerts beneficial hemodynamic , renal , and neurohormonal effects in heart failure ( HF ) . ^^^ However , chronic effects of AM administration on HF remain unknown . ^^^ This study sought to examine the effect of chronic infusion of AM on progression of HF in rat . ^^^ Human recombinant AM was administered by osmotic minipump for 7 weeks in the HF model of Dahl salt sensitive rats . ^^^ These results suggest that endogenous AM plays a compensatory role in HF and that chronic AM infusion attenuates progression of left ventricular dysfunction and improves survival , at least in part , through inhibition of circulating and myocardial neurohormonal activation . . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the differences of the concentrations of cardiac AM between pressure overloaded ( PO ) heart failure ( HF ) and volume overloaded ( VO ) HF in humans . ^^^ METHODS AND RESULTS : We measured AM mature and AM glycine by immunoradiometric assays in pericardial fluid and plasma in 38 patients who underwent valve replacement surgery ( PO HF : aortic stenosis , n=14 ; VO HF : aortic or mitral regurgitation , n=24 ) . ^^^ Plasma AM mature ( VO HF : +59 % , PO HF : +65 % , P < . 05 ) and AM glycine ( VO HF : +43 % , PO HF : +50 % , P < 0 . 05 ) were similarly higher in the 2 HF groups than in the control group . ^^^ Interestingly , pericardial fluid AM mature was markedly higher than that in plasma ( control : +789 % , VO HF : +1050 % , PO HF : +1745 % , all P < . 001 ) . ^^^ Pericardial fluid AM mature was higher in VO HF ( +106 % , P < . 01 ) than in controls and they were further increased in PO HF ( +243 % , P < . 05 ) . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| Hourly HF peaked between 11 pm and 5 am . ^^^ LF / HF peaked between 6 and 9 am as well as between 4 and 6 pm with the smallest values between midnight and 5 am . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Increased circulating adrenomedullin ( AM ) concentration has been reported in congestive heart failure ( HF ) and considered as a possible marker of cardiac dysfunction . ^^^ HYPOTHESIS : The study was undertaken to assess the relationship between circulating AM concentration and left ventricular ( LV ) functional state , estimated by echo Doppler techniques in patients with mild to moderate HF and different degrees of LV dysfunction . ^^^ METHODS : Plasma AM , B type natriuretic peptide ( BNP ) , and N terminal ( NT ) proBNP levels were measured in 55 patients with HF ( New York Heart Association [ NYHA ] 1 n = 8 , 2 n = 26 , 3 n = 21 ) and in 20 controls ; dP / dt was calculated by the Doppler tracing of the mitral regurgitation jet . ^^^ CONCLUSIONS : The combination of depressed contractility and increased AM may provide a clue for further characterization of the severity of LV dysfunction in HF , independent of baseline LV ejection fraction . . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| The mean values for HF over the entire 24 hour period and over the 5 hour nocturnal period ( 0 5 AM ) in the positive mismatch group were both significantly lower than those in the negative mismatch group ( P < 0 . 001 in both groups ) . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| The LF to HF ratio at 6 : 00 am was significantly higher in diabetic patients with a high CRP concentration than in those with a low or moderate CRP concentration ( P < . 001 and P < . 01 , respectively ) . ^^^ Only urinary albumin and hs CRP were independent factors predicting the LF to HF ratio at 6 : 00 am in diabetic patients . ^^^ |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08603 and P35318 |
Pubmed |
SVM Score :0.0 |
| NA |
|