| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| A receptor like protein tyrosine phosphatase PTPzeta / RPTPbeta binds a heparin binding growth factor midkine . ^^^ Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta . ^^^ In this study , we examined the binding of midkine to PTPzeta by solid phase binding assay . ^^^ Midkine and pleiotrophin binding to PTPzeta were equally inhibited by soluble pleiotrophin and also by some specific glycosaminoglycans . ^^^ These results suggested that PTPzeta is a common receptor for midkine and pleiotrophin . ^^^ |
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| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| Supporting these data , the cells examined expressed PTPzeta , a receptor type protein tyrosine phosphatase that exhibits high affinity to both midkine and pleiotrophin and harbors chondroitin sulfate chains . ^^^ Midkine further recruited PTPzeta and PI 3 kinase . ^^^ These results indicate that PTPzeta and concerted signaling involving PI 3 kinase and MAP kinase are required for midkine induced migration and demonstrate for the first time the synergism between midkine and platelet derived growth factor in cell migration . . ^^^ |
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| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| A chondroitin sulfate proteoglycan , protein tyrosine phosphatase zeta ( PTPzeta ) , is a receptor for MK and PTN . ^^^ MK binds to the chondroitin sulfate portion of PTPzeta with high affinity . ^^^ |
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| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| Low density lipoprotein receptor related protein ( LRP ) immunoreactivity , a cell membrane receptor of MK , was observed in anterior horn motor neurons , but receptor type protein tyrosine phosphatase zeta ( PTPzeta ) immunoreactivity as a signaling receptor complex of MK was not observed . ^^^ |
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| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23471 and P21741 |
Pubmed |
SVM Score :0.0 |
| NA |
|