| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.59359468 |
| Conversely , CDK 4 stably associates with both p 21 ( CIP 1 ) and p 27 ( KIP 1 ) in cyclin containing complexes , suggesting that CDK 4 is in equilibrium between INK 4 and p 21 ( CIP 1 ) or p 27 ( KIP 1 ) bound states . 0.59359468^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.63632775 |
| Immunoprecipitation experiments revealed that p27Kip1 preferentially associated with CdK 4 in Ang 2 treated LLC PK 1 cells and that the activity of this kinase was inhibited after Ang 2 treatment , an effect that may be generated by increased p27Kip1 binding to cyclin D 1 CdK4 complexes . 0.63632775^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.70941294 |
| It has been proposed that in TGF beta arrested epithelial cells , up regulation of p15INK4B and of p15INK4B binding to cdk 4 serves to destabilize the association of p27Kip1 with cyclin D1 / cdk4 , promoting p27Kip1 binding and inhibition of cyclin E / cdk2 . 0.70941294^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.63474165 |
| Immunoprecipitation experiments revealed that p27Kip1 protein associates with Cdk 2 and Cdk 4 , but not with Cdk 6 . 0.63474165^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.51406359 |
| Binding assays with recombinant p27Kip1 confirmed that tyrosine phosphorylated p27Kip1 preferentially bound to cdk 4 , whereas unphosphorylated protein preferentially associated with cdk 2 . 0.51406359^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| To elucidate the biochemical processes involved in the pathogenesis of B CLL and MCL , we analyzed the expression level of a set of genes that play central roles in apoptotic or cell proliferation pathways and of candidate genes from frequently altered genomic regions , namely ATM , BAX , BCL 2 , CCND 1 , CCND 3 , CDK 2 , CDK 4 , CDKN1A , CDKN1B , E2F1 , ETV 5 , MYC , RB 1 , SELL , TFDP 2 , TNFSF 10 , and TP 53 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In contrast , TGFB 1 supported CDKN1B degradation by involving MAPK 14 ( also known as p 38 Map Kinase ) and PKC , resulting in CDK 4 activation and DNA synthesis . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Kip 1 does not bind to CAK , but its association with cyclin D cdk 4 prevents CAK from phosphorylating and activating the holoenzyme . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The subcellular locations of p 15 ( Ink4b ) and p 27 ( Kip 1 ) coordinate their inhibitory interactions with cdk 4 and cdk 2 . ^^^ In dividing cells , p 27 ( Kip 1 ) is predominantly bound to cyclin D cdk 4 without inhibiting this kinase . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Removal of p 27 ( kip 1 ) from the cell extracts allowed the MO 15 holoenzyme to phosphorylate the Cdk 4 and in turn activate it , indicating that p 27 ( kip 1 ) plays a role in inhibiting the phosphorylation of Cdk 4 by MO 15 in the contact inhibited 3Y1 cells . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Here , we show that 8Br cAMP strongly blocks both the growth factor induced increase in cyclin D 1 protein expression and decrease in p 27 ( KIP 1 ) protein levels , leaving untouched the levels of cyclin D 3 , cdk 2 and cdk 4 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Although p 27 ( Kip 1 ) has been considered a general inhibitor of G 1 and S phase cyclin dependent kinases , we report that the interaction of p 27 with two such kinases , cyclin A Cdk 2 and cyclin D Cdk 4 , is different . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , we used the RNA alphavirus Sindbis to express three known cyclin dependent kinase inhibitors ( CKIs ) , p 16 ( ink 4 ) , p 21 ( waf / cip ) , and p 27 ( kip 1 ) , and dominant negative mutant forms of four known G 1 cyclin dependent kinases ( CDKs ) , Cdk 2 , Cdk 3 , Cdk 4 , and Cdk 6 , in primary cultured rat superior cervical ganglion sympathetic neurons . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Therefore , the MEK / ERK pathway not only acts transcriptionally to induce the cyclin D 1 gene but functions posttranslationally to regulate cyclin D 1 assembly with CDK 4 and to thereby help cancel p 27 ( Kip 1 ) mediated inhibition . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that cyclin D 1 , cdk 4 and their association act as promoting factors , and that both p 21 ( CIP 1 ) and p 27 ( KIP 1 ) may have physiological functions as adaptor proteins in additions to their roles as CDK inhibitors in rat liver regeneration . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The overall effect of rapamycin on cyclin D 1 leads , in turn , to impaired formation of active complexes with Cdk 4 , a process which triggers retargeting of the p 27 ( Kip 1 ) inhibitor to cyclin E / Cdk2 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Since we found that the p 27 ( kip 1 ) activity was dependent on cyclin D 3 and cdk 4 , we compared the substrate specificity of the active ternary complex containing p 27 ( kip 1 ) and the active cyclin D 3 lacking p 27 ( kip 1 ) by tryptic phosphopeptide mapping of GST Rb phosphorylated in vitro and also by comparing the relative phosphorylation activity toward a panel of peptide substrates . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We show that p 16 and Cdk 4 ( N 158 ) inhibit the kinase activity of cellular cyclin D 1 complexes through different mechanisms . p 16 dissociated cyclin D 1 Cdk4 complexes with the release of bound p 27 ( KIP 1 ) , while Cdk 4 ( N 158 ) formed complexes with cyclin D 1 and p 27 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Thus , p 21 [ CIP 1 ] and p 27 [ KIP 1 ] , act in concert to inhibit cyclin E / CDK2 activity which , together with CDK 4 inactivation , confers a G 1 phase arrest . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We show that Sindbis virus induced expression of CKIs p 16 ( ink 4 ) , p 21 ( waf / cip1 ) , and p 27 ( kip 1 ) , as well as DN Cdk 4 and 6 , but not DN Cdk 2 or 3 , protect sympathetic neurons against UV irradiation and AraC induced death . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Thus , upon the induction of p 16 ( INK4a ) , p 27 ( KIP 1 ) appears to switch its allegiance from CDK 4 to CDK 2 , and the accompanying reassortment of components leads to the inhibition of cyclin E CDK 2 by p 27 ( KIP 1 ) and p 21 ( CIP 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In parallel , we have observed a decline of p 27 ( KIP 1 ) associated to CDK 4 and a significant increase of the inhibitor associated to CDK 2 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The widely prevailing view that the cyclin dependent kinase inhibitors ( CKIs ) are solely negative regulators of cyclin dependent kinases ( CDKs ) is challenged here by observations that normal up regulation of cyclin D CDK 4 in mitogen stimulated fibroblasts depends redundantly upon p 21 ( Cip 1 ) and p 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Following IL 6 treatment of LNCaP , Western blot analysis showed that the protein levels of cyclin dependent kinase 2 ( CDK 2 ) , CDK 4 , and CDK 6 were decreased , while accumulation of CDK inhibitor p 27 ( Kip 1 ) was rapidly and markedly induced . ^^^ Further , a significant amount of p 27 ( Kip 1 ) was co precipitated with CDK 2 , CDK 4 and CDK 6 , as detected in immunoprecipitation experiments . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In these clones , binding of p 16 to cdk 4 and cdk 6 abrogated binding of cyclin D 1 , p 27 ( KIP 1 ) , and p 21 ( WAF1 / CIP1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Under these conditions , CDK 2 and CDK 4 protein expression remained unchanged compared with proliferating cells , but expression of cyclin D 1 and p 27 ( KIP 1 ) was down regulated and cyclin E accumulated in the inactive form . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The dissociation of p 21 ( CIP 1 ) and p 27 ( KIP 1 ) from their cdk complexes correlated well with the activation of cdk 2 , cdk 4 , and cdk 6 and the release from cell cycle arrest . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Targeted disruption of CDK 4 delays cell cycle entry with enhanced p 27 ( Kip 1 ) activity . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Nevertheless , cyclin D 3 and CDK 4 activity are essential in the cAMP dependent mitogenesis , and cAMP unmasks the DCS 22 epitope of cyclin D 3 and induces the nuclear translocations and assembly of cyclin D 3 and CDK 4 in a complex that also contains p 27 ( kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In this study , our aim was to delineate the molecular mechanism underlying cAMP and cGMP suppression of cell cycle transition in human SMCs . cAMP inhibits both platelet derived growth factor stimulated cyclin dependent kinase ( cdk ) 2 and cdk 4 activation through upregulation of the cdk 2 inhibitor p 27 ( Kip 1 ) and downregulation of cyclin D 1 expression , which leads to a complete arrest of the cells in phase G ( 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Here we present evidence that activation of a cAMP pathway correlates with multiple cellular changes in these cells : ( 1 ) increased expression of the transcription factor microphthalmia ; ( 2 ) increased melanogenesis ; ( 3 ) increased association of the cyclin dependent kinase inhibitors ( CDK Is ) p 27 ( KIP 1 ) and p 16 ( INK 4 ) with CDK 2 and CDK 4 , respectively ; ( 4 ) failure to phosphorylate the retinoblastoma protein ( pRB ) ; ( 5 ) decreased expression of E2F1 , E2F2 , and E2F4 proteins ; ( 6 ) loss of E2F DNA binding activity ; and ( 7 ) phenotypic changes characteristic of senescent cells . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In TSH stimulated cells , TGFbeta did not affect the expression of cyclin D 3 , cdk 4 , and p 27 ( kip 1 ) , nor the induced formation of cyclin D 3 cdk4 complexes , but it prevented the TSH induced relocalization of p 27 ( kip 1 ) from cdk 2 to cyclin D 3 cdk4 . ^^^ It prevented the nuclear translocations of cdk 4 and cyclin D 3 without altering the assembly of cyclin D 3 cdk4 complexes probably formed in the cytoplasm , where they were prevented from sequestering nuclear p 27 ( kip 1 ) away from cdk 2 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In contrast , cyclin D Cdk 4 was not inhibited by His ( 6 ) p 27 in vitro or p 27 ( Kip 1 ) in vivo . ^^^ These results suggest a concerted model of progestin action whereby p 27 ( Kip 1 ) and p 18 ( INK4c ) cooperate to inhibit cyclin E Cdk 2 and Cdk 4 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Time courses demonstrated that 4D5 treatment redirects p 27 ( Kip 1 ) onto Cdk 2 complexes , an event preceding increased p 27 ( Kip 1 ) expression ; this correlates with the downregulation of c Myc and D type cyclins ( proteins involved in p 27 ( Kip 1 ) sequestration ) and the loss of p 27 ( Kip 1 ) from Cdk 4 complexes . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Ceramide induced inhibition of cdk 2 and cdk 4 kinase activities was accompanied by increase of p 27 ( kip 1 ) in the cdks complexes . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We hypothesized that a variation in the inactivation of cdk 2 and cdk 4 during the G ( 1 ) phase of the cell cycle by p 27 ( Kip 1 ) , p 21 ( Cip 1 ) , and p 16 ( Ink 4 ) leads to different effects on VSMC growth in vitro and in vivo . ^^^ METHODS AND RESULTS : The expression of p 27 ( Kip 1 ) and p 21 ( Cip 1 ) in serum stimulated VSMCs inactivated cdk 2 and cdk 4 , leading to G ( 1 ) growth arrest . p 16 ( Ink 4 ) inhibited cdk 4 , but not cdk 2 , kinase activity , producing partial inhibition of VSMC growth in vitro . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| To better understand these mechanisms in long term cultured lymphocytes we have characterized two human long term cultured IL 2 dependent T cell lines regarding telomere length , telomerase activity , and the expression of selected cell cycle regulators ( pRb , p 53 , cyclin E , cyclin D 1 , cyclin D 2 , cyclin D 3 , cdk 4 , p 16 ( INK4a ) , p 21 ( WAF 1 ) , p 27 ( KIP 1 ) , c myc , bcl 2 , and NPAT ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Regardless of cell density , the activities of cdk 4 and cdk 2 were markedly repressed by p 27 ( kip 1 ) expression , as was the cdk 4 dependent dissociation of E2F4 / p130 complexes . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Treatment with salicylate prevented PDGF induced downregulation of p 21 ( Waf 1 ) and p 27 ( Kip 1 ) but not of the Cdk 4 / 6 inhibitor p 16 ( Ink 4 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In p 27 ( kip 1 ) p 21 ( cip 1 ) deficient cells , the cyclin D 3 pool consisted primarily of cyclin D 3 monomers , whereas in wild type cells , the majority of cyclin D 3 molecules were complexed to cdk 4 and either p 27 ( kip 1 ) or p 21 ( cip 1 ) or were monomeric . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We found that the expression of cyclin A and p 21 ( WAF 1 ) molecules was primarily modulated by TGFbeta 1 treatment while the expression of other regulatory components , like cyclins D , cyclin E , cdk 2 , cdk 4 , and cdk 6 or p 15 ( INK4B ) , p 16 ( INK4A ) , and p 27 ( KIP 1 ) was not significantly affected . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| At 300 microM , N BPs reduced expression of cyclin dependent kinase ( cdk ) 2 and cdk 4 and enhanced expression of p 21 ( waf 1 ) and p 27 ( kip 1 ) and their binding to cdks with corollary hypophosphorylation of retinoblastoma . ^^^ Growth inhibition , but not binucleation , was also caused by the geranylgeranyl transferase 1 inhibitor , GGTI 298 , which also enhanced cdk 2 and cdk 4 association with p 27 ( kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Of the cell cycle control proteins , PCNA , Cdk 2 , and cyclin A were detected at high concentrations ; cdc 2 , Cdk 4 , and cyclin B were detected at very low concentrations ; while cyclin D 1 , cyclin D 3 , Cip 1 , and Kip 1 were not detected . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We did not observe consistent changes in protein levels of cyclin D , cyclin E , CDK 4 , CDK 6 , CDK 2 , p 27 ( Kip 1 ) , p 16 ( INK4a ) , or RNA levels of p 15 ( INK4b ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Both p 21 ( Cip 1 ) and p 27 ( Kip 1 ) proteins were induced during erythroid differentiation , but only p 27 ( Kip 1 ) associated with the principal G ( 1 ) CDKs cdk 4 , cdk 6 , and cdk 2 . ^^^ The kinetics of binding of p 27 ( Kip 1 ) to CDK complexes was distinct in that p 27 ( Kip 1 ) associated primarily with cdk 4 ( and , to a lesser extent , cdk 6 ) early in differentiation , followed by subsequent association with cdk 2 . ^^^ Binding of p 27 ( Kip 1 ) to cdk 4 had no apparent inhibitory effect on cdk 4 kinase activity , whereas inhibition of cdk 2 kinase activity was associated with p 27 ( Kip 1 ) binding , accumulation of hypo phosphorylated retinoblastoma protein , and G ( 1 ) growth arrest . ^^^ Inhibition of cdk 4 kinase activity late in differentiation resulted from events other than p 27 ( Kip 1 ) binding or loss of cyclin D from the complex . ^^^ The data demonstrate that p 27 ( Kip 1 ) differentially regulates the activity of cdk 4 and cdk 2 during terminal erythroid differentiation and suggests a switching mechanism whereby cdk 4 functions to sequester p 27 ( Kip 1 ) until a specified time in differentiation when cdk 2 kinase activity is targeted by p 27 ( Kip 1 ) to elicit G ( 1 ) growth arrest . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| A particular role in the regulation of these phenomena is played by proteins involved in early G 1 phase regulation : pRb kinases : cyclin dependent kinases ( cdk ) : cdk 4 and cdk 6 activated by cyclins D , and universal cdk inhibitor p 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| This Cdk 4 mutation cooperates with p 53 and p 27 ( Kip 1 ) deficiencies in decreasing tumor latency and favoring development of specific tumor types . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Expression of cell cycle regulatory proteins , such as cyclin D 1 , cyclin E , cdk 2 , cdk 4 , p 21 ( Cip 1 ) , and p 27 ( Kip 1 ) was determined using immunofluorescent staining . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Postovulatory progesterone secretion was markedly impaired in Cdk 4 ( / ) mice , although granulosa cells initiated luteinization with induction of p 450 side chain cleavage cytochrome and p 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Expression of Cdk 4 , Cdk 2 , p 16 ( INK4A ) , and p 27 ( KIP 1 ) did not change . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The kinase activation was found to result from Tax induced expression of genes for cell cycle regulatory molecules including cyclin D 2 , cyclin E , E2F1 , CDK 2 , CDK 4 and CDK 6 , and Tax induced reduction of CDK inhibitors p 19 ( INK4d ) and p 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Raf activation increased the expression of Cdk 2 , Cdk 4 , cyclin A , cyclin D , cyclin E , p 21 ( Cip 1 ) and c Myc and decreased the expression of p 27 ( Kip 1 ) which are associated with G ( 1 ) progression . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Extracellular signal regulated protein kinase ( p44 / p42 ERK ) activity and expressions of cell cycle proteins ( cyclin D ( 1 ) , CDK 4 , pRB and p 27 ( Kip 1 ) ) were determined by Western blotting . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Although treatment of cells with TGF beta 1 up regulated accumulation of p 27 ( kip 1 ) in both nucleus and cytoplasm , the association of the p 27 ( kip 1 ) with cdk 2 , cyclin A , cyclin D 2 , cyclin D 3 , and cdk 4 was markedly down regulated , suggesting that p 27 ( kip 1 ) is not responsible for the downregulation of the kinase activity . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the Cdk4 / 6 specific Cdk inhibitor of Cdk 4 p16 ( INK4A ) was associated with increased association of p 27 ( KIP 1 ) with Cdk 2 , concomitant with disruption of D cyclin / Cdk4 complexes . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| While expression of the genes for cyclin D 1 , CDK 4 , and E2F1 increased in lung adenocarcinomas relative to normal lung , expression of p 15 ( Ink4b ) , p 16 ( Ink4a ) , p 21 ( Cip 1 ) , p 27 ( Kip 1 ) , p 57 ( Kip 2 ) , and pRb genes decreased in comparison . ^^^ Competitive RT PCR showed that the levels of cyclin D 1 and CDK 4 mRNAs were 2 and 3 fold higher , respectively , in lung adenocarcinomas than in normal lung , while the mRNAs for p 15 ( Ink4b ) , p 16 ( Ink4a ) , p 21 ( Cip 1 ) , p 27 ( Kip 1 ) , and pRb were 3 to 4 fold lower in adenocarcinomas than in normal lung , thus validating the macroarray findings . ^^^ Competitive RT PCR of microdissected lesions also showed that the levels of cyclin D 1 and CDK 4 mRNAs increased significantly , while the mRNAs for p 15 ( Ink4b ) and p 27 ( Kip 1 ) decreased significantly as lung tumorigenesis progressed . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In HepG 2 cells , this inhibition was associated with an arrest of the cell cycle in G ( 0 ) G ( 1 ) , increased cellular levels of p 21 ( CIP 1 ) , decreased levels of the hyperphosphorylated form of the retinoblastoma protein , and decreased levels of cyclin D 1 , but no significant changes were seen in the levels of the p 16 ( INK4a ) , p 27 ( KIP 1 ) , cyclin dependent kinase 4 , cyclin dependent kinase 6 , glycogen synthase kinase 3beta , or beta catenin proteins . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| G 1 arrest was accompanied by a decrease in CDK 2 , CDK 4 , and CDK 6 associated histone H 1 kinase activities , and an increase in the expression levels of cell cycle inhibitors p 27 ( KIP 1 ) and p 15 ( INK4B ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The activities of Cdk 2 , Cdk 4 , and Cdc 2 kinases were inhibited 24 hr after infection with Adp 27 ( Kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Ectopic overexpression of Jak 3 in 32Dcl3 cells resulted in an acceleration of the G CSF induced differentiation program that was preceded by G ( 1 ) cell cycle arrest , which was associated with the up regulation of the cyclin dependent kinase inhibitor p 27 ( Kip 1 ) and down regulation of Cdk 2 , Cdk 4 , Cdk 6 , and Cyclin E . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Ras signaling was investigated by analyzing Ras membrane localization and activation , ERK 2 phosphorylation , and p 27 ( kip 1 ) and cdk 4 levels . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Additional in vitro studies demonstrated a G 1 arrest that was preceded by depletion in cyclin D 3 , elevation of p 21 ( WAF 1 ) and p 27 ( KIP 1 ) leading to a loss in activity of G 1 cdks ( cdk 2 , cdk 4 ) , and reduction in pRb phosphorylation . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Downregulation of the kinase activities is mediated by induction of cyclin dependent kinase ( CDK ) inhibitor p 15 ( Ink4b ) which blocks CDK 4 and CDK 6 kinases and leads to binding of p 27 ( Kip 1 ) to CDK 2 cyclin E complex . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We show in this work that the inhibition of Cdk 4 ( 6 ) in Rb ( / ) 3T3 cells enhances the accumulation of the p 27 ( kip 1 ) cyclin dependent kinase inhibitor when these cells are induced into quiescence . ^^^ In summary , we report a new functional link between two important cell cycle regulators , Cdk 4 and p 27 ( kip 1 ) , and provide a mechanistic explanation to the previously reported epistatic relations between these two proteins . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Subcellular localization of proteins was determined by immunofluorescent staining and expression of cyclin dependent kinase 4 ( Cdk 4 ) , p 27 ( Kip 1 ) ( p 27 ) , phosphatidylinositol 3 ( PI 3 ) kinase , protein kinase B / Akt ( Akt ) , and beta actin was analyzed by immunoblot . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| These effects were associated with a decrease in cyclin D 1 expression , without a change in cyclin dependent kinase 4 or cyclin dependent kinase inhibitor , p 27 ( kip 1 ) expression . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Regulatory role of cAMP on expression of Cdk 4 and p 27 ( Kip 1 ) by inhibiting phosphatidylinositol 3 kinase in corneal endothelial cells . ^^^ The current study was designed to determine whether adenosine 3 ' , 5 ' monophosphate ( cAMP ) antagonizes FGF 2 by inhibiting PI 3 kinase / Akt pathways , thus leading to regulation of cyclin dependent kinase 4 ( Cdk 4 ) and p 27 ( Kip 1 ) ( p 27 ) expression . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The inactivation of p 27 ( kip 1 ) and the consequent disruption of normal colonic cell maturation in the mucosa were associated with modestly elevated c myc , cdk 4 , and cyclin D 1 expression . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Conditions that increased the abundance of the D cyclins also increased the abundance of enzymatically active D cyclin cdk 4 complexes in mouse embryo fibroblasts ( MEFs ) lacking both p 27 ( Kip 1 ) and p 21 ( Cip 1 ) ( p27 / p21 ( / ) ) . ^^^ However , as determined by treatment of wild type MEFs with MG 132 , maximal accumulation of D cyclin cdk 4 complexes required p 27 ( Kip 1 ) and p 21 ( Cip 1 ) and coincided with the formation of inactive D cyclin cdk 4 p27 ( Kip 1 ) or p 21 ( Cip 1 ) complexes . p 27 ( Kip 1 ) or p 21 ( Cip 1 ) also increased the abundance of D cyclin cdk 4 complexes and reduced amounts of cdk 4 activity when ectopically expressed in p27 / p21 ( / ) MEFs . ^^^ We conclude that ( 1 ) D cyclin cdk 4 complexes are formed and become active in the absence of p 27 ( Kip 1 ) and p 21 ( Cip 1 ) and ( 2 ) p 27 ( Kip 1 ) and p 21 ( Cip 1 ) maximize the accumulation but inhibit the activity of D cyclin cdk 4 complexes . ^^^ We suggest that D cyclin cdk 4 complexes are more stable when bound to p 27 ( Kip 1 ) or p 21 ( Cip 1 ) and that formation of ternary complexes also stabilizes the D cyclins . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| This was associated with increased protein content of cyclin D 1 and Cdk 4 and decreased activation of p 21 ( cip 1 ) and p 27 ( kip 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In rasREF cells treated with DE for 72 h in suspension culture ( a ) , the levels of cyclin D 1 , cyclin A , p 27 ( Kip 1 ) , and hyperphosphorylated Rb were decreased , but the levels of cdk 4 , cdk 6 , cdk 2 , p 16 ( INK4a ) , and p 21 ( Cip 1 ) were not affected . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| While the amounts of the cellular cyclin dependent kinase ( Cdk ) inhibitors p 21 ( Cip 1 ) , p 27 ( Kip 1 ) , and p 16 ( INK4a ) did not change in infected cells , MHV infection in asynchronous cultures induced a clear reduction in the amounts of Cdk 4 and G ( 1 ) cyclins ( cyclins D 1 , D 2 , D 3 , and E ) in both DBT and 17Cl 1 cells and a reduction in Cdk 6 levels in 17Cl 1 cells . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The effect on p 27 ( Kip 1 ) , CDK 4 and CDK 2 was only marginal . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| By contrast , Cdk 4 activity and p 27 ( Kip 1 ) expression were not significantly altered by inhibition of PI3K . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In OC 15 5 cells treated with 15d PGJ 2 , the expression of CDK inhibitor , p 27 ( Kip 1 ) , was up regulated , while that of p 21 ( WAF1 / Cip1 ) , p 18 ( INK4C ) CDK 2 , CDK 4 , and cyclin E was unchanged . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Moreover , ZD 1839 increased the protein levels of p 27 ( KIP 1 ) and retinoblastoma related Rb2 / p130 while decreased the expression of cyclin dependent kinase 2 ( CDK 2 ) , CDK 4 , CDK 6 and cyclin D 1 , cyclin D 3 . ^^^ Our results indicate that downregulation of the expression and function of CDK 2 , CDK 4 , CDK 6 , cyclin D 1 and cyclin D 3 , as well as upregulation of p 27 ( KIP 1 ) and pRb2 / p130 , are strong candidates for the cell cycle regulator that arrests ZD 1839 treated A 549 cells at G 1 phase . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| These cells developed a G2 / M cell cycle arrest with a concomitant decreased percentage of cells in S phase ( approximately 2 fold ) , associated with an increased expression of p 21 ( WAF 1 ) , p 27 ( KIP 1 ) , as well as cyclin B 1 and decreased levels of CDK 2 , CDK 4 , and E2F4 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We found that overexpression of wild type FAK promoted exit from G ( 1 ) in monolayer cultures of glioblastoma cells , enhanced the expression of cyclins D 1 and E while reducing the expression of p 27 ( Kip 1 ) and p 21 ( Waf 1 ) , and enhanced the kinase activity of the cyclin D 1 cyclin dependent kinase 4 ( cdk 4 ) complex . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Interestingly , cyclin D 3 and cdk 4 selectively interact with phosphorylated p 27 ( kip 1 ) in BL 40 cells . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Most of RA induced p 27 ( Kip 1 ) was bound to cyclin D1 / cyclin dependent kinase 4 complexes , probably contributing to the decreased cyclin dependent kinase 4 kinase activity and pRb hypophosphorylation observed in RA treated cells . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Temporal ectopic expression of either p 21 ( Cip 1 ) or p 27 ( Kip 1 ) arrested proliferation , inhibited Cdk 2 and Cdk 4 activities , and suppressed retinoblastoma phosphorylation . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Using gene targeted mouse models , we report in this article that Cdk 4 resistance to INK 4 inhibitors , due to the Cdk 4 R24C mutation , strongly cooperates with p 27 ( Kip 1 ) deficiency in tumor development . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Concomitantly , p 27 ( Kip 1 ) levels rose and the inhibitor accumulated in both Cdk 4 and Cdk 2 complexes , as these kinases were inactivated . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| HGF treatment of the cells led to a redistribution of p 21 ( CIP 1 ) and p 27 ( KIP 1 ) from Cdk 4 to Cdk 2 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Assessment of cdk 4 , cyclin D 1 and p 27 ( kip 1 ) expression revealed that only cdk 4 expression was increased in the cancers with mutant BAT RII . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In parallel , we measured the kinase activities and found that CDK 2 and CDK 4 were suppressed with commensurate increased levels of CDK inhibitors , p 21 ( Cip 1 ) and p 27 ( Kip 1 ) . ^^^ These data suggested that Epimedin C arrested the proliferation of these cells at G0 / G1 phase through inhibition of CDK 2 and CDK 4 activities via an increased induction of p 21 ( Cip 1 ) and p 27 ( Kip 1 ) . ^^^ Taken together , the molecular mechanisms of anti tumor activity of Epimedin C may be proceeded by the combined effects of the cell cycle blockage via either the inhibition of CDK 2 and CDK 4 activities , with commensurate increase in their inhibitors , p 21 ( Cip 1 ) and p 27 ( Kip 1 ) or negatively modulates the ERK / c Fos / AP 1 signaling pathway . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Cyclin D 1 was much more abundant in the infant than adult cells , but there was no difference according to the expression of cdk 4 , cdk 2 , cyclin E and cdk inhibitors ( p 16 ( Ink 4 ) ( p 16 ) , p 21 ( Cip1 / Waf1 ) ( p 21 ) and p 27 ( Kip 1 ) ( p 27 ) ) . 8 OHdG became high soon after cultivation , while it rapidly went down after day 2 both in the infant and adult cells . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The expressions of cyclin D 1 and c myc in HL 60 are suppressed by 8 chloroadenosine , whereas the cyclin dependent kinases inhibitor p 21 ( WAF1 / CIP1 ) is up regulated . 8 Chloroadenosine has less effect on the expressions of cyclin dependent kinase ( cdk ) 2 and cdk 4 , G ( 1 ) phase cyclin dependent kinases , and only moderately induces the expression of transforming growth factor beta 1 ( TGFbeta 1 ) and the mitotic inhibitor p 27 ( KIP 1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| By contrast , cyclin D 2 and cdk 6 are coordinately increased , thereby overriding the inhibition by cdk inhibitors p 18 ( INK4c ) and p 27 ( Kip 1 ) and phosphorylating Rb in conjunction with the existing cdk 4 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| To analyze the cell kinetics of ulcerative colitis ( UC ) associated dysplasia , cyclin A , cyclin D 1 , cyclin E , cdk 2 , cdk 4 , p 21 ( Waf 1 ) , and p 27 ( Kip 1 ) were immunohistochemically examined , in comparison with sporadic tubular adenomas . ^^^ In tubular adenomas , cyclin A , cdk 4 , p 27 ( Kip 1 ) , and p 21 ( Waf 1 ) were all expressed in the upper parts of the crypts . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Study of the key regulators of cell cycle progression by Western blot analysis showed that the expression of the cyclin dependent kinase inhibitor ( CDKI ) p 27 ( kip 1 ) , but not that of p 21 ( cip 1 ) , was enhanced , whereas that of c Myc , cyclin E , cyclin D 2 , and cyclin dependent kinases 2 and 4 ( CDK 2 and CDK 4 ) was decreased when these cells were treated with TZD 18 ( 10 or 20 microM ) . ^^^ Therefore , the up regulation of p 27 ( kip 1 ) and the down regulation of CDK 2 and CDK 4 may , at least in part , account for the G ( 1 ) cell cycle arrest . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In addition , overexpression of PKC delta increased binding of cdk inhibitor p 27 ( Kip 1 ) to cdk 4 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The interaction of p 27 ( Kip 1 ) loss with epithelial cell specific cyclin dependent kinase 4 overexpression identifies the thymic epithelium as a relevant site of p 27 ( Kip 1 ) activity for the regulation of thymus growth . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The mutation , an arginine to cysteine exchange at residue 24 , was part of the CDK 4 peptide recognized by CTLs and prevented binding of the CDK 4 inhibitor p16INK4a , but not of p 21 or of p27KIP1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Cyclic AMP inhibits expression of D type cyclins and cdk 4 and induces p27Kip1 in G CSF treated NFS 60 cells . ^^^ We show that the latter could be attributed to different effects of cAMP in these cells : ( 1 ) down regulation of the levels of cyclins D 2 and D 3 , and cdk 4 , and ( 2 ) induction of the p27Kip1 inhibitor of cdk4 . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Analysis of metabolically labelled cells revealed that cyclin D 2 , cyclin D 3 , and cdk 4 were also partnered with p27kip1 in quiescent BALB / c 3T3 cells and that this association decreased after platelet derived growth factor ( PDGF ) treatment . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| TGF beta 1 induced alterations in other cell cycle regulatory molecules , cyclin dependent kinase 4 , cyclin D 1 , pRB , and p27Kip1 , occurred late and were dispensable in some of the sensitive cell lines . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In murine C2C12 myoblast cells , G 1 CDK enzymes ( CDK 2 , CDK 4 , and CDK 6 ) associate with four CDK inhibitors : p18INK4c , p19INK4d , p 21 , and p27Kip1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| As cdk 4 and cdk 6 associated p15INK4B increased during TGF beta arrest of sensitive cells , there was a loss of cyclin D 1 , p21Cip1 , and p27Kip1 from these kinase complexes , and cyclin E cdk 2 associated p27Kip1 increased . ^^^ In HMEC , p15INK4B complexes did not contain detectable cyclin . p15INK4B from both sensitive and resistant cells could displace in vitro cyclin D 1 , p21Cip1 , and p27Kip1 from cdk 4 isolated from sensitive cells . ^^^ Furthermore , p27Kip1 binding shifts from cdk 4 to cyclin E cdk 2 during TGF beta mediated arrest . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Differential effects were observed with the G 1 cell cycle mediators CDK 4 , CDK 5 , and cyclin D 3 , p21Waf1 and p27Kip1 CDK inhibitory protein concentrations rose in accordance with the induction of DNA synthesis and histone H 1 kinase activity . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We found that status of p 107 , p 130 , p15INK4b , p18INK4c , p21Cip1 , p27Kip1 , cyclin D 1 , and Cdk 4 were not correlated with the growth inhibitory activity of exogenous p16INK4a . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical stains were carried out on tissue microarrays to evaluate the expression of proteins involved in the G ( 1 ) S transition and proteins that regulate apoptosis including Rb , E2F1 , cyclin D 1 , CDK 4 , CDK 6 , p 27 ( KIP 1 ) , p 21 ( WAF1 / CIP1 ) , p 53 , Mdm 2 , Bcl 2 , and Bax . ^^^ The positive phenotypes identified were as follows : Rb , 39 . 1 % ; E2F1 , 69 . 6 % ; cyclin D 1 , 30 . 4 % ; CDK 4 , 100 % ; CDK 6 , 30 . 4 % ; 39 . 1 % ; p 27 ( KIP 1 ) , 47 . 8 % ; p 21 ( WAF1 / CIP1 ) , 39 . 1 % ; p 53 , 43 . 5 % ; Mdm 2 , 17 . 4 % ; Bcl 2 , 91 . 3 % ; and Bax , 100 % . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Proliferating Mv1Lu mink lung epithelial cells and human keratinocytes contain high levels of the universal Cdk inhibitor p27Kip1 distributed in complexes with Cdk 2 , Cdk 4 , and Cdk 6 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Analysis of expression of genes regulating Rb phosphorylation revealed that activin A suppressed cyclin D 2 , the sole D type cyclin gene expressed in the hybridoma cells , and activated p21CIP1 / WAF1 but had no effect on expression of cyclin dependent kinases ( CDK 2 , CDK 4 , CDK 6 ) and other CDK inhibitors ( p27KIP1 , p16INK4a , p15INK4b ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| MadMyc does not cause alterations in the expression levels of cyclin E , CDK 2 , p27kip1 , cyclin D 1 or CDK 4 in G 1 arrested cells . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation experiments revealed that only small amounts of p27Kip1 protein from MMC grown in high glucose medium preferentially associates with CDK 2 but not with CDK 4 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The Rb cyclin D pathway was analyzed by studying the pRb protein , the p16MTS1 gene , cyclin D 1 , cyclin D 3 , p27Kip1 , cdk 4 , and cdk 6 proteins . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Expression of cyclin D 1 , CDK 4 and p27KIP1 is associated with the p16MTS1 gene status in human esophageal carcinoma cell lines . p16MTS1 / INK4A negatively regulates cell cycle progression by inhibiting the cyclin D / CDK4 complex that phosphorylates pRb . ^^^ All the p 16 negative cell lines expressed high levels of cyclin D 1 , CDK 4 and p27KIP1 proteins . ^^^ Interestingly , the expression level of cyclin D 1 was closely correlated to the levels of not only CDK 4 but also p27KIP1 protein in p 16 negative cell lines . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We report that IFN alpha inhibits the H 1 kinase activity associated with CDK 4 or CDK 2 due to induction of expression of CDK inhibitor p21WAF1 ( but not p27Kip1 ) as its immunodepletion from IFN treated extracts restored the CDK associated H 1 kinase activity . ^^^ In addition , we also show that IFN gamma induces expression of CDK inhibitors p21WAF1 and p27Kip1 and inhibited the H 1 kinase activity associated with CDK 2 or CDK 4 . ^^^ The observed IFN gamma mediated inhibition of CDK 2 and CDK 4 kinase activity was due to enhanced interactions with p21WAF1 and p27Kip1 , respectively . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| While the inhibition of CDK 4 may be attributed at least in part to the decline in CDK 4 protein level , CDK 2 activity reduction is rather due to the up regulation of the CDK inhibitor p27Kip1 and to its increased association to CDK2 . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The protein levels of cyclin dependent kinase 2 ( cdk 2 ) and cdk 4 were unaffected during this G 1 arrest and the total cellular levels of the cdk inhibitors p21cip1 and p27kip1 were not increased . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The decline in the expression of p27Kip1 and sequestering of the inhibitory protein by cdk 4 and cdk 6 correlated with the increase in cdk 2 kinase activity during the G 1 phase . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Removing p27kip1 from the cell extracts allowed MO 15 holoenzyme to phosphorylate the Cdk 4 and to activate it , indicating that an access of MO 15 to Cdk 4 was inhibited by p27kip1 in the contact inhibited 3Y1 . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The peak induction time of each cell cycle related protein during DEN induced cellular proliferation was diverse , and expressions of CDK 2 , CDK 4 , cdc 2 , p 53 , bcl 2 , p21Waf1 and p27Kip1 appear to be of the greatest interest . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Overall , these results demonstrate that RA treatment of EBV immortalized B lymphocytes is associated with multiple effects on G 1 regulatory proteins , including p27Kip1 up regulation , decreased levels of cyclins D 2 , D 3 and A , and inhibition of CDK 2 , CDK 4 and CDK 6 activity , which ultimately result in reduced pRb phosphorylation and G0 / G1 growth arrest . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Treatment with lovastatin revealed the increment of both CDK 2 and CDK 4 bound p27Kip1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The growth inhibition of OVCA 420 cells by mAb C 225 or 4D5 was associated with an increased G 1 cell population ; an increased level of a cyclin dependent kinase ( CDK ) inhibitor p27Kip1 with increased association of p27kip1 with CDK 2 , CDK 4 and CDK 6 ; and decreased activities of these CDKs . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Ang 2 had no significant effect on the steady state levels of cyclin dependent kinase ( CDK ) inhibitor ( CDKI ) , p27kip1 , and on the activities of CDK 2 and CDK 4 , although it caused a modest increase in cyclin E levels . ^^^ In contrast , PDGF BB induced depletion of p27kip1 and increased cyclins D 1 and E levels and CDK 2 and CDK 4 activities . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta ( TGF beta ) is a multifunctional polypeptide that inhibits cellular proliferation in most epithelial cells . cdk 4 and several cyclin dependent kinase ( cdk ) inhibitors ( p15INK4B , p21WAF1 / Cip1 and p27Kip1 ) have been implicated in the TGF beta induced cell cycle arrest . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The resulting growth inhibitory effect of HMBA was completely reversible and was analyzed in terms of percent cells in G 1 ; association of D type cyclins with cyclin dependent kinase ( cdk ) 4 and cdk 6 ; G 1 kinase activity ; association of retinoblastoma protein ( pRb ) and phosphorylated pRb with D type cyclins ; and association of p16INK4a , p15INK4b , and p27Kip1 with cdk 4 and cdk 6 . ^^^ At 5 h , treated cells showed a fivefold increase in cdk 4 associated p27Kip1 and , at 9 h , a fourfold increase in cdk 6 associated p27Kip1 over control levels . ^^^ The data suggest that HMBA induced growth inhibition is due to multifactorial mechanisms involving decreases in total cyclin D 1 and inhibition of cdk 4 and cdk 6 kinase activities through elevation of levels of cdk 4 and cdk 6 associated p27Kip1 and concomitant increases in hypophosphorylated pRb and stable cyclin D2 / pRb and cyclin D3 / pRb complexes that help maintain pRb in a functional state . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Specific immunoprecipitates of Cdk 2 but not Cdk 4 from androgen treated 104 R 1 cells contained both p21waf1 / cip1 and p27Kip1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Regulation of cyclin dependent kinase 4 during adipogenesis involves switching of cyclin D subunits and concurrent binding of p18INK4c and p27Kip1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The molecular events that lead to melanoma cell autonomous growth are not well defined , but are likely to include sustained activity of cyclin dependent kinases ( CDK 2 , CDK 4 and CDK 6 ) as a result of loss of CDK inhibitors ( such as p16INK4a and possibly p27KIP1 ) , and persistent upregulation of several cyclins ( cyclin D 1 , cyclin A and cyclin E ) , the positive regulators of CDKs . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that BMP 2 did not alter expression of cyclin D , cyclin E , cyclin dependent kinase 2 ( CDK 2 ) , CDK 4 , p27KIP1 , p16INK4a , or p15INK4b , but enhanced expression of p 21 ( CIP1 / WAF1 ) . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The oncogenic role of reduced , but not absent , levels of p27KIP1 is supported by recent studies in murine models and evidence that this protein not only inhibits the activity of complexes containing CDK 2 and cyclin E , but also promotes the assembly and catalytic activity of CDK 4 or CDK 6 in complexes with cyclin D . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Time dependent change of G 1 cyclins , cdk 2 and cdk 4 after addition of AP showed that expression level of cdk inhibitors , INK 4 family , and p27KIP1 did not altered , while that of p21WAF1 was downregulated . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| While members of the INK 4 family ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) interact specifically with CDK 4 and CDK 6 , the CIP / KIP inhibitors p21CIP1 / WAF1 , p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In Ewing cell lines , cyclin D 1 , CDK 4 , Rb , p27KIP1 and c Myc were consistently highly expressed whereas p57KIP2 , p15INK4B and p14ARF demonstrated undetectable or low expression levels . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| The current study is concerned with the evaluation of a key cyclin ( cyclin D 1 ) which activates cdk 4 and p27KIP1 which in turn inhibit cdk 2 in the proliferative responses of epidermal growth factor ( EGF ) and platelet derived growth factor ( PDGF ) and their modulation by TGF beta 1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Inhibition of CDK 2 , CDK 4 and cyclin E and increased expression of p27Kip1 during treatment with interferon alpha in carcinoid tumor cells . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| A second , more indirect role for CDK 4 is in late G 1 , where it may sequester the inhibitors p27KIP1 or p21CIP1 away from CDK 2 , and in doing so upregulate the CDK 2 activity necessary for cells to proceed completely through G 1 into S phase . ^^^ As the pivotal residues around the most predominant R24C activating CDK 4 mutation are invariant between CDK 2 and CDK 4 , we speculated that the pivotal arginine ( position 22 in CDK 2 ) , or a nearby residue , may be mutated in some melanomas , resulting in the diminution of its binding and inhibition by p27KIP1 or p21CIP1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Differential activity of TGF beta 2 on the expression of p27Kip1 and Cdk 4 in actively cycling and contact inhibited rabbit corneal endothelial cells . ^^^ Subcellular localization of cyclin dependent kinase 4 ( Cdk 4 ) , p27Kip1 ( p 27 ) , and phosphorylated p 27 ( pp 27 ) was determined by immunofluorescent staining followed by confocal laser microscopic analysis . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Cdk 4 and p27Kip1 play a role in PLC gamma 1 mediated mitogenic signaling pathway of 18 kDa FGF 2 in corneal endothelial cells . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Concomitantly , p27Kip1 ( where Kip is kinase inhibitory protein ) was induced markedly , whereas other negative cell cycle regulators , such as p21Cip1 ( where Cip is cyclin dependent kinase interacting protein ) , p15INK4B and p16INK4A ( where INK is inhibitors of cyclin dependent kinase 4 ) , were not , implying its association in the G 1 arrest . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Cdk activity was determined , and Cdk 2 , Cdk 4 and Cdc 2 kinase activities were inhibited , consistent with p27Kip1 over expression . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| We observed high levels of p27kip1 , cyclin D 2 , cyclin E , cdk 2 , and cdk 4 expression in freshly isolated B CLL cells . ^^^ Despite high levels of cyclins and cdks , little cdk 2 or cdk 4 activity was observed with p27kip1 in complex with cyclinD2 / cdk4 and cyclin E / cdk2 . ^^^ Remarkably , when B CLL cells were treated in vitro with fludarabine , p27kip1 underwent caspase specific degradation accompanied by an increase in cdk 4 activity . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic cyclin D 1 assembled with cyclin dependent kinase 4 ( CDK 4 ) , and the CDK inhibitors p21Cip1 and p27Kip1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| This was associated with reduced levels of cyclins A , B 1 and B 2 , cdk 4 , and cdc25A and increased p27KIP1 expression . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| In co transfected Chinese hamster ovary cells , AKAP 95 strongly interacted with the three D type cyclins , but not with CDK 4 ( cyclin dependent kinase 4 ) or with p27kip1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Biochemical analysis of tumors showed that CDK 4 sequesters the CDK 2 inhibitors p27Kip1 and p21Cip1 , suggesting that indirect activation of CDK 2 plays an important role in tumor development . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| End stage differentiation of neutrophil granulocytes in vivo is accompanied by up regulation of p27kip1 and down regulation of CDK 2 , CDK 4 , and CDK 6 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| METHODS : We examined expression patterns of cyclin D 1 ; cyclin E ; cyclin A ; cyclin B 1 ; cyclin dependent kinase ( CDK ) 2 ; CDK 4 ; such CDK inhibitors as p21WAF1 / CIP1 ( p 21 ) , p27kip1 ( p 27 ) , and p57kip2 ( p 57 ) ; and Wilms ' tumor protein 1 ( WT 1 ) in 12 renal biopsy specimens with the cellular lesion of FSGS and 6 renal biopsy specimens with no detectable abnormalities by immunohistochemistry and immunoelectron microscopy . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Do p27Kip1 and p21Cip1 function as activators or inhibitors of D cyclin cdk 4 activity . ^^^ In this perspective , we summarize the results of studies addressing the effects of p27Kip1 and p21Cip1 on the assembly and activation of D cyclin cdk 4 complexes . ^^^ Emphasis is placed on our experimental findings that support a model of cell cycle control in which p27Kip1 and p21Cip1 stabilize D cyclin cdk 4 complexes but inhibit D cyclin cdk 4 activity . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| By means of RT PCR and immunoblotting , we found that NaB significantly changed the expression of genes involved in proliferation : cyclins D 1 , A , E and cyclin dependent kinases Cdk 2 and Cdk 4 , whereas the amount of p21Waf1 and p27Kip1 inhibitors greatly increased . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Etodolac induced p21WAF1 / Cip1 and p27Kip1 expression and inhibited CDK 2 , CDK 4 , CDC 2 , cyclin A and cyclin B 1 expression , but did not affect cyclin D 1 or cyclin E . ^^^ In conclusion , p21WAF1 / Cip1 , p27Kip1 , CDK 2 , CDK 4 , CDC 2 , cyclin A , cyclin B 1 and the MAP kinase signaling pathway are involved in growth inhibition and cell cycle arrest by a selective COX 2 inhibitor in HCC cell lines . . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Biochemical analysis of the K 5 Myc epidermis showed that CDK 4 mediates the proliferative activities of Myc by sequestering p21Cip1 and p27Kip1 and thereby indirectly activating CDK 2 kinase activity . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Down regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D 1 and CDK 4 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Early onset of G 1 cell cycle arrest along with upregulation of the cyclin dependent kinase inhibitor p27Kip1 and downregulation of Cdk 2 , Cdk 4 , Cdk 6 , and Cyclin E has also been observed in Jak 3 overexpressing 32Dcl3 cells . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| From four successful cultures , three showed a high expression of cyclin D 1 , cyclin E , p16NK4A , and p27KIP1 with no variations in cyclin A , cyclin dependent kinase 2 ( CDK 2 ) , and CDK 4 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Viral K cyclin interacted with cyclin dependent kinases cdk 2 , cdk 4 , and cdk 6 and with the cyclin / cdk inhibitory proteins p21Cip1 and p27Kip1 in BC 3 cell lysates . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Flow cytometric analysis revealed that ircinin 1 resulted in G 1 arrest in cell cycle progression which was associated with a marked decrease in the protein expression of D type cyclins and their activating partners Cdk 4 and 6 with concomitant inductions of p21WAF1 / CIP1 and p27KIP1 . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| Several antigens were assessed immunohistochemically ( pRb 1 , p16INK4A , cyclin D 1 , cdk 4 , estrogen receptor ( ER ) , progesterone receptor ( PR ) , androgen receptor ( AR ) , p 53 , Ki 67 , p27KIP1 , PTEN , hMLh 1 , phospho AKT , collagen 4 , leptin and CD 90 ) in both tumors . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| TIMP 2 mediated inhibition of Cdk 4 and Cdk 2 activity is associated with increased binding of p27Kip1 to these complexes in vivo . ^^^ |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96TE0 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|