| Interacting proteins: P11802 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P84022 |
Pubmed |
SVM Score :0.0 |
| The results indicate that Smad 3 deficiency slows follicle growth , which is characterized by small follicle diameters , low levels of proliferating cell nuclear antigen , and low expression of cell cycle genes ( cyclin dependent kinase 4 and cyclin D 2 ) . ^^^ |
|
| Interacting proteins: P11802 and P84022 |
Pubmed |
SVM Score :0.0 |
| Finally , although these cki are dispensable for the suppression of T cell proliferation by TGF beta , we now describe a Smad 3 dependent down regulation of cdk 4 , suggesting a potential mechanism underlying to resistance of Smad 3 ( / ) T cells to the induction of growth arrest by TGF beta . ^^^ |
|
| Interacting proteins: P11802 and P84022 |
Pubmed |
SVM Score :0.0 |
| Rb family members were the only demonstrated substrates of CDK 4 until it was shown recently that Smad 3 , which plays a key role in mediating TGF beta antiproliferative responses , is phosphorylated by both CDK 4 and CDK 2 in vivo and in vitro . ^^^ |
|
| Interacting proteins: P11802 and P84022 |
Pubmed |
SVM Score :0.0 |
| Overall , the expression of the Smad 2 and Smad 3 proteins was low in the glioma cell lines , the phosphorylation and nuclear translocation of Smad 2 and Smad 3 were impaired , and the TGFbeta receptor signal did not affect the expression of the SnoN , p 21 , p 15 , cyclin D 1 , and CDK 4 proteins . ^^^ |
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