| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| We have isolated cDNA sequences , INK4d , encoding a 19 kDa protein that is associated with CDK 6 in several hematopoietic cell lines . p 19 shares equal similarity and a common ancestor with other identified inhibitors of the p16 / INK4 family . p 19 interacts with and inhibits the activity of both CDK 4 and CDK 6 and exhibits no detectable interaction with the other known CDKs . p 19 protein is present in both cell nuclei and cytoplasm . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| The four members of the INK 4 gene family , p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) , are known to bind to and inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G1 / S transition in the cell division cycle . ^^^ A possible mode of binding between p 19 ( INK4d ) and CDK 4 and CDK 6 could therefore involve the loop segments of p 19 ( INK4d ) . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The four members of the INK 4 gene family ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) ) inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G 1 > S transition in the cell division cycle . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| Mutation testing in melanoma families : INK4A , CDK 4 and INK4D . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| The INK 4 ( inhibitor of cyclin dependent kinase 4 ) family consists of four tumor suppressor proteins : p 15 ( INK4B ) , p 16 ( INK4A ) , p 18 ( INK4C ) , and p 19 ( INK4D ) . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| The INK 4 family of cyclin dependent kinase ( CDK ) inhibitors includes four 15 to 19 kDa polypeptides ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) , and p 19 ( INK4d ) ) that bind to CDK 4 and CDK 6 . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| During IL 6 induced macrophage differentiation of M 1 cells , IL 6 down regulated cyclin D 1 expression and induced p 19 ( INK4D ) expression , leading to reduction in cdk 4 activities . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| Analysis of normal B cell precursors by Western blotting indicated that CDK 4 , CDK 6 , p 19 ( INK4d ) , and p 57 ( KIP 2 ) were expressed , whereas p 16 ( INK4a ) was not detected . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| The kinase activation was found to result from Tax induced expression of genes for cell cycle regulatory molecules including cyclin D 2 , cyclin E , E2F1 , CDK 2 , CDK 4 and CDK 6 , and Tax induced reduction of CDK inhibitors p 19 ( INK4d ) and p 27 ( Kip 1 ) . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| P 19 ( INK4d ) is a tumor suppressing protein and belongs to a family of cyclin D dependent kinase inhibitors of CDK 4 and CDK 6 , which play a key role in human cell cycle control . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| The first group , including p16Ink4a , p15Ink4b , p18Ink4c and p19Ink4d , is specific for the G 1 CDKs , CDK 4 and CDK 6 , inhibiting the kinase activity of cyclin D / CDK4 CDK 6 complexes on pRb . p16Ink4a , down regulated by pRb , inhibits G 1 CDKs by competition with cyclin D ; p15Ink4b , the synthesis of which is induced by TGF beta , seems to be a mediator of TGF beta mediated cell cycle arrest . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| In murine C2C12 myoblast cells , G 1 CDK enzymes ( CDK 2 , CDK 4 , and CDK 6 ) associate with four CDK inhibitors : p18INK4c , p19INK4d , p 21 , and p27Kip1 . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NMR structural characterization of the CDK inhibitor p19INK4d . p19INK4d is a 165 amino acid protein that belongs to the INK 4 family of CDK 4 and CDK 6 inhibitors . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| We derived 32D cells in which the expression of p19INK4d , a specific polypeptide inhibitor of CDK 4 and CDK 6 , is regulated by the heavy metal inducible sheep metallothionein promoter . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| The p19INK4d and p18INK4c proteins formed complexes with either CDK 4 or CDK 6 in a temporal pattern consistent with the results of in situ hybridization . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| Within the INK 4 family , this regulatory mode appears restricted to p19INK4d whose ubiquitination was dependent on the integrity of lysine 62 , and binding to CDK 4 . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| Expression of p19INK4d , CDK 4 , CDK 6 in glioblastoma multiforme . ^^^ No gene rearrangement or deletion was observed in the p19INK4d gene in these cell lines ; however , expression of CDK 4 and CDK 6 was elevated relative to matched normal brain tissue in eight of 18 GBM tumours ( 44 % ) . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| While members of the INK 4 family ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) interact specifically with CDK 4 and CDK 6 , the CIP / KIP inhibitors p21CIP1 / WAF1 , p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK . ^^^ |
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| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| Importantly , experiments performed with CDK 4 mutants suggest that these p19INK4d effects would be independent of its role as a cell cycle checkpoint gene . ^^^ |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55273 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|