| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| Studies of variations of the cyclin dependent kinase inhibitor 1C and the cyclin dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| In this report we demonstrate that the CDK inhibitors p 21 ( CIP ) , p 27 ( KIP ) , and p 57 ( KIP 2 ) all promote the association of cdk 4 with the D type cyclins . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| Thus the 3 ( 10 ) helix motif may confer a specific regulatory mechanism by which p 57 differentially regulates Cdk 2 and Cdk 4 activities . . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitates of Cdk 2 and Cdk 4 from fiber cells contained p 57 ( kip 2 ) , supporting the view that this Cdk inhibitor blocks the activity of these Cdks in lens fibers . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| We investigated 3 normal adrenals , 31 adrenocortical tumors [ 11 tumors with normal expression of the IGF 2 gene ( mainly benign ) and 20 with IGF 2 gene overexpression ( mainly malignant ) ] , and the human adrenocortical tumor cell line NCI H295R for expression of the p57KIP2 gene , G 1 cyclins ( cyclin D 2 and E ) and G 1 CDK ( CDK 2 , CDK 3 and CDK 4 ) protein contents and for kinase activity of G 1 cyclin CDK complexes . ^^^ By contrast , abrogation of the p57KIP2 gene expression and increased expression of G 1 cyclins ( cyclin E ) and G 1 CDKs ( CDK 2 and CDK 4 ) were associated with high activity of G 1 cyclin CDK complexes in malignant tumors and in the H295R cell line . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| Using an in vitro competition / association assay , we demonstrate that cyclin D 1 alone , Cdk 4 alone and / or cyclin D1 / Cdk4 complexes do not compete for the p57Kip2 homodimers formation . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| While members of the INK 4 family ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) interact specifically with CDK 4 and CDK 6 , the CIP / KIP inhibitors p21CIP1 / WAF1 , p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| In Ewing cell lines , cyclin D 1 , CDK 4 , Rb , p27KIP1 and c Myc were consistently highly expressed whereas p57KIP2 , p15INK4B and p14ARF demonstrated undetectable or low expression levels . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| While expression of the genes for cyclin D 1 , CDK 4 , and E2F1 increased in lung adenocarcinomas relative to normal lung , expression of p 15 ( Ink4b ) , p 16 ( Ink4a ) , p 21 ( Cip 1 ) , p 27 ( Kip 1 ) , p 57 ( Kip 2 ) , and pRb genes decreased in comparison . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| METHODS : We examined expression patterns of cyclin D 1 ; cyclin E ; cyclin A ; cyclin B 1 ; cyclin dependent kinase ( CDK ) 2 ; CDK 4 ; such CDK inhibitors as p21WAF1 / CIP1 ( p 21 ) , p27kip1 ( p 27 ) , and p57kip2 ( p 57 ) ; and Wilms ' tumor protein 1 ( WT 1 ) in 12 renal biopsy specimens with the cellular lesion of FSGS and 6 renal biopsy specimens with no detectable abnormalities by immunohistochemistry and immunoelectron microscopy . ^^^ RESULTS : In controls , immunostaining for cyclin A , cyclin B 1 , CDK 2 , CDK 4 , and p 21 was almost negligible , but positive signals for cyclin D 1 , cyclin E , p 27 , and p 57 were observed in glomerular epithelial cells ( GECs ) . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| Analysis of normal B cell precursors by Western blotting indicated that CDK 4 , CDK 6 , p 19 ( INK4d ) , and p 57 ( KIP 2 ) were expressed , whereas p 16 ( INK4a ) was not detected . ^^^ |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49918 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|