| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.70107073 |
| In p18INK4C positive HCCs , p18INK4C dominantly interacted with Cdk 4 rather than with Cdk 6 . pRb phosphorylated at serine ( Ser ) 780 was detected more frequently in p18INK4C negative than in p18INK4C positive HCCs . 0.70107073^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| In addition , we screened the CDKN2B ( p 15 INK4b ) , CDKN2C ( p 18 INK4c ) , CDK 4 and p53R2 genes for mutations in the tumour tissues . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| The four members of the INK 4 gene family , p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) , are known to bind to and inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G1 / S transition in the cell division cycle . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The four members of the INK 4 gene family ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) ) inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G 1 > S transition in the cell division cycle . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| The INK 4 ( inhibitor of cyclin dependent kinase 4 ) family consists of four tumor suppressor proteins : p 15 ( INK4B ) , p 16 ( INK4A ) , p 18 ( INK4C ) , and p 19 ( INK4D ) . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| The INK 4 family of cyclin dependent kinase ( CDK ) inhibitors includes four 15 to 19 kDa polypeptides ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) , and p 19 ( INK4d ) ) that bind to CDK 4 and CDK 6 . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| However , an increase in the expression of the Cdk4 / 6 inhibitor p 18 ( INK4c ) and its extensive association with Cdk 4 and Cdk 6 were apparent following progestin treatment . ^^^ These results suggest a concerted model of progestin action whereby p 27 ( Kip 1 ) and p 18 ( INK4c ) cooperate to inhibit cyclin E Cdk 2 and Cdk 4 . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| In activated T cells , p 18 ( INK4c ) remained constant , and preferentially associated with and inhibited CDK 6 but not CDK 4 . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| In OC 15 5 cells treated with 15d PGJ 2 , the expression of CDK inhibitor , p 27 ( Kip 1 ) , was up regulated , while that of p 21 ( WAF1 / Cip1 ) , p 18 ( INK4C ) CDK 2 , CDK 4 , and cyclin E was unchanged . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| Lack of effect of extremely low frequency electromagnetic fields on cyclin dependent kinase 4 inhibitor gene p 18 ( INK4C ) in electric energy workers . ^^^ The putative tumor suppressor gene p 18 ( INK4C ) encodes a specific inhibitor of cyclin D cyclin dependent kinase 4 inhibitor complexes having an important role in cell cyclin regulation . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| No such cooperation is observed between Cdk 4 R24C and p 18 ( INK4c ) absence , suggesting that the only function of p18INK4c is inhibiting Cdk 4 in this model . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| By contrast , cyclin D 2 and cdk 6 are coordinately increased , thereby overriding the inhibition by cdk inhibitors p 18 ( INK4c ) and p 27 ( Kip 1 ) and phosphorylating Rb in conjunction with the existing cdk 4 . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| METHODS : Genes for the CDKIs p 16 ( INK4a ) and p 18 ( INK4c ) , a constitutively active form of retinoblastoma ( RB ) gene product , cyclin D 1 , and CDK 4 , were transferred into RA synovial fibroblasts ( RASFs ) . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| Screening of germline mutations in the CDK 4 , CDKN2C and TP 53 genes in familial melanoma : a clinic based population study . ^^^ The present investigation reports the results of screening the 100 Swedish melanoma families for germline mutations in the CDK 4 , CDKN2C and TP 53 genes . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| A single nucleotide polymorphism in the 3 ' untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B , CDKN2C , CDK 4 and p 53 genes are rare . ^^^ In this report we present the results of mutational analysis of the CDKN2B , CDKN2C , CDK 4 , p 53 genes and 5 ' UTR of the CDKN2A gene in a set of 44 sporadic primary melanomas , which had been earlier analysed for mutations in the CDKN2A ( p16 / p14 ( ARF ) ) gene . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| Specifically , the IFN alpha response of tumoral T cells is due to a combination of induction of apoptosis in which TNFSF 10 and HSXIAPAF 1 may play an important role and cell cycle arrest achieved by downregulation of CDK 4 and CCNG 2 and upregulation of CDKN2C and tumor suppressor genes ( TSGs ) . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| Progression through the G 1 phase of the cell cycle is dependent on the activity of holoenzymes formed between D type cyclins and their catalytic partners , the cyclin dependent kinases cdk 4 and cdk 6 . p16INK4a , p15INK4b , and p18INK4c , a group of structurally related proteins , function as specific inhibitors of the cyclin D dependent kinases and are likely to play physiologic roles as specific regulators of these kinases in vivo . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| The first group , including p16Ink4a , p15Ink4b , p18Ink4c and p19Ink4d , is specific for the G 1 CDKs , CDK 4 and CDK 6 , inhibiting the kinase activity of cyclin D / CDK4 CDK 6 complexes on pRb . p16Ink4a , down regulated by pRb , inhibits G 1 CDKs by competition with cyclin D ; p15Ink4b , the synthesis of which is induced by TGF beta , seems to be a mediator of TGF beta mediated cell cycle arrest . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| Induction of p18INK4c and its predominant association with CDK 4 and CDK 6 during myogenic differentiation . ^^^ In murine C2C12 myoblast cells , G 1 CDK enzymes ( CDK 2 , CDK 4 , and CDK 6 ) associate with four CDK inhibitors : p18INK4c , p19INK4d , p 21 , and p27Kip1 . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| We found that status of p 107 , p 130 , p15INK4b , p18INK4c , p21Cip1 , p27Kip1 , cyclin D 1 , and Cdk 4 were not correlated with the growth inhibitory activity of exogenous p16INK4a . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| The p19INK4d and p18INK4c proteins formed complexes with either CDK 4 or CDK 6 in a temporal pattern consistent with the results of in situ hybridization . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| The p18INK4c protein , a member of the p16 / INK4 cyclin dependent kinase ( CDK ) inhibitor family , is induced more than 50 fold during myogenic differentiation of mouse C2C12 myoblasts to become the predominant CDK inhibitor complexed with CDK 4 and CDK 6 in terminally differentiated myotubes . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| Regulation of cyclin dependent kinase 4 during adipogenesis involves switching of cyclin D subunits and concurrent binding of p18INK4c and p27Kip1 . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| The results suggest that loop 2 is likely to be part of the recognition surface of p18INK4C or p16INK4A for CDK 4 , and they provide quantitative functional contributions of specific residues . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| Tumor suppressor INK 4 : quantitative structure function analyses of p18INK4C as an inhibitor of cyclin dependent kinase 4 . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| While members of the INK 4 family ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) interact specifically with CDK 4 and CDK 6 , the CIP / KIP inhibitors p21CIP1 / WAF1 , p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK . ^^^ |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42773 and P11802 |
Pubmed |
SVM Score :0.0 |
| NA |
|