Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
INTRODUCTION : The purpose of this study was to determine whether the multiple tumor suppressor 2 ( MTS 2 ) gene , encoding an inhibitor ( p 15 ) of cyclin D dependent kinases 4 and 6 ( cdk 4 , cdk 6 ) , is deleted in head and neck squamous cell carcinomas ( HNSCC ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
These alterations include deletions of negative regulatory elements ( TP 53 , CDKN 2 , MTS 2 ) and amplification of positive factors ( MDM 2 , CDK 4 ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
We have isolated cDNA sequences corresponding to the MTS 2 genomic fragment that encodes the CDK 4 and CDK 6 associated p 14 protein . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Recently , two cell cycle regulators that inhibit the cyclin D 1 associated kinases cdk 4 and cdk 6 have been identified : p 16 and p 15 , the products of the INK4A ( also known as CDKN 2 , MTS 1 ) and INK4B ( also known as MTS 2 ) putative tumor suppressor genes located on 9p21 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors . p16INK4a and p15INK4b are cell cycle regulators that specifically bind to and inhibit the cyclin D dependent kinases , cdk 4 and cdk 6 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
One probable pathway for this growth inhibition is through the TGF beta mediated up regulation of the cyclin dependent kinase ( CDK ) inhibitor p15INK4B , which specifically inhibits the enzymatic activities of CDK 4 and CDK 6 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Addition of the antimitogenic cytokine transforming growth factor beta ( TGF beta ) elevates expression of the Cdk4 / 6 specific inhibitor p15Ink4B and induces the release of p 27 from Cdk 4 and Cdk 6 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
The first group , including p16Ink4a , p15Ink4b , p18Ink4c and p19Ink4d , is specific for the G 1 CDKs , CDK 4 and CDK 6 , inhibiting the kinase activity of cyclin D / CDK4 CDK 6 complexes on pRb . p16Ink4a , down regulated by pRb , inhibits G 1 CDKs by competition with cyclin D ; p15Ink4b , the synthesis of which is induced by TGF beta , seems to be a mediator of TGF beta mediated cell cycle arrest . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
It has been proposed that in TGF beta arrested epithelial cells , up regulation of p15INK4B and of p15INK4B binding to cdk 4 serves to destabilize the association of p27Kip1 with cyclin D1 / cdk4 , promoting p27Kip1 binding and inhibition of cyclin E / cdk2 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
As the genes encoding the CDK 4 and CDK 6 inhibitors ( CDK4 / 6 inhibitors ) p16INK4A / CDKN2 / MTS1 and p15INK4B / MTS2 have been found to be altered in many cancer cell lines and primary neoplastic tissues , CDK inhibitors in general and CDK4 / 6 inhibitors in particular are now a se : of candidate tumor suppressors . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Transforming growth factor beta stabilizes p15INK4B protein , increases p15INK4B cdk 4 complexes , and inhibits cyclin D 1 cdk4 association in human mammary epithelial cells . ^^^ As cdk 4 and cdk 6 associated p15INK4B increased during TGF beta arrest of sensitive cells , there was a loss of cyclin D 1 , p21Cip1 , and p27Kip1 from these kinase complexes , and cyclin E cdk 2 associated p27Kip1 increased . ^^^ In HMEC , p15INK4B complexes did not contain detectable cyclin . p15INK4B from both sensitive and resistant cells could displace in vitro cyclin D 1 , p21Cip1 , and p27Kip1 from cdk 4 isolated from sensitive cells . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
We found that status of p 107 , p 130 , p15INK4b , p18INK4c , p21Cip1 , p27Kip1 , cyclin D 1 , and Cdk 4 were not correlated with the growth inhibitory activity of exogenous p16INK4a . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
The tandemly linked p16INK4aMTS1 and p15INK4b / MTS2 genes on chromosome 9 , band p 21 encode proteins that function as specific inhibitors of the cyclin D dependent kinases CDK 4 and CDK 6 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Mutations of p16Ink4 / CDKN2 and p15Ink4B / MTS2 genes in biliary tract cancers . p16Ink4 and p15Ink4B are cyclin dependent kinase 4 inhibitors and link to the regulation of cell cycle in mammalian cells . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
We examined the genomic status of cyclin dependent kinase 4 and 6 inhibitors , p16INK4 , p15INK4B , and p 18 , in 40 primary lung cancers and 31 metastatic lung cancers . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Progression through the G 1 phase of the cell cycle is dependent on the activity of holoenzymes formed between D type cyclins and their catalytic partners , the cyclin dependent kinases cdk 4 and cdk 6 . p16INK4a , p15INK4b , and p18INK4c , a group of structurally related proteins , function as specific inhibitors of the cyclin D dependent kinases and are likely to play physiologic roles as specific regulators of these kinases in vivo . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Tax binding to p15ink4b inactivated its function and restored CDK 4 kinase activity . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
This resistance is associated with low expression of p15ink4b and p16ink4a , constitutive Rb phosphorylation and high levels of cdk 4 and cdk 2 kinase activity . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Both p15INK4B and p15 . 5INK4B bound to CDK 4 and CDK 6 , inhibited DNA synthesis , and caused replicative senescence of a human glioma cell line . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
In this study , we show that BMP 2 did not alter expression of cyclin D , cyclin E , cyclin dependent kinase 2 ( CDK 2 ) , CDK 4 , p27KIP1 , p16INK4a , or p15INK4b , but enhanced expression of p 21 ( CIP1 / WAF1 ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Within the tumor suppressor protein INK 4 ( inhibitor of cyclin dependent kinase 4 ) family , p15INK4B is the smallest and the only one whose structure has not been determined previously , probably due to the protein ' s conformational flexibility and instability . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
In the present study , we analyzed human ovarian carcinoma cell lines for abnormalities in the tumor suppressor gene Rb ( retinoblastoma ) and in cyclin dependent kinase 4 ( CDK 4 ) inhibitor genes ( p16INK4 and p15INK4B ) using molecular biology techniques . ^^^ These data suggest that abnormalities of Rb and CDK 4 inhibitor genes ( p16INK4 , p15INK4B ) may be involved in human ovarian carcinogenesis . . ^^^ Analysis of the Rb gene and cyclin dependent kinase 4 inhibitor genes ( p16INK4 and p15INK4B ) in human ovarian carcinoma cell lines . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Analysis of expression of genes regulating Rb phosphorylation revealed that activin A suppressed cyclin D 2 , the sole D type cyclin gene expressed in the hybridoma cells , and activated p21CIP1 / WAF1 but had no effect on expression of cyclin dependent kinases ( CDK 2 , CDK 4 , CDK 6 ) and other CDK inhibitors ( p27KIP1 , p16INK4a , p15INK4b ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
In epithelial cell lines , TGF beta 1 was previously shown to inhibit cell cycle progression through down regulation of Cdk 4 and / or up regulation of p15INK4b and / or p21WAF1 / Cip1 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
The resulting growth inhibitory effect of HMBA was completely reversible and was analyzed in terms of percent cells in G 1 ; association of D type cyclins with cyclin dependent kinase ( cdk ) 4 and cdk 6 ; G 1 kinase activity ; association of retinoblastoma protein ( pRb ) and phosphorylated pRb with D type cyclins ; and association of p16INK4a , p15INK4b , and p27Kip1 with cdk 4 and cdk 6 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Loss of function of p15INK4b and p16INK4a ( multiple tumor suppressor 1 and CDK 4 inhibitor ) determines impairment in the control of the cell cycle and contributes to the transformation of several cell types . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) is a multifunctional polypeptide that inhibits cellular proliferation in most epithelial cells . cdk 4 and several cyclin dependent kinase ( cdk ) inhibitors ( p15INK4B , p21WAF1 / Cip1 and p27Kip1 ) have been implicated in the TGF beta induced cell cycle arrest . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
The subcellular locations of p 15 ( Ink4b ) and p 27 ( Kip 1 ) coordinate their inhibitory interactions with cdk 4 and cdk 2 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
The four members of the INK 4 gene family , p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) , are known to bind to and inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G1 / S transition in the cell division cycle . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
BACKGROUND : The four members of the INK 4 gene family ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) ) inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G 1 > S transition in the cell division cycle . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
While p15INK4B and its binding to both cdk 4 and cdk 6 increased with increasing passage , some cyclin D 1 bound cdk 4 and cdk 6 persisted in senescent cells , whose inhibition could not be attributed to p15INK4B . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
While members of the INK 4 family ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) interact specifically with CDK 4 and CDK 6 , the CIP / KIP inhibitors p21CIP1 / WAF1 , p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
In Ewing cell lines , cyclin D 1 , CDK 4 , Rb , p27KIP1 and c Myc were consistently highly expressed whereas p57KIP2 , p15INK4B and p14ARF demonstrated undetectable or low expression levels . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Concomitantly , p27Kip1 ( where Kip is kinase inhibitory protein ) was induced markedly , whereas other negative cell cycle regulators , such as p21Cip1 ( where Cip is cyclin dependent kinase interacting protein ) , p15INK4B and p16INK4A ( where INK is inhibitors of cyclin dependent kinase 4 ) , were not , implying its association in the G 1 arrest . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
In addition , we screened the CDKN2B ( p 15 INK4b ) , CDKN2C ( p 18 INK4c ) , CDK 4 and p53R2 genes for mutations in the tumour tissues . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
To improve understanding of the role of this pathway in spermatogenesis , and its subversion in TGCTs , we examined immunohistochemical expression patterns of CDK 4 , p16INK4a , p15INK4b , and pRB , and established an in situ assay for cyclin D mediated phosphorylation of serine 795 , a phosphorylation event critical for neutralization of pRB ' s growth restraining ability . pRB was expressed throughout adult spermatogenesis and was detectable in teratomas , but was absent or grossly reduced in carcinoma in situ ( CIS ) and most seminomas and embryonal carcinomas . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
We found that the expression of cyclin A and p 21 ( WAF 1 ) molecules was primarily modulated by TGFbeta 1 treatment while the expression of other regulatory components , like cyclins D , cyclin E , cdk 2 , cdk 4 , and cdk 6 or p 15 ( INK4B ) , p 16 ( INK4A ) , and p 27 ( KIP 1 ) was not significantly affected . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Alterations of regulatory G ( 1 ) / S phase proteins like the retinoblastoma protein , cyclins D and E , cdk 4 and 6 , cdk inhibitors p 16 ( INK4A ) and p 15 ( INK4B ) , and p 53 are among the most frequent aberrations observed in human malignancies . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Lack of germ line mutations of CDK 4 , p 16 ( INK4A ) , and p 15 ( INK4B ) in families with glioma . ^^^ We hypothesized that germ line mutations in the p 16 ( INK4A ) , p 15 ( INK4B ) , or CDK 4 genes might contribute to some cases of familial gliomas . ^^^ We did not detect any functional mutations in the p 16 ( INK4A ) , p 15 ( INK4B ) , or CDK 4 genes , although two individuals did have a previously described A140T polymorphism in p 16 ( INK4A ) . ^^^ Thus , despite the association between the sporadic forms of high grade glioma and abnormalities of p 16 ( INK4A ) , p 15 ( INK4B ) , or CDK 4 , we found no evidence that germ line mutations in the coding region of these three genes predispose to inherited glial tumors . . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
TGFbeta 1 induces an up regulation of the CDK inhibitor p 15 ( INK4B ) with its subsequent association to CDK 4 , and a decline in CDK 4 protein level . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
We show that c Myc prevents induction of the cdk 4 inhibitor p 15 ( Ink4b ) and the subsequent inhibition of G ( 1 ) cdks by TGF beta . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
The INK 4 ( inhibitor of cyclin dependent kinase 4 ) family consists of four tumor suppressor proteins : p 15 ( INK4B ) , p 16 ( INK4A ) , p 18 ( INK4C ) , and p 19 ( INK4D ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
The INK 4 family of cyclin dependent kinase ( CDK ) inhibitors includes four 15 to 19 kDa polypeptides ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) , and p 19 ( INK4d ) ) that bind to CDK 4 and CDK 6 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Cellular response to oncogenic ras involves induction of the Cdk 4 and Cdk 6 inhibitor p 15 ( INK4b ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Although E2F 1 blocked IL 6 mediated terminal differentiation and its associated growth arrest , it did not prevent the rapid induction of both p 15 ( INK4B ) and p 16 ( INK4A ) , inhibition of cdk 4 kinase activity , and subsequent hypophosphorylation of pRb . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
However , RA had no effect on the levels of cyclins A , D 1 , D 3 , E , or H , or on Cdk 2 , Cdk 4 , Cdk 5 , CDk 6 , Cdk 7 , p 16 ( Ink4A ) , p 15 ( Ink4B ) , p 53 , or pRb proteins in CH 27 cells . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
We did not observe consistent changes in protein levels of cyclin D , cyclin E , CDK 4 , CDK 6 , CDK 2 , p 27 ( Kip 1 ) , p 16 ( INK4a ) , or RNA levels of p 15 ( INK4b ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
This pathway is deregulated in the vast majority of human tumors by genetic and epigenetic alterations that target at least some of its key members such as Cyclin D 1 , Cdk 4 , INK4a and INK4b , pRb etc . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
While expression of the genes for cyclin D 1 , CDK 4 , and E2F1 increased in lung adenocarcinomas relative to normal lung , expression of p 15 ( Ink4b ) , p 16 ( Ink4a ) , p 21 ( Cip 1 ) , p 27 ( Kip 1 ) , p 57 ( Kip 2 ) , and pRb genes decreased in comparison . ^^^ Competitive RT PCR showed that the levels of cyclin D 1 and CDK 4 mRNAs were 2 and 3 fold higher , respectively , in lung adenocarcinomas than in normal lung , while the mRNAs for p 15 ( Ink4b ) , p 16 ( Ink4a ) , p 21 ( Cip 1 ) , p 27 ( Kip 1 ) , and pRb were 3 to 4 fold lower in adenocarcinomas than in normal lung , thus validating the macroarray findings . ^^^ Competitive RT PCR of microdissected lesions also showed that the levels of cyclin D 1 and CDK 4 mRNAs increased significantly , while the mRNAs for p 15 ( Ink4b ) and p 27 ( Kip 1 ) decreased significantly as lung tumorigenesis progressed . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
G 1 arrest was accompanied by a decrease in CDK 2 , CDK 4 , and CDK 6 associated histone H 1 kinase activities , and an increase in the expression levels of cell cycle inhibitors p 27 ( KIP 1 ) and p 15 ( INK4B ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Downregulation of the kinase activities is mediated by induction of cyclin dependent kinase ( CDK ) inhibitor p 15 ( Ink4b ) which blocks CDK 4 and CDK 6 kinases and leads to binding of p 27 ( Kip 1 ) to CDK 2 cyclin E complex . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
In our study , we screened HCCs resulting from HCV infection ( 51 cases ) , HBV infection ( 26 cases ) or excess alcohol intake ( 23 cases ) for alterations in genes involved in the RB 1 pathway ( p 16 ( INK4a ) , p 15 ( INK4b ) , RB 1 , CDK 4 and cyclin D 1 ) , the p 53 pathway ( p 53 , p 14 ( ARF ) and MDM 2 ) and the Wnt pathway ( beta catenin , APC ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
No changes in protein level were observed for CDK 2 , CDK 4 , p 21 ( cip 1 ) , or p 15 ( INK4B ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
The expression of the p 21 ( cip 1 ) , p 15 ( INK4B ) , CDK 4 , and cyclin D 1 proteins was not altered by TGFbeta 1 , treatment , except in one cell line that displayed a slight increase in p 21 protein . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
CDKN 2 and CDKN2B belong to a family of cyclin dependent kinase 4 inhibitors ( INK 41 ) and control cell proliferation during the G 1 phase of the cell cycle . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
CDKN2A and CDKN2B inhibit cyclin dependent kinase 4 ( CDK 4 ) and CDK 6 and control cellular proliferation by preventing entry into the S phase of the cell cycle . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Analysis of the CDKN2A , CDKN2B and CDK 4 genes in 48 Australian melanoma kindreds . ^^^ All of these families have now been screened for mutations within CDKN2A and CDK 4 , as well as for mutations within the CDKN2A homolog and 9p21 neighbor , the CDKN2B gene , and the alternative exon 1 ( E1beta ) of CDKN2A . ^^^ In none of the ' CDKN2A negative ' families was melanoma found to segregate with either an untranscribed CDKN2A allele , an R24C CDK 4 mutation , a CDKN2B mutation , or an E1beta mutation . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Surprisingly , at the DNA level alone , 96 % ( 43 / 45 ) of melanoma cell lines examined were found to be deleted / mutated / methylated for CDKN2A ( 34 / 45 ) , homozygously deleted for CDKN2A ' s neighbor and homolog CDKN2B ( 6 / 45 ) , and / or mutated / amplified for CDK 4 ( 5 / 45 ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Components of the pRb pathway which are often altered in tumour progression include the INK 4 cyclin dependent kinase ( CDK ) inhibitors p16INK4a / CDKN2A and p15INK4b / CDKN2B , CDK 4 , D type cyclins and pRb . ^^^ CDK 4 was mutated or overexpressed in two melanoma cell lines with homozygously deleted CDKN2A and CDKN2B genes . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
These include mutation and / or deletion of the retinoblastoma ( RB 1 ) gene , homozygous deletion of the CDKN2A and CDKN2B genes , as well as amplification and overexpression of the CDK 4 and CDK 6 genes . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
In total , 11 / 12 MPNSTs showed DNA changes in one or more of the genes CDKN2A , CDKN2B , RB 1 , CDK 4 , MDM 2 , and CCND 2 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Sixty seven percent of GBs ( 91 / 136 ) and 21 % of AAs ( 8 / 39 ) had abnormalities of the G 1 S control system either by mutation / homozygous deletion of RB 1 , CDKN2A or CDKN2B , or amplification of CDK 4 . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
A single nucleotide polymorphism in the 3 ' untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B , CDKN2C , CDK 4 and p 53 genes are rare . ^^^ In this report we present the results of mutational analysis of the CDKN2B , CDKN2C , CDK 4 , p 53 genes and 5 ' UTR of the CDKN2A gene in a set of 44 sporadic primary melanomas , which had been earlier analysed for mutations in the CDKN2A ( p16 / p14 ( ARF ) ) gene . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
These included 3 genes coding for proteins in the p 53 pathway ( i . e . , TP 53 , p 14 ( ARF ) , and MDM 2 ) , 4 in the Rb 1 pathway ( i . e . , CDKN2A , CDKN2B , RB 1 , and CDK 4 ) , as well as PTEN and epidermal growth factor receptor . ^^^ RESULTS : We found that abnormalities in any of the four genes ( CDKN2A , CDKN2B , RB 1 , and CDK 4 ) coding for components of the Rb 1 pathway were associated with shorter survival ( P = 0 . 002 ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
Putative tumour suppressor genes CDKN2A and CDKN2B ( on chromosome 9p21 ) and CDKN2A interacting cell growth regulatory genes CDK 4 and Id 1 have been demonstrated to be involved in the pathogenesis of malignant melanoma ( MM ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
These included three genes coding for proteins in the p 53 pathway ( TP 53 , p 14 ( ARF ) and MDM 2 ) , four in the Rb 1 pathway ( CDKN2A , CDKN2B , RB 1 and CDK 4 ) and PTEN and EGFR . ^^^ We found that loss of both wild type copies of any of the three tumour suppressor genes CDKN2A , CDKN2B and RB 1 or gene amplification of CDK 4 , disrupting the Rb 1 pathway , were associated with shorter survival ( P=0 . 009 ) . ^^^
Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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Interacting proteins: P42772 and P11802	Pubmed	SVM Score :0.0
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