| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.55465988 |
| Here we show that in a squamous carcinoma cell line with 11 fold amplification of the CCND 1 gene , cyclin D 1 associates specifically with p33cdk4 ( PSK J 3 ) and p38cdk6 ( PLSTIRE ) , two closely related members of the cyclin dependent kinase ( CDK ) family . 0.55465988^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Cyclin D 1 ( CCND 1 ) and its catalytic partner cyclin dependent kinase 4 ( cdk 4 ) are known to play important roles in the G1 / S check point of the cell cycle , and CCND 1 overexpression has been reported to correlate with progression and prognosis of breast cancers . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| Melanomas with wild type BRAF or N RAS frequently had increases in the number of copies of the genes for cyclin dependent kinase 4 ( CDK 4 ) and cyclin D 1 ( CCND 1 ) , downstream components of the RAS BRAF pathway . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| Homozygous deletion frequency and expression levels of the CDKN 2 gene in human sarcomas relationship to amplification and mRNA levels of CDK 4 and CCND 1 . ^^^ Amplifications of CDK 4 and CCND 1 ( cyclin D 1 ) were observed in 11 % and 4 % of the sarcomas respectively , but never in tumours with CDKN 2 deletions . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| Amplification of the other two genes may not be important in the tumorigenesis of melanomas , as only one CDK 4 and no CCND 1 amplification was observed . ^^^ However , highly elevated CDK 4 mRNA levels , compared with that seen in a panel of normal tissues , were observed in 76 % of the tumours , accompanied in 71 % of the cases by high expression of the CCND 1 cyclin activator . ^^^ Although a low frequency of CDKN 2 DNA aberrations was observed , the high number of tumours that lacked CDKN 2 expression but showed overexpression of CDK 4 and / or CCND 1 , suggest that functional inactivation of pRb through this pathway may be involved in the development or progression of sporadic human melanomas . . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| In the glioblastomas with no alterations of CDKN2A , CDK 4 or RB 1 , several other genes ( CCND 1 , CCND 2 , CCND 3 , CDK 6 , E2F , CDK 7 , MYC and MYCN ) whose products take part in cell cycle regulation were examined . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| We investigated the status and expression of p 16 , p 15 , CCND 1 , CDK 4 and RB genes in the Ewing family of tumors . ^^^ Although no evidence for CDK 4 or CCND 1 amplification was obtained , expression of these genes varied considerably in the cell lines in a case specific manner . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| Twenty primary central nervous system lymphomas ( PCNSL ) from immunocompetent patients ( nineteen B cell lymphomas and one T cell lymphoma ) were investigated for genetic alterations and / or expression of the genes BCL 2 , CCND 1 , CDK 4 , CDKN1A , CDKN2A , MDM 2 , MYC , RB 1 , REL , and TP 53 . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| In two of these 43 cases , homozygous deletions of CDKN2A were detected along with a CDK 4 mutation or amplification of the cyclin D 1 ( CCND 1 ) gene . ^^^ These results suggest that ( 1 ) only melanoma cells with alterations in this pathway can be propagated in culture , and ( 2 ) the homozygous deletions on 9p21 in the cell lines , which are also mutated / amplified for CDK 4 or CCND 1 , could serve to target tumor suppressor genes other than CDKN2A . . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| We investigated overexpression of cyclin D 1 ( CCND 1 ) , cyclin D 2 ( CCND 2 ) , cyclin E ( CCNE ) , CDK 2 , and CDK 4 , in addition to p 27 , in 260 gastric cancer cases on the basis of Western blots , reverse transcriptase polymerase chain reaction Southern blots , and immunohistochemistry to clarify the roles of these proteins in tumor progression and prognosis . ^^^ Immunohistochemistry demonstrated 21 . 5 % , 34 . 2 % , 30 . 4 % , 44 . 2 % , and 48 . 0 % positivity for CCND 1 , CCND 2 , CCNE , CDK 2 , and CDK 4 , respectively , in the 260 gastric cancer cases . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| To investigate whether alteration of other components in pRb pathway is an alternative mechanism underlying the development of these chemically induced lymphomas , we have examined the genetic status of Rb 1 , Ccnd 1 and Cdk 4 genes that encode retinoblastoma protein , cyclin D 1 and cyclin dependence kinase 4 , respectively . ^^^ Gross alterations of the Rb 1 , Ccnd 1 , and Cdk 4 genes were not detected by Southern analysis in any of the tumors examined . ^^^ These results indicate that the mechanisms underlying the development of 2 ' , 3 ' dideoxycytidine and 1 , 3 butadiene induced lymphomas involve inactivation of p16 / p15 cyclin dependent kinase inhibitors but not genomic alterations of the Rb 1 , Ccnd 1 and Cdk 4 genes . . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| To compare the expression status of G 1 cyclins , these EBV associated lymphoma lines ( 6 EBV [ ] human SCID mouse lymphoma lines , 13 human B cell lymphomas and 8 samples of human tonsil tissue ) were examined by reverse transcription polymerase chain reaction Southern blotting , Western blotting and immunohistochemistry . mRNA expression of cyclin D 1 ( CCND 1 ) , cyclin D 2 ( CCND 2 ) , cyclin E ( CCNE ) , cyclin dependent kinase 2 ( CDK 2 ) and 4 ( CDK 4 ) was found in all 3 types of lymphomas . ^^^ Immunoprecipitation of EBV ( + ) and ( ) SCID mouse lymphomas for CCND 1 , CCND 2 and CCNE vs . p 21 , PCNA and CDK 2 or CDK 4 demonstrated that , in EBV ( + ) SCID lines , CCND2 / CDK4 complexes were present without binding to p 21 , suggesting independence from p 21 regulation . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| To elucidate the biochemical processes involved in the pathogenesis of B CLL and MCL , we analyzed the expression level of a set of genes that play central roles in apoptotic or cell proliferation pathways and of candidate genes from frequently altered genomic regions , namely ATM , BAX , BCL 2 , CCND 1 , CCND 3 , CDK 2 , CDK 4 , CDKN1A , CDKN1B , E2F1 , ETV 5 , MYC , RB 1 , SELL , TFDP 2 , TNFSF 10 , and TP 53 . ^^^ Statistical analysis of the expression data revealed the combination of CCND 1 and CDK 4 as the best classifier concerning separation of both lymphoma types . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| Matrix CGH revealed copy number gains of numerous oncogenes , i . e . , CCND 1 , MDM 2 , GLI , CDK 4 , MYB , ESR 1 , and AIB 1 , several of which correlate with a high level of transcripts from the respective gene . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| In cells exposed to rapamycin , we observed a dose dependent downregulation of CCND 1 ( cyclin D 1 ) and CDK 4 gene expression and late G 1 cell cycle arrest . ^^^ These results indicate that baseline Bcl 2 expression and therapy induced downexpression of CCND 1 and CDK 4 may be regarded as molecular markers enabling the prediction and follow up of the cellular effects on cell cycle and apoptosis induction of rapamycin in ovarian cancer . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| The expression status of the three cyclin D genes ( CCND 1 , CCND 2 and CCND 3 ) , the two cyclin D dependent kinase genes ( CDK 4 and CDK 6 ) and the p 16 ( INK4a ) gene was studied in a series of 47 Wilms ' tumors , 16 normal mature kidneys and two fetal kidneys . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| To determine whether known oncogenes take part in genomic rearrangements and to investigate the potential clinical significance of their amplifications , nine known oncogenes ( CMYC , MDM 2 , GLI 1 , CDK 4 , HER 2 , EGFR 1 , CCND 1 , FGF 3 , EMS ) were analyzed by fluorescent in situ hybridization ( FISH ) on a tissue microarray ( TMA ) containing 94 primary GIST . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| Microarray CGH more specifically detected genetic imbalances including gains in MDM 2 , MSH 2 , KCNK 12 , DCC , CDK 2 , ERBB 3 , SAS , and CDK 4 and losses in HRAS , RASSF 1 , and CCND 1 . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| Subsequent fluorescence in situ hybridization ( FISH ) analyses confirmed loss of the p 53 gene locus on the derivative chromosome 17 homolog and were negative for amplification of the MDM 2 , CDK 4 , c MYC , HER 2 / neu , CCND 1 , and COPS 3 gene loci . ^^^ |
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| Interacting proteins: P11802 and P24385 |
Pubmed |
SVM Score :0.0 |
| Many mechanisms may be responsible for activating the RB Cyclin D 1 pathway , including activating ( CDK 4 ) and inactivating mutations ( p16INK4A ) , deletions ( RB and p16INK4A ) , amplifications ( CCND 1 and CDK 4 ) , silencing methylation ( p16INK4A and RB ) , and hyper phosphorylation ( RB ) . ^^^ |
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