| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.95527253 |
| Association of CDK 4 with both CDC 37 and HSP 90 may also imply a mechanistic link between the functions of CDC 37 and HSP90 . . 0.95527253^^^ We have detected a specific association of CDK 4 with the molecular chaperon HSP 90 and a 44 kDa protein that we identify as mammalian CDC 37 . 0.68676857^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.73502763 |
| The facts that Hsp 90 interacts with Cdk 4 and that its inhibition induced Cdk 4 and cyclin D 1 translocation to the cytoplasm point to Hsp 90 as a good candidate for being the calmodulin binding protein involved in the nuclear accumulation of Cdk 4 and cyclin D1 . . 0.73502763^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| In addition , Hsp 90 family chaperone associated proteins , such as p185erbB2 , Raf 1 , cyclin dependent kinase 4 , and mutant p 53 , were depleted by KF 25706 at a dose comparable to that required for antiproliferative activity . ^^^ Finally , we confirmed the depletion of Hsp 90 associated signaling molecules ( Raf 1 and cyclin dependent kinase 4 ) with ex vivo Western blotting analysis using MX 1 xenografts . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| Mammalian p50Cdc37 is a protein kinase targeting subunit of Hsp 90 that binds and stabilizes Cdk 4 . ^^^ In insect cells , Cdc 37 is sufficient to target Hsp 90 to Cdk 4 and both in vitro and in vivo , Cdc37 / Hsp90 associates preferentially with the fraction of Cdk 4 not bound to D type cyclins . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| The relative stability of other proteins that associate with hsp 90 was determined with the following rank order of sensitivity to GA exposure : AhR > > c Raf 1 > glucocorticoid receptor > CDK 4 > > p 50 . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| The Cdc 37 gene encodes a 50 kDa protein which targets intrinsically unstable oncoprotein kinases such as Cdk 4 , Raf 1 , and src to the molecular chaperone Hsp 90 . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| CDC 37 encodes a 50 kDa protein that targets intrinsically unstable oncoprotein kinases including Cdk 4 , Raf 1 , and 5 src to the molecular chaperone Hsp 90 , an interaction that is thought to be important for the establishment of signaling pathways . ^^^ |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| Hsp 90 is a chaperone required for the conformational maturation of certain signaling proteins including Raf , cdk 4 , and steroid receptors . ^^^ |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| A particularly attractive feature of Hsp 90 as a cancer drug target is that it is required for the conformational stability and function of a wide range of oncogenic ' client ' proteins , including c Raf 1 , Cdk 4 , ErbB 2 , mutant p 53 , c Met , Polo 1 and telomerase hTERT . ^^^ |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| As a consequence Hsp 90 chaperone functionality is abrogated and the client proteins , mutant p 53 , Cdk 4 , Raf 1 , and Plk , are displaced from complexes with Hsp 90 , destabilized , and degraded via a proteasome independent pathway . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| However , in contrast to wild type Cdk 4 , Cdk 4 ( G15A ) , and Cdk 4 ( G18A ) had greatly reduced binding of cyclin D 1 , Cdc 37 , and Hsp 90 . ^^^ |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| Heat shock protein 90 ( HSP 90 ) is involved in the folding of proteins such as signal transduction molecules ( Src , Raf 1 , cdk 4 ) and steroid receptors and in enhancing the activity of telomerase and nitric oxide synthase . ^^^ |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| The compounds induce upregulation of HSP 70 and downregulation of the known HSP 90 client proteins Raf 1 , CDK 4 , and ErbB 2 , confirming that the molecules inhibit cell growth by a mechanism dependent on HSP 90 inhibition . ^^^ |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| Levels of known Hsp 90 client proteins such as phosphorylated AKT followed by AKT , cyclin D 1 preceding cdk 4 , and craf 1 declined as a result of drug treatment in all three melanoma cell lines . ^^^ |
|
| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| This mutant can bind not only other Hsp 90 client protein kinases , Akt 1 , Aurora B and Cdk 4 , but also Cdc 2 and Cdk 2 , which to date have not been shown to physically interact with Cdc 37 . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| Consistent with similar work done with the cyclin dependent kinase relative Cdk 4 , the presence of the G box motif of Cdk 2 was shown to be critical for Cdc 37 binding , whereas consistent with work done with the Src family tyrosine kinase Lck , the presence of helix alphaC and the stabilization of helix alphaE were shown to be needed for Hsp 90 binding . . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| Upregulation of p 16 ( INK4A ) , Hsp 90 , and Cdc 37 genes ; an increase in Cdc 37 Cdk4 complexes ; and a decrease in p 16 ( INK4A ) Cdk 4 complexes occurred in preneoplastic liver , nodules , and hepatocellular carcinoma of F 344 rats . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| Blockade of Hsp 90 results in reduced cellular levels of several proteins implicated in cancer including CDK 4 , ERBB 2 and C RAF , and causes simultaneous inhibition of cancer cell proliferation in culture and of tumor xenograft growth in vivo . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| Pharmacodynamic endpoints , such as induction of HSP 70 and downregulation of C RAF and CDK 4 in peripheral blood mononuclear cells and tumor biopsies from treated patients , provided evidence of HSP 90 inhibition at well tolerated doses . ^^^ |
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| Interacting proteins: P11802 and P07900 |
Pubmed |
SVM Score :0.0 |
| Structure of an Hsp 90 Cdc37 Cdk 4 complex . ^^^ We have now expressed and purified an Hsp 90 Cdc37 Cdk 4 complex , defined its stoichiometry , and determined its 3D structure by single particle electron microscopy . ^^^ Comparison with the crystal structure of Hsp 90 allows us to identify the locations of Cdc 37 and Cdk 4 in the complex and suggests a mechanism by which conformational changes in the kinase are coupled to the Hsp 90 ATPase cycle . . ^^^ |
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