| Interacting proteins: Q99704 and P06213 |
Pubmed |
SVM Score :0.0 |
| Because the other known PH PTB proteins ( insulin receptor substrates : IRS 1 , IRS 2 , IRS 3 , and IRS 4 , and the downstream of kinases : DOK 1 , DOK 2 , and DOK 3 ) are substrates of insulin and insulin like growth factor ( IGF ) 1 receptors , we asked whether these new proteins , termed IRS5 / DOK4 and IRS6 / DOK5 , might also have roles in insulin and IGF 1 signaling . ^^^ |
|
| Interacting proteins: Q99704 and P06213 |
Pubmed |
SVM Score :0.0 |
| This transfer is mediated by an insulin receptor substrate 1 related protein termed DOK 1 . ^^^ |
|
| Interacting proteins: Q99704 and P06213 |
Pubmed |
SVM Score :0.0 |
| DOK 1 is a member of insulin receptor substrate protein family that binds beta 3 and contains YXXL / I motifs that are potential binding sites for SHP 2 . ^^^ |
|
| Interacting proteins: Q99704 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase activating protein and Nck and is essential for inhibiting insulin stimulated activation of Ras and Akt . ^^^ |
|
| Interacting proteins: Q99704 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99704 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|