| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.71174978 |
| Caveolin 1 interacts with the insulin receptor and can differentially modulate insulin signaling in transfected Cos 7 cells and rat adipose cells . 0.71174978^^^ |
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| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor catalyzes the tyrosine phosphorylation of caveolin 1 . ^^^ |
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| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| The role of caveolin 1 in the Insulin Receptor ( IR ) signalling has been well investigated . ^^^ |
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| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Both caveolae fractions contained caveolin 1 and the insulin receptor . ^^^ |
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| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| We report here that tyrosine phosphorylation of caveolin is detected only in fully differentiated adipocytes , not in fibroblasts ( preadipocytes ) , despite the fact that both cell types express caveolin 1 and active insulin receptor . ^^^ |
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| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| To address this issue , we examined the status of insulin receptor signaling in caveolin 1 ( / ) deficient ( Cav 1 null ) mice . ^^^ In support of this notion , we demonstrate that recombinant expression of caveolin 1 in Cav 1 null mouse embryo fibroblasts rescues insulin receptor protein expression . ^^^ Caveolin 1 deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue . ^^^ However , it remains unknown whether caveolin 1 is normally required for proper insulin receptor signaling in vivo . ^^^ These data suggest that caveolin 1 acts as a molecular chaperone that is necessary for the proper stabilization of the insulin receptor in adipocytes in vivo . ^^^ |
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| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| It has now become apparent that effective insulin signaling in the adipocyte may be strictly dependent on localization of at least two insulin responsive elements to caveolae ( insulin receptor and GLUT 4 ) , as well as on a direct functional interaction between caveolin 1 and the insulin receptor . ^^^ |
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| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Despite the near total down regulation of caveolin 1 expression , the lipid raft targeting of diverse signaling proteins ( including the endothelial isoform of nitric oxide synthase , Src family tyrosine kinases , Galphaq and the insulin receptor ) was unchanged . ^^^ |
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| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Dissociation of insulin receptor expression and signaling from caveolin 1 expression . ^^^ Likewise , we determined that insulin dependent insulin receptor and IRS 1 tyrosine phosphorylation was not significantly different in the four cell lines representing parental , low , medium , and high levels of caveolin 1 expression . ^^^ We conclude that insulin receptor expression and ligand dependent signaling is independent of caveolin 1 expression . . ^^^ |
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| Interacting proteins: P06213 and Q03135 |
Pubmed |
SVM Score :0.0 |
| We now found that impairment of glimepiride induced lipolytic cleavage of GPI proteins in rat adipocytes by the novel inhibitor of glycosylphosphatidylinositol specific phospholipase C ( GPI PLC ) , GPI 2350 , caused almost complete blockade of ( 1 ) dissociation from caveolin 1 of pp 59 ( Lyn ) and GPI proteins , ( 2 ) their redistribution from high cholesterol ( hcDIGs ) to low cholesterol containing ( lcDIGs ) lipid rafts , ( 3 ) tyrosine phosphorylation of pp 59 ( Lyn ) and insulin receptor substrate 1 protein ( IRS 1 ) and ( 4 ) stimulation of glucose transport as well as ( 5 ) inhibition of isoproterenol induced lipolysis in response to glimepiride . ^^^ |
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