| Interacting proteins: P56539 and P06213 |
Pubmed |
SVM Score :0.0 |
| We found that overexpression of caveolin 3 augmented insulin stimulated phosphorylation of insulin receptor substrate 1 in 293T cells but not the phosphorylation of insulin receptor . ^^^ Furthermore , the insulin receptor bound to immobilized caveolin peptides , and this binding was inhibited in the presence of free caveolin 3 peptides . ^^^ |
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| Interacting proteins: P56539 and P06213 |
Pubmed |
SVM Score :0.0 |
| Caveolin 3 knockout mice show increased adiposity and whole body insulin resistance , with ligand induced insulin receptor instability in skeletal muscle . ^^^ |
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| Interacting proteins: P56539 and P06213 |
Pubmed |
SVM Score :0.0 |
| We also demonstrate that caveolin 3 , a marker of caveolae , is required for the insulin receptor mediated activation of the PI3K dependent pathway , which occurs 2 min after insulin stimulation . ^^^ Interestingly , caveolin 3 moves away from the plasma membrane toward the cytoplasm 5 min after insulin stimulation and temporarily interacts with flotillin 1 / GLUT4 containing domains before they reach the sarcolemma , with the consequent movement of the insulin receptor from caveolin 3 containing domains to flotillin 1 containing domains . ^^^ |
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